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1,234 results on '"Y. Sakakibara"'

1. Observation of Gamma Rays up to 320 TeV from the Middle-aged TeV Pulsar Wind Nebula HESS J1849−000

Author: M. Amenomori, S. Asano, Y. W. Bao, X. J. Bi, D. Chen, T. L. Chen, W. Y. Chen, Xu Chen, Y. Chen, Cirennima, S. W. Cui, Danzengluobu, L. K. Ding, J. H. Fang, K. Fang, C. F. Feng, Zhaoyang Feng, Z. Y. Feng, Qi Gao, A. Gomi, Q. B. Gou, Y. Q. Guo, Y. Y. Guo, Y. Hayashi, H. H. He, Z. T. He, K. Hibino, N. Hotta, Haibing Hu, H. B. Hu, K. Y. Hu, J. Huang, H. Y. Jia, L. Jiang, P. Jiang, H. B. Jin, K. Kasahara, Y. Katayose, C. Kato, S. Kato, I. Kawahara, T. Kawashima, K. Kawata, M. Kozai, D. Kurashige, Labaciren, G. M. Le, A. F. Li, H. J. Li, W. J. Li, Y. Li, Y. H. Lin, B. Liu, C. Liu, J. S. Liu, L. Y. Liu, M. Y. Liu, W. Liu, H. Lu, X. R. Meng, Y. Meng, K. Munakata, K. Nagaya, Y. Nakamura, Y. Nakazawa, H. Nanjo, C. C. Ning, M. Nishizawa, R. Noguchi, M. Ohnishi, S. Okukawa, S. Ozawa, X. Qian, X. L. Qian, X. B. Qu, T. Saito, Y. Sakakibara, M. Sakata, T. Sako, T. K. Sako, T. Sasaki, J. Shao, M. Shibata, A. Shiomi, H. Sugimoto, W. Takano, M. Takita, Y. H. Tan, N. Tateyama, S. Torii, H. Tsuchiya, S. Udo, H. Wang, S. F. Wang, Y. P. Wang, Wangdui, H. R. Wu, Q. Wu, J. L. Xu, L. Xue, Z. Yang, Y. Q. Yao, J. Yin, Y. Yokoe, Y. L. Yu, A. F. Yuan, L. M. Zhai, H. M. Zhang, J. L. Zhang, X. Zhang, X. Y. Zhang, Y. Zhang, Yi Zhang, Ying Zhang, S. P. Zhao, Zhaxisangzhu, X. X. Zhou, and Y. H. Zou
Subjects: Galactic cosmic rays, Pulsar wind nebulae, Gamma-ray sources, Gamma-ray astronomy, Gamma-ray observatories, Astrophysics, QB460-466
Abstract: Gamma rays from HESS J1849−000, a middle-aged TeV pulsar wind nebula (PWN), are observed by the Tibet air shower array and the muon detector array. The detection significance of gamma rays reaches 4.0 σ and 4.4 σ levels above 25 TeV and 100 TeV, respectively, in units of the Gaussian standard deviation σ . The energy spectrum measured between 40 TeV < E < 320 TeV for the first time is described with a simple power-law function of ${dN}/{dE}={(2.86\pm 1.44)\times {10}^{-16}(E/40\,\mathrm{TeV})}^{-2.24\pm 0.41}\,{\mathrm{TeV}}^{-1}\,{\mathrm{cm}}^{-2}\,{{\rm{s}}}^{-1}$ . The gamma-ray energy spectrum from the sub-TeV ( E < 1 TeV) to sub-PeV (100 TeV < E < 1 PeV) ranges, including the results of previous studies, can be modeled with the leptonic scenario, i.e., inverse Compton scattering by high-energy electrons accelerated by the PWN of PSR J1849−0001. On the other hand, the gamma-ray energy spectrum can also be modeled with the hadronic scenario in which gamma rays are generated from the decay of neutral pions produced by collisions between accelerated cosmic-ray protons and the ambient molecular cloud found in the gamma-ray-emitting region. The cutoff energy of cosmic-ray protons E _p,cut is estimated as ${\mathrm{log}}_{10}({E}_{{\rm{p}},\mathrm{cut}}/\mathrm{TeV})={3.73}_{-0.66}^{+2.98}$ , suggesting that protons are accelerated up to the PeV energy range. Our study thus proposes that HESS J1849−000 should be further investigated as a new candidate as a Galactic PeV cosmic-ray accelerator, or “PeVatron.”
Published: 2023
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2. Charge transfer to ground-state ions produces free electrons

Author: D. You, H. Fukuzawa, Y. Sakakibara, T. Takanashi, Y. Ito, G. G. Maliyar, K. Motomura, K. Nagaya, T. Nishiyama, K. Asa, Y. Sato, N. Saito, M. Oura, M. Schöffler, G. Kastirke, U. Hergenhahn, V. Stumpf, K. Gokhberg, A. I. Kuleff, L. S. Cederbaum, and K Ueda
Subjects: Science
Abstract: Slow electrons, which cause radiation damage, are efficiently produced by interatomic neutralization processes. Here, the authors show experimental evidence for the efficient neutralization of the ionic states produced in Auger decay, using large neon–krypton clusters as a prototype system.
Published: 2017
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3. ALPACA experiment: A new air shower array to explore the sub-PeV gamma-ray sky in the southern hemisphere

Author: Takashi Sako, M. Anzorena, A. Gomi, Y. Hayashi, K. Hibino, N. Hotta, A Jimenez-Meza, Y. Katayose, C. Kato, S. Kato, I. Kawahara, T. Kawashima, K. Kawata, T. Koi, H. Kojima, D. Kurashige, R. Mayta, P. Miranda, K. Munakata, K. Nagaya, Y. Nakamura, C. Nina, M. Nishizawa, R. Noguchi, S. Ogio, M. Ohnishi, S. Okukawa, A. Oshima, M. Raljevich, H. Rivera, T. Saito, Y. Sakakibara, T. Sasaki, S. Shibata, A. Shiomi, M. Subieta, N. Tajima, W. Takano, M. Takita, Y. Tameda, K. Tanaka, R. Ticona, I. Toledano-Juarez, H. Tsuchiya, Y. Tsunesada, S. Udo, K. Yamazaki, Y. Yokoe, C.A.H. Condori, Eduardo de la Fuente, and T. K. Sako
Published: 2022
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4. Hadronic Interaction Model Dependence in Cosmic Gamma-ray Flux Estimation Using an Extensive Air Shower Array with a Muon Detector

Author: S. Okukawa, M. Anzorena, S. Asano, C. A. H. Condori, E. de la Fuente, A. Gomi, K. Hibino, N. Hotta, A. Jimenez-Meza, Y. Katayose, C. Kato, S. Kato, T. Kawashima, K. Kawata, T. Koi, H. Kojima, D. Kurashige, J. Lozoya, R. Mayta, P. Miranda, K. Munakata, K. Nagaya, Y. Nakamura, Y. Nakazawa, C. Nina, M. Nishizawa, S. Ogio, M. Ohnishi, A. Oshima, M. Raljevic, H. Rivera, T. Saito, Y. Sakakibara, T. Sako, T. K. Sako, S. Shibata, A. Shiomi, M. Subieta, N. Tajima, W. Takano, M. Takita, Y. Tameda, K. Tanaka, R. Ticona, I. Toledano-Juarez, H. Tsuchiya, Y. Tsunesada, S. Udo, K. Yamazaki, and Y. Yokoe
Subjects: Space and Planetary Science, Astronomy and Astrophysics
Abstract: Observation techniques of high-energy gamma rays using air showers have remarkably progressed via the Tibet AS$\gamma$, HAWC, and LHAASO experiments. These observations have significantly contributed to gamma-ray astronomy in the northern sky's sub-Peta electron volts (PeV) region. Moreover, in the southern sky, the ALPACA experiment is underway at 4,740\,m altitude on the Chacaltaya plateau in Bolivia. This experiment estimates the gamma-ray flux from the difference between the number of on-source and off-source events by real data, utilizing the gamma-ray detection efficiency calculated through Monte Carlo simulations, which in turn depends on the hadronic interaction models. Even though the number of cosmic-ray background events can be experimentally estimated, this model dependence affects the estimation of gamma-ray detection efficiency. However, previous reports have assumed that the model dependence is negligible and have not included it in the error of gamma-ray flux estimation. Using ALPAQUITA, the prototype experiment of ALPACA, we quantitatively evaluated the model dependence on hadronic interaction models for the first time. We evaluate the model dependence on hadronic interactions as less than 3.6\,\% in the typical gamma-ray flux estimation performed by ALPAQUITA; this is negligible compared with other uncertainties such as energy scale uncertainty in the energy range from 6 to 300 TeV, which is dominated by the Monte Carlo statistics. This upper limit of 3.6\,\% model dependence is expected to apply to ALPACA.
Published: 2022
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5. Dual-Task Training Combining Cognitive Tasks and Occupations among Japanese Community-Dwelling Older Adults: A Pilot Study

Author: K. Yokoi, Y. Sakakibara, T. Inamoto, Y. Fujii, and H. Sakai
Subjects: Cognition, Japan, Occupational Therapy, Quality of Life, Humans, Pilot Projects, General Medicine, Independent Living, Occupations, Aged
Abstract: This study investigated whether dual tasks comprising cognitive tasks and occupations related to daily living can improve the mental and cognitive function of Japanese community-dwelling older adults. Participants included 30 older adults, equally divided into intervention and control groups. The outcome measures were memory, attention, depression, and health-related quality of life. No adverse effects of the intervention were observed in any participant in the intervention group. Logical memory I, logical memory II, and Center for Epidemiologic Studies Depression Scale scores showed a significant interaction. Dual tasks combining cognitive tasks and occupations may help improve delayed recall and alleviate depression. A novel attempt to integrate cognitive stimulation and activities valued by individuals may help mediate age-related cognitive function decline and reduce depressive symptoms in community-dwelling older adults.
Published: 2021

6. A simulation study on the performance of the ALPAQUITA experiment

Author: N. Hotta, N. Tajima, S Asano, S. Okukawa, J L Garcia-Luna, M. Subieta, Chihiro Kato, Y. Yokoe, Y. Nakamura, To. Saito, W. Takano, K Nagaya, R. Mayta, Y. Katayose, R. Ticona, M. Ohnishi, Akitoshi Oshima, M. Raljevich, F Aceves de la Cruz, Sei Kato, S. Udo, Masaki Nishizawa, Kazuoki Munakata, K. Yamazaki, F Orozco, A. Gomi, K. Tanaka, C. Nina, T. K. Sako, Shoichi Shibata, Y. Nakazawa, K. Hibino, P. Miranda, E de la Fuente, A. Shiomi, Shoichi Ogio, Yuichiro Tameda, Y Sakakibara, D. Kurashige, T Kawashima, H. Kojima, A. Jiménez-Meza, Masato Takita, K. Kawata, J. Lozoya, Harufumi Tsuchiya, H. Rivera, I. Toledano-Juarez, Y. Tsunesada, and Tatsumi Koi
Subjects: Physics, Particle physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Monte Carlo method, Detector, Gamma ray, Cosmic ray, Air shower, Sky, High Energy Physics::Experiment, Sensitivity (control systems), Energy (signal processing), media_common
Abstract: The ALPACA experiment is a new air shower experiment mainly aiming to explore the southern sky in the VHE gamma-ray regime beyond 100 TeV. As the prototype experiment, ALPAQUITA will start in late 2021. It consists of a surface air shower array (18,450 ${\rm m}^2$) and an underground muon detector array (900 ${\rm m}^2$). In this study, the performance of ALPAQUITA including the sensitivity to gamma-ray point sources is investigated using a Monte Carlo simulation to quantitatively evaluate the possibility of detection of gamma-ray sources in the prototype phase. Corsika 7.6400 and Geant4 v10.04.p02 are used to simulate air shower development in the atmosphere and detector response, respectively. The output data are then processed and analyzed in the same way as the experiment. As a result, the study finds that the air shower array has an energy resolution of $\pm21\%$ and the angular resolution of $\simeq 0.2^{\circ}$ for gamma rays with an energy of 100 TeV. The detection area of the air shower array for gamma rays reaches $\simeq 12, 600 \, {\rm m}^2$ above $\simeq 10\, {\rm TeV}$. The muon detector rejects $\simeq 99.9\%$ of background cosmic rays and maintains $\simeq 80\%$ of signal gamma rays. This high discrimination power will enable the detection of five southern known gamma-ray sources beyond 30 TeV and the extension of the energy spectrum of one out of the five, HESS J1702-420A, up to $\simeq 300\, {\rm TeV}$ during one calendar year observation. This study concludes that ALPAQUITA will provide data enough to discuss a hot topic of VHE gamma-ray astronomy before passing the baton to ALPACA.
Published: 2021
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7. Measurement of the Gamma-Ray Energy Spectrum beyond 100 TeV from the HESS J1843–033 Region

