109 results on '"Y. Tanikawa"'
Search Results
2. The prevalence of primary neck and shoulder pain, and its related factors in Japanese postpartum women
- Author
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H. Matsuo, K. Adachi, Y. Tanikawa, N. Ueyama, M. Kinkawa, and K. Koyasu
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Reproductive Medicine ,Obstetrics and Gynecology - Published
- 2015
3. Image Stabilization for In Vivo Microscopy by High-Speed Visual Feedback Control
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Yoshihiko Nakamura, T. Toujo, Sungon Lee, Katsu Yamane, H. Takahashi, Y. Tanikawa, and S. Takahashi
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Computer science ,business.industry ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Image processing ,Robotics ,Visual servoing ,Visual control ,Computer Science Applications ,law.invention ,Lens (optics) ,Image stabilization ,Control and Systems Engineering ,law ,Motion estimation ,Control system ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,business - Abstract
This paper presents image stabilization for microscopy using horizontal visual feedback control of the objective lens through a five-bar linkage and piezoelectric actuators, and its application to in vivo imaging. Even very small in vivo motion due to heartbeat and breathing makes microscopic observation difficult by blurring the microscope image or impossible by sending a region of interest out of view. In order to remove those unwanted effects of the motion, we have introduced motion-canceling robotic technologies into microscopy. Our image stabilization system through motion-canceling provides users with stabilized image sequences with respect to trembling of in vivo subjects. The developed image stabilization system, in term of robotics, corresponds to a visual feedback control system that consists of a robotic mechanism and a high-speed vision. A high-speed camera installed in the microscope detects the motion of the in vivo subject having topically applied fiducials. To virtually cancel this motion, we move the objective lens, synchronizing the motions of the subject and the lens to remove the relative motion between the two. As a result, we observe motion-free images to m. This technology is one of the very demanding technologies in biological research for in vivo observation with high resolution. In this paper, we verify the effectiveness of the developed system through in vivo experiments.
- Published
- 2008
4. The prevalence of primary neck and shoulder pain, and its related factors in Japanese postpartum women
- Author
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K, Koyasu, M, Kinkawa, N, Ueyama, Y, Tanikawa, K, Adachi, and H, Matsuo
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Adult ,Neck Pain ,Time Factors ,Depression ,Postpartum Period ,Severity of Illness Index ,Premenstrual Syndrome ,Breast Feeding ,Japan ,Pregnancy ,Risk Factors ,Shoulder Pain ,Surveys and Questionnaires ,Prevalence ,Quality of Life ,Humans ,Female - Abstract
This study investigated the prevalence, location, and severity of neck and shoulder pain (NSP), its disturbance of quality of life (QOL), and the factors related to NSP in Japanese postpartum women.The study involved 308 postpartum women who had a medical examination one month after delivery. The questionnaire consisted of the background and details of NSP. Mood states were evaluated using the Profile of Mood States-Brief (POMS-B), Japanese Version.The prevalence of NSP was 73.1%, one-fourth of which occurred after birth. The most common area was the superior part of the trapezium muscles. Prevalence was associated with past history of premenstrual syndrome (PMS), anemia during pregnancy, time per breastfeeding, and the mean POMS-B Fatigue score. Total breastfeeding time a day, the mean POMS-B score for Fatigue, Confusion, Anger-Hostility, and Depression were significantly higher for "worse" after birth than those for "no-change/relief". The disturbance of daily life due to NSP in postpartum women with past history of PMS and Hiesho were significant higher than that for women without those.The prevalence of NSP in postpartum women was very high. The factors which affect NSP were the mental states, breastfeeding, past history of PMS, and anemia during pregnancy.
- Published
- 2015
5. The Influx of Serum Albumin to Enamel Matrix in Rat Incisors after Trauma
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S. Tanase, Noémi Rózsa, Y. Tanikawa, I. Tarján, and Nobukazu Wakamatsu
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Pathology ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Hemorrhage ,Immunoenzyme Techniques ,Endocrinology ,stomatognathic system ,Amelogenesis ,Ameloblasts ,medicine ,Animals ,Orthopedics and Sports Medicine ,Serum Albumin ,Enamel paint ,Chemistry ,Outer enamel epithelium ,Inner enamel epithelium ,Enamel Organ ,Enamel organ ,Anatomy ,Enamel hypoplasia ,Enamel hypocalcification ,medicine.disease ,Rats ,Incisor ,stomatognathic diseases ,Animals, Newborn ,visual_art ,visual_art.visual_art_medium ,Autoradiography ,Ameloblast - Abstract
The most frequent results of trauma to tooth germs are enamel hypoplasia and enamel hypocalcification. These differing results may be due to the stage of amelogenesis at which trauma occurs. The cellular and biomolecullar events involved in the genesis of these defects are poorly understood. We hypothesized that one factor involved is the possibility that relatively high levels of serum albumin enter the enamel matrix through the damaged enamel organ, and impair mineralization of the matrix. The present study was undertaken to immunohistochemically and autoradiographically localize serum albumin in the enamel organs of rat incisors after trauma was inflicted to the mandibular incisor region of 4-day-old rats. Hemorrhage was seen surrounding the enamel organ and between the detached secretory-stage ameloblasts. One day after trauma, the most intense immunohistochemical (IHC) staining for albumin was localized in the outer layer of the enamel matrix adjacent to the detached secretory-stage ameloblasts. Albumin was also detected autoradiographically in the secretory-stage ameloblasts layer and enamel matrix. These findings indicate that serum albumin can leak between the detached ameloblasts and penetrate the enamel matrix after trauma. Leaked albumin was still present in the matrix during the maturation stage. Leaked albumin in the developing enamel could inhibit crystal growth and result in hypocalcification.
- Published
- 2002
6. Whole-Genome Effects of Ethyl Methanesulfonate-Induced Mutation on Nine Quantitative Traits in Outbred Drosophila melanogaster
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Alexey S. Kondrashov, Ana Y. Tanikawa, Wayne A. Van Voorhies, Joana C. Silva, and Hsiao Pei Yang
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Male ,Time Factors ,X Chromosome ,Ethyl methanesulfonate ,Genetic Linkage ,Offspring ,media_common.quotation_subject ,Genes, Recessive ,Quantitative trait locus ,chemistry.chemical_compound ,Quantitative Trait, Heritable ,Genetics ,Animals ,Allele ,Alleles ,Crosses, Genetic ,media_common ,Genome ,biology ,Temperature ,Longevity ,biology.organism_classification ,Fecundity ,Drosophila melanogaster ,chemistry ,Ethyl Methanesulfonate ,Infertility ,Mutation ,Epistasis ,Female ,Photoreceptor Cells, Invertebrate ,Mutagens ,Research Article - Abstract
We induced mutations in Drosophila melanogaster males by treating them with 21.2 mm ethyl methanesulfonate (EMS). Nine quantitative traits (developmental time, viability, fecundity, longevity, metabolic rate, motility, body weight, and abdominal and sternopleural bristle numbers) were measured in outbred heterozygous F3 (viability) or F2 (all other traits) offspring from the treated males. The mean values of the first four traits, which are all directly related to the life history, were substantially affected by EMS mutagenesis: the developmental time increased while viability, fecundity, and longevity declined. In contrast, the mean values of the other five traits were not significantly affected. Rates of recessive X-linked lethals and of recessive mutations at several loci affecting eye color imply that our EMS treatment was equivalent to ∼100 generations of spontaneous mutation. If so, our data imply that one generation of spontaneous mutation increases the developmental time by 0.09% at 20° and by 0.04% at 25°, and reduces viability under harsh conditions, fecundity, and longevity by 1.35, 0.21, and 0.08%, respectively. Comparison of flies with none, one, and two grandfathers (or greatgrandfathers, in the case of viability) treated with EMS did not reveal any significant epistasis among the induced mutations.
