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1. Recent progress of JT-60SA project toward plasma operation

Author

H. Shirai, K. Takahashi, E. Di Pietro, D. Abate, W. Abdel Maksoud, H. Abe, N. Aiba, T. Abe, M. Akimitsu, J. Ayllon-Guerola, T. Arai, J.-F. Artaud, N. Asakura, N. Ashikawa, L. Balbinot, P. Barabaschi, O. Baulaigue, E. Belonohy, A. Belpane, W. Bin, F. Bombarda, T. Bolzonella, F. Bonne, M. Bonotto, J. Botija, J. Buermans, S. Cabrera-Pérez, A. Cardella, D. Carralero, L. Carraro, J. Cavalier, M. Cavinato, M. Chernyshova, S. Chiba, S. Clement-Lorenzo, V. Cocilovo, S. Coda, R. Coelho, I. Coffey, B. Collin, V. Corato, A. Cucchiaro, T. Czarski, M. Dairaku, S. Davis, C. Day, E. Dela Luna, G. De Tommasi, P. Decool, L. Di Pace, M. Dibon, G. Disset, F. D’Lsa, A. Ejiri, Y. Endo, N. Ezumi, G. Falchetto, A. Fassina, P. Fejoz, A. Ferro, W. Fietz, L. Figini, T. Fornal, G. Frello, T. Fujita, T. Fukuda, K. Fukui, M. Fukumoto, H. Funaba, M. Furukawa, S. Futatani, L. Gabellieri, E. Gaio, K. Galazka, J. Garcia, J. Garcia-Dominguez, J. Garcia-Lopez, M. Garcia-Munoz, L. Garzotti, F. Gasparini, S. Gharafi, L. Giacomelli, G. Ginoulhiac, G. Giruzzi, L. Giudicotti, J. Gonzalez-Martin, R. Guillén-González, N. Hajnal, S. Hall, K. Hamada, K. Hanada, M. Hanada, K. Hasegawa, S. Hatakeyama, V. Hauer, N. Hayashi, T. Hayashi, R. Heller, J. Hidalgo-Salaverri, S. Higashijima, J. Hinata, S. Hiranai, J. Hiratsuka, R. Hiwatari, C. Hoa, H. Homma, A. Honda, M. Honda, K. Hoshino, H. Hurzlmeier, M. Iafrati, K. Ibano, H. Ichige, M. Ichikawa, M. Ichimura, K. Ida, S. Ide, H. Idei, M. Iguchi, T. Iijima, S. Iio, R. Ikeda, Y. Ikeda, T. Imai, R. Imazawa, S. Inagaki, M. Inomoto, S. Inoue, A. Isayama, S. Ishida, Y. Ishii, M. Isobe, F. Janky, E. Joffrin, A. Jokinen, S. Kado, S. Kajita, K. Kajiwara, Y. Kamada, I. Kamata, A. Kaminaga, K. Kamiya, D. Kanapienyte, Y. Kashiwa, M. Kashiwagi, K. Katayama, Y. Kawamata, G. Kawamura, K. Kawano, Y. Kazakov, K. Kimura, F. Kin, M. Kisaki, S. Kitajima, K. Kiyono, K. Kizu, Y. Ko, K. Kobayashi, M. Kobayashi, S. Kobayashi, Ta. Kobayashi, To. Kobayashi, G. Kocsis, A. Kojima, S. Kokusen, M. Komata, K. Komuro, S. Konishi, A. Kovacsik, I. Ksiazek, M. Kubkowska, G. Kühner, M. Kuramochi, K. Kurihara, T. Kurki-Suonio, A.B. Kurniawan, T. Kuwata, B. Lacroix, V. Lamaison, A. Lampasi, P. Lang, P. Lauber, K. Lawson, Q. LeCoz, A. Louzguiti, R. Maekawa, T. Maekawa, S. Maeyama, G. Maffia, P. Maget, J. Mailloux, I. Maione, A. Maistrello, K. Malinowski, A. Mancini, G. Marchiori, J.-L. Marechal, V. Massaut, S. Masuzaki, R. Matoike, G. Matsunaga, S. Matsunaga, A. Matsuyama, Ch Mayri, M. Mattei, M. Medrano, A. Mele, I. Meyer, F. Michel, T. Minami, Y. Miyata, J. Miyazawa, Y. Miyo, T. Mizuuchi, K. Mogaki, J. Morales, P. Moreau, T. Morisaki, S. Morishima, S. Moriyama, A. Moro, H. Murakami, M. Murayama, S. Murakami, K. Nagasaki, O. Naito, N. Nakamura, S. Nakamura, T. Nakano, Y. Nakashima, V. Nardino, E. Narita, Y. Narushima, K. Natsume, S. Nemoto, R. Neu, S. Nicollet, M. Nishikawa, S. Nishimura, T. Nishitani, M. Nishiura, T. Nishiyama, M. Nocente, Y. Nobuta, L. Novello, F. Nunio, S. Ochoa, K. Ogawa, T. Ogawa, Y. Ogawa, S. Ohdachi, Y. Ohmori, N. Ohno, Y. Ohtani, K. Ohtsu, M. Ohzeki, T. Oishi, J. Okano, K. Okano, Y. Onishi, M. Osakabe, T. Oshima, V. Ostuni, A. Owada, M. Oya, Y. Oya, T. Ozeki, M.M. Parody Guzmán, R. Pasqualotto, S. Pelli, E. Perelli, E. Peretti, G. Phillips, C. Piccinni, L. Pigatto, A. Pironti, A. Pizzuto, B. Plöckl, G. Polli, J.-M. Poncet, P. Ponsot, G. Pucella, M. Puiatti, D. Radloff, V. Raimondi, F. Ramos, P. Rancsik, D. Ricci, S. Ricciarini, N. Richermoz, E. Rincon, A. Romano, P. Rossi, P. Roussel, G. Rubino, H. Saeki, A. Sagara, S. Sakakibara, H. Sakamoto, Miki Sakamoto, Mizu Sakamoto, Y. Sakamoto, A. Sakasai, S. Sakata, R. Sakurai, B. Salanon, A. Salmi, G. Sannazzaro, R. Sano, A. Sanpei, T. Sasajima, S. Sasaki, H. Sasao, F. Sato, M. Sato, T. Sato, M. Sawahata, A. Scherber, S. Scully, J. Segado-Fernandez, M. Seki, N. Seki, S. Seki, Y. Shibama, Y. Shibata, T. Shikama, K. Shimada, M. Shimono, J. Shinde, T. Shinya, K. Shinohara, J. Shiraishi, S. Soare, A. Soleto, Y. Someya, S. Sonoda, C. Sozzi, E. Streciwilk-Kowalska, H. Strobel, M. Sueoka, A. Sukegawa, S. Sumida, H. Suzuki, Ma Suzuki, Mi Suzuki, S. Suzuki, T. Suzuki, Y. Suzuki, J. Svoboda, T. Szabolics, T. Szepesi, Y. Takase, M. Takechi, K. Takeda, Y. Takeiri, H. Takenaga, C. Taliercio, N. Tamura, Hiro Tanaka, Hito Tanaka, K. Tanaka, Y. Tanaka, K. Tani, H. Tanigawa, M. Tardocchi, A. Terakado, M. Terakado, T. Terakado, B. Teuchner, B. Tilia, H. Tobari, H. Tobita, K. Tobita, K. Toi, N. Toida, H. Tojo, M. Tokitani, T. Tokuzawa, V. Tormarchio, M. Tomine, A. Torre, T. Totsuka, K. Tsuchiya, N. Tsujii, D. Tsuru, H. Tsutsui, M. Uchida, Y. Ueda, J. Uno, H. Urano, K. Usui, H. Utoh, M. Valisa, M. Vallar, R. Vallcorba-Carbonel, J.-C. Vallet, J. Varela, J. Vega, M. Verrecchia, L. Vieillard, F. Villone, P. Vincenzi, K. Wada, R. Wada, T. Wakatsuki, M. Wanner, F. Watanabe, K. Watanabe, S. Watanabe, T. Wauters, S. Wiesen, M. Wischmeier, M. Yagi, J. Yagyu, M. Yajima, S. Yamamoto, H. Yamanaka, K. Yamauchi, Y. Yamauchi, H. Yamazaki, K. Yamazaki, R. Yamazaki, S. Yamoto, S. Yanagi, K. Yanagihara, S. Yokooka, M. Yokoyama, T. Yokoyama, M. Yoshida, M. Yoshimura, N. Yoshizawa, K. Yuinawa, L. Zani, and P. Zito

Subjects
JT-60SA, superconducting tokamak, risk mitigation measures, integrated commissioning, maintenance and enhancement, international collaboration, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Superconducting (SC) tokamak JT-60SA plays an essential role in fusion research and development by supporting and complementing the ITER project, providing directions to the DEMO design activity and fostering next generation scientists and engineers. Since the short circuit incident at the terminal joints of equilibrium field coil #1 during the integrated commissioning (IC) in March 2021, both EU and JA implementing agencies (IAs) have examined how to ensure safe operation of JT-60SA by mitigating the risk of possible discharge occurrence inside the cryostat. Based on the experience of the global Paschen tests, the IAs have established a strategy of risk mitigation measures, which is a combination of (i) reinforcement of insulation, (ii) avoiding unnecessary voltage application to the coil systems and (iii) immediate de-energization of the coils when deteriorated vacuum conditions are detected. Thanks to the considerable efforts of the Integrated Project Team members, the IC restarted in May 2023. After confirmation of the SC state of the coil systems (TF, EF and CS), the coil energization test and the plasma operation phase 1 (OP-1) started. The first plasma was successfully achieved on 23 October 2023 with a limited value of voltage and current applied to the coils. The plasma configuration control was also confirmed with low plasma current and low auxiliary heating power conditions. Based on the IO–F4E–QST collaboration, activities of JT-60SA have been shared with the IO and provided an important lesson for ITER assembly and commissioning, and will provide an outstanding contribution to fusion research at large. After OP-1, maintenance & enhancement phase 1 (M/E-1) starts from January 2024, in which in-vessel components are installed, and heating and diagnostic systems are extensively upgraded to allow a high power heating experiment planned in OP-2. In order to make the best use of JT-60SA, a newly organized JT-60SA experiment team will refine the research plan for the future high heating power operation phase.

Published
2024
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2. Characterization of early current quench time during massive impurity injection in JT-60SA

Author

T. Yokoyama, A. Matsuyama, Y. Yamamoto, S. Miyamoto, Y. Shibata, S. Inoue, S. Kojima, S. Nakamura, T. Wakatsuki, and M. Yoshida

Subjects
JT-60SA, disruptions, massive gas injection, current quench, runaway electrons, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Characteristics of the early current quench (CQ) time in mitigated disruptions are studied for a full-current (5.5 MA) scenario in the JT-60SA superconducting tokamak. Self-consistent evolution of the plasma temperature and current density profiles during the early CQ phase before the plasma moves vertically is simulated using the axisymmetric disruption code INDEX for given impurity source profiles. It is shown that the hollow (flat) impurity density profiles peaks (flattens) the current density, and it causes a temporal change in the internal inductance in this phase. However the resultant CQ time is found to be insensitive to the impurity source profile for the same assimilated quantity. The simulation results are interpreted by the L/R model including the temporal change in the internal inductance as well as the effect of a gap between the plasma and the conducting vessel structures and stabilizing plates. This results will improve the accuracy to estimate the amount of impurity assimilated into plasma from the observed CQ rate in the massive gas injection (MGI) experiment planned in JT-60SA. The accessible range in which the CQ time can be scanned as well as the electron densities to suppress runaway electrons is also shown for different injected amounts of neon, argon, and their deuterium mixture under the limitation of the MGI gas amount. Mitigated disruptions in JT-60SA typically lead to the CQ time shorter than the vessel wall time, which is expected to produce relevant contributions to disruption mitigation in ITER and future reactors.

Published
2023
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5. Effect of β-cryptoxanthin–rich Satsuma mandarin juice supplementation on pulse wave velocity: A randomized controlled trial

Author

M. Nakamura, M. Sugiura, Y. Shibata, and T. Ojima

Subjects
Antioxidants, Carotenoids, Citrus fruit, Arteriosclerosis, Oxidative stress, Nutrition. Foods and food supply, TX341-641, Biochemistry, QD415-436
Abstract

Background and Aims: Cohort studies in Japan indicate that citrus fruit and β-cryptoxanthin–rich Satsuma mandarin are candidate foods for lowering cardiovascular risk; however, there have been few intervention studies of β-cryptoxanthin and Satsuma mandarin supplementation. Methods and Results: A randomized, placebo-controlled, double-blind parallel trial was performed. Apparently healthy men and women were randomly assigned to two groups: one receiving concentrated β-cryptoxanthin–rich Satsuma mandarin juice (β-cryptoxanthin 4 mg per 125 mL/day: active group) and one receiving β-cryptoxanthin–deprived Satsuma mandarin juice (β-cryptoxanthin 0 mg per 125 mL/day: control group) for 12 weeks. The primary outcome was brachial-ankle pulse wave velocity (baPWV), which assesses arterial stiffness. An oxidative stress biomarker and clinical outcomes were also evaluated. Effect of the intervention on the outcome variables was analyzed using generalized linear mixed models. After the trial, a prespecified 8-month follow-up examination was conducted. One hundred eighteen subjects were randomly assigned, and 117 completed the intervention. Serum β-cryptoxanthin concentration was increased among the active group after β-cryptoxanthin–rich Satsuma mandarin juice supplementation. Both supplementations lowered baPWV and oxidative stress biomarker levels; however, there was no additional effect in the active group compared with the control group. At the 8-month examination, the increase in baPWV among the active group was smaller than that among the control group. Conclusion: Satsuma mandarin juice supplementation is potentially beneficial for reducing cardiovascular risk; however, additional β-cryptoxanthin supplementation did not enhance this effect. Further study is needed to evaluate the long-term effect of β-cryptoxanthin supplementation. Registration: UMIN-CTR, UMIN000013579.