Author: M. Amenomori, S. Asano, Y. W. Bao, X. J. Bi, D. Chen, T. L. Chen, W. Y. Chen, Xu Chen, Y. Chen, null Cirennima, S. W. Cui, null Danzengluobu, L. K. Ding, J. H. Fang, K. Fang, C. F. Feng, Zhaoyang Feng, Z. Y. Feng, Qi Gao, A. Gomi, Q. B. Gou, Y. Q. Guo, Y. Y. Guo, H. H. He, Z. T. He, K. Hibino, N. Hotta, Haibing Hu, H. B. Hu, K. Y. Hu, J. Huang, H. Y. Jia, L. Jiang, P. Jiang, H. B. Jin, K. Kasahara, Y. Katayose, C. Kato, S. Kato, T. Kawashima, K. Kawata, M. Kozai, D. Kurashige, null Labaciren, G. M. Le, A. F. Li, H. J. Li, W. J. Li, Y. Li, Y. H. Lin, B. Liu, C. Liu, J. S. Liu, L. Y. Liu, M. Y. Liu, W. Liu, X. L. Liu, Y.-Q. Lou, H. Lu, X. R. Meng, Y. Meng, K. Munakata, K. Nagaya, Y. Nakamura, Y. Nakazawa, H. Nanjo, C. C. Ning, M. Nishizawa, M. Ohnishi, S. Okukawa, S. Ozawa, L. Qian, X. Qian, X. L. Qian, X. B. Qu, T. Saito, Y. Sakakibara, M. Sakata, T. Sako, T. K. Sako, J. Shao, M. Shibata, A. Shiomi, H. Sugimoto, W. Takano, M. Takita, Y. H. Tan, N. Tateyama, S. Torii, H. Tsuchiya, S. Udo, H. Wang, Y. P. Wang, null Wangdui, H. R. Wu, Q. Wu, J. L. Xu, L. Xue, Z. Yang, Y. Q. Yao, J. Yin, Y. Yokoe, N. P. Yu, A. F. Yuan, L. M. Zhai, C. P. Zhang, H. M. Zhang, J. L. Zhang, X. Zhang, X. Y. Zhang, Y. Zhang, Yi Zhang, Ying Zhang, S. P. Zhao, null Zhaxisangzhu, and X. X. Zhou
Subjects: Space and Planetary Science, Astronomy and Astrophysics
Abstract: HESS J1843–033 is a very high energy gamma-ray source whose origin remains unidentified. This work presents, for the first time, the energy spectrum of gamma rays beyond 100 TeV from the HESS J1843–033 region using the data recorded by the Tibet air shower array and its underground muon detector array. A gamma-ray source with an extension of 0.°34 ± 0.°12 is successfully detected above 25 TeV at (α, δ) = (281.°09 ± 0.°10, −3.°76 ± 0.°09) near HESS J1843–033 with a statistical significance of 6.2σ, and the source is named TASG J1844–038. The position of TASG J1844–038 is consistent with those of HESS J1843–033, eHWC J1842–035, and LHAASO J1843–0338. The measured gamma-ray energy spectrum in 25 TeV < E < 130 TeV is described with dN / dE = ( 9.70 ± 1.89 ) × 10 − 16 (E/40 TeV)−3.26±0.30 TeV−1 cm−2 s−1, and the spectral fit to the combined spectra of HESS J1843–033, LHAASO J1843–0338, and TASG J1844–038 implies the existence of a cutoff at 49.5 ± 9.0 TeV. Associations of TASG J1844–038 with SNR G28.6–0.1 and PSR J1844–0346 are also discussed in detail for the first time.
Published: 2022
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8. High protein intake after subarachnoid hemorrhage improves ingestion function and temporal muscle volume

Author: Y. Sakakibara, T. Mogamiya, H. Onodera, H. Nakamura, T. Sase, M. Mori, and S. Matsushima
Subjects: medicine.medical_specialty, Nutrition and Dietetics, Subarachnoid hemorrhage, business.industry, Endocrinology, Diabetes and Metabolism, High protein, medicine.disease, Temporal muscle, Volume (thermodynamics), Internal medicine, medicine, Cardiology, Ingestion, business
Published: 2020
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9. All-Polarization Maintaining, Bi-directional, Er-doped, Dual-comb Fiber Laser with Single Wall Carbon Nanotube

Author: S. Saito, M. Yamanaka, Y. Sakakibara, E. Omoda, H. Kataura, and N. Nishizawa
Published: 2019
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10. Dispersion Managed, High Power Tm-doped Ultrashort Pulse Fiber Laser at 1.9 um Using Single Wall Carbon Nanotube Polyimide Film

Author: K. Watanabe, Y. Zhou, A. Saitoh, Y. Sakakibara, and N. Nishizawa
Published: 2019
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11. Construction of KAGRA: an underground gravitational-wave observatory

Author: S. Ota, M. Marchio, T. Furuhata, Yoichi Aso, J. Park, Shinji Miyoki, Y. Sasaki, Masashi Ohkawa, T. Kagawa, D. Jia, Kieran Craig, Y. Sugimoto, T. Uehara, Takaaki Yokozawa, M. Asano, Y. Liu, Akito Araya, Koki Okutomi, K. Kawaguchi, S. Yamaguchi, Nobuyuki Kanda, T. Miyamoto, Kazuyuki Tanaka, Takahiro Tanaka, H. K. Tanaka, Y. Saito, E. J. Son, Jinsook Kim, Yuichiro Sekiguchi, Hirotaka Takahashi, Eiichi Hirose, Kouji Nakamura, Toshihiro Tsuzuki, K. Awai, K. Miyake, Sho Fujibayashi, N. Uchikata, Akiteru Takamori, T. Miener, Kentaro Komori, F. Matsushima, Kazuhiro Yamamoto, Y. Kitaoka, Satoshi Tsuchida, M. Morioka, T. Wakamatsu, Mitsuhiro Fukushima, Tomotada Akutsu, Nobuyuki Matsumoto, K. Miyo, K. Oohara, N. Mio, Eric Hennes, Kazuhiro Agatsuma, Takashi Uchiyama, K. Shiga, A. Hagiwara, T. Ushiba, Tatsuya Kume, Innocenzo M. Pinto, Tomasz Starecki, Yoshinori Fujii, Y. Tachibana, C-Y. Lin, Kunihito Ioka, S. Harita, A. Shoda, Ken-ichi Nakao, R. Flaminio, Norichika Sago, H. Suwabe, Masatake Ohashi, Masako Kakizaki, J. Kato, Motoyuki Saijo, Simon Zeidler, T. Matsui, Yousuke Itoh, H. Kakuhata, Suguru Takada, Ken Ono, T. Shimoda, Ryoji Takahashi, J. V. van Heijningen, Y. Sato, Ayaka Kumeta, Takaaki Kajita, Yuki Susa, Yutaka Shikano, S. Ueki, S. Kanbara, T. Saito, K. Hashino, S. Yamamoto, M. Murakoshi, Hiroyuki Nakano, Yuki Inoue, Shinya Kanemura, Hyang Woon Lee, Tatsuya Narikawa, M. A. Barton, M. Fujisawa, Sakae Araki, T. Utsuki, T. Hirayama, F. E. Peña Arellano, Keiko Kokeyama, J. F. J. van den Brand, Osamu Miyakawa, Jun'ichi Yokoyama, L. Zheng, Mitsuru Musha, T. Arima, Yuta Michimura, Toshikazu Suzuki, Alessandro Bertolini, T. Ogawa, Y. Ono, Hideharu Ishizaki, Seiji Kawamura, Y. Muraki, M. Toritani, T. Kaji, A. Yanagida, Hideyuki Tagoshi, K. Sakai, A. Miyamoto, R. Goetz, S. Sato, D. Chen, C. L. Mueller, Makoto Uyeshima, Rajesh Kumar, Y. Hayashida, N. Hirata, Koji Nagano, M. Kamiizumi, L. Baiotti, Hirotaka Yuzurihara, W. Morii, Masa-Katsu Fujimoto, T. Yamamoto, T. Nonomura, Leo Tsukada, Hisa-aki Shinkai, M. Nakano, C. Tokoku, David B. Tanner, N. Arai, Daisuke Tatsumi, Yuya Kuwahara, K. Kobayashi, J. Kasuya, Yoshiyuki Obuchi, Kentaro Somiya, Soichiro Morisaki, Kyung-Suk Cho, Y. Zhao, N. Someya, A. Khalaidovski, K. Yano, K. Doi, Masaki Ando, Hironori Nakao, S. Atsuta, Maria Ilaria Del Principe, T. Narita, N. Ohishi, H. Tamura, Hyun Lee, Kyoko Okino, K. Hasegawa, B. Ikenoue, Kazunari Eda, Kazuhiro Hayama, Yasufumi Kojima, Masashi Hasegawa, Chunglee Kim, Fumihiro Uraguchi, Y. Sakakibara, Sadakazu Haino, K. Ueno, Ettore Majorana, John J. Oh, Koji Kubo, Kimio Tsubono, Nobuyuki Kawai, Hiroki Takeda, Souichi Telada, Tai Hyun Yoon, Y. Hashimoto, W. S. Kim, Wei-Tou Ni, S. Koike, T. Sekiguchi, Shuhei Mano, Y. Moriwaki, T. Sato, N. Kimura, Shigeo Nagano, Kei Kotake, Takayuki Tomaru, S. Saitou, Y. Oda, Takashi Nakamura, J. Guscott, Hideki Ishitsuka, Hideki Asada, Masaru Shibata, T. Yaginuma, Seog Oh, K. Hirai, S. Wada, M. H.P.M. Van Putten, M. Kaneyama, Yutaro Enomoto, Fumiko Kawazoe, J. Kim, Y. Akiyama, A. Suemasa, Y. Kataoka, Naoki Aritomi, Kazuaki Kuroda, R. DeSalvo, Noriaki Ohmae, (Astro)-Particles Physics, and KAGRA Collaboration
Subjects: Physics - Instrumentation and Detectors, Gravitational-wave observatory, Design, Physics::Instrumentation and Detectors, FOS: Physical sciences, General Physics and Astronomy, Laser, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, General Relativity and Quantum Cosmology, gravitational-wave detector, 11. Sustainability, 0103 physical sciences, ddc:530, KAGRA, Interferometer, Kamioka, Aerospace engineering, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, 010308 nuclear & particles physics, Gravitational wave, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Vibration, Interferometry, seismic motion, High Energy Physics::Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract: 著者人数: 227名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 東谷, 千比呂), Number of authors: 227 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Tokoku, Chihiro), Accepted: 2017-11-21, 資料番号: SA1170370000
Published: 2018
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12. Application of phyto-Fenton process in constructed wetland for the continuous removal of antibiotics

Author: Y. Inagaki, S. Nara, Y. Sakakibara, K. Matsumoto, and V. P. Ranjusha
Subjects: Scientific method, Environmental engineering, Constructed wetland, Environmental science
Abstract: Phyto-Fenton process utilizes the endogenous hydrogen peroxide in plants to degrade organic pollutants in presence of iron catalyst. In this study, we have applied the magnetite particles in continuous treatment system of constructed wetland (CW) to study the effectiveness in removing sulfamethoxazole (SMX) antibiotics. Experimental results demonstrated that SMX was removed by constructed wetlands in the presence and absence of magnetite fine particles. OH radical formation was observed in the plant+Fe system with electron spin resonance spectroscopy. The magnetite addition favoured the plant growth and endogenous H2O2. However, enhanced treatments by phyto-Fenton process were not enhanced in the presence of magnetite particles, but the plants+soil CWs showed better removal efficiencies compared to the soil CWs.
Published: 2020
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13. EP1.09-02 Expression of Intratumoral GFPT2 in Lung Adenocarcinoma

Author: T. Hara, Hiroyuki Shimada, K. Shimaya, K. Yamanaka, O. Matsubara, Yasuto Jin, Y. Sakakibara, Y. Inoue, and Naohiko Inase
Subjects: Pulmonary and Respiratory Medicine, Lung, medicine.anatomical_structure, Oncology, business.industry, medicine, Cancer research, Adenocarcinoma, medicine.disease, business
Published: 2019
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14. P2.03-032 Efficacy and Safety of Osimertinib as Third-Line or Later Therapy for T790M-Positive Advanced Non-Small Cell Lung Cancer

Author: Shuta Yamauchi, Y. Sasahara, K. Yamanaka, R. Imase, H. Majima, T. Hara, S. Endo, Yasuto Jin, A. Kobayashi, T. Ozawa, Y. Sakakibara, K. Yamazaki, O. Matsubara, T. Shinmura, and Hiroyuki Shimada
Subjects: Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, medicine.disease, T790M, Third line, Internal medicine, medicine, Osimertinib, Non small cell, Lung cancer, business
Published: 2017
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15. Immunity to virus infection (excluding retroviruses) (PP-025)