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- 2001
7. 2. Cosmic Ray Research in Japan before World War II, Taketani's Methodology and the Meson Theory, Social and Political Background
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Y. Tanikawa, Yoichi Fujimoto, Ziro Maki, T. Takabayasi, Rokuo Kawabe, Laurie M. Brown, S. Hayakawa, M. Nagasaki, T. Tsuji, M. Kobayasi, and M. Konuma
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Physics ,Physics and Astronomy (miscellaneous) ,media_common.quotation_subject ,World War II ,Cosmic ray ,nobody ,Field (geography) ,Epistemology ,Politics ,Theoretical physics ,Subtitle ,Function (engineering) ,Nature study ,media_common - Abstract
Hayakawa Most of my discussion this morning will be based upon my book Cosmic Rays. This is a semi-popular book, whose aim was to present the nature of cosmic ray research to non-scientists. I) I feel, although I am not a historian, that the study of history of science is very important if we try to predict what developments may come in the near future. I am responsible for a branch of the Institute of Plasma Physics, which is involved in the planning of research. As an example of the kind of study which can be useful, here is a graph showing the number of papers per year on solitons as a function of time: 2l,3l The curve shows a knee around 1965, and can be analyzed into two parts. The first one corresponds to the interest in solitons in lattice dynamics and plasma physics; second part which shows a steep rise is related to their use in elementary particle physics. The study shows that one should enter a field when the slope is positive, and not when the excitement is all over. Unless you intend to be the person responsible for the beginning of the positive slope ! The vertical scale of the graph corresponds, by the way, to something like 200 papers per year in the last year. Now turning to cosmic rays, the subtitle of my book translates as something like: Progress in the Study of Nature. Nobody even knew of the existence of cosmic rays before the present century, although they must have existed even before the earth was born. Knowledge of their existence is closely related to the development of instru
- Published
- 1991
8. 3. Particle Physics in Japan in the 1940's Including Meson Physics in Japan after the First Meson Paper
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Y. Nogami, M. Konuma, T. Takabayasi, M. Kobayasi, T. Tsuji, Ziro Maki, Y. Tanikawa, Yoichi Fujimoto, Laurie M. Brown, and S. Hayakawa
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Nuclear physics ,Physics ,Particle physics ,Physics and Astronomy (miscellaneous) ,Meson - Published
- 1991
9. Influence of habitual physical activity in late pregnancy on the duration of labor
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Yoko Okuyama, S. Tanaka, M. Shirakata, Rei Ono, Yuki Kondo, Ryuichi Sawa, Masayo Takada, Aoi Ebina, Hiromi Fujii, K. Soke, and Y. Tanikawa
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medicine.medical_specialty ,Duration (music) ,Obstetrics ,business.industry ,Physical activity ,medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business ,Late pregnancy - Published
- 2015
10. Influence of kinesiophobia at late pregnancy on depression at 1 month after delivery among pregnant women with pregnancy-related lumbopelvic pain
- Author
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Y. Tanikawa, Yoko Okuyama, Hiromi Fujii, Ryuichi Sawa, Rei Ono, Masayo Takada, M. Shirakata, K. Soke, Yuki Kondo, S. Tanaka, and Aoi Ebina
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medicine.medical_specialty ,Pregnancy ,Kinesiophobia ,business.industry ,International studies ,Physical Therapy, Sports Therapy and Rehabilitation ,medicine.disease ,Late pregnancy ,Health science ,Family medicine ,Community health ,Physical therapy ,medicine ,business ,Depression (differential diagnoses) ,Biomedical sciences - Abstract
A. Ebina 1, R. Sawa2, Y. Kondo1, M. Takada3, H. Fujii 3, Y. Okuyama3, Y. Tanikawa4, K. Soke5, S. Tanaka5, M. Shirakata 5, R. Ono2 1 Faculty of Health Science, School of Medicine, Kobe University, Kobe, Japan; 2 Kobe University Graduate School of Health Sciences, Department of Community Health Sciences, Kobe, Japan; 3 Faculty of Nursing, Kobe City College of Nursing, Kobe, Japan; 4 Faculty of Health Science, Kansai University of International Studies, Miki, Japan; 5 Nadeshiko Ladies Hospital, Kobe, Japan
- Published
- 2015
11. A 64 b RISC microprocessor for a parallel computer system
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T. Okamoto, Katsuyuki Kaneko, J. Nishikawa, Hiroshi Kadota, Y. Nakakura, Y. Tanikawa, M. Nakajima, and S. Gokita
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Very-large-scale integration ,Instructions per cycle ,Reduced instruction set computing ,business.industry ,Computer science ,Controller (computing) ,Parallel computing ,computer.software_genre ,FLOPS ,law.invention ,Instructions per second ,Microprocessor ,CMOS ,law ,Embedded system ,Compiler ,business ,computer ,Computer hardware - Abstract
A description is given of a microprocessor that is designed as a processing element (PE) of a parallel computer system, executing a 64-b floating-point ADD/SUB/MULT in 50 ns and a DIV in 350 ns because of its pipelined structure and dedicated floating-point blocks. The processor employs RISC (reduced-instruction-set-computer) architecture and executes most of its 47 instructions in one 50-ns cycle. The chip is fabricated in 1.2- mu m n-well CMOS technology and contains 440 K transistors in a 14.4*13.5-mm/sup 2/ die. The processor provides high-speed double-precision floating-point operation, high reliability in data handling, communication capability between PEs and the host controller device, and hardware support for efficient code generation by the compiler. The maximum performance of the processor is 20 MFLOPS (million floating-point operations per second) or 20 MIPS (million instructions per second). Typical performance is 4 MFLOPS, measured during execution of Gaussian elimination operation. The major characteristics and performance of the processor are summarized. >
- Published
- 2003
12. Molecular nature of 11 spontaneous de novo mutations in Drosophila melanogaster
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Ana Y. Tanikawa, Alexey S. Kondrashov, and Hsiao Pei Yang
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Mutation rate ,Locus (genetics) ,Biology ,Frameshift mutation ,Genetics ,Melanogaster ,Coding region ,Animals ,Allele ,Frameshift Mutation ,Alleles ,Crosses, Genetic ,Eye Color ,Models, Genetic ,Exons ,biology.organism_classification ,Molecular biology ,Blotting, Southern ,Drosophila melanogaster ,Homo sapiens ,Mutation ,Photoreceptor Cells, Invertebrate ,Gene Deletion ,Research Article - Abstract
To investigate the molecular nature and rate of spontaneous mutation in Drosophila melanogaster, we screened 887,000 individuals for de novo recessive loss-of-function mutations at eight loci that affect eye color. In total, 28 mutants were found in 16 independent events (13 singletons and three clusters). The molecular nature of the 13 events was analyzed. Coding exons of the locus were affected by insertions or deletions >100 nucleotides long (6 events), short frameshift insertions or deletions (4 events), and replacement nucleotide substitutions (1 event). In the case of 2 mutant alleles, coding regions were not affected. Because ∼70% of spontaneous de novo loss-of-function mutations in Homo sapiens are due to nucleotide substitutions within coding regions, insertions and deletions appear to play a much larger role in spontaneous mutation in D. melanogaster than in H. sapiens. If so, the per nucleotide mutation rate in D. melanogaster may be lower than in H. sapiens, even if their per locus mutation rates are similar.