Published
2017
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6. Removal of PolyA Tails from Full-Length cDNA Libraries for High-Efficiency Sequencing

Author

Y. Shibata, P. Carninci, K. Sato, N. Hayatsu, T. Shiraki, Y. Ishii, T. Arakawa, A. Hara, N. Ohsato, M. Izawa, K. Aizawa, M. Itoh, K. Shibata, A. Shinagawa, J. Kawai, Y. Ota, S. Kikuchi, N. Kishimoto, M. Muramatsu, and Y. Hayashizaki

Subjects
Biology (General), QH301-705.5
Abstract

We have developed a method to overcome sequencing problems caused by the presence of homopolymer stretches, such as polyA/T, in cDNA libraries. PolyA tails are shortened by cleaving before cDNA cloning with type IIS restriction enzymes, such as GsuI, placed next to the oligo-dT used to prime the polyA tails of mRNAs. We constructed four rice Cap-Trapper-selected, full-length normalized cDNA libraries, of which the average residual polyA tail was 4 bases or shorter in most of the clones analyzed. Because of the removal of homopolymeric stretches, libraries prepared with this method can be used for direct sequencing and transcriptional sequencing without the slippage observed for libraries prepared with currently available methods, thus improving sequencing accuracy, operations, and throughput.

Published
2001
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7. Cloning Full-Length, Cap-Trapper-Selected cDNAs by Using the Single-Strand Linker Ligation Method

Author

Y. Shibata, P. Carninci, A. Watahiki, T. Shiraki, H. Konno, M. Muramatsu, and Y. Hayashizaki

Subjects
Biology (General), QH301-705.5
Abstract

We have developed the single-strand linker ligation method (SSLLM), which uses DNA ligase to add a dsDNA linker to singlestranded (ss) full-length cDNA. The linkers have random 6-bp (dN6 or dGN5) 3′ overhangs that can ligate to any cDNA sequence, thereby facilitating the production of cDNA libraries with titers exceeding 1 × 106 independent clones. We confirmed that the 5′ ends of cDNA inserts cloned by using SSLLM are full-length and include the 5′ untranslated regions. The great advantage of our method is that the elimination of the GC tail simplifies the sequencing and protein translation of the full-length clones. Further, our method tags ss cDNAs more efficiently than does the traditional RNA ligase reaction.

Published
2001
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8. Temporal characteristics of monoenergetic electron beams generated by the laser wakefield acceleration

Author

T. Ohkubo, A. Maekawa, R. Tsujii, T. Hosokai, K. Kinoshita, K. Kobayashi, M. Uesaka, A. Zhidkov, K. Nemoto, Y. Kondo, and Y. Shibata

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Pulse length of quasimonoenergetic electrons accelerated by the wakefield generated by 12 TW, 40 fs laser pulses in a gas jet is determined via spectral measurements using a bolometer to detect coherent transition radiation. A quasimonoenergetic electron beam with its mean energy E=21 MeV, dispersion ΔE=4 MeV, total charge q∼30 pC, and the geometrical emittance 0.07π mm mrad is generated with high reproducibility. The averaged duration of only the quasimonoenergetic electron bunches peaked around 20 MeV is 130±30 fs (FWHM), while it is 250±70 fs (FWHM) for electron bunches with quasimonoenergetic distributions peaked around 4 MeV, at a distance of 180 mm far from the gas jet because of relatively large electron energy spread. Pulse elongation of the electron bunch with the quasimonoenergetic distribution after 180 mm path is 60–220 fs (FWHM). Therefore, the initial duration of the electron bunch at the gas-jet rear is expected to be less than 100 fs (FWHM).

Published
2007
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10. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting

Author

Tetsuya Matoba, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Yukihiro Koretsune, Takafumi Hiro, Tetsuya Sumiyoshi, Kazumi Kimura, Yoichiro Hashimoto, Teruyuki Hirano, Hiroyuki Daida, Yasushi Okada, Tsutomu Yamazaki, A. Nakamura, E. Tamiya, T. Yamamoto, S. Suetake, T. Noguchi, S. Nakamura, A. Matsumura, J. Kojima, S. Suwa, H. Yamaguchi, K. Kaikita, T. Yasu, A. Nakajima, T. Yamada, H. Arai, Y. Hata, T. Sakanashi, H. Tateishi, T. Nakayama, Y. Nozaki, M. Akao, Y. Okumura, M. Tokue, N. Kuroki, Y. Maruyama, T. Matoba, N. Hagiwara, H. Suzuki, Y. Nishida, M. Ajioka, K. Yumoto, S. Shimizu, T. Aoyama, H. Shimomura, T. Takeda, K. Oshiro, N. Sugishita, Y. Shibata, T. Otonari, H. Kihara, H. Ogawa, A. Ohno, M. Hazama, M. Shimizu, K. Tsukahara, S. Haruta, T. Wakeyama, T. Haruna, M. Ito, K. Fujii, N. Atsuchi, M. Sata, K. Kimura, N. Hasebe, Y. Kobayasi, K. Ohsato, K. Hironaga, Y. Naganuma, K. Anzaki, K. Oiwa, S. Okazaki, Y. Nakagawa, K. Tokuhiro, K. Tanaka, T. Momose, Y. Fukushima, R. Kametani, K. Kawamitsu, Y. Saito, S. Akashi, K. Kumagai, K. Eshima, T. Tobaru, T. Seo, K. Okuhara, K. Kozuma, Y. Ikari, T. Takahashi, I. Michishita, H. Fujikura, S. Momomura, Y. Yamamoto, K. Otomo, T. Matsubara, H. Tashiro, T. Inoue, M. Ishihara, I. Shiojima, E. Tachibana, J. Ako, K. Sumii, N. Yamamoto, N. Ohmura, T. Nakamura, Y. Morita, N. Takahashi, K. Watanabe, H. Fujinaga, M. Maruyama, T. Oka, T. Shirayama, T. Amano, K. Fukui, K. Ando, S. Oshima, S. Kagiyama, H. Teragawa, M. Yuge, S. Ono, T. Koga, K. Fujiu, M. Kuwabara, Y. Ohya, Y. Yumoto, N. Kuji, M. Ikemura, K. Kario, K. Chatani, K. Sato, H. Miyagi, M. Murakami, K. Saito, M. Hoshiga, S. Sato, N. Kubo, Y. Sakamoto, K. Ashida, H. Sakamoto, S. Murasaki, H. Uehara, T. Akasaka, Y. Ooba, S. Nakahara, Y. Hanaoka, T. Nishimiya, R. Tsunoda, Y. Onuma, S. Higuchi, A. Tani, A. Wada, M. Kato, H. Obata, Y. Higuchi, T. Endo, R. Katou, T. Matsunaga, T. Matsuoka, H. Noguchi, M. Usui, T. Hayashi, Y. Otsuji, T. Osaki, H. Zaizen, H. Yoshihara, K. Kadota, T. Hirose, T. Miyazawa, A. Mori, M. Takano, W. Shimizu, M. Wake, S. Oriso, M. Yoshiyama, S. Kakinoki, T. Nishioka, T. Ozaki, K. Nomoto, K. Seki, K. Kawai, Y. Ozaki, S. Miura, M. Kawasaki, R. Funada, K. Dote, T. Nagano, S. Okamoto, T. Kubo, Y. Murozono, T. Owada, T. Doke, T. Matsumura, M. Horiuchi, A. Takaishi, M. Yamamoto, H. Nakashima, M. Munemasa, Y. Sakata, N. Inoue, T. Ota, Y. Hamano, N. Abe, T. Tsubokura, M. Goto, I. Kubota, M. Yano, K. Umetani, T. Date, H. Morimoto, T. Noda, S. Goto, K. Hibi, A. Nakano, S. Hiramitsu, Y. Kihara, M. Sugi, N. Shiba, D. Izumi, T. Sato, S. Tayama, T. Matsui, A. Suzuki, K. Ajiki, M. Oishi, M. Kiryu, T. Ko, H. Ando, S. Miyazaki, T. Kinugawa, H. Otake, H. Kitaoka, Y. Hirata, S. Honda, M. Manita, Y. Ishii, H. Oka, Y. Nanba, M. Nishino, T. Sakamoto, T. Saito, H. Sakai, M. Ichikawa, S. Namiuchi, K. Inoue, N. Komiyama, Y. Akashi, Y. Nakamura, T. Komaru, T. Hosokawa, T. Chikamori, H. Tanaka, O. Arasaki, K. Aonuma, Y. Wakasa, T. Yoshizawa, T. Sugano, N. Yokota, A. Kakutani, T. Suzuki, Y. Abe, T. Kataoka, H. Okayama, H. Yokoi, K. Chin, K. Hasegawa, H. Tomita, H. Honzyo, H. Kawai, K. Yamamoto, Y. Morino, S. Tsujiyama, S. Hamasaki, Y. Niijima, Y. Mizuno, A. Maki, K. Tanabe, T. Murohara, S. Naomi, M. Arikawa, T. Kato, N. Matsumoto, T. Minamino, H. Sairenji, N. Miyamoto, H. Ito, Y. Matsuura, S. Hata, Y. Nakatsu, T. Onodera, M. Yoshimura, H. Amano, E. Tokutake, M. Kasao, M. Moriguchi, M. Tsuji, H. Yamamoto, Y. Yanbe, T. Iwasawa, M. Suzuki, and H. Mori

Subjects
Rivaroxaban, medicine.medical_specialty, business.industry, Unstable angina, medicine.medical_treatment, Percutaneous coronary intervention, Atrial fibrillation, medicine.disease, Thrombosis, Coronary artery disease, Internal medicine, medicine, Cardiology, cardiovascular diseases, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Stroke, medicine.drug
Abstract

Objectives The aim of this AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial subgroup analysis was to examine rivaroxaban monotherapy benefits and their relation to the time between stenting and enrollment among patients after coronary stenting. Background Of 2,215 patients with atrial fibrillation and stable coronary artery disease in the AFIRE trial, rivaroxaban monotherapy was noninferior to rivaroxaban plus antiplatelet therapy (combination therapy) in terms of efficacy and superior for safety endpoints. However, thrombotic risk after antiplatelet therapy cessation remained a concern among 1,444 patients who had undergone coronary stenting >1 year before enrollment. Methods The benefits of rivaroxaban monotherapy in coronary stenting subgroups were assessed for efficacy (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death of any cause), safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria), ischemic endpoints, net adverse clinical event, and time between stenting and enrollment. Results Efficacy and safety endpoints for monotherapy were superior to combination therapy, with HRs of 0.70 for efficacy (95% CI: 0.50-0.98; P = 0.036) and 0.55 for safety (95% CI: 0.33-0.92; P = 0.019). For ischemic endpoints, the HR was 0.82 (95% CI: 0.58-1.15; P = 0.240). The HR became smaller with longer time between stenting and enrollment (efficacy, P for interaction = 0.158; safety, P = 0.097). Conclusions In patients with atrial fibrillation after coronary stenting, the benefits of rivaroxaban monotherapy for efficacy and safety endpoints were consistent with those in the whole AFIRE trial population. The benefits became apparent with longer time between stenting and enrollment. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study [AFIRE]; UMIN000016612 , NCT02642419 )

Published
2021
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14. POST-AZACITIDINE CLONE SIZE PREDICTS LONG-TERM OUTCOME OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES AND RELATED MYELOID NEOPLASMS

Author

Y. Nannya, M. Tobiasson, S. Sato, E. Bernard, S. Ohtake, J. Takeda, M. Creignou, M. Kusakabe, Y. Shibata, N. Nakamura, M. Watanabe, N. Hiramoto, Y. Shiozawa, Y. Shiraishi, H. Tanaka, K. Yoshida, N. Kakicuchi, H. Makishima, M. Nakagawa, K. Usuki, K. Imada, H. Handa, M. Taguchi, T. Kiguchi, K. Ohyashiki, T. Ishikawa, A. Takaori, H. Tsurumi, S. Kasahara, S. Chiba, T. Naoe, S. Miyano, E. Papaemmanuil, Y. Miyazaki, E. Hellstrom-Lindberg, and S. Ogawa

Subjects
Cancer Research, Oncology, Hematology
Published
2023
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15. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy

Author

M. E. Fenstermacher, J. Abbate, S. Abe, T. Abrams, M. Adams, B. Adamson, N. Aiba, T. Akiyama, P. Aleynikov, E. Allen, S. Allen, H. Anand, J. Anderson, Y. Andrew, T. Andrews, D. Appelt, R. Arbon, N. Ashikawa, A. Ashourvan, M. Aslin, Y. Asnis, M. Austin, D. Ayala, J. Bak, I. Bandyopadhyay, S. Banerjee, K. Barada, L. Bardoczi, J. Barr, E. Bass, D. Battaglia, A. Battey, W. Baumgartner, L. Baylor, J. Beckers, M. Beidler, E. Belli, J. Berkery, T. Bernard, N. Bertelli, M. Beurskens, R. Bielajew, S. Bilgili, B. Biswas, S. Blondel, J. Boedo, I. Bogatu, R. Boivin, T. Bolzonella, M. Bongard, X. Bonnin, P. Bonoli, M. Bonotto, A. Bortolon, S. Bose, N. Bosviel, S. Bouwmans, M. Boyer, W. Boyes, L. Bradley, R. Brambila, D. Brennan, S. Bringuier, L. Brodsky, M. Brookman, J. Brooks, D. Brower, G. Brown, W. Brown, M. Burke, K. Burrell, K. Butler, R. Buttery, I. Bykov, P. Byrne, A. Cacheris, K. Callahan, J. Callen, G. Campbell, J. Candy, J. Canik, P. Cano-Megias, N. Cao, L. Carayannopoulos, T. Carlstrom, W. Carrig, T. Carter, W. Cary, L. Casali, M. Cengher, G. Cespedes Paz, R. Chaban, V. Chan, B. Chapman, I. Char, A. Chattopadhyay, R. Chen, J. Chen, X. Chen, M. Chen, Z. Chen, M. Choi, W. Choi, G. Choi, L. Chousal, C. Chrobak, C. Chrystal, Y. Chung, R. Churchill, M. Cianciosa, J. Clark, M. Clement, S. Coda, A. Cole, C. Collins, W. Conlin, A. Cooper, J. Cordell, B. Coriton, T. Cote, J. Cothran, A. Creely, N. Crocker, C. Crowe, B. Crowley, T. Crowley, D. Cruz-Zabala, D. Cummings, M. Curie, D. Curreli, A. Dal Molin, B. Dannels, A. Dautt-Silva, K. Davda, G. De Tommasi, P. De Vries, G. Degrandchamp, J. Degrassie, D. Demers, S. Denk, S. Depasquale, E. Deshazer, A. Diallo, S. Diem, A. Dimits, R. Ding, S. Ding, W. Ding, T. Do, J. Doane, G. Dong, D. Donovan, J. Drake, W. Drews, J. Drobny, X. Du, H. Du, V. Duarte, D. Dudt, C. Dunn, J. Duran, A. Dvorak, F. Effenberg, N. Eidietis, D. Elder, D. Eldon, R. Ellis, W. Elwasif, D. Ennis, K. Erickson, D. Ernst, M. Fasciana, D. Fedorov, E. Feibush, N. Ferraro, J. Ferreira, J. Ferron, P. Fimognari, D. Finkenthal, R. Fitzpatrick, P. Fox, W. Fox, L. Frassinetti, H. Frerichs, H. Frye, Y. Fu, K. Gage, J. Galdon Quiroga, A. Gallo, Q. Gao, A. Garcia, M. Garcia Munoz, D. Garnier, A. Garofalo, A. Gattuso, D. Geng, K. Gentle, D. Ghosh, L. Giacomelli, S. Gibson, E. Gilson, C. Giroud, F. Glass, A. Glasser, D. Glibert, P. Gohil, R. Gomez, S. Gomez, X. Gong, E. Gonzales, A. Goodman, Y. Gorelov, V. Graber, R. Granetz, T. Gray, D. Green, C. Greenfield, M. Greenwald, B. Grierson, R. Groebner, W. Grosnickle, M. Groth, H. Grunloh, S. Gu, W. Guo, H. Guo, P. Gupta, J. Guterl, W. Guttenfelder, T. Guzman, S. Haar, R. Hager, S. Hahn, M. Halfmoon, T. Hall, K. Hallatschek, F. Halpern, G. Hammett, H. Han, E. Hansen, C. Hansen, M. Hansink, J. Hanson, M. Hanson, G. Hao, A. Harris, R. Harvey, S. Haskey, E. Hassan, A. Hassanein, D. Hatch, R. Hawryluk, W. Hayashi, W. Heidbrink, J. Herfindal, J. Hicok, D. Hill, E. Hinson, C. Holcomb, L. Holland, C. Holland, E. Hollmann, J. Hollocombe, A. Holm, I. Holmes, K. Holtrop, M. Honda, R. Hong, R. Hood, A. Horton, L. Horvath, M. Hosokawa, S. Houshmandyar, N. Howard, E. Howell, D. Hoyt, W. Hu, Y. Hu, Q. Hu, J. Huang, Y. Huang, J. Hughes, T. Human, D. Humphreys, P. Huynh, A. Hyatt, C. Ibanez, L. Ibarra, R. Icasas, K. Ida, V. Igochine, Y. In, S. Inoue, A. Isayama, O. Izacard, V. Izzo, A. Jackson, G. Jacobsen, A. Jaervinen, A. Jalalvand, J. Janhunen, S. Jardin, H. Jarleblad, Y. Jeon, H. Ji, X. Jian, E. Joffrin, A. Johansen, C. Johnson, T. Johnson, C. Jones, I. Joseph, D. Jubas, B. Junge, W. Kalb, R. Kalling, C. Kamath, J. Kang, D. Kaplan, A. Kaptanoglu, S. Kasdorf, J. Kates-Harbeck, P. Kazantzidis, A. Kellman, D. Kellman, C. Kessel, K. Khumthong, E. Kim, H. Kim, J. Kim, S. Kim, K. Kim, C. Kim, W. Kimura, M. King, J. King, J. Kinsey, A. Kirk, B. Kiyan, A. Kleiner, V. Klevarova, R. Knapp, M. Knolker, W. Ko, T. Kobayashi, E. Koch, M. Kochan, B. Koel, M. Koepke, A. Kohn, R. Kolasinski, E. Kolemen, E. Kostadinova, M. Kostuk, G. Kramer, D. Kriete, L. Kripner, S. Kubota, J. Kulchar, K. Kwon, R. La Haye, F. Laggner, H. Lan, R. Lantsov, L. Lao, A. Lasa Esquisabel, C. Lasnier, C. Lau, B. Leard, J. Lee, R. Lee, M. Lee, Y. Lee, C. Lee, S. Lee, M. Lehnen, A. Leonard, E. Leppink, M. Lesher, J. Lestz, J. Leuer, N. Leuthold, X. Li, K. Li, E. Li, G. Li, L. Li, Z. Li, J. Li, Y. Li, Z. Lin, D. Lin, X. Liu, J. Liu, Y. Liu, T. Liu, C. Liu, Z. Liu, D. Liu, A. Liu, A. Loarte-Prieto, L. Lodestro, N. Logan, J. Lohr, B. Lombardo, J. Lore, Q. Luan, T. Luce, T. Luda Di Cortemiglia, N. Luhmann, R. Lunsford, Z. Luo, A. Lvovskiy, B. Lyons, X. Ma, M. Madruga, B. Madsen, C. Maggi, K. Maheshwari, A. Mail, J. Mailloux, R. Maingi, M. Major, M. Makowski, R. Manchanda, C. Marini, A. Marinoni, A. Maris, T. Markovic, L. Marrelli, E. Martin, J. Mateja, G. Matsunaga, R. Maurizio, P. Mauzey, D. Mauzey, G. Mcardle, J. Mcclenaghan, K. Mccollam, C. Mcdevitt, K. Mckay, G. Mckee, A. Mclean, V. Mehta, E. Meier, J. Menard, O. Meneghini, G. Merlo, S. Messer, W. Meyer, C. Michael, C. Michoski, P. Milne, G. Minet, A. Misleh, Y. Mitrishkin, C. Moeller, K. Montes, M. Morales, S. Mordijck, D. Moreau, S. Morosohk, P. Morris, L. Morton, A. Moser, R. Moyer, C. Moynihan, T. Mrazkova, D. Mueller, S. Munaretto, J. Munoz Burgos, C. Murphy, K. Murphy, C. Muscatello, C. Myers, A. Nagy, G. Nandipati, M. Navarro, F. Nave, G. Navratil, R. Nazikian, A. Neff, G. Neilson, T. Neiser, W. Neiswanger, D. Nelson, A. Nelson, F. Nespoli, R. Nguyen, L. Nguyen, X. Nguyen, J. Nichols, M. Nocente, S. Nogami, S. Noraky, N. Norausky, M. Nornberg, R. Nygren, T. Odstrcil, D. Ogas, T. Ogorman, S. Ohdachi, Y. Ohtani, M. Okabayashi, M. Okamoto, L. Olavson, E. Olofsson, M. Omullane, R. Oneill, D. Orlov, W. Orvis, T. Osborne, D. Pace, G. Paganini Canal, A. Pajares Martinez, L. Palacios, C. Pan, Q. Pan, R. Pandit, M. Pandya, A. Pankin, Y. Park, J. Park, S. Parker, P. Parks, M. Parsons, B. Patel, C. Pawley, C. Paz-Soldan, W. Peebles, S. Pelton, R. Perillo, C. Petty, Y. Peysson, D. Pierce, A. Pigarov, L. Pigatto, D. Piglowski, S. Pinches, R. Pinsker, P. Piovesan, N. Piper, A. Pironti, R. Pitts, J. Pizzo, U. Plank, M. Podesta, E. Poli, F. Poli, D. Ponce, Z. Popovic, M. Porkolab, G. Porter, C. Powers, S. Powers, R. Prater, Q. Pratt, I. Pusztai, J. Qian, X. Qin, O. Ra, T. Rafiq, T. Raines, R. Raman, J. Rauch, A. Raymond, C. Rea, M. Reich, A. Reiman, S. Reinhold, M. Reinke, R. Reksoatmodjo, Q. Ren, Y. Ren, J. Ren, M. Rensink, J. Renteria, T. Rhodes, J. Rice, R. Roberts, J. Robinson, P. Rodriguez Fernandez, T. Rognlien, A. Rosenthal, S. Rosiello, J. Rost, J. Roveto, W. Rowan, R. Rozenblat, J. Ruane, D. Rudakov, J. Ruiz Ruiz, R. Rupani, S. Saarelma, S. Sabbagh, J. Sachdev, J. Saenz, S. Saib, M. Salewski, A. Salmi, B. Sammuli, C. Samuell, A. Sandorfi, C. Sang, J. Sarff, O. Sauter, K. Schaubel, L. Schmitz, O. Schmitz, J. Schneider, P. Schroeder, K. Schultz, E. Schuster, J. Schwartz, F. Sciortino, F. Scotti, J. Scoville, A. Seltzman, S. Seol, I. Sfiligoi, M. Shafer, S. Sharapov, H. Shen, Z. Sheng, T. Shepard, S. Shi, Y. Shibata, G. Shin, D. Shiraki, R. Shousha, H. Si, P. Simmerling, G. Sinclair, J. Sinha, P. Sinha, G. Sips, T. Sizyuk, C. Skinner, A. Sladkomedova, T. Slendebroek, J. Slief, R. Smirnov, J. Smith, S. Smith, D. Smith, J. Snipes, G. Snoep, A. Snyder, P. Snyder, E. Solano, W. Solomon, J. Song, A. Sontag, V. Soukhanovskii, J. Spendlove, D. Spong, J. Squire, C. Srinivasan, W. Stacey, G. Staebler, L. Stagner, T. Stange, P. Stangeby, R. Stefan, R. Stemprok, D. Stephan, J. Stillerman, T. Stoltzfus-Dueck, W. Stonecipher, S. Storment, E. Strait, D. Su, L. Sugiyama, Y. Sun, P. Sun, Z. Sun, A. Sun, D. Sundstrom, C. Sung, J. Sungcoco, W. Suttrop, Y. Suzuki, T. Suzuki, A. Svyatkovskiy, C. Swee, R. Sweeney, C. Sweetnam, G. Szepesi, M. Takechi, T. Tala, K. Tanaka, X. Tang, S. Tang, Y. Tao, R. Tao, D. Taussig, T. Taylor, K. Teixeira, K. Teo, A. Theodorsen, D. Thomas, K. Thome, A. Thorman, A. Thornton, A. Ti, M. Tillack, N. Timchenko, R. Tinguely, R. Tompkins, J. Tooker, A. Torrezan De Sousa, G. Trevisan, S. Tripathi, A. Trujillo Ochoa, D. Truong, C. Tsui, F. Turco, A. Turnbull, M. Umansky, E. Unterberg, P. Vaezi, P. Vail, J. Valdez, W. Valkis, B. Van Compernolle, J. Van Galen, R. Van Kampen, M. Van Zeeland, G. Verdoolaege, N. Vianello, B. Victor, E. Viezzer, S. Vincena, M. Wade, F. Waelbroeck, J. Wai, T. Wakatsuki, M. Walker, G. Wallace, R. Waltz, W. Wampler, L. Wang, H. Wang, Y. Wang, Z. Wang, G. Wang, S. Ward, M. Watkins, J. Watkins, W. Wehner, Y. Wei, M. Weiland, D. Weisberg, A. Welander, A. White, R. White, S. Wiesen, R. Wilcox, T. Wilks, M. Willensdorfer, H. Wilson, A. Wingen, M. Wolde, M. Wolff, K. Woller, A. Wolz, H. Wong, S. Woodruff, M. Wu, Y. Wu, S. Wukitch, G. Wurden, W. Xiao, R. Xie, Z. Xing, X. Xu, C. Xu, G. Xu, Z. Yan, X. Yang, S. Yang, T. Yokoyama, R. Yoneda, M. Yoshida, K. You, T. Younkin, J. Yu, M. Yu, G. Yu, Q. Yuan, L. Zaidenberg, L. Zakharov, A. Zamengo, S. Zamperini, M. Zarnstorff, E. Zeger, K. Zeller, L. Zeng, M. Zerbini, L. Zhang, X. Zhang, R. Zhang, B. Zhang, J. Zhang, L. Zhao, B. Zhao, Y. Zheng, L. Zheng, B. Zhu, J. Zhu, Y. Zhu, M. Zsutty, M. Zuin, Fenstermacher, M. E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., De Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., Mcardle, G., Mcclenaghan, J., Mccollam, K., Mcdevitt, C., Mckay, K., Mckee, G., Mclean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., Van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., Zuin, M., Fenstermacher, M, Abbate, J, Abe, S, Abrams, T, Adams, M, Adamson, B, Aiba, N, Akiyama, T, Aleynikov, P, Allen, E, Allen, S, Anand, H, Anderson, J, Andrew, Y, Andrews, T, Appelt, D, Arbon, R, Ashikawa, N, Ashourvan, A, Aslin, M, Asnis, Y, Austin, M, Ayala, D, Bak, J, Bandyopadhyay, I, Banerjee, S, Barada, K, Bardoczi, L, Barr, J, Bass, E, Battaglia, D, Battey, A, Baumgartner, W, Baylor, L, Beckers, J, Beidler, M, Belli, E, Berkery, J, Bernard, T, Bertelli, N, Beurskens, M, Bielajew, R, Bilgili, S, Biswas, B, Blondel, S, Boedo, J, Bogatu, I, Boivin, R, Bolzonella, T, Bongard, M, Bonnin, X, Bonoli, P, Bonotto, M, Bortolon, A, Bose, S, Bosviel, N, Bouwmans, S, Boyer, M, Boyes, W, Bradley, L, Brambila, R, Brennan, D, Bringuier, S, Brodsky, L, Brookman, M, Brooks, J, Brower, D, Brown, G, Brown, W, Burke, M, Burrell, K, Butler, K, Buttery, R, Bykov, I, Byrne, P, Cacheris, A, Callahan, K, Callen, J, Campbell, G, Candy, J, Canik, J, Cano-Megias, P, Cao, N, Carayannopoulos, L, Carlstrom, T, Carrig, W, Carter, T, Cary, W, 