Author: R. M. Welsh, H. Momtaz, A. R. Thomsen, Y. Watanabe, V. Combes, X. Kong, W. T. Rothwell, M. Kanno, B. Kazemi, A. Shirani, D. Khachapuridze, M. Odenthal, R. Yanagisawa, Z. Ling, P. S. Ohashi, M. L. Freeman, Y. Lee, M Hernández, J. Miles, G. N. Milligan, Z. Liang, Paul G. Thomas, J. Tanaka, Ralph A. Tripp, E. Aguirre, S. Workman, A. Aguilar-Setien, T. Laurinolli, S. Lin, D. Kłosowska, S. Wang, O. Ikeda, K. Ostrow, K. Bogunia-Kubik, U. Kalinke, K. Lee, T. M. Ha, Katherine Kedzierska, G. K. Vikulov, M. Khodabandeh, R. J. Betts, Lisbeth Berrueta, M. Pasparakis, E. Kekäläinen, M. Hoshi, Z. Zeng, T. Toma, G. E. Kaiko, K. Huang, K. S. Lang, T. Ito, R. Hancock, L. Pham Van, U. B. Hellstrom, A. Lange, A. Meyers, R. Petraityte, E. Rizopulu, F. Xu, R. M. Zinkernagel, Y. Girerd-Chambaz, Katayoun Samimi-Rad, Seyed Moayed Alavian, T. Hsu, M. Schaller, D. S. Bowden, M. S. Rolph, H. Fujii, P. A. Lang, M. Akihiro, T. Furuta, S. P. Sylvan, Florian Kern, H. Shibata, Y. Ogawa, X. Zhang, F. Lai, H. Kida, U. Kumaraguru, J. Cardosa, Peter C. Doherty, Mark M. Davis, J. Pätzold, M. Matloubian, Y. Sakoda, P. Chaux, S. Lai, N. Nakajima, Y. Chen, K. Markiewicz, T. Tran, P. Chong, I. Lagereva, B. Sierra, E. Nazarov, M. Kikuchi, H. Ishida, C. Ferrari, David L. Woodland, A. G. Bean, M. H. Nelson, Z. J. Chen, D. M. Estes, M. R. Azar Pajoh, K. Vogt, M. A. Blackman, R. Todaka, S. Ma, W. Li, J. Sun, P. Lukianov, K. Gärtner, A. Vaheri, P. Wark, A. W. S. Yeung, A. Matsumura, L. Cao, I. Beĭkin, M. Recher, K. Eriksson, V. Wang, D. Webster, H. Yoshizawa, K. Hosiawa-Meagher, P. Sun, K. Katayama, H. Bisceglia, J. Du, M. Matsumoto, Z. Qu, P. J. Gaddi, M. R. Edwards, J. R. Carlyle, T. U. Aripova, A. G. Telcian, J. S. Yi, V. I. Afanasyeva, R. Kumar, B. Shaffaedin, S. Schoenberger, A. S. Khodjaeva, S. C. Weaver, D. Verthelyi, R. Sugamata, F. Ershov, R. Jafari Shakib, G. N. Feketea, A. Brook, H. Lei, Z. Qin, F. Vahedi, M. G. Guzmán, J. Huang, C. Ventura, A. Izquierdo, W. Siew Cheng, T. Kawamura, H. Keyvani, C. Ørskov, C. Tami, T. T. Tran, J. H. Fine, H. Kato, Z. J. Rakhmankulova, Y. A. Chen, J. C. Huang, K. Kobayashi, K. Kitamura, W. F. Carson, Azam Bolhassani, R. Rochford, J. Li, M. A. Bolkov, H. Liu, T. Ospelnikova, P. Storm, S. T. Smiley, L. A. Stanciu, F. Sánchez-García, M. Nakayama, M. B. Moreno-Altamrano, T. Wada, J. Deng, A. Perez, M. Puig, N. W. Lukacs, G. Liang, S. Jeon, L. C. Bonifaz-Alfonzo, S. Shimada, G. García, H. Marshall, A. Górski, S. Phipps, H. Tran, H. Kanegane, G. Korczak-Kowalska, C. Boni, J. Kyd, L. Rocha-Zavaleta, F. Garib, H. T. Q. Vu, M. Simadu, J. P. Twohig, B. G. Oliver, Shine Thomas, D. Chu, S. M. Cuff, Y. Lin, Z. Tian, S. Mäkelä, N. Mosaffa, M. Gołebiowska Wawrzyniak, R. Anderson, M. Brückel, T. P. Salazar-Mather, G. E. Grau, H. G. Durkin, I. R. Humphreys, W. Xi, H. Lin, Y. Sakakibara, A. Toga, P. Chen, K. Saito, Yasaman Taslimi, Leidith Berrueta-Carrillo, Y. Itoh, J. Sung, F. Liao, V. Emery, Y. Sato, S. Voigt, H. Horie, L. Simson, M. Larki, A. Hayashi, S. L. Rossi, R. Milne, R. Mirzaei, B. Evengård, Y. Liu, P. G. Mohr, B. Weiss-Steider, T. Nishimura, M. J. Crane, M. Høgh-Petersen, E. Sandalova, A. Dehghan, Z. Sharifnia, E. C. Y. Wang, H. Volk, M. L. Mora-García, C. M. Hogaboam, J. M. Clingan, A. T. Tan, N. Evstigneeva, P. Knolle, S. Hsieh, I. Kucinskaite-Kodze, M. Alvarez, Darrell L. Peterson, D. Tran, Sima Rafati, T. Seya, S. Marques, Tania Cukalac, F. Goshima, L. Perea-Martìnez, N. La Gruta, S. Kawachi, I. Hirono, M. Raeiszadeh, M. Koura, P. Holst, P. Kourilsky, R. Ganjali, J. P. Christensen, N. Hirankarn, L. Yao, A. Jakimiuk, J. Browne, I. V. Nesterova, M. Lu, M. Rezvani, C. Lin, B. A. Wu-Hsieh, G. P. Nolan, L. P. Bykova, B. Agrawal, K. Pérz-Saldaña, P. M. Niedzwiedzka-Rystwej, B. Pliego-Rivero, M. Farhadi, A. P. Godovalov, E. W. Newell, G. Hsu, L. T. P. Nguyen, Y. Chang, F. Rashidi, J. Tanguy, P. Kaiser, H. Lauterbach, F. Saito, R. Chua, P. W. Mason, I. A. Pashnina, H. Neekdan, Jamie Rossjohn, M. Toporkova, Luisa Barboza, H. Mitsui, M. C. Zaragoza-Ortega, E. L. Istomina, L. T. Dang, S. N. Boyarsky, A. Mesci, S. Vázquez, O. A. Aguilar, K. Shinoda, C. G. Silva, Stacie Woolard, M. Sadeghi, M. Jones, Farnaz Zahedifard, L. Wyatt, H. Dobashi, J. Simas, Henry Montes, N. Levchik, P. Kokhaei, C. Bartholdy, S. L. Kunkel, K. Suzuki, E. E. Ooi, Ashish Kumar, I. P. Balmasova, J. Ettinger, T. Nakayama, A. J. Zajac, R. Eftekhari, R. Lachmann, H. Inoue, D. Häussinger, D. Zhao, S. Koyasu, Chi Ma, Y. Keynan, M. V. Chikhladze, A. Hsu, F. Khodapanahandeh, W. Sun, K. Ogasawara, L. S. Tsai, M. Asano, A. Yachie, Stephanie Gras, J. Körner, N. Gaius, R. Gholamian-Dehkordi, Y. R. Sepiashvili, Y. Lu, Xinghao Ding, N. Vasilakis, D. Laccabue, H. Wu, J. Feng, S. Liu, X. Liang, M. Nowakowski, M. Krönke, K. I. Mattaei, D. V. Tran, K. L. O. Antonsdotter, K. Wong, B. Tzang, B. Dabirmanesh, H. Hochrein, Stephen J. Turner, A. Kulawik, D. Omagari, L. Skljar, O. Kovalenko, M. Seishima, H. Dienes, E. Rubinstein, L. Cervantes-Barragan, Y. Kim, I. Moro, U. Protzer, R. Sun, T. Mironova, D. M. Kemeny, J. Tavakkol Afshari, J. Mustonen, J. W. Lowenthal, T. P. Arstila, S. Kiabi, J. L. Munoz-Jordan, Z. S. Kamalov, Z. Wawrzyniak, C. Ahlm, K. Soda, Z. Mohtasham Amiri, Y. Aratani, T. Chumachenko, Y. Teruhito, Ali Eslamifar, J. Pedras-Vasconcelos, A. P. Durbin, N. J. C. King, H. Vu, M. Suter, T. Burgess, Z. Atai, T. Vo, E. R. Jellison, F. Li, M. C. Mohanty, E. V. Vlasova, T. Ball, H. Ishigaki, I. A. Tuzankina, C. R. Stewart, A. Flavigny, L. Nguyen, T. Sata, S. Akira, V. Kalihevich, E. Jaskula, O. Takeuchi, C. Aitken, K. Mohtashami, M. Bharadwaj, A. Bertoletti, Melisa Colmenares, H. Jenssen, S. Chen, J. Ramos-Castaneda, J. S. Ahn, D. Xilei, L. Hsu, A. Verschoor, M. Bandehpour, H. D. Volk, M. H. Bluth, M. Du, M. Tadashi, S. Mahalingam, C. Tsai, M. Arikata, Sophie A. Valkenburg, A. Monroy-García, M. Okamatsu, K. Rytwinski, K. Schmolke, D. B. Lewis, Siham Salmen, H. A. Mahgoub, C. Butts, A. Krishnamurthy, S. Moneer, H. Kondo, Ali Khamesipour, P. Ghyasemi-Dehkordi, L. Valdés, R. Aoki, L. A. Sandoval-Escobar, H. Ito, Natasha G. Swan, K. Dahlman-Wright, B. J. Hanson, P. M. Hansbro, P. Foster, M. Yasunami, Q. Ge, K. Tomizawa, U. Nivarthi, W. Wu, J. McCluskey, Y. Wang, J. Lee, J. McGrath, K. Yamamoto, J. Jan, L. Kjer-Nielsen, S. L. Johnston, H. Takaki, N. Prabhu, T. J. Standiford, B. Moss, L. Sanchez, P. Sodsai, M. Guzman, P. S. Foster, E. V. Shmeleva, A. Shestakov, T. Satoh, R. S. Kuzyaev, P. Wierzbicki, K. Fink, H. Rafat Panah, H. Ohtaki, J. Nakkuntod, E. S. Malova, K. Hirayama, H. Yagita, A. Zvirbliene, S. V. Mayer, B. Jin, L. Zuo, Z. Ardemasova, N. Harris, A. Kozar, S. Vostrukhin, J. Chang, C. Zhao, S. Kurata, S. Noorbakhsh, M. Muramatsu, E. Guillemard, O. Mikhailova, T. V. Vo, C. Fuentes-Miranda, P. Chaplin, D. Stabenow, N. Burdin, S. C. D. D. Abedelmalek, Y. Kuznetsova, Mohammad Taghikhani, D. K. Hong, A. B. Pérez, S. Yuichi, J. Hernández-Montes, O. Cruz y Cruz, T. Maciejewski, G. Siritsa, Elham Mohit, K. Morita, Y. Jiang, D. K. Krishnadas, K. Sasnauskas, W. M. Deptuła, H. Nguyen, J. Borysowski, K. Komiyama, C. Chuang, E. Markelova, N. Babel, K. R. Fowke, D. Thammanichanond, R. Kassub, C. Chirathaworn, A. Rizopulu, I. Gorelova, N. Van Rooijen, F. Pak, N. Bourne, D. Townsend, C. Krings, Y. Nishiyama, B. Ludewig, E. R. Winkelmann, J. M. Deshpande, S. Tsai, P. A. MacAry, Y. Mitsuya, S. Marashi, J. Niu, N. Watanabe, J. Schrezenmeir, R. M. Locksley, J. Jang, N. D. Yushchuk, Y. Su, S. Chowdhury, J. A. Juno, F. Ghazi, M. Hellard, H. Hengartner, Y. Ohmoto, W. Yang, R. B. Tesh, A. W. Ho, P. Kupatawintu, Z. Wang, P. Brundin, S. de la Motte, S. C. Bendall, M. Oshima, P. Tangkijvanich, T. Nagao, and B. M. M. Moreno-Altamirano
Subjects: Immunity, Immunology, Immunology and Allergy, General Medicine, Biology, Virology, Virus, Oncovirus
Published: 2010
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16. P1.03-010 Efficacy and Safety of Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitors in ALK-Positive Non-Small Cell Lung Cancer

Author: Shuta Yamauchi, T. Hara, R. Imase, A. Kobayashi, T. Ozawa, H. Majima, Yasuto Jin, K. Yamazaki, K. Yamanaka, T. Shinmura, Hiroyuki Shimada, Y. Sakakibara, O. Matsubara, S. Endo, and Y. Sasahara
Subjects: Pulmonary and Respiratory Medicine, Oncology, business.industry, ALK-Positive, Cancer research, Medicine, Anaplastic lymphoma kinase, Non small cell, business, Lung cancer, medicine.disease, Tyrosine kinase
Published: 2017
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17. Modified distal tibial rotational osteotomy for osteoarthritis of the ankle