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- 2001
13. The immunohistochemical localization of phospholipase Cgamma and the epidermal growth-factor, platelet-derived growth-factor and fibroblast growth-factor receptors in the cells of the rat molar enamel organ during early amelogenesis
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Y. Tanikawa and James W. Bawden
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medicine.medical_specialty ,Cervical loop ,Biology ,Fibroblast growth factor ,Mesoderm ,Rats, Sprague-Dawley ,stomatognathic system ,Epidermal growth factor ,Amelogenesis ,Internal medicine ,medicine ,Ameloblasts ,Animals ,Frozen Sections ,Receptors, Platelet-Derived Growth Factor ,Coloring Agents ,General Dentistry ,Dental Pulp ,Platelet-Derived Growth Factor ,Epidermal Growth Factor ,Phospholipase C gamma ,Enamel organ ,Enamel Organ ,Cell Differentiation ,Cell Biology ,General Medicine ,Dentinogenesis ,Immunohistochemistry ,Molar ,Receptors, Fibroblast Growth Factor ,Cell biology ,Rats ,ErbB Receptors ,Fibroblast Growth Factors ,Isoenzymes ,Endocrinology ,Freeze Drying ,Otorhinolaryngology ,Fibroblast growth factor receptor ,Type C Phospholipases ,Dentin ,biology.protein ,Ameloblast ,Platelet-derived growth factor receptor ,Tooth Calcification ,Signal Transduction - Abstract
Findings on the localization and possible roles of the major growth factors, epidermal (EGF), platelet-derived (PDGF) and fibroblast (FGF) in early amelogenesis are contradictory and inconclusive. This study sought to localize immunohistochemically phospholipase (PLCgamma) and the EGF, PDGF and FGF receptors in the cells of the enamel organ during the events leading directly to early enamel formation in rat molars. PLCgamma is an immediate, downstream, signal-transduction pathway effector unique to the three receptors. A whole-head, freeze-dried sectioning method was used to reduce the possibilities of false-negative staining. A modification of the avidin/biotin complex method of immunohistochemical localization was used. Anti-PLCgamma and antibodies to each of EGF, PDGF and FGF receptors colocalized in the preameloblasts of the cervical loop, adjacent to the undifferentiated mesenchymal cells of the dental pulp. This staining disappeared shortly after the beginning of dentine mineralization. Staining for all four antibodies appeared on the proximal ends of the differentiating presecretory ameloblasts at the level of the beginning of predentine matrix deposition and continued in the secretory ameloblasts. It appears that EGF, PDGF and FGF have roles in the differentiation of ameloblasts and in control of cellular functions in presecretory and secretory ameloblasts. Their roles may represent redundancy of the kind seen in highly conserved tissues.
- Published
- 1999
14. [Clinicopathological analysis of leiomyosarcomas of the small intestine and a review of the Japanese literature]
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K, Matsuda, O, Hosokawa, T, Kaizaki, Y, Takashima, Y, Kasahara, H, Misaki, K, Murakita, K, Nakagawa, T, Takeda, and Y, Tanikawa
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Adult ,Leiomyosarcoma ,Male ,Jejunal Neoplasms ,Middle Aged ,Ileal Neoplasms ,Survival Rate ,Japan ,Intestinal Perforation ,Intestinal Neoplasms ,Intestine, Small ,Humans ,Female ,Aged - Abstract
An analysis has been made of 9 cases of a leiomyosarcoma of the small intestine that were treated from 1974 through 1989. In two patients (22.2%), a perforation was seen, and a case report of a 59-year-old woman is presented. Further, case reports of leiomyosarcomas in the Japanese literature from 1980 through 1989 were clinico-pathologically analyzed. The frequency of a perforation was found to be 8.6%, and the distribution of the perforated leiomyosarcomas was the same as for the non-perforated cases. The five-year postoperative survival rate was 41.2%. Of note is that 3 out of 10 patients that had survived for 5 years subsequently died of sarcomatosis.
- Published
- 1990
15. A phase II study of carboplatin (C) and weekly paclitaxel (P) with a selective cyclooxygenase-2 (COX-2) inhibitor, meloxicam, in advanced non-small cell lung cancer (NSCLC)
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Masashi Yamamoto, Hiroyuki Taniguchi, T. Oishi, Yoshinori Hasegawa, Y. Tanikawa, S. Nomura, Joe Shindo, Ryujiro Suzuki, Kaoru Shimokata, and Hideo Saka
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Cancer Research ,biology ,business.industry ,Weekly paclitaxel ,non-small cell lung cancer (NSCLC) ,Phases of clinical research ,medicine.disease ,Carboplatin ,chemistry.chemical_compound ,Meloxicam ,Oncology ,chemistry ,biology.protein ,Cancer research ,medicine ,COX-2 inhibitor ,Cyclooxygenase ,business ,Lung cancer ,medicine.drug - Abstract
18007 Background: COX-2 overexpression is seen in many malignancies including lung cancer. Recent pre-clinical studies have shown that selective COX-2 inhibitors have demonstrated promising results when used with chemotherapy. Based on these observations, we are assessing the efficacy and tolerability of the combination chemotherapy consisting of C and P with meloxicam, a selective COX-2 inhibitor. Methods: Patients with stage IIIB or IV, ECOG PS 0 or 1, who had adequate organ function, were eligible. Patients received P 70 mg/m2 weekly for 3 of 4 weeks with C (AUC 6) on day 1, as well as daily meloxicam (10 mg/day). Response rate was the primary endpoint. Secondary endpoints were overall survival, toxicity profile and QOL (Using EORTC QLQ-C30 and LC13). Results: From March 2005 until September 2006, forty-four patients were evaluated in this study. Gender M/F; 31/13, median age; 64 yr (range, 34–75), stage IIIB/IV; 11/33, PS0/1; 22/22, histology Ad/Sq/Others; 29/6/9. Partial response was observed in 19 patients (43%), and no complete response, yielding an overall response rate of 43% (95% confidence interval, 28.5%-57.8%). Nineteen patients (43%) had stable disease. Seven patients (16%) had grade (G) 3 and three (7%) had G4 neutropenia. Three patients (7%) had G3 thrombocytopenia. As for non-hematological toxicities, one G4 toxicity (perforation of jejunum) was observed, but the other toxicities were mild (one muscle pain, 2 liver dysfunction, 1 fatigue and 1 nausea G3). Grade 2 peripheral neuropathy was observed in only one patient. Using EORTC QLO questioner, the global health status did not changed significantly during this therapy (before and 4 and 8 weeks later). Median follow-up was 9.6 months (range, 1.8–22.7 months). At the time of the final analysis (January 2007), 16 patients had died. The one-year survival rate was 70% and MST was not reached till now. Conclusions: Meloxicam in combination with C and weekly P chemotherapy showed promising activity with encouraging survival. This therapy is relatively well-tolerated in advanced NSCLC. No significant financial relationships to disclose.
- Published
- 2007
16. Meloxicam, a selective cyclooxygenase-2 (COX-2) inhibitor, enhances the response to carboplatin and weekly paclitaxel in advanced non-small cell lung cancer (NSCLC)
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O. Nishiyama, Hiroyuki Taniguchi, Tomoki Kimura, Ryujiro Suzuki, Kaoru Shimokata, K. Kato, Y. Kondoh, M. Aoyama, and Y. Tanikawa
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Cancer Research ,biology ,business.industry ,non-small cell lung cancer (NSCLC) ,Weekly paclitaxel ,medicine.disease ,Carboplatin ,Meloxicam ,chemistry.chemical_compound ,Oncology ,chemistry ,Tumor progression ,medicine ,biology.protein ,Cancer research ,COX-2 inhibitor ,Cyclooxygenase ,business ,medicine.drug - Abstract
7312 Background: Constitutive overexpression of COX-2 is common in NSCLC, and this could be linked to tumor progression. Some preclinical studies suggest that a selective COX-2 inhibitor may augmen...