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P, Finkenthal, D, Fitzpatrick, R, Fox, P, Fox, W, Frassinetti, L, Frerichs, H, Frye, H, Fu, Y, Gage, K, Quiroga, J, Gallo, A, Gao, Q, Garcia, A, Munoz, M, Garnier, D, Garofalo, A, Gattuso, A, Geng, D, Gentle, K, Ghosh, D, Giacomelli, L, Gibson, S, Gilson, E, Giroud, C, Glass, F, Glasser, A, Glibert, D, Gohil, P, Gomez, R, Gomez, S, Gong, X, Gonzales, E, Goodman, A, Gorelov, Y, Graber, V, Granetz, R, Gray, T, Green, D, Greenfield, C, Greenwald, M, Grierson, B, Groebner, R, Grosnickle, W, Groth, M, Grunloh, H, Gu, S, Guo, W, Guo, H, Gupta, P, Guterl, J, Guttenfelder, W, Guzman, T, Haar, S, Hager, R, Hahn, S, Halfmoon, M, Hall, T, Hallatschek, K, Halpern, F, Hammett, G, Han, H, Hansen, E, Hansen, C, Hansink, M, Hanson, J, Hanson, M, Hao, G, Harris, A, Harvey, R, Haskey, S, Hassan, E, Hassanein, A, Hatch, D, Hawryluk, R, Hayashi, W, Heidbrink, W, Herfindal, J, Hicok, J, Hill, D, Hinson, E, Holcomb, C, Holland, L, Holland, C, Hollmann, E, Hollocombe, J, Holm, A, Holmes, I, Holtrop, K, Honda, M, Hong, R, Hood, R, Horton, A, Horvath, L, Hosokawa, M, Houshmandyar, S, Howard, N, Howell, E, Hoyt, D, Hu, W, Hu, Y, Hu, Q, Huang, J, Huang, Y, Hughes, J, Human, T, Humphreys, D, Huynh, P, Hyatt, A, Ibanez, C, Ibarra, L, Icasas, R, Ida, K, Igochine, V, In, Y, Inoue, S, Isayama, A, Izacard, O, Izzo, V, Jackson, A, Jacobsen, G, Jaervinen, A, Jalalvand, A, Janhunen, J, Jardin, S, Jarleblad, H, Jeon, Y, Ji, H, Jian, X, Joffrin, E, Johansen, A, Johnson, C, Johnson, T, Jones, C, Joseph, I, Jubas, D, Junge, B, Kalb, W, Kalling, R, Kamath, C, Kang, J, Kaplan, D, Kaptanoglu, A, Kasdorf, S, Kates-Harbeck, J, Kazantzidis, P, Kellman, A, Kellman, D, Kessel, C, Khumthong, K, Kim, E, Kim, H, Kim, J, Kim, S, Kim, K, Kim, C, Kimura, W, King, M, King, J, Kinsey, J, Kirk, A, Kiyan, B, Kleiner, A, Klevarova, V, Knapp, R, Knolker, M, Ko, W, Kobayashi, T, Koch, E, Kochan, M, Koel, B, Koepke, M, Kohn, A, Kolasinski, R, Kolemen, E, Kostadinova, E, Kostuk, M, Kramer, G, Kriete, D, Kripner, L, Kubota, S, Kulchar, J, Kwon, K, La Haye, R, Laggner, F, Lan, H, Lantsov, R, Lao, L, Esquisabel, A, Lasnier, C, Lau, C, Leard, B, Lee, J, Lee, R, Lee, M, Lee, Y, Lee, C, Lee, S, Lehnen, M, Leonard, A, Leppink, E, Lesher, M, Lestz, J, Leuer, J, Leuthold, N, Li, X, Li, K, Li, E, Li, G, Li, L, Li, Z, Li, J, Li, Y, Lin, Z, Lin, D, Liu, X, Liu, J, Liu, Y, Liu, T, Liu, C, Liu, Z, Liu, D, Liu, A, Loarte-Prieto, A, Lodestro, L, Logan, N, Lohr, J, Lombardo, B, Lore, J, Luan, Q, Luce, T, Di Cortemiglia, T, Luhmann, N, Lunsford, R, Luo, Z, Lvovskiy, A, Lyons, B, Ma, X, Madruga, M, Madsen, B, Maggi, C, Maheshwari, K, Mail, A, Mailloux, J, Maingi, R, Major, M, Makowski, M, Manchanda, R, Marini, C, Marinoni, A, Maris, A, Markovic, T, Marrelli, L, Martin, E, Mateja, J, Matsunaga, G, Maurizio, R, Mauzey, P, Mauzey, D, Mcardle, G, Mcclenaghan, J, Mccollam, K, Mcdevitt, C, Mckay, K, Mckee, G, Mclean, A, Mehta, V, Meier, E, Menard, J, Meneghini, O, Merlo, G, Messer, S, Meyer, W, Michael, C, Michoski, C, Milne, P, Minet, G, Misleh, A, Mitrishkin, Y, Moeller, C, Montes, K, Morales, M, Mordijck, S, Moreau, D, Morosohk, S, Morris, P, Morton, L, Moser, A, Moyer, R, Moynihan, C, Mrazkova, T, Mueller, D, Munaretto, S, Burgos, J, Murphy, C, Murphy, K, Muscatello, C, Myers, C, Nagy, A, Nandipati, G, Navarro, M, Nave, F, Navratil, G, Nazikian, R, Neff, A, Neilson, G, Neiser, T, Neiswanger, W, Nelson, D, Nelson, A, Nespoli, F, Nguyen, R, Nguyen, L, Nguyen, X, Nichols, J, Nocente, M, Nogami, S, Noraky, S, Norausky, N, Nornberg, M, Nygren, R, Odstrcil, T, Ogas, D, Ogorman, T, Ohdachi, S, Ohtani, Y, Okabayashi, M, Okamoto, M, Olavson, L, Olofsson, E, Omullane, M, Oneill, R, Orlov, D, Orvis, W, Osborne, T, Pace, D, Canal, G, Martinez, A, Palacios, L, Pan, C, Pan, Q, Pandit, R, Pandya, M, Pankin, A, Park, Y, Park, J, Parker, S, Parks, P, Parsons, M, Patel, B, Pawley, C, Paz-Soldan, C, Peebles, W, Pelton, S, Perillo, R, Petty, C, Peysson, Y, Pierce, D, Pigarov, A, Pigatto, L, Piglowski, D, Pinches, S, Pinsker, R, Piovesan, P, Piper, N, Pironti, A, Pitts, R, Pizzo, J, Plank, U, Podesta, M, Poli, E, Poli, F, Ponce, D, Popovic, Z, Porkolab, M, Porter, G, Powers, C, Powers, S, Prater, R, Pratt, Q, Pusztai, I, Qian, J, Qin, X, Ra, O, Rafiq, T, Raines, T, Raman, R, Rauch, J, Raymond, A, Rea, C, Reich, M, Reiman, A, Reinhold, S, Reinke, M, Reksoatmodjo, R, Ren, Q, Ren, Y, Ren, J, Rensink, M, Renteria, J, Rhodes, T, Rice, J, Roberts, R, Robinson, J, Fernandez, P, Rognlien, T, Rosenthal, A, Rosiello, S, Rost, J, Roveto, J, Rowan, W, Rozenblat, R, Ruane, J, Rudakov, D, Ruiz, J, Rupani, R, Saarelma, S, Sabbagh, S, Sachdev, J, Saenz, J, Saib, S, Salewski, M, Salmi, A, Sammuli, B, Samuell, C, Sandorfi, A, Sang, C, Sarff, J, Sauter, O, Schaubel, K, Schmitz, L, Schmitz, O, Schneider, J, Schroeder, P, Schultz, K, Schuster, E, Schwartz, J, Sciortino, F, Scotti, F, Scoville, J, Seltzman, A, Seol, S, Sfiligoi, I, Shafer, M, Sharapov, S, Shen, H, Sheng, Z, Shepard, T, Shi, S, Shibata, Y, Shin, G, Shiraki, D, Shousha, R, Si, H, Simmerling, P, Sinclair, G, Sinha, J, Sinha, P, Sips, G, Sizyuk, T, Skinner, C, Sladkomedova, A, Slendebroek, T, Slief, J, Smirnov, R, Smith, J, Smith, S, Smith, D, Snipes, J, Snoep, G, Snyder, A, Snyder, P, Solano, E, Solomon, W, Song, J, Sontag, A, Soukhanovskii, V, Spendlove, J, Spong, D, Squire, J, Srinivasan, C, Stacey, W, Staebler, G, Stagner, L, Stange, T, Stangeby, P, Stefan, R, Stemprok, R, Stephan, D, Stillerman, J, Stoltzfus-Dueck, T, Stonecipher, W, Storment, S, Strait, E, Su, D, Sugiyama, L, Sun, Y, Sun, P, Sun, Z, Sun, A, Sundstrom, D, Sung, C, Sungcoco, J, Suttrop, W, Suzuki, Y, Suzuki, T, Svyatkovskiy, A, Swee, C, Sweeney, R, Sweetnam, C, Szepesi, G, Takechi, M, Tala, T, Tanaka, K, Tang, X, Tang, S, Tao, Y, Tao, R, Taussig, D, Taylor, T, Teixeira, K, Teo, K, Theodorsen, A, Thomas, D, Thome, K, Thorman, A, Thornton, A, Ti, A, Tillack, M, Timchenko, N, Tinguely, R, Tompkins, R, Tooker, J, De Sousa, A, Trevisan, G, Tripathi, S, Ochoa, A, Truong, D, Tsui, C, Turco, F, Turnbull, A, Umansky, M, Unterberg, E, Vaezi, P, Vail, P, Valdez, J, Valkis, W, Van Compernolle, B, Van Galen, J, Van Kampen, R, Van Zeeland, M, Verdoolaege, G, Vianello, N, Victor, B, Viezzer, E, Vincena, S, Wade, M, Waelbroeck, F, Wai, J, Wakatsuki, T, Walker, M, Wallace, G, Waltz, R, Wampler, W, Wang, L, Wang, H, Wang, Y, Wang, Z, Wang, G, Ward, S, Watkins, M, Watkins, J, Wehner, W, Wei, Y, Weiland, M, Weisberg, D, Welander, A, White, A, White, R, Wiesen, S, Wilcox, R, Wilks, T, Willensdorfer, M, Wilson, H, Wingen, A, Wolde, M, Wolff, M, Woller, K, Wolz, A, Wong, H, Woodruff, S, Wu, M, Wu, Y, Wukitch, S, Wurden, G, Xiao, W, Xie, R, Xing, Z, Xu, X, Xu, C, Xu, G, Yan, Z, Yang, X, Yang, S, Yokoyama, T, Yoneda, R, Yoshida, M, You, K, Younkin, T, Yu, J, Yu, M, Yu, G, Yuan, Q, Zaidenberg, L, Zakharov, L, Zamengo, A, Zamperini, S, Zarnstorff, M, Zeger, E, Zeller, K, Zeng, L, Zerbini, M, Zhang, L, Zhang, X, Zhang, R, Zhang, B, Zhang, J, Zhao, L, Zhao, B, Zheng, Y, Zheng, L, Zhu, B, Zhu, J, Zhu, Y, Zsutty, M, Zuin, M, Lawrence Livermore National Laboratory, Princeton Plasma Physics Laboratory, Princeton University, General Atomics, Max-Planck-Institut für Plasmaphysik, Imperial College London, National Institute for Fusion Science, Universidade de São Paulo, University of Texas at Austin, ITER, College of William and Mary, University of California Los Angeles, University of California San Diego, Columbia University, Massachusetts Institute of Technology, Oak Ridge National Laboratory, Eindhoven University of Technology, Oak Ridge Associated Universities, West Virginia University, University of Tennessee, Knoxville, National Research Council of Italy, Stony Brook University, Purdue University, University of Seville, University of Science and Technology of China, Carnegie Mellon University, Institute for Plasma Research, Peking University, University of California Davis, University of California Irvine, Commonwealth Fusion Systems, University of Liverpool, University of Illinois at Urbana-Champaign, University of Milan - Bicocca, Georgia Institute of Technology, Southwestern Institute of Physics, University of Toronto, Auburn University, Polytechnic University of Turin, Universidade Lisboa, Association CCFE, KTH Royal Institute of Technology, San Diego State University, Durham University, Lehigh University, Fusion and Plasma Physics, University of Washington, Department of Applied Physics, Sandia National Laboratories, Ghent University, Technical University of Denmark, CEA, University of Colorado Boulder, Harvard University, National Technical University of Athens, Coventry University, University of Stuttgart, Czech Academy of Sciences, Harvey Mudd College, Seoul National University, Donghua University, University of York, Dalian University of Technology, University of California Berkeley, Los Alamos National Laboratory, United States Department of Energy, University of British Columbia, Pacific Northwest National Laboratory, University of Wisconsin, Michigan State University, University of Strathclyde, Pennsylvania State University, Rensselaer Polytechnic Institute, University of Southern California, Chalmers University of Technology, University of Virginia, University of Naples Federico II, University of Oxford, VTT Technical Research Centre of Finland, National Institute of Technology, University of Connecticut, DIFFER, CIEMAT, Hanyang University, Brigham Young University, UiT The Arctic University of Norway, Australian National University, Russian Research Centre Kurchatov Institute, Forschungszentrum Jülich, Zhejiang University, The University of Tokyo, University of Michigan, Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile, Aalto-yliopisto, Aalto University, DIII-D Team, Complex Ionized Media, Elementary Processes in Gas Discharges, Applied Physics and Science Education, Science and Technology of Nuclear Fusion, and Control Systems Technology

