1. Application value of liquid fiducial marker in image-guided radiotherapy
- Author
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HUANG Yulin, YANG Haifang, JIANG Bin, ZHANG Wang, ZHANG Chao, LIU Jianping, and TIAN Long
- Subjects
liquid fiducial marker ,image guided radiotherapy ,application value ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
This study was conducted to evaluate the application value of a degradable liquid fiducial marker (LFM) in image-guided radiotherapy. In vitro experiment: using a solid fiducial marker (SFM) as a reference, the visibility, artifact, and optimal injection volume of an LFM under different cone beam CT tube voltage conditions were evaluated. In vivo experiment: using the SFM as a reference, the stability and degradation status of the LFM in nude mice were evaluated. Nude mice implanted with tumor cells were randomly divided into four groups: single fraction radiotherapy group (16 Gy/fraction) without LFM injection, single fraction radiotherapy group (16 Gy/fraction) with LFM injection, 2 fractions radiotherapy group (8 Gy/fraction) with LFM injection, and 4 fractions radiotherapy group (4 Gy/fraction) with LFM injection. The impact of LFM on tumor growth was evaluated based on the irradiation results. Compared with SFM, the LFM artifacts were significantly smaller (all p
- Published
- 2023
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