- Published
- 2005
17. A VLSI RISC with 20-MFLOPS peak, 64-bit floating-point unit
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Y. Nakakura, Y. Tanikawa, Masaitsu Nakajima, S. Gokita, T. Okamoto, J. Nishikawa, Katsuyuki Kaneko, and Hiroshi Kadota
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Very-large-scale integration ,Multi-core processor ,Floating point ,Reduced instruction set computing ,business.industry ,Computer science ,Transistor ,Floating-point unit ,Parallel computing ,FLOPS ,Chip ,law.invention ,Microprocessor ,CMOS ,Parallel processing (DSP implementation) ,law ,Multiplication ,Electrical and Electronic Engineering ,business ,Computer hardware - Abstract
A microprocessor designed as a processing element of a scientific parallel computer system is described. This chip consists of a simple integer processor core and dedicated floating-point hardware and executes 64-bit floating-point addition, subtraction, and multiplication at a rate of every 50 ns and division every 350 ns. The processor, which employs RISC architecture and Harvard-style bus organization, executes most of the 47 instructions in one 50-ns cycle. The chip is fabricated in 1.2- mu m n-well CMOS technology, containing 440K transistors in a 14.4*13.5-mm/sup 2/ die. The authors provide an overview of the processor, especially focusing on the functions for a parallel system, floating-point hardware, and the new divide algorithm. >
- Published
- 1989
18. ABSTRACTS of the papers presented to the Symposium on the Theory of Elementary Particles
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M. Nogami, I. Sato, S. Ozaki, S. Noma, Y. Tanikawa, M. Hirano, M. Tatsuoka, T. Miyazima, S. Hayakawa, Y. Miyamoto, S. Tomonaga, H. Suzuki, G. Araki, I. Imai, K. Husimi, R. Utiyama, E. Kanai, S. Watanabe, H. Yukawa, and S. Sakata
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Physics and Astronomy (miscellaneous) - Published
- 1949
19. On the Quantum Theory of Radiation Damping and the Lifetime of the Meson
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Y. Tanikawa
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Physics ,Cross section (physics) ,X-ray Raman scattering ,Physics and Astronomy (miscellaneous) ,Scattering ,Quantum electrodynamics ,Quantum mechanics ,Compton scattering ,Optical theorem ,Scattering length ,Scattering theory ,Inelastic scattering - Published
- 1948
20. Abstracts of the papers presented to the Symposium on the Theory of Elementary Particles: at Physics Department, Kyoto University, November 24-25, 1947
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G. Iwata, K. Ono, Y. Nambu, Z. Koba, S. Hayakawa, Y. Miyamoto, S. Kanesawa, T. Tati, S. Tomonaga, D. Ito, T. Miyazima, O. Hara, H. Umezawa, S. Sakata, Y. Tanikawa, K. Sawada, G. Araki, E. Kanai, M. Nogami, N. Shono, M. Tanifuji, H. Enatsu, S. Noma, S. Hiroshi, H. Yukawa, and Y. Oda
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Physics ,Physics and Astronomy (miscellaneous) ,Library science ,Elementary particle ,Engineering physics - Published
- 1948
21. On the Theory of -Disintegration
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Y. Tanikawa
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Physics ,Theoretical physics ,Physics and Astronomy (miscellaneous) ,Relationship between string theory and quantum field theory ,Abstract model theory - Published
- 1948
22. [Clinical evaluation on application of hydroxyapatite implant in periodontal surgery. Observation for six months]
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H, Shinbori, T, Ogawa, M, Shirakawa, Y, Tanikawa, K, Nakanishi, T, Higashi, Y, Yasutomi, M, Fujita, T, Wada, and H, Okamoto
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Dental Implants ,Humans ,Biocompatible Materials ,Hydroxyapatites ,Periodontal Diseases - Published
- 1989
23. [Prevalence of periodontal disease in junior high schoolchildren in Hiroshima region. Part III. Findings of third examination]
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H, Okamoto, K, Furugen, H, Shinbori, S, Furuya, Y, Tanikawa, K, Nakanshi, T, Ogawa, T, Higashi, and M, Shirakawa
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Adolescent ,Japan ,Humans ,Periodontal Pocket ,Longitudinal Studies ,Periodontal Index ,Child ,Periodontal Diseases - Published
- 1987
24. [Prevalence of periodontal disease in junior high schoolchildren in Hiroshima region. Part I. Findings of first examination]
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H, Okamoto, Y, Tanikawa, T, Ogawa, H, Shinbori, K, Nakanishi, T, Higashi, and M, Shirakawa
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Adolescent ,Japan ,Humans ,Longitudinal Studies ,Periodontal Index ,Child ,Periodontal Diseases - Published
- 1987
25. [Combination chemotherapy with cis-diammine-di-chloro-platinum (II) and bleomycin in advanced head and neck cancer]
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T, Sasaki, T, Ibuka, K, Imai, Y, Sakai, M, Hayakawa, Y, Tanikawa, H, Miyashita, Y, Komiya, and T, Matsuda
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Adult ,Male ,Bleomycin ,Head and Neck Neoplasms ,Humans ,Drug Therapy, Combination ,Female ,Cisplatin ,Middle Aged ,Drug Administration Schedule ,Aged - Abstract
Combination chemotherapy of cis-diammine dichloro platinum (II) (CDDP) and bleomycin was given to 10 patients with advanced squamous cell carcinoma of the head and neck. Nine patients had received prior radical radiotherapy, 2 had major ablative surgical procedures, and one had been previously treated with chemotherapy. Responses were as follows (duration in months): 2 CRs (4,6+), 2 PRs (1.5,1.5), and 2 minors. Vomiting related to CDDP was observed in 5 patients, nephrotoxicity and hypocalcemia in one patient were also observed.
- Published
- 1982
26. On the Cosmic-Ray Meson and the Nuclear Meson
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Y. Tanikawa
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Physics ,Particle physics ,Physics and Astronomy (miscellaneous) ,Meson ,Eta meson ,Cosmic ray - Published
- 1947
27. Galvanocautirization Therapy for Polyp and Edematous Change in Vocal Cords
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Y. Tanikawa and H. Okubo
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Pathology ,medicine.medical_specialty ,business.industry ,medicine ,Anatomy ,business - Published
- 1964
28. On the Relations between the Cosmic-ray Mesons and Nuclear Mesons. I
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Y. Tanikawa
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Physics ,Nuclear physics ,Pseudoscalar ,Particle physics ,Pion ,Muon ,Physics and Astronomy (miscellaneous) ,Meson ,Cosmic ray ,Spin (physics) - Published
- 1948
29. The Supplementary Note to the Generalized Transformation Fuction
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Y. Tanikawa
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Algebra ,Physics ,Physics and Astronomy (miscellaneous) ,Transformation (music) - Published
- 1947
30. On the Relations between the Cosmic-ray Mesons and the Nuclear Mesons. II
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Y. Tanikawa
- Subjects
Physics and Astronomy (miscellaneous) - Published
- 1948
31. On the Cosmic-Ray Meson and the Nuclear Meson*
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Y. Tanikawa
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Physics ,Particle physics ,Physics and Astronomy (miscellaneous) ,Meson ,Eta meson ,Cosmic ray - Published
- 1955
32. Errata: On the Generalized Transformation Functions
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Y. Tanikawa
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Physics ,Physics and Astronomy (miscellaneous) ,Transformation (music) ,Mathematical physics - Published