Subjects
Nuclear and High Energy Physics, Tokamak, Technology and Engineering, DIII-D, Nuclear engineering, TOKAMAKS, MITIGATION, law.invention, Plasma physics, mitigation, law, plasma physic, tokamak, Physics, Core-edge integration, Basis (linear algebra), plasma physics, core-edge integration, scenarios, Fusion power, Condensed Matter Physics, SCENARIOS, fusion energy, Fusion energy
Abstract

Funding Information: This material is based upon work supported by the US Department of Energy, Office of Science, Office of Fusion Energy Sciences, using the DIII-D National Fusion Facility, a DOE Office of Science user facility, under Awards DE-FC02-04ER54698 and DE-AC52-07NA27344. Publisher Copyright: © 2022 IAEA, Vienna. DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.

Published
2022
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17. Preoperative MRI for predicting pathological changes associated with surgical difficulty during laparoscopic cholecystectomy for acute cholecystitis

Author

A. Arimoto, A. Ito, K. Hiramatsu, K. Omiya, Takehito Kato, M Yoshihara, Y. Shibata, and T. Aoba

Subjects
medicine.medical_specialty, Necrosis, medicine.medical_treatment, Preoperative care, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, medicine, General, Abscess, Pathological, medicine.diagnostic_test, business.industry, Gallbladder, Magnetic resonance imaging, Original Articles, General Medicine, medicine.disease, medicine.anatomical_structure, HPB, 030220 oncology & carcinogenesis, Original Article, 030211 gastroenterology & hepatology, Cholecystectomy, Radiology, medicine.symptom, business
Abstract

Background Severe inflammation with necrosis and fibrosis of the gallbladder in acute cholecystitis increases operative difficulty during laparoscopic cholecystectomy. This study aimed to assess the use of preoperative MRI in predicting pathological changes of the gallbladder associated with surgical difficulty. Methods Patients who underwent both preoperative MRI and early cholecystectomy for acute cholecystitis between 2012 and 2018 were identified retrospectively. On the basis of the layered pattern of the gallbladder wall on MRI, patients were classified into three groups: high signal intensity (HSI), intermediate signal intensity (ISI), and low signal intensity (LSI). The endpoint was the presence of pathological changes of the gallbladder associated with surgical difficulty, such as necrosis, abscess formation and fibrosis. Results Of 229 eligible patients, pathological changes associated with surgical difficulty were found in 17 (27 per cent) of 62 patients in the HSI group, 84 (85 per cent) of 99 patients in the ISI group, and 66 (97 per cent) of 68 patients in the LSI group (P, Variations in the layered pattern of the gallbladder wall on MRI were significantly associated with fibrosis and necrosis of the gallbladder wall in acute cholecystitis. Intermediate to low signal intensity of the gallbladder wall on MRI had a sensitivity of 90 per cent and a specificity of 73 per cent for predicting pathological changes in the gallbladder wall associated with surgical difficulty during laparoscopic cholecystectomy for acute cholecystitis. The results indicate that MRI could be a novel method of predicting surgical difficulty in laparoscopic cholecystectomy. MRI could possilby predict surgical difficulty of cholecystectomy.

Published
2020
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18. 997P Phase I study of brigatinib plus panitumumab in patients with advanced EGFR-mutated non-small cell lung cancer resistant to osimertinib (BEBOP): Early termination due to severe early onset pneumonitis by brigatinib

Author

H. Izumi, T. Sakamoto, K. Uchibori, K. Nishino, J. Sakakibara-Konishi, S. Nomura, K. Ryohei, H. Udagawa, Y. Shibata, T. Ikeda, S. Niho, T. Sakai, Y. Zenke, K. Nosaki, S. Matsumoto, K. Yoh, and K. Goto

Subjects
Oncology, Hematology
Published
2022
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20. High-efficiency AlInSb mid-infrared LED with dislocation filter layers for gas sensors

Author

D. Yasuda, Y. Shibata, Koichiro Ueno, Osamu Morohara, Y. Sakurai, Hirotaka Geka, H. Fujita, and Naohiro Kuze

Subjects
010302 applied physics, Materials science, business.industry, 02 engineering and technology, Luminous intensity, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Emission intensity, Active layer, law.invention, Inorganic Chemistry, Wavelength, law, 0103 physical sciences, Materials Chemistry, Optoelectronics, Dislocation, 0210 nano-technology, Absorption (electromagnetic radiation), business, Luminous efficacy, Light-emitting diode
Abstract

To fabricate low-consumption and high-resolution gas sensors, especially for methane (CH4) gas (which has absorption around wavelength of 3.3 μm), mid-infrared LEDs are required. Accordingly, to reduce Shockley Read Hall recombination and achieve high luminous intensity at 3.3 μm, an AlxIn1-xSb LED with dislocation filter layers was developed. Dislocation density of the active layer was significantly reduced from 3.5 × 108 to 1.1 × 108/cm2, and luminous efficiency was doubled compared to that of conventionally structured LEDs. To our knowledge, emission intensity at 3.3 μm under injection current of 100 mA is the highest of any commercial LEDs.

Published
2019
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21. Peak Points Detection Using Spline Interpolation Based on FPGA Implementation

Author

R. Kamasaka, F. Kurokawa, Y. Shibata, T. Manabe, and A. M. Colak

Subjects
architecture, lcsh:Computer engineering. Computer hardware, General Computer Science, Computer science, fungi, detection, food and beverages, lcsh:TK7885-7895, spline, peak, Peak detection, Spline (mathematics), lcsh:Electrical engineering. Electronics. Nuclear engineering, Electrical and Electronic Engineering, Spline interpolation, Field-programmable gate array, lcsh:TK1-9971, Algorithm, field programmable gate arrays
Abstract

Peak detection of any time serial signals can be done using different methods. However, exact positions of the peaks cannot be achieved, if the method does not have a high sensitivity detection capability. It is known that various errors appear between the real peak value and the measured value; therefore, a true peak value can be obtained from the measured value by using a highly sensitive detection method. For this reason, spline interpolation is used to estimate the peak points from measured values. In this paper, highly sensitive peak detection of high-frequency signals based on FPGA is proposed using spline algorithm, which is capable of calculating the middle points using the first and last points on the signal. To evaluate the system, the histograms, the mean, and the variance of the peak values before and after spline interpolation are compared. Simulation results show that calculated peak points using splines and real peak values of a signal are very close to each other since the spline algorithm has very high calculation sensitivity. In addition, spline results show us how much error the existing peak values have.

Published
2019
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22. Primary solitary fibrous tumour of the prostate: A case report and literature review

Author

Y, Okubo, S, Nukada, Y, Shibata, K, Osaka, E, Yoshioka, M, Suzuki, K, Washimi, K, Kawachi, T, Kishida, T, Yokose, and Y, Miyagi

Subjects
Adult, Male, Solitary Fibrous Tumors, Biomarkers, Tumor, Humans, Prostatic Neoplasms, STAT6 Transcription Factor
Abstract

Solitary fibrous tumour (SFT) is a rare mesenchymal tumour with intermediate malignant potential. Although this tumour arises in several sites, prostatic SFT is an extremely rare neoplasm and may prove confusing owing to the lack of clinical experience because of tumour rarity. The diagnosis may be further difficult because SFTs can manifest positive immunoreactivity for CD34 and progesterone receptor, which are known markers of prostatic stromal tumours. Herein, we describe a case of prostatic SFT that was difficult to differentiate from a prostatic stromal tumour of uncertain malignant potential because of positive immunoreactivity to CD34 and progesterone receptor.A 40-year-old Japanese man presented with lower abdominal pain. Computed tomography revealed a prostatic mass; furthermore, prostate core needle biopsy revealed proliferating bland spindle cells, without necrosis or prominent mitoses. Tumour cells were positive for CD34 and progesterone receptor on immunohistochemical analysis; thus, a prostatic stromal tumour of uncertain malignant potential was initially suspected. However, as the tumour cells showed positive immunoreactivity for STAT6, the final diagnosis was an SFT of the prostate. The patient underwent tumour resection, and at the 6-month postoperative follow-up, neither local recurrence nor distant metastasis occurred.For an accurate diagnosis of an SFT of the prostate, STAT6 immunohistochemistry should be conducted for all mesenchymal tumours of the prostate. When STAT6 immunohistochemical analysis is unfeasible, pathologists should be aware that the morphological and immunohistochemical characteristics of SFT variable from case to case and diagnose with combined analysis of several immunohistochemical markers.

Published
2020

23. Clinical Analysis of Epithelial Biomarkers in Patients with Idiopathic Pulmonary Fibrosis

Author

R. Togawa, Y. Tanino, T. Nikaido, Y. Sato, T. Kawamata, N. Fukuhara, H. Tomita, N. Watanabe, T. Umeda, M. Rikimaru, J. Morimoto, T. Koizumi, Y. Suzuki, M. Uematsu, H. Minemura, A. Fukuhara, J. Saito, K. Kanazawa, and Y. Shibata

Subjects
medicine.medical_specialty, Idiopathic pulmonary fibrosis, Clinical pathology, business.industry, Internal medicine, medicine, In patient, business, medicine.disease, Gastroenterology
Published
2020
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27. 1666TiP Phase II study of berzosertib (M6620) + topotecan in patients with relapsed platinum-resistant SCLC: DDRiver SCLC 250

Author

Luis Paz-Ares, Alexis B. Cortot, B. Sarholz, C. Ying, J. Ferrer-Playan, Federico Cappuzzo, J. Bolleddula, A. Kalapur, Thierry Berghmans, N. Reguart Aransay, Z. Jianying, Y. Shibata, A. Thomas, Y. Chen, C. Moulin, T. Yoshida, and Nobuyuki Yamamoto

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Phases of clinical research, In patient, Topotecan, Hematology, business, Platinum resistant, medicine.drug
Published
2021
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28. InAsSb photodiodes grown on GaAs substrates for long-wavelength-infrared gas-sensing applications

Author

Y. Shibata, K. Kinoshita, M. Suzuki, Osamu Morohara, D. Yasuda, Hirotaka Geka, Y. Sakurai, H. Fujita, and Naohiro Kuze

Subjects
Materials science, Sensing applications, Infrared, business.industry, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Photodiode, law.invention, Long wavelength, law, Materials Chemistry, Optoelectronics, Electrical and Electronic Engineering, Dislocation, business
Published
2021
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29. Comparison between dexmedetomidine and midazolam as a sedation agent with local anesthesia in inguinal hernia repair: randomized controlled trial

Author

Kazuhiro Hiramatsu, Taro Aoba, Y. Shibata, Toshisada Aiba, N. Yamaguchi, M. Yoshihara, T. Mishina, and Takehito Kato

Subjects
Male, medicine.medical_specialty, Midazolam, Sedation, medicine.medical_treatment, Conscious Sedation, Hernia, Inguinal, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, 030202 anesthesiology, law, medicine, Humans, Hypnotics and Sedatives, Single-Blind Method, Local anesthesia, Dexmedetomidine, Herniorrhaphy, Aged, business.industry, Middle Aged, Hernia repair, medicine.disease, Surgery, Inguinal hernia, Anesthesia, Administration, Intravenous, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Anesthesia, Local, medicine.drug, Abdominal surgery
Abstract

In Japan, inguinal hernia repair is widely performed with local anesthesia. The objective of this study was to evaluate safety and efficacy of intravenous dexmedetomidine as a sedation agent with local anesthesia in inguinal hernia repair. We performed this randomized, single-blind study for 200 patients who were scheduled to undergo inguinal hernia repair with local anesthesia. Patients were randomly divided into two groups (dexmedetomidine group: Group D, midazolam group: Group M). The primary outcome was to evaluate the safety of intravenous dexmedetomidine. Secondary outcomes were to analyze results of operators’ surveys and patients’ questionnaires and evaluate implementation of conscious sedation. Incidence of respiratory depression was significantly higher in Group M than Group D (p = 0.03). Other adverse events examined did not differ significantly. All three operators’ questionnaires indicated that results were better in Group D than Group M. More than 70% of patients in both groups were satisfied with the surgery. More than 80% of Group D patients and 74% of Group M patients achieved a state of conscious sedation. This study demonstrated that intravenous dexmedetomidine during hernia repair with local anesthesia is safe and the results were satisfactory to both operators and patients.

Published
2017
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30. Effect of β-cryptoxanthin–rich Satsuma mandarin juice supplementation on pulse wave velocity: A randomized controlled trial

Author

Minoru Sugiura, Y. Shibata, Mieko Nakamura, and Toshiyuki Ojima

Subjects
0301 basic medicine, medicine.medical_specialty, Arteriosclerosis, Endocrinology, Diabetes and Metabolism, β cryptoxanthin, lcsh:TX341-641, 030204 cardiovascular system & hematology, Gastroenterology, Mandarin Chinese, Antioxidants, law.invention, lcsh:Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, lcsh:QD415-436, Pulse wave velocity, 030109 nutrition & dietetics, Nutrition and Dietetics, Traditional medicine, business.industry, medicine.disease, Carotenoids, language.human_language, Oxidative stress, Arterial stiffness, language, Biomarker (medicine), business, Citrus fruit, lcsh:Nutrition. Foods and food supply, Food Science, Cohort study
Abstract

Background and Aims Cohort studies in Japan indicate that citrus fruit and β-cryptoxanthin–rich Satsuma mandarin are candidate foods for lowering cardiovascular risk; however, there have been few intervention studies of β-cryptoxanthin and Satsuma mandarin supplementation. Methods and Results A randomized, placebo-controlled, double-blind parallel trial was performed. Apparently healthy men and women were randomly assigned to two groups: one receiving concentrated β-cryptoxanthin–rich Satsuma mandarin juice (β-cryptoxanthin 4 mg per 125 mL/day: active group) and one receiving β-cryptoxanthin–deprived Satsuma mandarin juice (β-cryptoxanthin 0 mg per 125 mL/day: control group) for 12 weeks. The primary outcome was brachial-ankle pulse wave velocity (baPWV), which assesses arterial stiffness. An oxidative stress biomarker and clinical outcomes were also evaluated. Effect of the intervention on the outcome variables was analyzed using generalized linear mixed models. After the trial, a prespecified 8-month follow-up examination was conducted. One hundred eighteen subjects were randomly assigned, and 117 completed the intervention. Serum β-cryptoxanthin concentration was increased among the active group after β-cryptoxanthin–rich Satsuma mandarin juice supplementation. Both supplementations lowered baPWV and oxidative stress biomarker levels; however, there was no additional effect in the active group compared with the control group. At the 8-month examination, the increase in baPWV among the active group was smaller than that among the control group. Conclusion Satsuma mandarin juice supplementation is potentially beneficial for reducing cardiovascular risk; however, additional β-cryptoxanthin supplementation did not enhance this effect. Further study is needed to evaluate the long-term effect of β-cryptoxanthin supplementation. Registration UMIN-CTR, UMIN000013579.