Author: A. Teramoto, Kota Watanabe, T. Kamiya, H. Shoji, S. Nuka, Y. Sakakibara, T. Yamashita, and T. Kobayashi
Subjects: Orthodontics, medicine.anatomical_structure, business.industry, Medicine, Orthopedics and Sports Medicine, Osteoarthritis, Ankle, business, medicine.disease, Rotational osteotomy
Published: 2017
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18. Mechanical loss of a multilayer tantala/silica coating on a sapphire disk at cryogenic temperatures: Toward the KAGRA gravitational wave detector

Author: Kouichi Waseda, I. W. Martin, Eiichi Hirose, Kieran Craig, Kyohei Watanabe, Kazuhiro Yamamoto, Toshikazu Suzuki, P. G. Murray, Norikatsu Mio, Shigenori Moriwaki, Masatake Ohashi, Y. Sakakibara, Sheila Rowan, and Hideki Ishitsuka
Subjects: Physics, Nuclear and High Energy Physics, Gravitational-wave observatory, business.industry, Annealing (metallurgy), Detector, engineering.material, Optics, Coating, engineering, Sapphire, Optoelectronics, KAGRA, business, Silica coating
Abstract: We report the results of a new experimental setup to measure the mechanical loss of coating layers on a thin sapphire disk at cryogenic temperatures. Some of the authors previously reported that there was no temperature dependence of the mechanical loss from a multilayer tantala/silica coating on a sapphire disk, both before and after heat treatment, although some reports indicate that Ta2O5 and SiO2 layers annealed at 600 °C have loss peaks near 20 K. Since KAGRA—the Japanese gravitational-wave detector, currently under construction—will be operated at 20 K and have coated sapphire mirrors, it is very important to clarify the mechanical loss behavior of tantala/silica coatings around this temperature. We carefully investigate a tantala/silica-coated sapphire disk with the new setup, anneal the disk, and then investigate the annealed disk. We find that there is no distinct loss peak both before and after annealing under particular conditions. The mechanical loss for the unannealed disk at 20 K is about 5×10−4, as previously reported, while that for the annealed disk is approximately 6.4×10−4.
Published: 2014
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19. Sapphire screws and strength test on them at liquid nitrogen temperature

Author: Eiichi Hirose, Takashi Ishii, Yukihiko Igarashi, and Y. Sakakibara
Subjects: Screw thread, Materials science, Ultimate tensile strength, Sapphire, Liquid nitrogen, Composite material, Cryogenic temperature, Instrumentation, Structural element, Tensile testing
Abstract: We fabricated several sapphire screw threads and performed a strength test on them at the liquid nitrogen temperature of 77 K. The screw threads were subjected to and withstood a 3000 N load. To the best of our knowledge, this is the first strength test of sapphire screw threads at a cryogenic temperature. The result suggests a new way of connecting sapphire components. Although sapphire is already used in many applications, the result may provide a new way to use the material as a structural element in even more applications.
Published: 2014

20. Progress and challenges in advanced ground-based gravitational-wave detectors

Author: V. V. Frolov, V. Malvezzi, G. L. Mansell, B. Champagnon, R. Flaminio, Benno Willke, V. Dolique, L. Anghinolfi, E. Coccia, Stefan Hild, M. Doets, Andreas Freise, Peter Wessels, A. Rocchi, Denis Martynov, K. Shibata, Joseph Gleason, T. Theeg, L. Pinard, C. L. Mueller, Mirko Prato, D. A. Brown, Takashi Uchiyama, M. Granata, A. Schimmel, P. Risson, Ludovic Bellon, Daniel A. Shaddock, L. Carbone, Felipe Aguilar, M.H. Evans, G. Vajente, M. Adier, M. Stefszky, Guido Mueller, Dominique de Ligny, P. Puppo, Enrico Serra, Alain Mermet, Ettore Majorana, A. Kumeta, I. Nardecchia, Gianpietro Cagnoli, Kimio Tsubono, M. G. Beker, Z. Liu, R. Gustafson, J. P. Zendri, Ayaka Shoda, Kazuaki Kuroda, G. A. Prodi, E. Cesarini, L. Naticchioni, H. J. Bulten, M. Neri, T. T. Fricke, Alessandro Bertolini, Yoshito Niwa, C. Bogan, Kenneth A. Strain, S. E. Dwyer, M. Gross, D. H. Shoemaker, V. Quetschke, Peter Fritschel, D. Sigg, S. Farinon, M. Leonardi, Fumiko Kawazoe, F. Mul, M. Daloisio, D. Feldbaum, A. S. Bell, D. Chen, T. Meier, D. Friedrich, Lutz Winkelmann, J. Macarthur, M. Blom, B. Sassolas, N. D. Smith-Lefebvre, N. Kimura, Hartmut Grote, G. Losurdo, S. Koike, P. Kwee, N. Saito, Y. Saito, Toshikazu Suzuki, T. Kume, Danièle Forest, Ben C. Buchler, Nadja S. Magalhães, A. R. Wade, K. Okada, S. H. Huttner, J. Marque, C. M. Mow-Lowry, Grant David Meadors, R. L. Ward, A. Conte, Seiji Kawamura, C. Vorvick, D. Lumaca, M. Lorenzini, K. Yamamoto, Maik Frede, R. M. S. Schofield, J. F. J. van den Brand, N. Straniero, Y. Sakakibara, Giacomo Ciani, Carlos Frajuca, Kentaro Somiya, Koji Ishidoshiro, R. M. Martin, David H. Reitze, K. Kawabe, O. Puncken, Christian Gräf, M. Cortese, M. Geitner, Ryutaro Takahashi, D. Nanda Kumar, N. A. Gordon, Masaki Ando, Yoichi Aso, M. Factourovich, B. Sorazu, K. L. Dooley, C. Michel, Lisa Barsotti, Slawomir Gras, V. Sequino, K. Izumi, Andrea Chincarini, R. Day, M. A. Arain, P. Fulda, B. Lagrange, David E. McClelland, S. Leavey, F. S. Bortoli, Stefan Goßler, V. Fafone, Masatake Ohashi, Nergis Mavalvala, Jerome Degallaix, P. Antonini, M. Kasprzack, Y. Minenkov, Ping Koy Lam, E. Schreiber, Matthew Heintze, C. Bond, P. Oppermann, Maurizio Canepa, V. Mangano, Eric Hennes, M. M. Hanke, C. Tokoku, David B. Tanner, T. Akutsu, M. Landry, L. Mudadu, Roman Schnabel, T. Li, H. Vahlbruch, Alexander Khalaidovski, Carl Blair, G. Tellez, Sheon Chua, J. Poeld, A. Chtanov, M. Damjanic, S. Ueda, B. Barr, L. Williams, Gianluca Gemme, Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Observatoire de Bédoin, Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Lumière Matière [Villeurbanne] ( ILM ), Laboratoire Kastler Brossel ( LKB (Lhomond) ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Virgo, Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Hubert Curien [Saint Etienne] ( LHC ), Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Physics and Atmospheric Science [Halifax], Dalhousie University [Halifax], Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Institute for Cosmic Ray Research ( ICRR ), The University of Tokyo, Meteorological Research Institute [Tsukuba] ( MRI ), Japan Meteorological Agency ( JMA ), Department of Chemistry, Graduate School of Science and Engineering, Department of Chemistry, (Astro)-Particles Physics, Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Laboratoire Kastler Brossel (LKB (Lhomond)), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institute for Cosmic Ray Research (ICRR), The University of Tokyo (UTokyo), Meteorological Research Institute [Tsukuba] (MRI), Japan Meteorological Agency (JMA), MIT Kavli Institute for Astrophysics and Space Research, Barsotti, Lisa, Evans, Matthew J, Fritschel, Peter K, Gras, Slawomir, Mavalvala, Nergis, Shoemaker, David H, Smith, Nicolas de Mateo, École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Hubert Curien [Saint Etienne] (LHC), and Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Physics and Astronomy (miscellaneous), POWER, [ PHYS.COND.CM-MS ] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 01 natural sciences, 010309 optics, Gravitational wave detectors, 0103 physical sciences, KAGRA, Session (computer science), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, Gravitational wave, Detector, Astronomy, [ SDU.ASTR.IM ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Optics, Interferometry, LIGO, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], LIGHT, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], MODES, [ PHYS.ASTR.IM ] Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]
Abstract: The Amaldi 10 Parallel Session C3 on Advanced Gravitational Wave detectors gave an overview of the status and several specific challenges and solutions relevant to the instruments planned for a mid-decade start of observation. Invited overview talks for the Virgo, LIGO, and KAGRA instruments were complemented by more detailed discussions in presentations and posters of some instrument features and designs. © 2014 Springer Science+Business Media New York.
Published: 2014
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21. Fully depleted 20-nm SOI CMOSFETs with W-clad gate/source/drain layers

Author: T. Ohno, M. Takahashi, K. Takayama, and Y. Sakakibara
Subjects: Materials science, Equivalent series resistance, business.industry, Subthreshold conduction, Electrical engineering, Silicon on insulator, chemistry.chemical_element, Chemical vapor deposition, Tungsten, Electronic, Optical and Magnetic Materials, Ion implantation, chemistry, MOSFET, Optoelectronics, Field-effect transistor, Electrical and Electronic Engineering, business
Abstract: Fully-depleted 20-nm SOI complementary metal-oxide-semiconductor field effect transistors (CMOSFETs) were successfully fabricated without a raised source/drain (S/D) structure, instead using low-temperature selective tungsten CVD (SWCVD) technology that can reduce the S/D series resistance. The thickness of the residual SOI layer under the W-clad layer in the S/D region was 6 nm for an nMOSFET and 9 nm for a pMOSFET. For 0.15-/spl mu/m-gate CMOSFETs, the subthreshold swings were 70 and 75 mV/dec for the nMOSFET and pMOSFET, respectively. The effectiveness of SWCVD technology when applied to ultrathin SOI devices was confirmed by small Si consumption and good continuity between the W and SOI layers. We expect that the S/D series resistance can be reduced to less than 1 k/spl Omega/-/spl mu/m by optimizing the S/D implantation conditions.
Published: 2001
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22. Development of a model for the lean NOx catalytic reaction with hydrocarbon adsorption and desorption

Author: Yoshihide Watanabe, T Kondo, Y Sakakibara, Akihiko Asano, and Masahiro Sugiura
Subjects: inorganic chemicals, chemistry.chemical_classification, Diesel exhaust, Chemistry, Process Chemistry and Technology, technology, industry, and agriculture, respiratory system, Diesel engine, complex mixtures, Catalysis, Diesel fuel, Adsorption, Hydrocarbon, Chemical engineering, Desorption, Organic chemistry, Diesel exhaust fluid, human activities, NOx, General Environmental Science
Abstract: A numerical model for lean NOx catalytic reaction in consideration of hydrocarbon adsorption and desorption process, which is capable of predicting the performance of diesel lean NOx catalyst using diesel fuel as a supplemental reductant, has been developed. This model is based on our simplified kinetics for the adsorption and desorption of hydrocarbons, for the oxidation of hydrocarbons, and for the reduction of NOx by hydrocarbons including the desorbed one. The adsorption of diesel exhaust hydrocarbons was expressed by the Freundlich-type isotherm that has the adsorption equilibrium constant of exponential temperature dependence. The behavior of HC and NOx reactions and HC adsorption and desorption in diesel exhaust has been simulated successfully.
Published: 2001
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23. A Rapid-Scanning Spectrometer with Wavelength Synchronization by a Laser Rotary Encoder for Versatile Applications to Atomic Emission Spectrometry

Author: Shin Tsuge, Y. Sakakibara, and Kuniyuki Kitagawa
Subjects: Rotary encoder, Spectrometer, business.industry, Chemistry, Atomic emission spectroscopy, Analytical chemistry, Physics::Optics, Grating, Laser, Analytical Chemistry, law.invention, Synchronization (alternating current), Wavelength, Optics, law, business, Encoder, Spectroscopy
Abstract: A rapid-scanning spectrometer was developed for versatile use in atomic emission spectroscopy. The sine bar was removed and a laser rotary encoder was fitted to the grating shaft for wavelength synchronization. The pulses produced by the encoder when the grating shaft was driven back and forth in sector movements were counted to detect the grating angle and the wavelength. The wavelength accuracy and precision obtained were ±0.26 and ±0.013 nm, respectively. The maximum scanning speed was limited below 4000 nm/s by a malfunction in wavelength synchronization. The rapid-scanning spectrometer was successfully used for multielement determinations, correction of background emission, and characterization of an inductively coupled plasma.
Published: 1999
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24. Numerical Study of Oscillation Mechanism in Underexpanded Jet Impinging on Plate

Author: J. Iwamoto and Y. Sakakibara
Subjects: Shock wave, Physics, Jet (fluid), Oscillation, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Mechanical Engineering, Bubble, Boundary (topology), Mechanics, Flow field, Physics::Fluid Dynamics, Unsteady flow, Mechanism (engineering), Optics, High Energy Physics::Experiment, business
Abstract: The mechanism of the oscillatory phenomena of an underexpanded jet impinging on a flat plate is studied numerically. Pressure changes generated in the flow field near the plate propagate radially in the surrounding region of the jet. The configuration of the jet boundary is changed by them and so, the waves forming the underexpanded jet are displaced when they are reflected from the jet boundary. And then, the pressure disturbances return to the region near the plate. Unsteady flow with repetition of growth and decay of the separation bubble on the plate is also found under certain conditions.
Published: 1998
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25. Cryogenic system for the interferometric cryogenic gravitationalwave telescope, KAGRA - design, fabrication, and performance test