- 1946
33. Predicting residual pressure gradients after balloon angioplasty in patients with femoropopliteal artery lesions.
- Author
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Yoshioka N, Morita Y, Shimada T, Kobayashi H, Tanikawa Y, Minamiya A, Yamada T, and Morishima I
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- Humans, Male, Female, Retrospective Studies, Aged, Middle Aged, Treatment Outcome, Aged, 80 and over, Vascular Patency, Risk Factors, Femoral Artery physiopathology, Femoral Artery diagnostic imaging, Popliteal Artery diagnostic imaging, Popliteal Artery physiopathology, Angioplasty, Balloon adverse effects, Angioplasty, Balloon methods, Peripheral Arterial Disease physiopathology, Peripheral Arterial Disease therapy, Peripheral Arterial Disease diagnosis, Ultrasonography, Interventional methods
- Abstract
In endovascular therapy (EVT) for femoropopliteal artery (FPA) lesions, studies examining the relationship between lesion morphology and hemodynamic status are limited. The purpose of this study was to investigate FPA lesion characteristics, including imaging findings and their cutoff values that can predict hemodynamic significance after balloon angioplasty. This single-center retrospective study enrolled 50 de novo FPA lesions from 43 patients treated under intravascular ultrasound (IVUS) usage between June 2022 and March 2023. As a physiological parameter, the pressure gradient was measured, and the cutoff value of the residual pressure gradient (RPG) was defined as a systolic pressure > 10 mmHg through the lesions after balloon angioplasty. The pressure gradients were measured using a 0.014-inch wire-guided, rapid exchange-type microcatheter, Navvus II (Acist, Eden Prairie, Minnesota, USA). Predictive risk factors for RPG were analyzed using the random forest (RF) method. The relationship between the variables, RPG, and the cutoff points of each predictor was assessed using the partial dependence plot (PDP) method. RPG was observed in 20% of the lesions after balloon angioplasty. The RF model revealed that the percent diameter stenosis (%DS) and minimum lumen area (MLA) on IVUS assessment were strong predictive factors for RPG after balloon angioplasty. The PDP model revealed that a higher %DS (cutoff 30%) and smaller MLA (cutoff 10 mm
2 ) could predict RPG after balloon angioplasty. Conventional lesion parameters such as %DS and MLA can predict hemodynamic significance during EVT for FPA lesions., (© 2024. Springer Nature Japan KK, part of Springer Nature.)- Published
- 2024
- Full Text
- View/download PDF
34. Aseptic meningitis followed by mononeuritis multiplex in a patient with primary Sjögren's syndrome.
- Author
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Nakamura H, Tanikawa Y, Nishihara M, Tsukamoto M, Nagasawa Y, Akiya K, Natori N, Kitamura N, Takayama T, and Nakajima H
- Subjects
- Humans, Female, Adult, Methylprednisolone therapeutic use, Sjogren's Syndrome complications, Meningitis, Aseptic complications, Peripheral Nervous System Diseases, Mononeuropathies
- Abstract
A 38-year-old woman was admitted to hospital because of fever and headache. Increased cerebrospinal cell count and protein without evidence of infection led to a diagnosis of aseptic meningitis. Although she improved with acyclovir and glyceol, she experienced left forearm pain and sensory disturbance with drop fingers. Poor derivation of compound muscle action potentials in the left radial nerve was observed, leading to a diagnosis of mononeuritis multiplex with sensorimotor neuropathy. Because the patient had primary Sjögren's syndrome with anti-Ro/SS-A antibody and salivary gland hypofunction, treatment with methylprednisolone, intravenous immunoglobulin, and intravenous cyclophosphamide was followed by oral glucocorticoid therapy. After these intensive therapies, her drop fingers gradually improved, although sensory disturbance remained. In conclusion, we report a case of aseptic meningitis and subsequent mononeuritis multiplex that was successfully treated with intensive immunotherapy in a patient with primary Sjögren's syndrome.
- Published
- 2023
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35. Risk factors associated with relapse after methotrexate dose reduction in patients with rheumatoid arthritis receiving golimumab and methotrexate combination therapy.
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Kitamura N, Kobayashi H, Nagasawa Y, Sugiyama K, Tsuzuki H, Tanikawa Y, Ikumi N, Okada Y, Takahashi Y, Asai S, Tamura N, Ogasawara M, Kawamoto T, Kuwatsuru R, Tamaki H, Kidoguchi G, Tateishi M, Kimura M, Mochida Y, Harigane K, Shimazaki T, Koike T, Tanimura K, Kataoka H, Amano K, Yasuoka H, and Takei M
- Subjects
- Humans, Young Adult, Adult, Methotrexate adverse effects, Drug Tapering, Retrospective Studies, Treatment Outcome, Drug Therapy, Combination, Risk Factors, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Chronic Disease, Arthritis, Rheumatoid drug therapy, Antirheumatic Agents therapeutic use
- Abstract
Aim: To identify risk factors for relapse after methotrexate (MTX) dose reduction in rheumatoid arthritis (RA) patients receiving golimumab (GLM)/MTX combination therapy., Method: Data on RA patients ≥20 years old receiving GLM (50 mg) + MTX for ≥6 months were retrospectively collected. MTX dose reduction was defined as a reduction of ≥12 mg from the total dose within 12 weeks of the maximum dose (≥1 mg/wk average). Relapse was defined as Disease Activity Score in 28 joints using C-reactive protein level (DAS28-CRP) score ≥3.2 or sustained (≥ twice) increase of ≥0.6 from baseline., Results: A total of 304 eligible patients were included. Among the MTX-reduction group (n = 125), 16.8% of patients relapsed. Age, duration from diagnosis to the initiation of GLM, baseline MTX dose, and DAS28-CRP were comparable between relapse and no-relapse groups. The adjusted odds ratio (aOR) of relapse after MTX reduction was 4.37 (95% CI 1.16-16.38, P = 0.03) for prior use of non-steroidal anti-inflammatory drugs (NSAIDs), and the aORs for cardiovascular disease (CVD), gastrointestinal disease and liver disease were 2.36, 2.28, and 3.03, respectively. Compared to the non-reduction group, the MTX-reduction group had a higher proportion of patients with CVD (17.6% vs 7.3%, P = 0.02) and a lower proportion of prior use of biologic disease-modifying antirheumatic drugs (11.2% vs. 24.0%, P = 0.0076)., Conclusion: Attention should be given to RA patients with history of CVD, gastrointestinal disease, liver disease, or prior NSAIDs-use when considering MTX dose reduction to ensure benefits outweigh the risks of relapse., (© 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Published
- 2023
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36. Determination of Picolinic Acid by HPLC Coupled With Postcolumn Photo Irradiation Using Zinc Acetate as a Fluorescent Derivatization Reagent.
- Author
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Mawatari KI, Tanikawa Y, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, and Oku N
- Abstract
For the fluorometric determination of picolinic acid in human serum, HPLC-postcolumn UV irradiation using zinc acetate has been developed. Picolinic acid in serum sample was separated on a Capcell Pak C18. The mobile phase consisted of 0.1 mol/L sodium phosphate solution (adjusted to pH 3.0) containing 3.0 mmol/L zinc acetate and 3.5 mmol/L trimethylamine, and delivered at a flow rate of 0.8 mL/minutes. In order to stabilize the retention time (6.5 minutes), a back pressure tube (0.4 m × 0.13 mm i.d.) was attached after the photoreaction tube. Column effluent was irradiated with ultraviolet light to produce fluorescence, excitation wavelength of 336 nm and emission wavelength of 448 nm. The calibration graph for picolinic acid showed linearity when the amount was in the range of 0.89 to 455 pmol, and the detection limit (S/N = 3) was determined to be 0.30 pmol. The pretreatment of serum sample consisted of deproteinized by perchloric acid, potassium hydroxide, and mobile phase. The mean recovery of picolinic acid from serum was 99.0%. Using this procedure, the concentration of picolinic acid in serum of a healthy subject was determined., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.)
- Published
- 2023
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37. Tips and pitfalls to improve accuracy and reduce radiation exposure in intraoperative CT navigation for pediatric scoliosis: a systematic review.