Published
2017
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31. Reverse roll coating with a deformable roll operating at negative gaps

Author

Hadj Benkreira, K. Ito, and Y. Shibata

Subjects
Materials science, Applied Mathematics, General Chemical Engineering, Flow (psychology), Nanotechnology, 02 engineering and technology, General Chemistry, Mechanics, engineering.material, 021001 nanoscience & nanotechnology, 01 natural sciences, Lubrication theory, Industrial and Manufacturing Engineering, 010305 fluids & plasmas, Roll-to-roll processing, Viscosity, Coating, Natural rubber, Cascade, visual_art, 0103 physical sciences, engineering, visual_art.visual_art_medium, Metering mode, 0210 nano-technology
Abstract

Reverse roll coating is probably the most widely used coating operation, yet its full potential has not been exploited as it is shown in this paper which considers operation with a negative gap. We demonstrate through a wide range of experimental data that such operation can yield very thin and stable films with no ribbing or cascade instabilities when low viscosity fluids are used. Typically, stable film thickness less than 5 μm can be obtained at speeds up to 150 m/min when a rubber roller is used at −100 μm gap with fluids of viscosity in the range 10–200 mPa s. These film thicknesses can be made to decrease further down to 1 or 2 µm with a judicious choice of speed ratios (applicator to metering roller) and rubber hardness. Such new findings make this simple coating method an attractive roll to roll technique for application in the newer coating technologies, such as in the production of solar cells and plastic electronics. The data obtained in this study have been underpinned by a model based on the classical lubrication theory, well developed for such flow situations. Essentially it is shown that the film thickness non dimensionalised with respect to the set negative gap is controlled through a single parameter, the elasticity number Ne which combines all the operating parameters. Of course, this flow problem has complexities, particularly at high speed ratios and at zero gap so the data obtained here can serve as a basis for more comprehensive modelling of this classical fluid mechanic problem.

Published
2017
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33. Clinical presentation, aetiology and outcomes of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Author

Habib G., Erba P. A., Iung B., Donal E., Cosyns B., Laroche C., Popescu B. A., Prendergast B., Tornos P., Sadeghpour A., Oliver L., Vaskelyte J. -J., Sow R., Axler O., Maggioni A. P., Lancellotti P, C P Gale, B Beleslin, A Budaj, O Chioncel, N Dagres, N Danchin, J Emberson, D Erlinge, M Glikson, A Gray, M Kayikcioglu, A P Maggioni, V K Nagy, A Nedoshivin, A-S Petronio, J Roos-Hesselink, L Wallentin, U Zeymer, G Habib, P Lancellotti, B Cosyns, E Donal, P Erba, B Iung, B A Popescu, B Prendergast, P Tornos, M Andarala, C Berle, A Brunel-Lebecq, E Fiorucci, C Laroche, V Missiamenou, C Taylor, N N Ali Tatar-Chentir, M Al-Mallah, M Astrom Aneq, G Athanassopoulos, L P Badano, S Benyoussef, E Calderon Aranda, N M Cardim, K-L Chan, I Cruz, T Edvardsen, G Goliasch, A Hagendorff, K Hristova, O Kamp, D-H Kang, W Kong, S Matskeplishvili, M Meshaal, M Mirocevic, A N Neskovic, M Pazdernik, E Plonska-Gosciniak, M Raissouni, R Ronderos, L E Sade, A Sadeghpour, A Sambola, S Sengupta, J Separovic-Hanzevacki, M Takeuchi, E Tucay, A C Tude Rodrigues, A Varga, J Vaskelyte, K Yamagata, K Yiangou, H Zaky, I Granada, M Mahia, S Ressi, F Nacinovich, A Iribarren, P Fernandez Oses, G Avegliano, E Filipini, R Obregon, M Bangher, J Dho, L Cartasegna, M L Plastino, V Novas, C Shigel, G Reyes, M De Santos, N Gastaldello, M Granillo Fernandez, M Potito, G Streitenberger, P Velazco, J H Casabé, C Cortes, E Guevara, F Salmo, M Seijo, F Weidinger, M Heger, R Brooks, C Stöllberger, C-Y Ho, L Perschy, L Puskas, C Binder, R Rosenhek, M Schneider, M-P Winter, E Hoffer, M Melissopoulou, E Lecoq, D Legrand, S Jacquet, M Massoz, L Pierard, S Marchetta, R Dulgheru, C D Emal, C Oury, S Droogmans, D Kerkhove, D Plein, L Soens, C Weytjens, A Motoc, B Roosens, I Lemoine, I Rodrigus, B Paelinck, B Amsel, P Unger, D Konopnicki, C Beauloye, A Pasquet, J L Vanoverschelde, S Pierard, D Vancraeynest, F Sinnaeve, J L Andrade, K Staszko, R Dos Santos Monteiro, M H Miglioranza, D L Shuha, M Alcantara, V Cravo, L Fazzio, A Felix, M Iso, C Musa, A P Siciliano, F Villaca Filho, A Rodrigues, F Vilela, J Braga, R Silva, D Rodrigues, L Silva, S Morhy, C Fischer, M Vieira, T Afonso, J Abreu, S N Falcao, V A Moises, A Gouvea, F J Mancuso, A C Souza, C Y Silva, G João, C S Abboud, R Bellio de Mattos Barretto, A Ramos, R Arnoni, J E Assef, D J Della Togna, D Le Bihan, L Miglioli, A P Romero Oliveira, R Tadeu Magro Kroll, D Cortez, C L Gelape, M D C Peirira Nunes, T C De Abreu Ferrari, K Hay, V Le, M Page, F Poulin, C Sauve, K Serri, C Mercure, J Beaudoin, P Pibarot, I A Sebag, L G Rudski, G Ricafort, B Barsic, V Krajinovic, M Vargovic, D Lovric, V Reskovic-Luksic, J Vincelj, S Jaksic Jurinjak, V Yiannikourides, M Ioannides, C Pofaides, V Masoura, J Pudich, A Linhart, M Siranec, J Marek, K Blechova, M Kamenik, R Pelouch, Z Coufal, M Mikulica, M Griva, E Jancova, M Mikulcova, M Taborsky, J Precek, M Jecmenova, J Latal, J Widimsky, T Butta, S Machacek, R Vancata, J Spinar, M Holicka, F Pow Chon Long, N Anzules, A Bajana Carpio, G Largacha, E Penaherrera, D Moreira, E Mahfouz, E Elsafty, A Soliman, Y Zayed, J Aboulenein, M Abdel-Hay, A Almaghraby, M Abdelnaby, M Ahmed, B Hammad, Y Saleh, H Zahran, O Elgebaly, A Saad, M Ali, A Zeid, R El Sharkawy, A Al Kholy, R Doss, D Osama, H Rizk, A Elmogy, M Mishriky, P Assayag, S El Hatimi, S Hubert, J-P Casalta, F Gouriet, F Arregle, S Cammilleri, L Tessonnier, A Riberi, E Botelho-Nevers, A Gagneux-Brunon, R Pierrard, C Tulane, S Campisi, J-F Fuzellier, M Detoc, T Mehalla, D Boutoille, A S Lecompte, M Lefebvre, S Pattier, O Al Habash, N Asseray-Madani, C Biron, J Brochard, J Caillon, C Cueff, T Le Tourneau, R Lecomte, M M Magali Michel, J Orain, S Delarue, M Le Bras, J-F Faucher, V Aboyans, A Beeharry, H Durox, M Lacoste, J Magne, D Mohty, A David, V Pradel, V Sierra, A Neykova, B Bettayeb, S Elkentaoui, B Tzvetkov, G Landry, C Strady, K Ainine, S Baumard, C Brasselet, C Tassigny, V Valente-Pires, M Lefranc, B Hoen, B Lefevre, E Curlier, C Callier, N Fourcade, Y Jobic, S Ansard, R Le Berre, F Le Ven, M-C Pouliquen, G Prat, P Le Roux, F Bouchart, A Savoure, C Alarcon, C Chapuzet, I Gueit, C Tribouilloy, Y Bohbot, F Peugnet, M Gun, X Duval, X Lescure, E Ilic-Habensus, N Sadoul, C Selton-Suty, F Alla, F Goehringer, O Huttin, E Chevalier, R Garcia, V Le Marcis, P Tattevin, E Flecher, M Revest, C Chirouze, K Bouiller, L Hustache-Mathieu, T Klopfenstein, J Moreau, D Fournier, A-S Brunel, P Lim, L Oliver, J Ternacle, A Moussafeur, P Chavanet, L Piroth, A Salmon-Rousseau, M Buisson, S Mahy, C Martins, S Gohier, O Axler, F Baumann, S Lebras, C Piper, D Guckel, J Börgermann, D Horstkotte, E Winkelmann, B Brockmeier, D Grey, G Nickenig, R Schueler, C Öztürk, E Stöhr, C Hamm, T Walther, R Brandt, A-C Frühauf, C T Hartung, C Hellner, C Wild, M Becker, S Hamada, W Kaestner, K Stangl, F Knebel, G Baldenhofer, A Brecht, H Dreger, C Isner, F Pfafflin, M Stegemann, R Zahn, B Fraiture, C Kilkowski, A-K Karcher, S Klinger, H Tolksdorf, D Tousoulis, C Aggeli, S Sideris, E Venieri, G Sarri, D Tsiapras, I Armenis, A Koutsiari, G Floros, C Grassos, S Dragasis, L Rallidis, C Varlamos, L Michalis, K Naka, A Bechlioulis, A Kotsia, L Lakkas, K Pappas, C Papadopoulos, S Kiokas, A Lioni, S Misailidou, J Barbetseas, M Bonou, C Kapelios, I Tomprou, K Zerva, A Manolis, E Hamodraka, D Athanasiou, G Haralambidis, H Samaras, L Poulimenos, A Nagy, A Bartykowszki, E Gara, K Mungulmare, R Kasliwal, M Bansal, S Ranjan, A Bhan, M Kyavar, M Maleki, F Noohi Bezanjani, A Alizadehasl, S Boudagh, A Ghavidel, P Moradnejad, H R Pasha, B Ghadrdoost, D Gilon, J Strahilevitz, M Wanounou, S Israel, C d'Agostino, P Colonna, L De Michele, F Fumarola, M Stante, N Marchionni, V Scheggi, B Alterini, S Del Pace, P Stefano, C Sparano, N Ruozi, R Tenaglia, D Muraru, U Limbruno, A Cresti, P Baratta, M Solari, C Giannattasio, A Moreo, B De Chiara, B Lopez Montero, F Musca, C A Orcese, F Panzeri, F Spano, C F Russo, O Alfieri, M De Bonis, S Chiappetta, B Del Forno, M Ripa, P Scarpellini, C Tassan Din, B Castiglioni, R Pasciuta, S Carletti, D Ferrara, M Guffanti, G Iaci, E Lapenna, T Nisi, C Oltolini, E Busnardo, U Pajoro, E Agricola, R Meneghin, D Schiavi, F Piscione, R Citro, R M Benvenga, L Greco, L Soriente, I Radano, C Prota, M Bellino, D Di Vece, F Santini, A Salsano, G M Olivieri, F Turrini, R Messora, S Tondi, A Olaru, V Agnoletto, L Grassi, C Leonardi, S Sansoni, S Del Ponte, G M Actis Dato, A De Martino, N Ohte, S Kikuchi, K Wakami, K Aonuma, Y Seo, T Ishizu, T Machino-Ohtsuka, M Yamamoto, N Iida, H Nakajima, Y Nakagawa, C Izumi, M Amano, M Miyake, K Takahashi, I Shiojima, Y Miyasaka, H Maeba, Y Suwa, N Taniguchi, S Tsujimoto, T Kitai, M Ota, S Yuda, S Sasaki, N Hagiwara, K Yamazaki, K Ashihara, K Arai, C Saitou, S Saitou, G Suzuki, Y Shibata, N Watanabe, S Nishino, K Ashikaga, N Kuriyama, K Mahara, T Okubo, H Fujimaki, H Shitan, H Yamamoto, K Abe, M Terada, S Takanashi, M Sata, H Yamada, K Kusunose, Y Saijo, H Seno, O Yuichiro, T Onishi, F Sera, S Nakatani, H Mizuno, K Sengoku, S W Park, K Eun Kyoung, L Ga Yeon, J-W Hwang, C Jin-Oh, S-J Park, L Sang-Chol, C Sung-A, S Y Jang, R Heo, S Lee, J-M Song, E Jung, J Plisiene, A Dambrauskaite, G Gruodyte, R Jonkaitiene, V Mizariene, J Atkocaityte, R Zvirblyte, R Sow, A Codreanu, T Staub, C Michaux, E C L De la Vega, L Jacobs-Orazi, C Mallia Azzopardi, R G Xuereb, T Piscopo, J Farrugia, M Fenech, E Pllaha, C Vella, D Borg, R Casha, L Grib, E Raevschi, A Grejdieru, D Kravcenco, E Prisacari, E Samohvalov, S Samohvalov, N Sceglova, E Panfile, L Cardaniuc, V Corcea, A Feodorovici, V Gaina, L Girbu, P Jimbei, G Balan, I Cardaniuc, I Benesco, V Marian, N Sumarga, B Bozovic, N Bulatovic, P Lakovic, L Music, R Budde, A Wahadat, T Gamela, T Meijers, J P Van Melle, V M Deursen, H J Crijns, S C Bekkers, E C Cheriex, M Gilbers, B L Kietselaer, C Knackstedt, R Lorusso, S Schalla, S A Streukens, S Chamuleau, M-J Cramer, A Teske, T Van der Spoel, A Wind, J Lokhorst, O Liesbek, H Van Heusden, W Tanis, I Van der Bilt, J Vriend, H De Lange-van Bruggen, E Karijodikoro, R Riezebos, E van Dongen, J Schoep, V Stolk, J T Offstad, J O Beitnes, T Helle-Valle, H Skulstad, R Skardal, N Qamar, S Furnaz, B Ahmed, M H Butt, M F Khanzada, T Saghir, A Wahid, T Hryniewiecki, P Szymanski, K Marzec, M Misztal-Ogonowska, W Kosmala, M Przewlocka-Kosmala, A Rojek, K Woznicka, J Zachwyc, A Lisowska, M Kaminska, J D Kasprzak, E Kowalczyk, D F Strzecka, P Wejner-Mik, M Trabulo, P Freitas, S Ranchordas, G Rodrigues, P Pinto, C Queiros, J Azevedo, L Marques, D Seabra, L Branco, M Cruz, A Galrinho, R Moreira, P Rio, A T Timoteo, M Selas, V Carmelo, B Duque Neves, H Pereira, A Guerra, A Marques, I Pintassilgo, M C Tomescu, N-M Trofenciuc, M Andor, A Bordejevic, H S Branea, F Caruntu, L A Velcean, A Mavrea, M F Onel, T Parvanescu, D Pop, A L Pop-Moldovan, M I Puticiu, L Cirin, I M Citu, C A Cotoraci, D Darabantiu, R Farcas, I Marincu, A Ionac, D Cozma, C Mornos, F Goanta, I Popescu, R Beyer, R Mada, R Rancea, R Tomoaia, H Rosianu, C Stanescu, Z Kobalava, J Karaulova, E Kotova, A Milto, A Pisaryuk, N Povalyaev, M Sorokina, J Alrahimi, A Elshiekh, A Jamiel, A Ahmed, N Attia, B Putnikovic, A Dimic, B Ivanovic, S Matic, D Trifunovic, J Petrovic, D Kosevic, I Stojanovic, I Petrovic, P Dabic, P Milojevic, I Srdanovic, S Susak, L Velicki, A Vulin, M Kovacevic, A Redzek, M Stefanovic, T C Yeo, W Kf Kong, K K Poh, I Vilacosta, C Ferrera, C Olmos, M Abd El-Nasser, F Calvo Iglesias, E Blanco-Gonzalez, M Bravo Amaro, E Lopez-Rodriguez, J Lugo Adan, A N Germinas, P Pazos-Lopez, M Pereira Loureiro, M T Perez, S Raposeiras-Roubin, S Rasheed Yas, M-M Suarez-Varela, F Vasallo Vidal, D Garcia-Dorado, N Fernandez-Hidalgo, T Gonzalez-Alujas, J Lozano, O Maisterra, N Pizzi, R Rios, A Bayes-Genis, L Pedro Botet, N Vallejo, C Llibre, L Mateu, R Nunez, D Quesada, E Berastegui, D Bosch Portell, J Aboal Vinas, X Albert Bertran, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, M A Arnau, A Bel, M Blanes, A Osa, M Anguita, F Carrasco, J C Castillo, J L Zamorano, J L Moya Mur, M Alvaro, C Fernandez-Golfin, J M Monteagudo, E Navas Elorza, M C Farinas Alvarez, J Aguero Balbin, J Zarauza, J F Gutierrez-Diez, C Arminanzas, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, R Rodriguez-Alvarez, J Goikoetxea, M Montejo, J M Miro, M Almela, J Ambrosioni, A Moreno, E Quintana, E Sandoval, A Tellez, J M Tolosana, B Vidal, C Falces, D Fuster, C Garcia-de-la-Maria, M Hernandez-Meneses, J Llopis, F Marco, I Ruiz-Zamora, A Bardaji Ruiz, E Sanz Girgas, G Garcia-Pardo, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, L Abid, R Hammami, S Kammoun, M S Mourali, F Mghaieth Zghal, M Ben Hlima, S Boudiche, S Ouali, L Zakhama, S Antit, I Slama, O Gulel, M Sahin, E Karacaglar, S Kucukoglu, O Cetinarslan, U Y Sinan, U Canpolat, B Mutlu, H Atas, R Dervishova, C Ileri, J Alhashmi, J Tahir, P Zarger, F Baslib, S Woldman, L Menezes, C Primus, R Uppal, I Bvekerwa, B Chandrasekaran, A Kopanska, J Chambers, J Hancock, J Klein, R Rajani, M P Ursi, S Cannata, R Dworakowski, A Fife, J Breeze, M Browne-Morgan, M Gunning, S Streather, F M Asch, M Zemedkun, B Alyavi, J Uzokov, G., Habib, P. A., Erba, B., Iung, E., Donal, B., Cosyn, C., Laroche, B. A., Popescu, B., Prendergast, P., Torno, A., Sadeghpour, L., Oliver, J. -J., Vaskelyte, R., Sow, O., Axler, A. P., Maggioni, P, Lancellotti, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, Petronio, A-S, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, P Badano, L, Benyoussef, S, Calderon Aranda, E, M Cardim, N, Chan, K-L, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D-H, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, Ho, C-Y, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M-P, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, Dos Santos Monteiro, R, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, Le Bihan, D, Miglioli, L, P Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, L Gelape, C, C Peirira Nunes, M D, C De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J-P, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J-F, Detoc, M, Mehalla, T, Boutoille, D, S Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, M Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J-F, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M-C, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A-S, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Börgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Öztürk, C, Stöhr, E, Hamm, C, Walther, T, Brandt, R, Frühauf, A-C, T Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A-K, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, R Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, A Orcese, C, Panzeri, F, Spano, F, F Russo, C, Alfieri, O, DE BONIS, Michele, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, M Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, M Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, M Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, W Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J-W, Jin-Oh, C, Park, S-J, Sang-Chol, L, Sung-A, C, Y Jang, S, Heo, R, Lee, S, Song, J-M, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, L De la Vega, E C, Jacobs-Orazi, L, Mallia Azzopardi, C, G Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, P Van Melle, J, M Deursen, V, J Crijns, H, C Bekkers, S, C Cheriex, E, Gilbers, M, L Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, A Streukens, S, Chamuleau, S, Cramer, M-J, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, T Offstad, J, O Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, H Butt, M, F Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, D Kasprzak, J, Kowalczyk, E, F Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, T Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, C Tomescu, M, Trofenciuc, N-M, Andor, M, Bordejevic, A, S Branea, H, Caruntu, F, A Velcean, L, Mavrea, A, F Onel, M, Parvanescu, T, Pop, D, L Pop-Moldovan, A, I Puticiu, M, Cirin, L, M Citu, I, A Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, C Yeo, T, Kf Kong, W, K Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, N Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, T Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M-M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, A Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, Navas Elorza, E, C Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, Arnaiz de Las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Y Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University Medical Center Groningen [Groningen] (UMCG), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Université de Médecine Carol Davila, Guy's and St Thomas' Hospital [London], CHU Henri Mondor, Centre Hospitalier Universitaire de Liège (CHU-Liège), AstraZeneca, Bayer, Edwards Lifesciences, Servier, Abbott Vascular Int., Amgen Cardiovascular, Pfizer Alliance, Daiichi Sankyo Europe GmbH, Alliance Daiichi Sankyo Europe GmbH, Gedeon Richter Plc., Menarini Int. Op., Vifor, Boehringer Ingelheim, Boston Scientific Corporation, Bristol-Myers Squibb, Eli Lilly and Company, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service de pathologies cardiovasculaires intensives, UCL - (SLuc) Service de soins intensifs, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Oxford University Hospitals NHS Trust, University of Oxford [Oxford], Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Bordeaux (UB), Research Center [Associazione Nazionale Medici Cardiologi Ospedalieri] (ANMCO Research Center), Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Service de cardiologie [Liège], CHU de Liège-Domaine Universitaire du Sart Tilman, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Exeter, Instituto Nacional de Tecnología Agropecuaria, Pergamino, Argentina, Laboratory of In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel (VUB), Centre National de la Recherche Scientifique (CNRS), Division of Engineering and Applied Science, California Institute of Technology, California Institute of Technology (CALTECH), Departamento de Biologia de la Reproduccion, Universidad Autónoma Metropolitana Iztapalapa (UAMI), Universidade Federal de Itajubá, Departamento de Física [Coimbra] (DFC), Universidade de Coimbra [Coimbra], Section of Internal Medicine and Endocrine and Metabolic Sciences, Università degli Studi di Perugia (UNIPG), LIP-Coimbra & Department of Physics of the University of Coimbra, Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Quebec Heart Institute/Laval Hospital, Université Laval [Québec] (ULaval)-Quebec Heart Institute, Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU AMU), CHU Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de bactériologie et hygiène hospitalière [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Centre Hospitalier Universitaire de Reims (CHU Reims), Anesthésie et réanimation en chirurgie cardiaque [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU), Service des maladies infectieuses et tropicales [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cardiology [Ospedali del Tigullio], Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Cardiologie [CHRU Nancy], Service des maladies infectieuses et réanimation médicale, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Service de chirurgie thoracique cardiaque et vasculaire [Rennes], Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), service de maladies infectieuses CHU J Minjoz Besancon, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Département d'infectiologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Virologie et pathogenèse virale (VPV), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institute for Advanced Studies in Basic Sciences, affiliation inconnue, Dipartamento di Fisica 'E.R. Caianiello', Università degli Studi di Salerno (UNISA), The University of Tokyo, Northern Research Station, Forestry Commission, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Instituto de Investigaciones Marinas (CSIC), Faculté des Sciences Pharmaceutiques, EA 4529, Laboratoire de Biochimie, Université Paris-Sud - Paris 11 (UP11), Istituto di Virologia Vegetale, Università degli studi di Torino (UNITO), Universidad Nacional Autónoma de México (UNAM), Service de Chirurgie Cardiovasculaire, University Hospital of Cruces, Geneva University Hospital (HUG), Institut Jean Le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Preventive Medicine Unit, University Hospital Joan XXIII, IISPV, Rovira and Virgili University, Popescu, B, Maggioni, A, Gale, C, Nagy, V, Petronio, A, Ali Tatar-Chentir, N, Badano, L, Cardim, N, Chan, K, Kang, D, Neskovic, A, Sade, L, Tude Rodrigues, A, Plastino, M, Casabe, J, Stollberger, C, Ho, C, Winter, M, Emal, C, Vanoverschelde, J, Andrade, J, Miglioranza, M, Shuha, D, Siciliano, A, Falcao, S, Moises, V, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Assef, J, Della Togna, D, Romero Oliveira, A, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Sebag, I, Rudski, L, Casalta, J, Fuzellier, J, Lecompte, A, Magali Michel, M, Faucher, J, Pouliquen, M, Brunel, A, Borgermann, J, Ozturk, C, Stohr, E, Fruhauf, A, Hartung, C, Karcher, A, Pasha, H, Orcese, C, Russo, C, De Bonis, M, Benvenga, R, Olivieri, G, Actis Dato, G, Park, S, Hwang, J, Jang, S, Song, J, De la Vega, E, Xuereb, R, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Kietselaer, B, Streukens, S, Cramer, M, Offstad, J, Beitnes, J, Butt, M, Khanzada, M, Kasprzak, J, Strzecka, D, Timoteo, A, Tomescu, M, Trofenciuc, N, Branea, H, Velcean, L, Onel, M, Pop-Moldovan, A, Puticiu, M, Citu, I, Cotoraci, C, Yeo, T, Poh, K, Germinas, A, Perez, M, Suarez-Varela, M, Arnau, M, Castillo, J, Zamorano, J, Moya Mur, J, Monteagudo, J, Farinas Alvarez, M, Gutierrez-Diez, J, Miro, J, Tolosana, J, Mourali, M, Yasar, U, Ursi, M, Asch, F, Clinical sciences, Cardio-vascular diseases, Cardiology, Medical Imaging, Cardiovascular Centre (CVC), Service de médecine nucléaire [Marseille], Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), MGSOG Scientific staff, MUMC+: MA Cardiologie (9), Cardiologie, RS: Carim - H01 Clinical atrial fibrillation, RS: CARIM - R2.01 - Clinical atrial fibrillation, RS: CARIM - R3.11 - Imaging, Promovendi CD, Fysiologie, MUMC+: MA Med Staf Artsass CTC (9), RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, RS: CARIM - R2.02 - Cardiomyopathy, CTC, MUMC+: MA Med Staf Spec CTC (9), RS: Carim - V04 Surgical intervention, RS: CARIM - R2.12 - Surgical intervention, RS: FdR IC Aansprakelijkheid, Graduate School, ACS - Heart failure & arrhythmias, Radiotherapy, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Male, SURGERY, Embolism, Infective endocarditi, Infective endocarditis, Registry, Valve disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Africa, Northern, Positron Emission Tomography Computed Tomography, 030212 general & internal medicine, Hospital Mortality, Prospective Studies, Registries, Prospective cohort study, Abscess, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, Staphylococcal Infections, 3. Good health, Cardiac surgery, Community-Acquired Infections, Europe, Treatment Outcome, Positron emission tomography, Echocardiography, Heart Valve Prosthesis, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, ECHOCARDIOGRAPHY, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Asia, Prosthesis-Related Infections, DIAGNOSIS, 03 medical and health sciences, Fluorodeoxyglucose F18, Internal medicine, Streptococcal Infections, medicine, MANAGEMENT, Journal Article, Humans, Aged, business.industry, EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY, Endocarditis, Bacterial, South America, medicine.disease, Heart failure, Etiology, Radiopharmaceuticals, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Enterococcus
Abstract

Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

Published
2019
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34. P135 Proximal Extension of lower rectal Ulcerative Proctitis

Author

Tsutomu Masuda, Syusaku Yoshikawa, K Okamoto, T Higashio, Mizumi Inagaki, Naoki Inatsugi, Hideki Uchida, Takeshi Nakao, Y Shibata, Kentaro Yamaoka, Takashi Yokoo, and S Terauchi

Subjects
medicine.medical_specialty, Pancolitis, medicine.diagnostic_test, business.industry, Gastroenterology, Rectum, General Medicine, medicine.disease, Endoscopy, medicine.anatomical_structure, Internal medicine, medicine, Mann–Whitney U test, Age of onset, Colitis, medicine.symptom, business, Survival rate, Proctitis
Abstract

Background Previous studies have shown proximal extension (PE) rate of ulcerative proctitis (UP) is approximately 50%. This rate teach us the importance of treating UP adequately. Basically, we have to treat them with topical 5-ASA. But in clinical practice, we sometimes experience the case whose inflammation remain endoscopically, even though the symptoms have been relieved. Should we strengthen our treatment at this situation, especially inflammation at lower rectum? We aimed to know PE rate of lower rectal UP and optimize the treatment. Methods We retrospectively investigated the medical charts of patients with UP from 2010 to 2020 at Kenseikai Nara Coloproctology Center. We excluded the patients with UP shrinking from left-sided or pancolitis as a result of the treatment. The cases with missing value were excluded too. Variables of interest included gender, onset age, disease location, initial mayo endoscopic subscore (MES) and treatment, and the time to PE. To compare the cohorts we used Fisher’s exact test and Mann-Whitney test. Proximal extension free survival (PEFS) was calculated using the Kaplan-Meier method. Results Sixty-five patients were recruited. Mean age was 42 years old, the ratio of males to females was 1.17. The number of lower rectal UP patients at first examination was 24. We observed MES 1 inflammation for 30 patients, and MES 2 for 35. Median follow-up duration was 73.5 months. PE occurred in 34 patients: 28 patients had left-sided colitis and 6 had pancolitis. Fifty-four patients were medicated and other 11 patients were just observed. Among the patients medicated, 23 patients were took only topical drugs, 18 were took only oral drugs and other 13 were took both. We couldn’t find any relationships between initial medication and PE rate. The multivariate analysis revealed that having peri-appendiceal red patch and lower rectal UP were reduce the risk of PE. MES was not related to PE (table 1). PEFS at 1 year, 2 year are 81%, 81% for lower rectal UP (Rb group), and 66%, 61% for the patients having the disease beyond middle Houston’s valve (Not-Rb group), though we couldn’t find significant difference (Fig.1). Among 34 patients having PE, we used biologics for only five patients and got their inflammation under control. Conclusion Patients with lower rectal UP is less likely to extent their disease location. There’s no difference between the route of treatment and PE rate, but it’s important to carefully check PE within first one year.