Author: S. Goto, K. Kuroda, K. Yamamoto, H. Nezuka, Nobuhiro Kimura, D. Chen, S. Koike, M. Tanaka, T. Suzuki, M. Ohashi, Takashi Uchiyama, S. Ioka, K. Nakamoto, T. Kume, Chihiro Tokoku, and Y. Sakakibara
Subjects: Cryostat, Physics, Fabrication, Physics::Instrumentation and Detectors, Gravitational wave, Cryogenic system, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Cryocooler, law.invention, Telescope, Interferometry, Optics, law, KAGRA, business
Abstract: KAGRA is the cryogenic interferometric gravitational wave telescope designed for the direct detection of gravitational waves from the astronomical sources. To achieve the best sensitivity, one of the most difficult challenges is cooling the mirrors to 20K to reduce the thermal noise. We developed four cryostats and sixteen very-low-vibration cryocooler units to accomplish our purpose. In this paper, we describe the outline of the cryogenic design and fabrication, and the results of the cryogenic performance test of the cryostats and cryocooler units.
Published: 2014
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26. Vibration measurement in the KAGRA cryostat

Author: Seiji Kawamura, C. Tokoku, Toshikazu Suzuki, S. Koike, L. Naticchioni, Ettore Majorana, Kazuhiko Yamamoto, Takashi Uchiyama, Y. Sakakibara, Dan Chen, Nobuhiro Kimura, and A. Khalaidovski
Subjects: Physics, Cryostat, Gravitational-wave observatory, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Acoustics, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Seismic noise, Cryocooler, Noise (electronics), Nuclear magnetic resonance, Measuring instrument, KAGRA
Abstract: The Japanese gravitational wave observatory KAGRA will be operated at cryogenic temperatures to reduce thermal noise. Four main mirrors and their suspension systems, called cryogenic payloads, will be cooled in the cryostat. Vibrations of the cryostat and the cryocooler can contaminate the output of the detector. One of the noise paths is the heat link made from the pure soft metal between the cryogenic payload and cryocoolers to cool the payload. In order to evaluate this noise amplitude, we measured the vibration of the radiation shield at cryogenic temperatures at the cryostat production site in Yokohama, Japan. For this measurement, we developed cryogenic accelerometers. Based on the result of this measurement, we calculated the noise in the KAGRA interferometer. Our results show that with the current design, the seismic noise goal formulated for KAGRA cannot be achieved. Finally, we present a possible design optimization that is meant to reach the nominal sensitivity of the detector.
Published: 2014

27. Maldistribution of Multidose Blood Cardioplegia: Pharmacologic Intervention to Prevent Subendocardial Hypoperfusion by Alpha-Adrenergic Blockade

Author: Y Sakakibara
Subjects: medicine.medical_specialty, Phenoxybenzamine, Myocardial Ischemia, Dogs, medicine, Animals, Lactic Acid, Cardioplegic Solutions, Adrenergic alpha-Antagonists, Endocardium, biology, business.industry, Myocardium, Fissipedia, Heart, biology.organism_classification, Coronary Vessels, Blockade, Cardiac surgery, medicine.anatomical_structure, Anesthesia, Coronary vessel, Heart Arrest, Induced, Potassium, Vascular resistance, Vascular Resistance, Surgery, business, Perfusion, Blood Flow Velocity, medicine.drug
Abstract: Maldistribution of multidose blood cardioplegia (BCP) continues to be a problem causing perioperative subendocardial damage. However, it is not known whether alpha-adrenergic stimulation contributes to the maldistribution of multidose BCP. We have evaluated the effects of phenoxybenzamine (POB) on multidose BCP distribution, with a right heart bypass model in 14 dogs. Although gradual increases in coronary vascular resistance (CVR) were noted in the control group (CP-1: 0.53 +/- 0.08, CP-2: 0.57 +/- 0.07, CP-3: 0.78 +/- 0.10 mm Hg/ml/min/100 g), there was no significant rise in CVR in the POB group (CP-1: 0.36 +/- 0.03, CP-2: 0.37 +/- 0.04, CP-3: 0.42 +/- 0.04 mm Hg/ml/min/100 g). Improved delivery of BCP was observed in the POB group during CP-3 (endo/epicardial flow ratio 1.72 +/- 0.07 vs. 1.21 +/- 0.18 in the control group; p < 0.05). These data indicate that improved delivery of BCP can be obtained by alpha-adrenergic blockade, if multiple injections of BCP are used for cardiac surgery.
Published: 1997
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28. Education and Imaging. Gastrointestinal: Unusual duodenal follicular lymphoma observed by magnifying endoscopy with narrow-band imaging

Author: S, Nakazuru, T, Yoshio, S, Suemura, R, Iwasaki, H, Hasegawa, Y, Sakakibara, E, Mita, H, Ikeda, K, Mori, and M, Mano
Subjects: Male, Narrow Band Imaging, Proto-Oncogene Proteins c-bcl-2, Duodenal Neoplasms, Biomarkers, Tumor, Humans, Neprilysin, Endoscopy, Digestive System, Antigens, CD20, Lymphoma, Follicular, Aged, Neoplasm Staging
Published: 2013

29. Standardized procedure for calibrating height scales in atomic force microscopy on the order of 1 nm

Author: T. Futatsuki, Y. Sakakibara, M. Yasutake, S. Aoyama, H. Takami, T. Osada, A. Nakano, A. J. Kelly, Y. Suzuki, Mineharu Suzuki, and T. Takenobu
Subjects: Standard sample, Atomic force microscopy, business.industry, Chemistry, Analytical chemistry, Surfaces and Interfaces, Surface finish, Condensed Matter Physics, Sample (graphics), Standard deviation, Surfaces, Coatings and Films, Optics, Calibration, Surface structure, Order (group theory), business
Abstract: We propose a standard stepped sample and specify a procedure for determining the step height for height‐scale calibration of atomic force microscopy (AFM) instruments on the order of sub‐nm to nm. The stepped Si(111) surface structure was confirmed to be the most appropriate for the standard sample by a series of round‐robin measurements carried out by a group comprising AFM instrument manufacturers and user organizations. By specifying a standard measurement procedure, the mean standard deviation of the step heights is decreased by 50%. It is also confirmed that the measured Si step height is accurate to ±5%, which is consistent with the accuracy obtained for higher step standard samples. A prototype common data processing software program containing the algorithm of the specified procedure was used to allow direct comparison of the untreated measurement data from each organization.
Published: 1996
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30. A Study of Cooling Time Reduction of Interferometric Cryogenic Gravitational Wave Detectors Using a High-Emissivity Coating

Author: Nobuhiro Kimura, Chihiro Tokoku, S. Koike, Toshikazu Suzuki, Kazuaki Kuroda, Masatake Ohashi, D. Chen, Takashi Uchiyama, Kazuhiro Yamamoto, and Y. Sakakibara
Subjects: Materials science, Physics - Instrumentation and Detectors, Gravitational wave, business.industry, Payload, Detector, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Instrumentation and Detectors (physics.ins-det), engineering.material, Noise (electronics), General Relativity and Quantum Cosmology, Interferometry, Optics, Coating, Heat transfer, engineering, Emissivity, business, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: In interferometric cryogenic gravitational wave detectors, there are plans to cool mirrors and their suspension systems (payloads) in order to reduce thermal noise, that is, one of the fundamental noise sources. Because of the large payload masses (several hundred kg in total) and their thermal isolation, a cooling time of several months is required. Our calculation shows that a high-emissivity coating (e.g. a diamond-like carbon (DLC) coating) can reduce the cooling time effectively by enhancing radiation heat transfer. Here, we have experimentally verified the effect of the DLC coating on the reduction of the cooling time., Comment: 8 pages, 9 figures, Proceedings of CEC/ICMC 2013
Published: 2013
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31. Status of the cryogenic payload system for the KAGRA detector

Author: Takayuki Tomaru, Dan Chen, T. Kajita, Hiroki Tanaka, Rajesh Kumar, Y Sakakibara, Toshikazu Suzuki, Kazuhiro Yamamoto, A Hagiwara, and T. Miyamoto
Subjects: Physics, History, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Gravitational wave, Payload, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, 01 natural sciences, Computer Science Applications, Education, law.invention, Telescope, Interferometry, Optics, law, 0103 physical sciences, High Energy Physics::Experiment, KAGRA, 010306 general physics, business
Abstract: KAGRA is a large scale cryogenic gravitational wave telescope currently under construction in Japan. The detector is located 200 m underground in the Kamioka mine and will employ cryogenic technologies to achieve high sensitivity. The mirrors of the interferometer will be in the form of multiple pendulums and the final stages will employ cryogenic sapphire suspension system operating at 20 Kelvin. In this paper we report the ongoing activities of the cryogenic payload group involved in the design and fabrication of the cryogenic payload system for the KAGRA detector
Published: 2016
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32. Vacuum and cryogenic compatible black surface for large optical baffles in advanced gravitational-wave telescopes

Author: S. Koike, Dan Chen, Simon Zeidler, C. Tokoku, Yoshio Saito, Yoshihiro Sato, Tomotada Akutsu, Yoshito Niwa, Nobuhiro Kimura, Y. Sakakibara, Kouichi Ikeyama, Kazuhiro Yamamoto, Yusuke Ariyama, and Toshikazu Suzuki
Subjects: Materials science, 010308 nuclear & particles physics, Gravitational wave, business.industry, Stray light, 01 natural sciences, Electronic, Optical and Magnetic Materials, 010309 optics, Interferometry, Outgassing, Optics, 0103 physical sciences, Astronomical interferometer, Optoelectronics, Light beam, KAGRA, business, Surface finishing
Abstract: This paper reports on the optical properties, outgassing rate, and cryogenic performance of surface finishing we have adopted for large optical baffles absorbing stray light in KAGRA, an advanced interferometer for detecting gravitational waves. The surface finishing is based on an electroless nickel-phosphorus-tungsten (NiPW) plating, applicable to large surface area up to ~ 800 mm in diameter, and achieves less than 3% total reflectance against a light beam at 1064 nm with a reasonable scattering distribution ~ 0.05/sr. The outgassing rate from the black coating meets our requirements of 3×10−7 Pa · m3 s−1 m−2. The black coating can tolerate low temperature down to 12 K, and can be installed close to cold mirrors indispensable for the future interferometers.
Published: 2016
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33. Dental health examination of children from nursery schools in Tokyo using the DIAGNO-DENT caries detector

Author: Y Sakakibara, N Ohata, T Sunaga, R Kosino, T Kobayakawa, T Tsuda, T Tunasima, K Akimoto, and S Suga
Subjects: Orthodontics, Diagnostic methods, business.industry, Dental health, Dentistry, General Medicine, Dental cavity, Caries Detector, stomatognathic diseases, stomatognathic system, Medicine, Diagnostic data, Visual observation, Data recording, Pre school, business
Abstract: Background : Examination of decayed cavities by means of dental probes has been suggested to destroy decalcified enamel that still may be re-calcified, ultimately causing the development of dental caries. In the present study, we utilized the DIAGNO-DENT caries detector for examination of dental caries. Materials and methods : A total number of 193 teeth of children from eight nursery schools in the Azabu-Akasaka area of Tokyo was examined. The examination procedures consisted of visual observation, data recording, reexamination of teeth diagnosed as C0 and C1, recording of the numerical results, examining the restored teeth and data collection. Results : Dental cavities visually diagnosed as C0 or C1 showed high counting by DIAGNO-DENT examination. The degree of infection was in contrast with DIAGNO-DENT detection. Specifically, there were 12 visually diagnosed C2 that indicated DIAGNO-DENT counting under 18, suggesting that the reference counting 18–25 may not be a definitive indication of cavity preparation. Conclusion : It is possible to conclude that DIAGNO-DENT is noninvasive, easy to use and a reproductive diagnostic method. The use of DIAGNO-DENT for dental cavity detection gives more accurate diagnostic data than the traditional technique.
Published: 2003
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34. Role of a putative tyrosine-O-sulfate receptor in the targeting and/or intracellular transport of tyrosine-sulfated proteins