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Oba H, Uehara M, Ikegami S, Hatakenaka T, Kamanaka T, Miyaoka Y, Kurogouchi D, Fukuzawa T, Mimura T, Tanikawa Y, Koseki M, Ohba T, and Takahashi J
- Subjects
- Humans, Child, Female, Retrospective Studies, Spine, Tomography, X-Ray Computed adverse effects, Tomography, X-Ray Computed methods, Scoliosis diagnostic imaging, Scoliosis surgery, Scoliosis etiology, Pedicle Screws adverse effects, Radiation Exposure adverse effects, Radiation Exposure prevention & control, Surgery, Computer-Assisted adverse effects, Spinal Fusion adverse effects
- Abstract
Background Context: An increasing number of medical centers are adopting an intraoperative computed tomography (iCT) navigation system (iCT-Navi) to provide three-dimensional navigation for pediatric scoliosis surgery. While iCT-Navi has been reported to provide higher pedicle screw (PS) insertion accuracy, it may also result in higher radiation exposure to the patient. What innovations and studies have been introduced to reduce radiation exposure and further improve PS insertion?, Purpose: Evaluate the level of evidence and quality of papers while categorizing the tips and pitfalls regarding pediatric scoliosis surgery using iCT-Navi. Compare iCT-Navi with other methods, including preoperative CT navigation., Study Design: Systematic review., Patient Sample: Articles on pediatric scoliosis surgery with iCT-Navi published through to June 2022., Outcome Measures: PS perforation rate and patient intraoperative radiation dose., Methods: Following PRISMA guidelines, the Cochrane Library, Google Scholar, and PubMed databases were searched for articles satisfying the criteria of iCT-Navi use and pediatric scoliosis surgery. The level of evidence and quality of the articles meeting the criteria were evaluated according to the guidelines of the North American Spine Society and American Academy of Orthopedic Surgeons, respectively. The articles were also categorized by theme and summarized in terms of PS insertion accuracy and intraoperative radiation dose. The origins and characteristics of five major classification methods of PS perforation grade were summarized as well., Results: The literature search identified 811 studies, of which 20 papers were included in this review. Overall, 513 pediatric scoliosis patients (381 idiopathic, 44 neuromuscular, 39 neurofibromatosis type 1, 28 congenital, 14 syndromic, seven other) were evaluated for PS perforations among 6,209 iCT-Navi insertions. We found that 232 (3.7%) screws were judged as major perforations (G2 or G3), 55 (0.9%) screws were judged as dangerous deviations (G3), and seven (0.1%) screws were removed. There were no reports of neurovascular injury caused by PSs. The risk factors for PS perforation included more than six vertebrae distance from the reference frame, more than nine consecutive insertions, upper thoracic level, thinner pedicle, upper instrumented vertebra proximity, short stature, and female. The accuracy of PS insertion did not remarkably decrease when the radiation dose was reduced to 1/5 or 1/10 by altering the iCT-Navi protocol., Conclusions: iCT-Navi has the potential to reduce PS perforation rates compared with other methods. The use of low-dose radiation protocols may not significantly affect PS perforation rates. Although several risk factors for PS perforation and measures to reduce radiation dose have been reported, the current evidence is limited by a lack of consistency in classifying PS perforation and evaluating patient radiation dose among studies. The standardization of several outcome definitions is recommended in this rapidly developing field., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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38. Immersion optical clearing of adipose tissue in rats: ex vivo and in vivo studies.
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Yanina IY, Tanikawa Y, Genina EA, Dyachenko PA, Tuchina DK, Bashkatov AN, Dolotov LE, Tarakanchikova YV, Terentuk GS, Navolokin NA, Bucharskaya AB, Maslyakova GN, Iga Y, Takimoto S, and Tuchin VV
- Subjects
- Adipose Tissue, Animals, Light, Necrosis, Rats, Immersion, Skin
- Abstract
Optical clearing (OC) of adipose tissue has not been studied enough, although it can be promising in medical applications, including surgery and cosmetology, for example, to visualize blood vessels or increase the permeability of tissues to laser beams. The main objective of this work is to develop technology for OC of abdominal adipose tissue in vivo using hyperosmotic optical clearing agents (OCAs). The maximum OC effect (77%) was observed for ex vivo rat adipose tissue samples exposed to OCA on fructose basis for 90 minutes. For in vivo studies, the maximum effect of OC (65%) was observed when using OCA based on diatrizoic acid and dimethylsulfoxide for 120 minutes. Histological analysis showed that in vivo application of OCAs may induce a limited local necrosis of fat cells. The efficiency of OC correlated with local tissue damage through cell necrosis due to accompanied cell lipolysis., (© 2022 Wiley-VCH GmbH.)
- Published
- 2022
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39. Successful treatment for eosinophilic granulomatosis with polyangiitis causing severe myocarditis followed by cardiac magnetic resonance.
- Author
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Asatani S, Kobayashi H, Nagasawa Y, Nishihara M, Tanikawa Y, Hamaguchi M, Yoshizawa S, Tsuzuki H, Sugiyama K, Tsukamoto M, Kitamura N, and Nakamura H
- Subjects
- Adult, Contrast Media, Female, Gadolinium, Humans, Magnetic Resonance Spectroscopy adverse effects, Churg-Strauss Syndrome diagnosis, Granulomatosis with Polyangiitis complications, Granulomatosis with Polyangiitis diagnosis, Granulomatosis with Polyangiitis drug therapy, Myocarditis diagnosis, Myocarditis drug therapy, Myocarditis etiology
- Abstract
A 38-year-old woman had a history of asthma for 20 years. Bullous lesions had appeared on her left side of the back. Two months before admission, the biopsy revealed eosinophilic cellulitis. One month later, she experienced numbness in both legs. She was admitted to our hospital for emergency treatment due to chest pain and loss of consciousness. Emergency coronary angiography revealed triple-vessel vasospasm. She had cardiac arrest for 4 min during the examination. We suspected eosinophilic granulomatosis with polyangiitis due to pulmonary infiltrate, eosinophilia, and a history of illness. We, therefore, started methylprednisolone pulse therapy. Although her condition and laboratory findings improved, cardiac magnetic resonance (CMR) imaging performed on day 16 showed myocardial oedema and myocardial fibrosis on late gadolinium enhancement. Coronary angiography on day 35 revealed no spasm, and myocardial biopsy showed the absence of vasculitis. There was no improvement in myocardial oedema. CMR showed enlargement of late gadolinium enhancement and formation of a ventricular aneurysm. As myocarditis did not improve sufficiently, five courses of intravenous cyclophosphamide pulse therapy were administered. CMR on day 152 showed the disappearance of myocardial oedema. We report a unique case of successful treatment of severe myocarditis and the usefulness of follow-up CMR., (© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
- Full Text
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40. Intraoperative Cone Beam CT in Hybrid Operation Room for Pediatric Scoliosis Patients: Comparison of Pedicle Screw Violation Rate at Normal and Low Radiation Doses.
- Author
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Tanikawa Y, Oba H, Fujii M, Ikegami S, Uehara M, Mimura T, Miyagawa J, Hatakenaka T, Kuraishi S, Takizawa T, Munakata R, Kamanaka T, Miyaoka Y, Michihiko K, and Takahashi J
- Subjects
- Adolescent, Child, Cone-Beam Computed Tomography, Female, Humans, Male, Radiation Dosage, Retrospective Studies, Tomography, X-Ray Computed, Pedicle Screws adverse effects, Scoliosis diagnostic imaging, Scoliosis surgery, Spinal Fusion adverse effects, Spinal Fusion methods, Surgery, Computer-Assisted methods
- Abstract
Study Design: Retrospective observational study., Objective: This study aimed to determine the effect of reducing the radiation dose of intraoperative cone beam computed tomography (CBCT) during posterior spinal fusion (PSF) for pediatric scoliosis on the rate of pedicle screw (PS) violation., Summary of Background Data: Intraoperative CBCT for pediatric scoliosis improves the accuracy of PS insertion in PSF. However, few reports have addressed the PS perforation rate from reduced radiation doses in hybrid navigation., Methods: We evaluated 855 PSs inserted into 58 pediatric scoliosis patients (11 male and 47 female, mean age: 16.6 yr) who underwent PSF using CBCT. A radiation dose of 1/3 or 1/5 of the normal dose (ND) was defined as a low dose (LD). After PS insertion, intraoperative CBCT images were reviewed to assess the degree of PS perforation. G2-3 (i.e., perforations of 4 mm or more) was defined as a violation. The PS violation rate was compared between the groups, and factors associated with violations were examined., Results: A total of 567 and 288 screws were inserted in the ND group and LD group, respectively. The PS violation rate was comparable at 1.8% in the ND group and 1.7% in the LD group. Multiple logistic regression analysis showed that distance from the upper instrumented vertebra (UIV) was an independently associated factor of PS violation (+1 vertebra, operation room 0.73, P = 0.038). In addition, the mean height of patients with PS violations (148.8 ± 3.6 cm) was significantly shorter than that of patients without violations (157.9 ± 1.2 cm) ( P = 0.034)., Conclusion: There was no increase in PS violation rate with lower doses of radiation for intraoperative navigation CBCT. Extra care is warranted for vertebrae close to the UIV and patients of shorter stature.Level of Evidence: 3., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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41. Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding.