Author: M C, Liu, Y, Sakakibara, and M, Suiko
Subjects: Article
Abstract: By employing the affinity gel fraction technique, we have detected a 175 kDa tyrosine-O-sulfate (TyrS)-binding protein in sodium choleate extracts of the microsomal membrane fractions of bovine liver and pancreas, as well as canine liver and pancreas. Western blot analysis revealed the presence of the bovine liver TyrS-binding protein in complexes with tyrosine-sulfated proteins both in vivo and in vitro, suggesting the putative role of the former being the receptor for the latter. Using filter-grown Madin-Darby canine kidney (MDCK) cells as a model, it was demonstrated that the tyrosine-sulfated proteins synthesized were predominantly secreted into the apical medium. The results further indicate the production and differential polarized secretion of different sulfated forms of the two major secretory proteins produced by MDCK cells, fibronectin (FN) and an 80 kDa glycoprotein (gp 80), with their tyrosine-sulfated forms being predominantly secreted from the apical surface. Treatment of filter-grown MDCK cells with glycosylation inhibitors, swainsonine and 1-deoxymannojirimycin, appeared to enhance the apical secretion of tyrosine-sulfated FN and gp 80. A similar 175 kDa membrane-bound 'TyrS receptor', cross-reactive toward antiserum against the canine liver TyrS receptor, was shown to be present in MDCK cells. Pulse-chase experiments revealed its presence in complexes with newly synthesized FN and gp 80. A hypothetical model for TyrS residues serving as an apical targeting signal during the biosynthetic transport of tyrosine-sulfated proteins, as mediated by the TyrS receptor, in MDCK cells is proposed.
Published: 2012

35. Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii

Author: S. Yamamoto and N. Okuju Y. Sakakibara
Subjects: Genetics, General Medicine, Molecular Biology, Biochemistry, Microbiology
Published: 1994
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36. Structural requirements of Bacillus subtilis alpha-amylase signal peptide for efficient processing: in vivo pulse-chase experiments with mutant signal peptides

Author: Kiyofumi Tsutsumi, Kazuhiro Nakamura, Kunio Yamane, and Y Sakakibara
Subjects: Signal peptide, Sequence analysis, Molecular Sequence Data, Bacillus subtilis, Protein Sorting Signals, Cleavage (embryo), Microbiology, Structure-Activity Relationship, Enzyme Stability, Escherichia coli, Peptide bond, Amino Acid Sequence, Amino Acids, Protein Precursors, Molecular Biology, Peptide sequence, chemistry.chemical_classification, Alanine, Base Sequence, Sequence Homology, Amino Acid, Edman degradation, biology, Valine, biology.organism_classification, Amino acid, Kinetics, Biochemistry, chemistry, Mutation, alpha-Amylases, Protein Processing, Post-Translational, Sequence Analysis, Research Article
Abstract: The Bacillus subtilis alpha-amylase signal peptide consists of 33 amino acids from its translation initiation site. To analyze the structural requirements for efficient processing of the signal peptide, single and repeated Ala-X-Ala sequences and their modifications were introduced into B. subtilis alpha-amylase signal peptides of different lengths and the mature thermostable alpha-amylase. Then the cleavage positions and processing rates of the signal peptides were analyzed by the NH2-terminal amino acid sequences of the exported thermostable alpha-amylases and by in vivo pulse-chase experiments. In B. subtilis, the most efficient cleavage site was located at the peptide bond between Ala-33 and amino acid X at position 34, even though Val-X-Ala and six repeating Ala-X-Ala sequences were present around the cleavage site. However, the cleavage site was shifted to the peptide bond between Ala-31 and amino acid X when Ala-33 was deleted, and it was also shifted to Ala-35 and X when Ala-33 was replaced with Val-33. The shorter signal peptide consisting of 31 amino acids reduced the processing rate and alpha-amylase production. In contrast, those signal peptides were cleaved preferentially at the peptide bond between Ala-31 and amino acid X in Escherichia coli. In addition to the presence of an Ala residue at the -1 amino acid position, the length of the signal peptide was another important requirement for efficient processing.
Published: 1993
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37. ChemInform Abstract: Studies of the Synthesis of Vitamin D Derivatives. Part 1. Synthesis of 1α-Hydroxy Vitamin D3 (I)

Author: M. Takahashi, A. Oosako, and Y. Sakakibara
Subjects: Vitamin, chemistry.chemical_compound, Stereochemistry, Chemistry, Vitamin D and neurology, Organic chemistry, General Medicine
Published: 2010
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38. ChemInform Abstract: Syntheses of Vitamin D Derivatives. Part 2. Convenient Synthesis of 1. alpha.,25-Dihydroxyvitamin D3 from Vitamin D2

Author: Y. Sakakibara and M. Takahashi
Subjects: Vitamin, chemistry.chemical_compound, Biochemistry, chemistry, 1-alpha-25-Dihydroxyvitamin D3, Stereochemistry, Vitamin D and neurology, General Medicine
Published: 2010
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39. Characterization of the sodium current in single human atrial myocytes

Author: Hongjun Jia, C. E. Arentzen, J. A. Wasserstrom, Y. Sakakibara, R S Hartz, T. Furukawa, and Donald H. Singer
Subjects: Adult, medicine.medical_specialty, Adolescent, Heart Diseases, Physiology, Sodium, Kinetics, chemistry.chemical_element, Tetrodotoxin, Sodium Channels, Membrane Potentials, chemistry.chemical_compound, medicine, Humans, Myocyte, Heart Atria, Child, Reversal potential, Aged, Binding Sites, Dose-Response Relationship, Drug, Myocardium, Pipette, Middle Aged, Surgery, Electrophysiology, Dose–response relationship, chemistry, Child, Preschool, Biophysics, Cardiology and Cardiovascular Medicine
Abstract: Patch-clamp recording techniques have permitted measurement of the fast Na+ current (INa) in isolated cardiac cells from a number of species in recent years. However, there is still only very little information concerning human cardiac INa. The purpose of this study was to describe the kinetics of INa in normal-appearing, Ca(2+)-tolerant, enzymatically isolated human atrial myocytes using whole-cell voltage-clamp techniques. Atrial specimens were obtained from 46 patients undergoing open heart surgery. Cs+ was substituted for K+ in both pipette and external solutions and F- was added to the former. The reversal potential of the rapid inward current varied approximately 57 mV at 17 +/- 1 degrees C with a 10-fold change in [Na+]o, and the current was completely blocked by 100 microM tetrodotoxin, findings typical of the fast cardiac Na+ current. The tetrodotoxin dose-response curve was best fitted by an equation describing binding to high- and low-affinity sites. INa was activated at a voltage threshold of -70 to -60 mV, and peak inward current was obtained at approximately -30 mV (holding potential, -140 mV). The inactivation time course was voltage dependent and was fitted best by the sum of two exponentials. The relation between voltage and steady-state availability (h infinity) was sigmoidal with the half-inactivation at -95.8 +/- 0.9 mV and a slope factor of 5.3 +/- 0.1 mV (n = 46), and we did not observe a significant difference with disease and age. The overlap of the h infinity and activation curves suggested the presence of a Na+ "window" current. Recovery from inactivation also was voltage dependent and best fitted by a model describing the sum of two exponentials. Recovery occurred after an initial delay at potentials positive to -140 mV, suggesting that inactivation of human atrial INa is a multistate process. We conclude that INa of normal-appearing, Ca(2+)-tolerant human atrial myocytes is similar to that of other mammalian cardiac cells with the possible exception of having two tetrodotoxin binding sites.
Published: 1992
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40. Threshold currents of 1.2-1.55 mu m P-substrate buried crescent laser diodes

Author: Y. Sakakibara, M. Fujiwara, Akira Takemoto, Y. Nakajima, and S. Kakimoto
Subjects: Materials science, Wavelength range, business.industry, Semiconductor materials, Substrate (electronics), Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, law.invention, Wavelength, Optics, law, Optoelectronics, Electrical and Electronic Engineering, Electric current, business, Diode
Abstract: P-substrate buried crescent (PCB) laser diodes whose wavelength ranged from 1.2 to 1.55 mu m have been fabricated. The threshold currents as low as 10 mA have been obtained in this wavelength range experimentally. The calculated threshold currents of 13, 13, and 14 mA at 1.2, 1.3, and 1.55 mu m almost coincide with the measured values. >
Published: 1992
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41. Two Dimension Spatial Light Modulator with an Over-Two-Octave Bandwidth for High-Powered Monocycle Optical Pulses

Author: S. Fang, Takashi Tanigawa, K. Hazu, Masahiro Yamashita, N. Nakagawa, Taro Sekikawa, and Y. Sakakibara
Subjects: Physics, Optics, Optical modulator, Spatial light modulator, Dimension (vector space), business.industry, Group delay dispersion, Chirp, Electro-optic modulator, Optoelectronics, business, Octave bandwidth, Compensation (engineering)
Abstract: We carried out feedback chirp compensation using a two-dimension spatial light modulator operating in a wavelength range from 260 to 1100 nm, which is useful for the application to ultrabroadband and high-powered optical pulses.
Published: 2009
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42. Liquid Crystal Spatial Light Modulator for Arbitrary Amplitude Modulation from Ultraviolet to Near-infrared

Author: Taro Sekikawa, S. Fang, Y. Sakakibara, T. Tanigawa, Jiangfeng Zhu, and Masahiro Yamashita
Subjects: Spatial light modulator, Materials science, business.industry, Physics::Optics, Electro-optic modulator, Pulse shaping, Amplitude modulation, Optical modulator, Optics, Modulation, Optoelectronics, business, Phase modulation, Pulse-width modulation
Abstract: We fabricated a new liquid-crystal spatial light modulator for amplitude modulation of 315–1100 nm spectrum. Applied voltage and pulse width dependent transmission was characterized, which paves the way for monocycle-pulse shaping and attosecond pulse measurement.
Published: 2009
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43. Synchrotron radiation lithography applied to fabrication of deep-submicrometer NMOS devices at all exposure levels

Author: Y. Sakakibara, M. Miyake, E. Yamamoto, A. Yoshikawa, Toshiyuki Horiuchi, Kimiyoshi Deguchi, and T. Kitayama
Subjects: Materials science, Fabrication, business.industry, Synchrotron radiation, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Laser linewidth, Optics, Optoelectronics, Electrical and Electronic Engineering, business, Lithography, Exposure latitude, NMOS logic
Abstract: The feasibility of synchrotron radiation lithography for the fabrication of deep-submicrometer devices has been demonstrated through the test application to the small geometry NMOS device process at all exposure levels. Excellent exposure latitude for the linewidth control was confirmed. However, improvement in overlay accuracy is still needed.
Published: 1990
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44. Distributed feedback laser diode and module for CATV systems

Author: Y. Sakakibara, H. Watanabe, Junichiro Yamashita, Akira Takemoto, S. Kakimoto, Tatsuo Hatta, Y. Nakajima, and Miyake Yoshio
Subjects: Coupling constant, Total harmonic distortion, Distributed feedback laser, Analog transmission, Computer Networks and Communications, business.industry, Computer science, Heterojunction, Amplitude distortion, Wavelength, Attenuation distortion, Distortion, Harmonics, Optoelectronics, Continuous wave, Electrical and Electronic Engineering, business, Frequency modulation, Diode
Abstract: Harmonic distortion of distributed feedback laser diodes (DFB-LDs) for analog transmission systems is investigated. It is shown that, under a modulation frequency of less than 1 GHz, the harmonic distortion depends on the nonlinearity of the light output power-current (P-I) curve under the continuous wave (CW) condition, which is determined by the coupling constant kappa L, and that the distortion can be minimized at kappa L approximately 1. A 1.3 mu m wavelength InGaAsP DFB-PPIBH (p-substrate partially inverted buried heterostructure) LD and its module, with low distortion by the control of a coupling constant, have been developed. >
Published: 1990
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45. Extremely narrow spectral linewidth and low chirping of the MQW-DFB-PPIBH laser diode

Author: Y. Nakajima, Akira Takemoto, Y. Sakakibara, N. Yoshida, H. Watanabe, and S. Kakimoto
Subjects: Distributed feedback laser, Materials science, Laser diode, business.industry, Optical communication, Semiconductor device, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, Photodiode, law.invention, Laser linewidth, Optics, law, Optoelectronics, Electrical and Electronic Engineering, business, Diode
Abstract: The low threshold current of 9 mA, the high side-mode suppression ratio of more than 45 dB, the extremely narrow spectral linewidth of 1.1 MHz, and the low chirping of 2.8 AA at -20 dB at 2 Gb/s nonreturn to zero (NRZ) modulation have been achieved in the multiple quantum well (MQW) distributed feedback (DFB) p-substrate partially inverted buried heterostructure (PPIBH) laser diode. The spectral linewidth of 1.1 MHz is the narrowest value among 300- mu m-length solitary laser diodes. These results suggest that the MQW-DFB laser diodes are a promising light source for longer distance and higher bit-rate optical communication systems and coherent optical communication systems. >
Published: 1990
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46. Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

Author: B. Sakmann, J. Schrader, B. Brenner, H. Murer, J. Boeckh, H. O. Handwerker, P. HonerjÄger, M. Dugas, G. Wang, A. DeLuca, H. Brinkmeier, B. Fakler, T. Pröbstle, R. Rüdel, J. -A. Pohl, H. Meves, B. Kroll, S. Bremer, B. Tümmler, E. Frömter, J. S. Schwegler, W. Steigner, S. Silbernagl, Michael Pusch, P. Niemann, J. Schmidtmayer, W. Ulbricht, G. Hansen, U. Lönnendonker, B. Neumcke, R. Eickhorn, D. Hornung, H. Antoni, R. Penner, E. Neher, H. Takeshima, S. Nishimura, S. Numa, W. Melzer, D. Feldmeyer, B. Pohl, P. Zöllner, T. H. Müller, D. Swandulla, U Misgeld, V. Ya. Ganitkevich, G. Isenberg, A. Cavalié, T. J. A. Allen, W. Trautwein, Siegried Pelzer, Yaroslav M. Shuba, Tatsuya Asai, Wolfgang Trautwein, Arthur M. Brown, Lutz Birnbauner, Terence F. McDonald, Dieter Pelzer, R. Eckert, J. Hescheler, W. Rosenthal, S. Offermann, D. Krautwurst, G. Schultz, Helmut Kettenmahn, J. Trotter, Alexe J N. Verkhratsky, Alexej N. Savtchenko, Alexej N. Verkhratsky, A. Schiefer, U. Klöckner, L. D. Partridge, S. SchÄfer, P. Jonas, D. S. Koh, K. Kampe, M. Hermsteiner, W. Vogel, C. K. Bauer, J. R. Schwarz, R. H. A. Fink, E. Wettwer, R. Weik, E. Schlatter, M. Bleich, M. Granitzer, T. Leal, W. Nagel, J. Crabbé, F. Lang, E. Kahn, F. Friedrich, M. Paulmichl, M. Hammerer, K. Maly, H. Grunicke, T. Böhm, B. Nilius, H. Gögelein, D. Dahlem, H. Weiss, S. Waldegger, E. Woell, R. Paulmichl, J. P. Ruppersberg, K. H. Schröter, M. Stocker, O. Pongs, R. Wittka, G. Boheim, R Lichtinghagen, C. K. Augustine, W. Stühmer, Dorothe Hoppe, D. Hoppe, K. E. Zittlau, C. Walther, H. Hatt, C. Franke, S. Quasthoff, E. Wischmeyer, H. Jockusch, M. Friedrich, K. Benndorf, G. Bollmann, Hj. Hirche, F. Hollunder-Reese, M. Mohrmann, R. Greger, S. Weber-Schürholz, T. Schürholz, M. Akabas, D. Landry, Q. Al-Awqati, A. H. Guse, G. Gercken, W. Meyerhof, H. -J. Westphale, U. Kerstins, H. Oberleithner, M. Tilmann, K. Kunzelmann, T. Klitsch, D. Siemen, A. Draguhn, T. A. Verdoorn, D. B. Pritchett, P. H. Seeburg, P. Malherbe, H. Möhler, J. Dudel, P. Stern, F. Zufall, J. Rosenheimer, D. O. Smith, R. Dörner, K. Ballanyi, W. -R. Schlue, B. Kalthof, L. Pott, C. Busch, T. Konno, M. Stenql, Ch. Reinhardt, H. Kaiser, R. Baumann, M. Wilimzig, R. Eichenlaub, E. Neumann, V. Lessmann, K. Gottmann, I. D. Dietzel, B. U. Keller, Y. Yaari, A. Konnerth, K. H. Backus, T. Giller, F. Knoflach, P. Pflimlin, G. Trübe, G. von Blankenfeld, S. Ymer, H. Sontheimer, M. Ewert, H. Kettenmann, R. Schneggenburger, D. Paschke, D. F. Hülser, J. Ubl, H. A. Kolb, J. Ströttchen, S. Boheim, F. Wehner, D. Guth, R. K. H. Kinne, H. R. Polder, D. Bödeker, Susanne Hoppe, H. Höller, W. Hampe, H. Ruf, I. Schulz, M. Dehlinger-Kremer, T. Ozawa, L. Vasilets, G. Schmalzing, K. MÄdefessel, H. Biel, W. Schwarz, B. C. Burckhardt, N. Stallmach, H. MairbÄurl, J. F. Hoffman, E. Schömig, A. Heuner, B. O. Göbel, W. Siffert, A. Butke, G. Hoffmann, M. -K. Meyer zu Brickwedde, H. Vetter, R. Düsing, D. Rosskopf, U. Osswald, J. Steffgen, H. Koepsell, H. Martens, M. Rübbelke, G. GÄbel, J. Arens, J. Stabel, Y. Fischer, J. Thomas, H. Rose, H. Kammermeier, Thomas Munsch, Joachim W. Deitmer, B. Engelmann, J. Duhm, D. Gunzel, S. Galler, H. Fischer, W. Clauss, W. Van Driessche, A Köckerling, JD Schulzke, D Sorgenfrei, M Fromm, B. Simon, V. Ganapathy, F. H. Leibach, G. Burckhardt, R. Krattenmacher, Rosita Voigt, S. Dietrich, A. Leyssens, S. L. Zhang, R. Weltens, P. Steels, B. Hoffmann, M. Heinz, B. Habura, A. Dörge, G. Rechkemmer, W. von Engelhardt, O. StrauB, M. Wiederholt, D. -G. Margineanu, K. M. Kreusel, M. Fromm, U. Lempart, D. Sorgenfrei, U. Hegel, A. J. Augustin, R. . Goldstein, E. Purucker, J. Lutz, B. Illek, K -P. Thiele, JS. Schwealer, J. Dittmer, C. Bauer, K. -U. Eckardt, R. Neumann, A. Kurtz, H. Fromm, J. D. Schulzke, P. Clausen, A. Krohn, S. Lüderitz, K. Hierholzer, U. Kersting, L. Woinowski, R. Gro\mann, X. U. Bin, F. Ellendorff, R. Nitschke, U. Fröbe, H. Scholz, R. della Bruna, H. Ehmke, P. B. Persson, M. Seyfarth, H. R. Kirchheim, M. S. Dietrich, N. Parekh, M. Steinhausen, C. P. Bührle, R. Nobiling, K. J. Ullrich, G. Rumrich, S. Klöss, F. Papavassiliou, J. Hoyer, C. Schmitt, A. Jungwirth, M. Ritter, H. J. Westphale, C. Bevan, C. Theiss, Liliana Denek, Johann S. Schwegler, Roland SchÄfer, Albert J. Augustin, August Heidland, B. Nafz, A. Just, M. Steidl, G. Pinggera, R. Gerstberger, H. Schütz, E. Simon, E. Lohrmann, B. Masereel, J. Delarge, H. J. Lang, H. C. Englert, D. Caliebe, M. Mályusz, P. Wrigge, G. Gronow, N. Klause, H. Zinnert, H. Fagel, W. Jelkmann, Ch. Weiss, R. Keil, W. Schmidt, C. Kröger, E. G. Brabant, A. Hilgendorf, S. Strauch, F. Lane, A. Prick, N. Golenhofen, S. Mildenberger, B. Flemming, D. Roloff, T. Wronski, G. Drews, A. Debuyser, J. C. Henquin, M. B. Jackson, S. A. DeRiemer, A. Schmid, S. Schnefel, A. Pröfrock, K. -D. Hinsch, J. Milz, G. Lamprecht, U. Seidler, W. Silen, O. Aziz, W. Reschke, G. Fischer, N. De Decker, T. Hayes, G. Coast, E. Van Kerkhove, F. von zur Mühlen, F. Eckstein, U Hegel, CJ Bentzel, EO Riecken, C. Siemer, P. Rothenpieler, E. Smith, K. R. Lutnicki, J. T. Wróbel, A. Ledwożyw, E. PietraŚ, S. Sender, Klaus D. Jürgens, T. Kleinschmidt, F. Werkmeister, H. Kiwull-Schöne, P. Kiwull, J. Vahle, M. Ott, R. E. Zimmermann, J. G. Elsing, D. Million, P. Zillner, M. Thiel, H. Bardenheuer, K. Peter, J. Fandrey, C. P. Siegers, H. Rupp, V. Elimban, N. S. Dhalla, I. Morano, B. Agostini, M. Mühleisen, W. F. H. M. Mommaerts, K. Ono, M. Wussling, W. Schenk, W. Boldt, P. Lipp, K. Schüttler, G. Szymanski, M. F. Wendt-Gallitelli, J. W. Herzig, H. Depersin, G. Grupp, I. Grupp, H. G. Glitsch, H. Pusch, Ch. Zylka, M. Brāndle, R. Jacob, T. Stein, W. Isselhard, J. Sturz, T. Minor, P. Wingenfeld, B. Siegmund, T. Klietz, P. Schwartz, H. M. Piper, Christa Linder, Stefan SchÄfer, Gerd Heusch, B. F. Becker, N. Reinholz, P. Raschke, B. Leipert, E. Gerlach, B. Dierberger, R. W. Gülch, M. Leverkus, T. Mitsuiye, U. Pohl, S. Y. Wang, R. Meyer, H. G. Haas, H. Ph Christmann, Th Dörner, D. Hock, R. Hertel, M. Gagelmann, W. G. Forssmann, W. J. Leijendekker, G. Kissling, H. Michel, A. Goetz, M. Freya, G. Fleckenstein-Grün, Jochen D. Schipke, Yasuhiko Harasawa, Seiryo Sugiura, Joe Alexander, Daniel Burkhoff, L. Kling, B. Müller-Beckmann, M. Schroth, G. Sponer, E. Böhm, K. Strein, A. Dorszewski, G. Arnold, G. K. Pike, D. J. Bryant, M. L. Roberts, R. H. Fink, Ch. Ross, A. Skyschally, R. Schulz, C. Linder, G. Heusch, J. D. Schipke, D. Burkhoff, J. Alexander, F. Gollnick, Kh. Peter, R. Franken-Weyers, M. M. Borst, A. Deussen, S. Pöpping, H. Hose, K. H. Strotmann, B. Lukascek, T. Karnath, K. Güttier, W. Klaus, K. Haverkampf, M. Guhlmann, S. Schmidt-Ott, U. Heuschen, G. Mall, G. Pfitzer, J. Rösch, A. Arner, J. C. Rüegg, K. Kröger, V. ThÄmer, Thomas Ehring, Volker ThÄmer, B. D. Guth, Ph A. Schnabel, A. Schmiedl, M. M. Gebhard, J. Richter, H. J. Bretschneider, R. J. Oudiz, Ph. Schnabel, J . Richter, H. Watanabe, R. Spahr, O. Obst, H. Mertens, A. Mülsch, R. Busse, D. Lamontagne, K. Herlan, A. Huang, E. Bassenae, J. R. L. Mackert, L. Schilling, A. A. Parsons, M. Wahl, M. Ph. Christmann, F. Thimm, M. Frey, a. A. Fleckenstein, H. Theilen, U. Göbel, W. Kuschinsky, Th. Elbert, M. Tafil-Klawe, H. Rau, W. Lutzenberger, A. Fleckenstein, H. Forst, M. Haller, C. Santjohanser, L. Lauterjung, Y. Smieško, D. J. Lang, P. C. Johnson, H. Schröck, T. Elbert, B Geiger, G. Koch, H. E. Koralewski, F. H. Perschel, K. Wagner, U. Krüger, M. Albrecht, G. Hohlbach, N. Maassen, M. Foerster, J. Mühling, F. Bari, K. Pleschka, H. D. Schmidt, H. Gro, W. Loock, C. Stick, U. Diefenbacher, D. Gronewold, M. Tobinsky, A. Walther-Behrends, E. Witzleb, M. Brummermann, R. E. Reinertsen, H. Rogausch, W. M. Rohn, H. Acker, M. Delpiano, E. Dufau, J. Hentschel, H. Heller, K. -D. Schuster, R. Siekmeier, H. Kronenberger, H. Lintl, Ch. F. Schiller-Scotland, J. Gebhart, J. Heyder, J. Meier-Sydow, W. Stahlhofen, K. Mottaghy, C. Geisen, W. Richter, J. Beckman, W. Marek, W. T. Ulmer, A. E. Thiele, F. Raschke, J. H. Peter, G. Hildebrandt, T. Kullmer, G. Kozianka-Burghof, M. E. Schlaefke, H. Gnuschke, T. Schaefer, D. Schaefer, C. Schaefer, Ronald J. Bradley, Raimund Sterz, Klaus Peper, R. Benterbusch, Th. Kraft, L. C. Yu, H. J. Kuhn, K. Blankenbach, G. Asmussen, I. Kunze, K. -S. Pieper, J. Steinmetz, H. Schmidt, P. Krippeit-Drews, U. Hübschen, A. C. Nacimiento, D. Günzel, W. Rathmayer, U. Gaunitz, D. Költgen, E. Zachar, B. Soltau, L. De Martino, W. Hasselbach, F. Kössler, P. Lange, G. Küchler, C. Zeugner, J. Van Eyk, R. S. Hodges, H. Lorkovic, N. Clemens, P. Scheid, Th. Noack, P. Deitmer, K. Golenhofen, E. Lammel, Andrea Welling, Jochen Felbel, Franz Hofmann, S. Katoch, T. Watanabe, K. Mandrek, K. Milenov, K. Hammer, W. Rössler, H. Sann, Fr -K. Pierau, H. Nguyen-Duong, P. Schneider, F. Stahl, A. Lepple-Wienhues, C. Korbmacher, H. Haller, M. Gebauer, U. Willner, C. Bialojan, M. Lengsfeld, V. Kyrtatas, Peter C. Dartsch, P. J. Boels, W. Fischer, T. Lenz, U. Thei, V. A. W. Kreye, T. Ohkubo, H. Kupp, M. Vonderlage, V. Schreiner, M. Dorlöchter, M. Brinkers, A. Irintchev, A. Wernig, B. Langenfeld, W. Finger, H. Wolburg, A. Beer, Ch. Schwejda, D. Scheller, U. Heister, F. Tegtmeier, Thomas Knöpfel, Andreas Spuler, Peter Grafe, Beat GÄhwiler, M. Bijak, U. Misgeld, W. Müller, G. Rausche, F M. Leweke, D. Bingmann, I. Moraidis, E. -J. Speckmann, M. Madeja, U. Mu\hoff, A Lehmenkühler, D. Kuhlmann, M. Hans, H. D. Lux, H. StrÄub, J. Waiden, R. E. Baker, R. Grantyn, M. Perouansky, K Kraszewski, Chr Lehmenkühler, H. U. Dodt, W. ZieglgÄnsberger, H. Pawelzik, W. ZieglgÄngsberger, K. Mann, H. Wiethölter, D. Albrecht, J. Dreier, E. Ficker, H. Beck, B J. Corrette, F. Dreyer, H. Repp, J. Dreessen, G. J. Augustine, A. Lehmenkühler, D. Büsselberg, B. Heimrich, H. L. Haas, S. Birnstiel, B. Schönrock, U. Altrup, H. Reith, C. Alzheimer, G. ten Bruagencate, B. Fruhstorfer, E. Mignot, S. Nishino, W. C. Dement, C. Guilleminault, Christa Simon-Oppermann, Olaf Günther, J. Stehle, S. Reuss, A. Seidel, R. Riemann, L. Vollrath, Susanne Reimer, Volker HölIt, U. Sonnhof, J. Krupp, H Claus, P. Hinckel, H. B. H. Dick, C. Hiemke, A. Jussofie, T. Dorn, S. Uhlig, O. W. Witte, B. Bother, M. Eiselt, H. Witte, ö Zwiener, M Rother, H. Eiseit, A. Taghavy, A. KrÄtzer, H. Clusmann, U. Heinemann, F. Block, K. -H. Sonatg, M. Falkeristein, J. Hohnsbein, J. Hoormann, A. Frieling, I. M. Tarkka, W. Kullmann, B. Bromm, M. Chr Hirsch, H. Wissing, H. A. Braun, P. Igelmund, F. W. Klu\mann, W. H. Ehrenstein, N. Yakimoff, S. Mateeff, M. L. Zeise, J. Arriagada, A. Teschemacher, T. Pöppelmann, R. Köhling, P. Boerrigter, K. Anders, W. Ohndorf, R. Dermietzel, D. W. Richter, T. R. Tölle, J. M. Castro-Lopes, Klinische Neuropharmakologie, J. Sandkühler, J. D. Leah, T. Herdegen, M. Zimmermann, D. Vaitl, H. Gnippe, M. K. Herbert, M. K. C. Mengel, K. -D. Kniffki, R. Linke, C. Vahle-Hinz, J. Schenda, K. Matsumura, Q. -G. fu, C. Forster, W. D. Hutchison, C. R. Morton, J. Aschoff, Z. Wilhelm, S. W. Schwarzacher, M Wasserschaff, M. Hörner, H. Kümmel, U. Windhorst, J. L. Feldman, K. Schmid, A. S. Foutz, M. Denavit-Saubié, M. A. Pak, P. Wehling, C. Evans, G. Bandara, F. Awiszus, H. Feistner, H. -J. Heinze, M. Illert, M. Wasserschaff, D. Kleinebeckel, G. Böhmer, W. Schauer, H. -H. Abel, D. Klü\endorf, H. P. Koepchen, W Jarolimek, St König, J. Czachurski, H. Seller, R. L. Meckler, E. M. McLachlan, A. Boczek-Funcke, H. -J. HÄbler, W. JÄnig, M. Michaelis, K. Dembowsky, S. Königr, Harald Rau, M. Unger, G. Merker, J. Roth, E. Zeisberger, H. Gao, M. Hunold, F. Kirchner, K. Takano, K. Schulze, M. Pokorski, Y. Sakakibara, A. Masuda, T. Morikawa, B. Ahn, S. Takaishi, P. -E. Paulev, Y. Honda, G. Flügge, E. Fuchs, S. König, U. Th. Eysel, R. Schmidt-Kastner, W. Skrandies, T. Geib, C. Baumann, K. -F. Schmidt, A. G. Knapp, J. E. Dowling, M. Kuba, N. Toyonaga, Z. Kubová, P. Jacobi, G. N. Nöll, Ch. Baumann, M. Tabata, Ch. Martin, H. Meissl, Th. Knottenberg, H. Scheibner, Hans P. Zenner, Ulrike Zimmennann, Alfred H. Gitter, D. Ding, J. W. T. Smolders, R. Klinke, I. Boekhoff, K. Raming, J. Krieger, E. Tareilus, J. Strotinann, H. Breer, D. Schild, J. A. DeSimone, S. Hellwig, A. H. Gitter, P. K. Plinkert, H. P. Zenner, M. Koltzenbwg, E. Pinter, K. SchÄfer, R. Necker, U. Hanesch, B. Heppelmann, R. F. Schmidt, S. Mense, U. Hoheisel, K. H. Steen, F. Anton, P. W. Reek, G. R. Lewin, S. B. McMahon, G. Heyer, O. P. Hornstein, W. Klement, J. O. Arndt, W. Maeerl, G. GrÄmer, K. Schepelmann, K. Me\linger, H. -G. Schaible, R. D. Treede, R. A. Meyer, J. N. Campbell, D. Claus, B. Neundörfer, R. Ernst, A. M. Tick-Waider, F. Bretschneider, R. C. Peters, P. F. M. Tennis, P. F. M. Teunis, D. Hoheisel, R. Scherotzke, A. Bub, G. Manzl, C. Jessen, B. Nuesslein, I. Schmidt, J. Wetzig, M. Reiser, N. Bregenzer, R. J. von Baumgarten, E. Mohr, H. Krzywanek, G. Warncke, K. -L. Schuchmann, H. Linow, F. H. Klu\mann, U. Redlin, G. Heldmaier, A Bamler, A. Koller, S. Felber, C. Haid, K. Wicke, E. Raas, Wang Xuemin, Chen Kerning, Shi Ying, Shi Hanping, Günther Warncke, R. Voisord, P. C. Dortsch, E. Betz, U. Karbach, S. Walenta, M. W. Gross, W. Mueller-Klieser, P. Vaupel, P. Okunieff, W. -K. Mayer, M. Stohrer, W. Krüger, W. Müller-Klieser, M. Strupp, P. Weial, H. Bostock, K. Piwernetz, R. Renner, P. Grafe, J. Lankers, W. Zangemeister, K. Kunze, S. Tries, H. Heinle, N. V. Beckerath, W. Maier-Rudolph, G. Mehrke, K. Günther, L. Goedel-Meinen, J. Daut, A. Kopp, T. Noll, A. Goellner, S. Gerlach, H. F. Teutsch, K. Schienger, R. Schwab, M. Höckel, Z. Fotev, M. Nienhaus, Gabriele Kaczmarczyk, Dinah Richter, Gabriele Korte, J. Förther, H. W. Reinhardt, R. Schreiber, J. Rupp, G. Murphy, J. Fingerle, O. Kloiber, T. Miyazawa, M. Höhn-Berlage, K. -A. Hossmann, H. Schad, W. Heimisch, R. Blasini, F. Haas, M. Mendier, A. Spuler, F. Lehmann-Hom, U. Wolfram, M. Fenske, N. Sachser, Ch. Weis, W. Marktl, B. Kopta, N. Klammer, B. Rudas, H. Pohl, A. Nienartowicz, W. Moll, M. Klempt, S. Blum, H. Bühler, I. Lichtenstein, A. Novak, H. Siebe, and K. Peper
Subjects: 0303 health sciences, Physiology, Chemistry, Clinical Biochemistry, Tibialis Anterior, Human physiology, 030204 cardiovascular system & hematology, Pharmacology, Spring (mathematics), Article, Atrial Natriuretic Peptide, 03 medical and health sciences, 0302 clinical medicine, Atrial natriuretic peptide, Physiology (medical), Spreading Depression, Capsaicin, Extensor Digitorum Longus, 030304 developmental biology
Published: 1990