- Author
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Matsusaki M, Okada R, Tanikawa Y, Kanemura S, Ito D, Lin Y, Watabe M, Yamaguchi H, Saio T, Lee YH, Inaba K, and Okumura M
- Abstract
P5 is one of protein disulfide isomerase family proteins (PDIs) involved in endoplasmic reticulum (ER) protein quality control that assists oxidative folding, inhibits protein aggregation, and regulates the unfolded protein response. P5 reportedly interacts with other PDIs via intermolecular disulfide bonds in cultured cells, but it remains unclear whether complex formation between P5 and other PDIs is involved in regulating enzymatic and chaperone functions. Herein, we established the far-western blot method to detect non-covalent interactions between P5 and other PDIs and found that PDI and ERp72 are partner proteins of P5. The enzymatic activity of P5-mediated oxidative folding is up-regulated by PDI, while the chaperone activity of P5 is stimulated by ERp72. These findings shed light on the mechanism by which the complex formations among PDIs drive to synergistically accelerate protein folding and prevents aggregation. This knowledge has implications for understanding misfolding-related pathology.
- Published
- 2021
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42. Nivolumab Effective for Gastric and Lung Cancers but Not for Multiple Myeloma in a Multiple Primary Cancer Patient.
- Author
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Yasuda T, Hiraga J, Narita M, Tanikawa Y, and Tsuzuki T
- Abstract
The case of a 76-year-old man with multiple primary cancers that were treated with nivolumab is presented. Six years earlier, he was diagnosed with multiple myeloma (MM) and was treated with several chemotherapies. He was also diagnosed with gastric cancer with liver metastasis and primary lung cancer by upper gastrointestinal endoscopy and computed tomography (CT). Nivolumab treatment was given as third-line therapy, and it was effective for gastric and lung cancers. But MM worsened, and the patient died. There is no standard treatment for multiple primary cancers, and the development of effective treatments for multiple primary cancers is important., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 Tsukasa Yasuda et al.)
- Published
- 2021
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43. Successful early introduction of mepolizumab for peripheral neuropathy with a peripheral circulatory disorder in a patient with myeloperoxidase anti-neutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis.
- Author
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Nishihara M, Hamaguchi M, Ikumi N, Nishiwaki A, Sugiyama K, Nagasawa Y, Tsuzuki H, Yoshizawa S, Tanikawa Y, Asatani S, Kobayashi H, Takei M, and Kitamura N
- Subjects
- Adult, Antibodies, Antineutrophil Cytoplasmic, Churg-Strauss Syndrome, Female, Granulomatosis with Polyangiitis, Humans, Peroxidase immunology, Treatment Outcome, Antibodies, Monoclonal, Humanized therapeutic use, Peripheral Nervous System Diseases drug therapy
- Abstract
A 26-year-old woman presented with abdominal pain, diarrhoea, vomiting, fever, and progressive paralysis in the lower limbs. She had a history of bronchial asthma and experienced sinusitis, progressive peripheral neuropathy, polyarthritis, and leukocytosis with prominent eosinophilia. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Abdominal pain was considered to be an ischaemic enteritis associated with EGPA. She was administered 1,000 mg/day of methylprednisolone for 3 days and intravenous immunoglobulin (400 mg/kg/day of γ-globulin for 5 days) followed by 50 mg (1 mg/kg)/day of oral prednisolone due to rapidly progressing peripheral neuropathy. Her symptoms temporarily improved; however, peripheral neuropathy recurred after a week, and the eosinophil count increased. Eighteen days after following the resumed treatment, 300 mg of mepolizumab, a humanised monoclonal antibody, was administered. Subjective symptoms, nerve conduction velocity, and skin perfusion pressure (an index of peripheral circulation in the lower extremities) improved after 4 weeks. Although mepolizumab has been approved for EGPA, there is no evidence of its efficacy against peripheral neuropathy. Early introduction of mepolizumab may contribute to an the early improved progressive peripheral neuropathy with eosinophilia.
- Published
- 2021
- Full Text
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44. Ca 2+ Regulates ERp57-Calnexin Complex Formation.
- Author
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Tanikawa Y, Kanemura S, Ito D, Lin Y, Matsusaki M, Kuroki K, Yamaguchi H, Maenaka K, Lee YH, Inaba K, and Okumura M
- Subjects
- Disulfides metabolism, Humans, Models, Biological, Oxidation-Reduction, Protein Aggregates, Protein Binding, Protein Folding, Thermodynamics, Calcium metabolism, Calnexin metabolism, Protein Disulfide-Isomerases metabolism
- Abstract
ERp57, a member of the protein disulfide isomerase family, is a ubiquitous disulfide catalyst that functions in the oxidative folding of various clients in the mammalian endoplasmic reticulum (ER). In concert with ER lectin-like chaperones calnexin and calreticulin (CNX/CRT), ERp57 functions in virtually all folding stages from co-translation to post-translation, and thus plays a critical role in maintaining protein homeostasis, with direct implication for pathology. Here, we present mechanisms by which Ca
2+ regulates the formation of the ERp57-calnexin complex. Biochemical and isothermal titration calorimetry analyses revealed that ERp57 strongly interacts with CNX via a non-covalent bond in the absence of Ca2+ . The ERp57-CNX complex not only promoted the oxidative folding of human leukocyte antigen heavy chains, but also inhibited client aggregation. These results suggest that this complex performs both enzymatic and chaperoning functions under abnormal physiological conditions, such as Ca2+ depletion, to effectively guide proper oxidative protein folding. The findings shed light on the molecular mechanisms underpinning crosstalk between the chaperone network and Ca2+ .- Published
- 2021
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45. Impact of the state of emergency enacted due to the COVID-19 pandemic on the physical activity of the elderly in Japan.
- Author
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Miyahara S, Tanikawa Y, Hirai H, and Togashi S
- Abstract
[Purpose] In Japan, the government issued a state of emergency due to the spread of COVID-19 in April 2020. In this study, we measured physical activity before and after the state of emergency, and assessed the factors that affected physical activity. [Participants and Methods] We included thirteen elderly people living in Hiroshima Prefecture, Japan, in the study. The participants wore 3-axis accelerometer on their hips to measure physical activity for a week, before (in October 2019) and after the state of emergency. According to the median rate of decrease in physical activity (23.6%), we divided the participants into two groups: one group had participants with a high rate of decrease (low physical activity) and the other had participants with a low rate of decrease (high physical activity). [Results] The following factors decreased after the state of emergency: total physical activity, amount of moderate-intensity physical activity and activities of daily living, amount of light-intensity physical activity and walking, daily activity time, and daily steps. Statistical analysis showed that engaging in housework was associated with high physical activity. [Conclusion] Elderly people who engaged in household chores had a smaller decrease in physical activity. In order to reduce the decrease in physical activity and the risk of cardiovascular events, the elderly should perform as many daily activities and hobbies as they can while paying attention to the infection control measures., Competing Interests: None., (2021©by the Society of Physical Therapy Science. Published by IPEC Inc.)
- Published
- 2021
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46. [A rare synchronous occurrence of multiple myeloma and pulmonary adenocarcinoma with multiple solitary extramedullary plasmacytomas of the liver].