47. Oxygen-doped and nitrogen-doped silicon films prepared by molecular beam epitaxy

Author: Michiharu Tabe, M. Takahashi, T. Ichimori, and Y. Sakakibara
Subjects: inorganic chemicals, Materials science, Silicon, Doping, technology, industry, and agriculture, Metals and Alloys, Analytical chemistry, chemistry.chemical_element, Surfaces and Interfaces, Substrate (electronics), Epitaxy, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Overlayer, chemistry, Electron diffraction, Materials Chemistry, Arsenic, Molecular beam epitaxy
Abstract: Oxygen-doped and nitrogen-doped silicon films deposited under ultrahigh vacuum were studied for applications in silicon hetero-bipolar transistors (HBTs). It was found through reflection high energy electron diffraction observations that films of SiOx and SiNx can be epitaxially grown for x as high as 0.1. Incorporation of oxygen and nitrogen into the film can be controlled by the substrate temperature and the oxygen or ammonia pressure respectively, and is consistent with previous results of adsorption on the clean silicon surface. The crystalline quality of the films depends on the distance from the epi-substrate interface, and it is better near the heterointerface than in the surface region. HBTs with an SiOx and an SiNx emitter are fabricated using arsenic diffusion from a poly-silicon overlayer for n-type doping, and their test results are described. For improving the HBT characteristics, we have studied in situ arsenic doping into SiOx and SiNx films. The experiment of in situ doping indicates that a high concentration of arsenic prevents oxygen and nitrogen doping.
Published: 1990
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48. [Epicardial atrial pacing using an active fixation bipolar endocardial lead in children]

Author: M, Noma, N, Atsumi, Y, Hiramatsu, H, Horigome, M, Takahashi, Y, Enomoto, S, Matsushita, and Y, Sakakibara
Subjects: Male, Pacemaker, Artificial, Heart Block, Cardiac Pacing, Artificial, Humans, Infant, Child, Pericardium, Electrodes, Implanted
Abstract: Good performance was observed over 10 years after implantation of bipolar epicardial atrial pacing using an active fixation bipolar endocardial lead in 3 pediatric patients with congenital heart block. The bipolar endocardial lead which was supposed to be fixed transvenously was implanted on the atrial surface by first screwing the lead's helix into the myocardium. The catheter was then laid down on the atrial surface, and both electrodes were wrapped by the atrial tissue. The good performance of this pacing lead seemed to depend on stable positioning of the electrode. This lead is superior to the commercially available, and steroid eluting epicardial bipolar pacing lead, on the point of its small size in head and body, and could be applied to dual chamber pacing in smaller children.
Published: 2007

49. Performance test of pipe-shaped radiation shields for cryogenic interferometric gravitational wave detectors

Author: Tomotada Akutsu, Kazuaki Kuroda, Toshikazu Suzuki, Y. Sakakibara, and Nobuhiro Kimura
Subjects: Physics, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, business.industry, Gravitational wave, Detector, Shields, Physics::Fluid Dynamics, Interferometry, Optics, Thermal radiation, Shield, Duct (flow), KAGRA, business
Abstract: One of the most important challenges in cryogenic interferometric gravitational wave detectors is to reduce the undesirable thermal radiation coming through holes in the radiation shield, which are necessary for the laser beam to pass through. For this purpose, pipe-shaped radiation shields called duct shields are used. Here, we have manufactured duct shields for KAGRA in Japan, one of the cryogenic interferometric gravitational wave detectors, and measured the thermal radiation coming through the duct shields. The measured result was found to be consistent with the calculation result that the duct shield can reduce the thermal radiation to less than 1%. This fact confirmed that the amount of thermal radiation coming through the duct shields was smaller than KAGRA?s requirement.
Published: 2015
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50. An experiment to distinguish between diffusive and specular surfaces for thermal radiation in cryogenic gravitational-wave detectors

Author: Y. Sakakibara, Nobuhiro Kimura, Toshikazu Suzuki, Takashi Uchiyama, Kazuhiro Yamamoto, Kazuaki Kuroda, and Chihiro Tokoku
Subjects: Physics, Photon, Optics, Gravitational wave, Thermal radiation, business.industry, Reflection (physics), General Physics and Astronomy, Cosmic ray, Specular reflection, Electron, Cryogenics, business
Abstract: An experiment to distinguish between diffusive and specular surfaces for thermal radiation in cryogenic gravitational-wave detectors Yusuke Sakakibara1,∗, Nobuhiro Kimura2, Toshikazu Suzuki2, Kazuhiro Yamamoto1, Chihiro Tokoku3, Takashi Uchiyama1, and Kazuaki Kuroda1 1Institute for Cosmic Ray Research (ICRR), University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8582, Japan 2High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan 3Research Center for Electron Photon Science, Tohoku University, 1-2-1 Mikamine, Taihaku-ku, Sendai, Miyagi 982-0826, Japan ∗E-mail: ysakaki@icrr.u-tokyo.ac.jp
Published: 2015
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