- Author
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Ohara F, Harada Y, Tanikawa Y, Narita M, Kagami Y, and Hiraga J
- Subjects
- Female, Humans, Liver, Middle Aged, Neoplasm Recurrence, Local, Adenocarcinoma, Multiple Myeloma therapy, Plasmacytoma
- Abstract
We report the case of a 62-year-old woman with multiple liver tumors. She was diagnosed with synchronous occurrence of multiple myeloma (MM) and primary pulmonary adenocarcinoma 4 years ago. She was treated with bortezomib and dexamethasone for MM, and then she underwent thoracoscopic lobectomy. After the surgery, she received autologous peripheral blood stem cell transplantation. However, recurrence of MM was observed 9 months later. She received multiple chemotherapies for MM, but the effect was limited. Meanwhile, brain metastasis of pulmonary adenocarcinoma was observed; therefore, she underwent surgical resection and received radiation therapy. Furthermore, she had elevated levels of liver enzymes, and ultrasonography revealed multiple liver tumors. Because of thrombocytopenia, liver biopsy could not be performed, and chemotherapies for MM did not improve the tumors. Therefore, we clinically determined that the liver tumors were metastatic pulmonary adenocarcinomas. The epidermal growth factor receptor mutation was present in the pulmonary adenocarcinoma, so gefitinib was administered. However, the tumors were uncontrollable and the patient died within 1 month. From autopsy, the liver lesion was confirmed to be MM. Synchronous occurrence of MM and other primary cancers is very rare, and no standard treatment has yet been established. Thus, it is crucial to accumulate synchronous cases and develop treatment methods in the future.
- Published
- 2021
- Full Text
- View/download PDF
47. The effects of mepolizumab on peripheral circulation and neurological symptoms in eosinophilic granulomatosis with polyangiitis (EGPA) patients.
- Author
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Kitamura N, Hamaguchi M, Nishihara M, Ikumi N, Sugiyama K, Nagasawa Y, Tsuzuki H, Yoshizawa S, Tanikawa Y, Oshima M, Asatani S, Kobayashi H, and Takei M
- Subjects
- Adult, Aged, Antibodies, Monoclonal, Humanized pharmacology, Blood Circulation drug effects, C-Reactive Protein analysis, Eosinophilia blood, Eosinophilia immunology, Eosinophilia physiopathology, Eosinophils immunology, Female, Granulomatosis with Polyangiitis blood, Granulomatosis with Polyangiitis immunology, Granulomatosis with Polyangiitis physiopathology, Humans, Immunoglobulin E blood, Interleukin-5 antagonists & inhibitors, Leukocyte Count, Male, Middle Aged, Nitric Oxide immunology, Retrospective Studies, Sural Nerve drug effects, Sural Nerve physiology, Antibodies, Monoclonal, Humanized therapeutic use, Eosinophilia drug therapy, Granulomatosis with Polyangiitis drug therapy
- Published
- 2021
- Full Text
- View/download PDF
48. [Experience with Secondary Pulmonary Lymphoma Diagnosed by Surgical Biopsy].
- Author
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Imamura Y, Okasaka T, Hiraga J, Watanabe H, Takashima K, Tanikawa Y, and Hiramatsu Y
- Subjects
- Aged, Biopsy, Bronchoscopy, Female, Humans, Tomography, X-Ray Computed, Lung Neoplasms, Lymphoma
- Abstract
Pulmonary malignant lymphoma presents diverse imaging findings, thus making an imaging-based diagnosis difficult. Furthermore, because of the low histological diagnostic rate of approximately 30% based on transbronchial lung biopsy, there are difficulties in the early diagnosis of pulmonary malignant lymphoma. We report a case of pulmonary malignant lymphoma that was difficult to diagnose until a surgical biopsy was performed. A 72-year-old female was referred to our hospital with an abnormal chest shadow on a medical examination. Chest computed tomography(CT) scan demonstrated groundglass opacity and consolidation in both lung fields. Bronchoscopy was performed but a histological definitive diagnosis could not be obtained. We suspected organized pneumonia and initiated steroid therapy that resulted in improvement in the chest shadow. However, new multiple lung nodules and mediastinal lymphadenopathy were noticed on CT scan performed 9 months after the initiation of steroid therapy, and a lung biopsy and mediastinal lymph node biopsy were performed. Finally, the diagnosis was malignant lymphoma with pulmonary infiltrates.
- Published
- 2020
49. Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes.
- Author
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Tsugoshi Y, Watanabe Y, Tanikawa Y, Inoue C, Sugihara K, Kojima H, and Kitamura S
- Subjects
- Animals, Carboxylesterase chemistry, Enzyme Assays, Enzyme Inhibitors chemistry, Kinetics, Molecular Structure, Organophosphates chemistry, Rats, Structure-Activity Relationship, Carboxylesterase antagonists & inhibitors, Enzyme Inhibitors pharmacology, Microsomes, Liver drug effects, Organophosphates pharmacology
- Abstract
We investigated the inhibitory effects of 13 organophosphate esters (OPEs) and hydrolytic metabolites on the carboxylesterase activity of rat liver microsomes in vitro in order to examine whether there might be a potential impact on human health, and to elucidate the structure activity relationship. Among the test compounds, 2-ethylhexyl diphenyl phosphate (EDPhP) was the most potent inhibitor of carboxylesterase activity, as measured in terms of 4-nitrophenol acetate hydrolase activity, followed by tri-m-cresyl phosphate (TmCP), cresyl diphenyl phosphate (CDPhP) and triphenyl phosphate (TPhP). The IC
50 values were as follows: EDPhP (IC50 : 0.03 μM) > TmCP (0.4 μM) > CDPhP (0.8 μM) > TPhP (14 μM) > tris(1,3-dichloro-2-propyl) phosphate (17 μM) > tris(2-ethylhexyl) phosphate (77 μM) > tri-n-propyl phosphate (84 μM) > tris(2-chloroethyl) phosphate (104 μM) > tris(2-butoxyethyl) phosphate (124 μM) > tri-n-butyl phosphate (230 μM). The IC50 value of EDPhP was three orders of magnitude lower than that of bis(4-nitrophenyl) phosphate, which is widely used as an inhibitor of carboxylesterase. Trimethyl phosphate, triethyl phosphate and tris(2-chloroisopropyl) phosphate slightly inhibited the carboxylesterase activity; their IC50 values were above 300 μM. Lineweaver-Burk plots indicated that the inhibition by several OPEs was non-competitive. Diphenyl and monophenyl phosphates, which are metabolites of TPhP, showed weaker inhibitory effects than that of TPhP., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
50. Exclusive detection of cerebral hemodynamics in functional near-infrared spectroscopy by reflectance modulation of the scalp surface.
- Author
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Kawaguchi H, Tanikawa Y, and Yamada T
- Subjects
- Brain diagnostic imaging, Brain Mapping, Hemodynamics, Humans, Infant, Newborn, Scalp, Spectroscopy, Near-Infrared
- Abstract
Significance: Functional near-infrared spectroscopy (fNIRS) is a technique for detecting regional hemodynamic responses associated with neural activation in the cerebral cortex. The absorption changes due to hemodynamic changes in the scalp cause considerable signal contamination in the fNIRS measurement. A method for extracting hemodynamic changes in the cerebral tissue is required for reliable fNIRS measurement., Aim: To exclusively detect cerebral functional hemodynamic changes, we developed an fNIRS technique using reflectance modulation of the scalp surface., Approach: The theoretical feasibility of the proposed method was proven by a simulation calculation of light propagation. Its practical feasibility was evaluated by a phantom experiment and brain activation simulation mimicking human fNIRS experiments., Results: The simulation calculation revealed that the partial path length of the scalp was changed by reflectance modulation of the scalp surface. The influence of absorption change in the superficial layer was successfully reduced by the proposed method, using only measurement data, in the phantom experiment. The proposed method was applicable to human experiments of standard designs, achieving statistical significance within an acceptable experimental time-frame., Conclusions: Removal of the scalp hemodynamic effect by the proposed technique will increase the quality of fNIRS data, particularly in measurements in neonates and infants that typically would require a dense optode arrangement.
- Published
- 2020
- Full Text
- View/download PDF
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