Published
2021
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35. Fluorescence intensity changes depending on viscoelasticity of lipid shell coating microbubbles labeled with an indocyanine green derivative

Author

Y. Shibata, Ebata Masahiko, Hideki Hayashi, C. Kaneko, Taro Toyota, Katsuya Saito, Kenji Yoshida, Yiting Zhang, and Tadashi Yamaguchi

Subjects
Materials science, Physics and Astronomy (miscellaneous), technology, industry, and agriculture, General Engineering, Phospholipid, Shell (structure), General Physics and Astronomy, engineering.material, Viscoelasticity, Fluorescence intensity, chemistry.chemical_compound, chemistry, Coating, engineering, Biophysics, Microbubbles, Indocyanine green, Derivative (chemistry)
Abstract

Lipid-coated microbubbles (MBs) with an indocyanine green (ICG) derivative were fabricated for ultrasound and near-infrared (NIR) fluorescence dual imaging. We characterized the NIR-fluorescence intensity, stability and viscoelastic properties of the encapsulating lipid shell, focusing on the influence of the ICG derivative and lipid compositions. In terms of the NIR fluorescence intensity, the fluorescence intensity of the MBs (with the ICG derivative) was significantly affected by the lipid composition of the MB shell. Regarding the contrast agent used for ultrasound imaging, the stability of the MBs and viscoelastic properties of shell also depended on the lipid compositions, while the incorporation of the ICG derivative into the MB shells had a negligible effect. The performance of this contrast agent for ultrasound and NIR fluorescence dual-imaging exhibited a significant trade-off relationship for the lipid composition.

Published
2021
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38. Accelerated Hypofractionated Radiation Therapy for the Central and Ultracentral Tumors of the Lung – Analysis of Doses to the Organs at Risk

Author

Y. Shibata, T. Shimizuguchi, S. Kitou, Hiroaki Ogawa, Sara Hayakawa, K. Taguchi, Kumiko Karasawa, Y. Machitori, and K. Ito

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Hypofractionated Radiation Therapy, Lung, medicine.anatomical_structure, Oncology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, business
Published
2020
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39. Identification of potent small molecule allosteric inhibitors of SHP2

Author

Nicola G. Wallis, Valerio Berdini, S. Hiscock, T.G. Davies, H. Ochiiwa, Keisha Hearn, Y. Nakatsuru, Tomoko Smyth, Sharna J. Rich, Sandra Muench, Alpesh Shah, A. Price, Y. Shibata, T. Shimamura, Nicola E. Wilsher, C.N. Johnson, G. Chessari, Vanessa Martins, J.E.H. Day, and C. Hamlett

Subjects
Cancer Research, Oncology, Biochemistry, Chemistry, Allosteric regulation, Identification (biology), Small molecule
Published
2020
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40. Usefulness of presepsin for detecting sepsis in urinary-tract infections

Author

Seiji Arai, Daisuke Oka, Y. Shibata, T. Syuto, Kazuhiro Suzuki, Yoshitaka Sekine, H. Koike, Y. Miyazawa, M. Nomura, K. Kotani, H. Matsui, and Hiroshi Nakayama

Subjects
medicine.medical_specialty, business.industry, Urology, Urinary system, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, lcsh:RC254-282, Gastroenterology, Sepsis, Internal medicine, medicine, business
Published
2020
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41. Synchronicity of the East Asian Summer Monsoon variability and Northern Hemisphere climate change since the last deglaciation

Author

Masao Uchida, Tetsuya Shinozaki, Y. Shibata, S. F. Rella, Miyuki Kondo, and Koji Minoura

Subjects
Ice core, Climatology, Global warming, Deglaciation, Subtropical ridge, Holocene climatic optimum, Climate change, Global cooling, Geology, Holocene
Abstract

Understanding of the mechanism of the East Asian Summer Monsoon (EASM) is required for the prediction of climate change in East Asia in a scenario of modern global warming. In this study, we present high-resolution climate records from peat sediments in Northeast Japan to reconstruct the EASM variability based on peat bulk cellulose δ13C since the last deglaciation. We used a 8.8 m long peat sediment core collected from the Tashiro Bog, Northeast Japan. Based on 42 14C measurements, the core bottom reaches ~15.5 ka. δ13C, accumulation rate and accumulation flux time-series correlate well to Greenland ice core δ18O variability, suggesting that the climate record in Northeast Japan is linked to global climate changes. The δ13C record at Tashiro Bog and other paleo-EASM records at Northeast and Southern China consistently demonstrate that hydrological environments were spatially different in mid-high and mid-low latitude regions over the last 15.5 kyr. During global cooling (warming) periods, mid-high and mid-low latitude regions were characterized by wet (dry) and dry (wet) environments, respectively. We suggest that these climatic patterns are related to the migration of the EASM-related rain belt during global climate changes, as a consequence of variations in intensity and location of both the Intertropical Convergence Zone (ITCZ) and the Western Pacific Subtropical High (STH). The location of the rain belt largely influences the East Asian hydrological environment. Our δ13C time-series are characterized by a 1230 yr throughout the Holocene and a 680 yr periodicity during the early Holocene. The 1230 yr periodicity is in agreement with North Atlantic ice-rafted debris (IRD) events, suggesting a teleconnection between the Northeast Japan and the North Atlantic during the Holocene. In addition, it is the first evidence that the Bond events were recorded in terrestrial sediment in Japan. On the other hand, the 680 yr periodicity between 10.0 and 8.0 kyr is consistent with a prominent 649 yr solar activity cycle, suggesting that solar activity affected EASM precipitation during the Hypsithermal, when orbital-scale solar insolation was at a maximum in the Northern Hemisphere.

Published
2018

42. Decreased regional cerebral blood flow in patients with diphenylarsinic acid intoxication

Author

N. Iwasaki, T. Masuda, Y. Shibata, Akira Tamaoka, Tohoru Takeda, K. Nemoto, and Kazuhiro Ishii

Subjects
Adult, Male, Physiology, Statistical parametric mapping, Asymptomatic, Arsenicals, Cuneus, 03 medical and health sciences, 0302 clinical medicine, Arsenic Poisoning, Medicine, Humans, In patient, 030212 general & internal medicine, Diphenylarsinic acid, Aged, Tomography, Emission-Computed, Single-Photon, business.industry, Drinking Water, Brain, Human brain, Middle Aged, medicine.anatomical_structure, Neurology, Cerebral blood flow, Nails, Cerebrovascular Circulation, Female, Neurology (clinical), Occipital Lobe, medicine.symptom, business, Occipital lobe, 030217 neurology & neurosurgery, Hair
Abstract

BACKGROUND AND PURPOSE Diphenylarsinic acid (DPAA) intoxication caused by drinking contaminated well water was found in Kamisu, Japan. The symptoms indicated cerebellar-brainstem and temporo-occipital involvement. However, it remains unclear how it affects the human brain. To elucidate the effect of DPAA on the human brain, we analyzed cerebral blood flow (CBF) data after the drinking of DPAA-contaminated water was stopped and investigated the correlation between DPAA exposure level and CBF by single-photon emission computed tomography (CBF-SPECT). METHODS The DPAA-exposed inhabitants (n = 78) were divided into 35 symptomatic and 43 asymptomatic subjects and compared with 38 healthy controls. The DPAA concentration in nails or hair and well water was measured using a high-performance liquid chromatography system and coupled plasma mass spectrometry after adequate extraction treatment. CBF-SPECT data, obtained within 1 year after the drinking of contaminated well water was stopped, were analyzed by statistical parametric mapping. We also examined the relationship between variations in CBF-SPECT signals and variations in DPAA concentrations in the hair or nails of the subjects. RESULTS Compared with control subjects, CBF in symptomatic DPAA-exposed subjects was significantly lower in the occipital lobe, including the cuneus and inferior occipital gyri. The DPAA concentration in the nails or hair of subjects was inversely and significantly related to their CBF. CONCLUSION These data suggest that CBF-SPECT may be useful as a clinical marker to infer the effect of accumulated DPAA on the brain.

Published
2018

43. CRP at 1 month after treatment of nivolumab as a predictive marker of efficacy in advanced renal cell carcinoma

Author

H. Hasumi, N. Nakaigawa, Tetsuro Sasada, Takeshi Kishida, Takahisa Suzuki, S. Tsutsumi, K. Osaka, Y. Shibata, G. Noguchi, Keiichi Kondo, Kazuhiko Kobayashi, S. Umemoto, S. Ohtake, M. Yao, and K. Muraoka

Subjects
Oncology, medicine.medical_specialty, Predictive marker, Renal cell carcinoma, business.industry, Urology, Internal medicine, medicine, Nivolumab, medicine.disease, business, After treatment
Published
2019
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44. Radiation Therapy and Risk of Herpes Zoster in General Cancer Patients: A Propensity Score Matched Analysis

Author

K. Taguchi, Yujiro Nakajima, T. Shimizuguchi, Sara Hayakawa, Kumiko Karasawa, Keiji Nihei, Y. Miyake, Hiroaki Ogawa, Y. Shibata, K. Ito, and Y. Machitori

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Cancer, medicine.disease, Radiation therapy, Internal medicine, Propensity score matching, Medicine, Radiology, Nuclear Medicine and imaging, business
Published
2019
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45. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer

Author

D Rafael, M Pernigo, S Gheghici, ZH Cherneva, MH Miglioranza, J Schmid, R Teixeira, R Bica, R Murzilli, E Galli, M Brand, A Brecht, MS Amzulescu, R Verseckaite, S Dorlet, T Aktemur, TL Wang, BW Michalski, B Castaldi, C M Van De Heyning, XX Luo, C Venner, J Willis, S Nishino, L C Lervik Nilsen, K Stathogiannis, O M Galuszka, F Graziani, A Borizanova, AB Gevaert, AH Van Craenenbroeck, B Shivalkar, K Lemmens, CJ Vrints, EM Van Craenenbroeck, D Somleva, N Zlatareva- Gronkova, E Kinova, A Goudev, A Camporeale, M Pieroni, D Pedicino, MP Laurito, E Verrecchia, GA Lanza, R Manna, F Crea, M Reinthaler, S Rutschow, M Gross, U Landmesser, M Kasner, K Toutouzas, M Drakopoulou, G Latsios, A Synetos, O Kaitozis, G Trantalis, A Mastrokostopoulos, R Kotronias, D Tousoulis, BB Brekke, SA Aase, MT Lonnebakken, D Stensvag, B Amundsen, H Torp, A Stoylen, N Watanabe, T Kimura, T Nakama, M Furugen, H Koiwaya, K Ashikaga, N Kuriyama, Y Shibata, DX Augustine, D Knight, J Sparey, G Coghlan, J Easaw, O Huttin, D Voilliot, M Mercy, T Villemin, A Olivier, D Mandry, A Chaouat, Y Juilliere, C Selton-Suty, F Fang, S Li, ZH Zhang, CM Yu, PB Bertrand, C De Maeyer, D De Bock, BP Paelinck, MJ Claeys, E Reffo, M Balzarin, F Zulian, O Milanesi, D Miskowiec, K Kupczynska, L Peczek, B Nawrot, P Lipiec, JD Kasprzak, H Li, XY Jin, N Poci, C Kaymaz, V Manenti, S Carillo, F Chabot, V Mizariene, D Rimkeviciute, M Bieseviciene, R Jonkaitiene, R Jurkevicius, C Roy, A Slimani, L Boileau, C De Meester, D Vancraeynest, A Pasquet, JL Vanoverschelde, AC Pouleur, BL Gerber, S Oertelt-Prigione, U Seeland, M Ruecke, V Regitz-Zagrosek, V Stangl, F Knebel, D Laux, J Roeing, T Butz, M Christ, M Grett, R Wennemann, H- J Trappe, M Fournet, C Leclercq, E Samset, J-C Daubert, E Donal, LA Leo, E Pasotti, C Klersy, T Moccetti, FF Faletra, D Dobre, S Darmon, S Dumitrescu, P Calistru, R Monteiro, M Ribeiro, J Garcia, N Cardim, L Goncalves, R Kaufmann, MR Grubler, N Verheyen, F Weidemann, JS Binder, RT Santanna, MM Rover, T Leiria, R Kalil, E Picano, L Gargani, ZK Kuneva, DV Vasilev, R Ianula, M Dasoveanu, C Calin, C Homentcovsci, R Siliste, C Bergamini, A Mantovani, S Bonapace, P Lipari, E Barbieri, E Bonora, G Targher, AC Camarozano, CL Pereira Da Cunha, SL Padilha, AM Souza, and AKE Freitas

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2015
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46. Circularly polarized near-field scanning optical microscope for investigations of edge states of a two-dimensional electron system

Author

Tomoya Ohira, Shintaro Nomura, Tatsushi Akazaki, M. Yamaguchi, Syuhei Mamyouda, Luno Yoshikawa, H. Ito, Satoshi Kashiwaya, Hiroyuki Tamura, Y. Shibata, and Youiti Ootuka

Subjects
Physics, Diffraction, Scanning Hall probe microscope, business.industry, General Chemistry, Quantum Hall effect, Edge (geometry), law.invention, Magnetic field, Optics, Optical microscope, law, General Materials Science, Near-field scanning optical microscope, business, Circular polarization
Abstract

We report on investigations of the quantum Hall chiral edge states using a near-field scanning optical microscope that enables us to irradiate circularly polarized light from the probe tip with spatial resolution below the diffraction limit. We have found a clear evidence for the formation of spin-split incompressible strips near the edge of a two-dimensional electron system in high magnetic fields.

Published
2015
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47. Disaster state information management gis system based on tiled diplay environment

Author

Akira Sakuraba and Y. Shibata

Subjects
Geographic information system, Database, Computer science, business.industry, Controller (computing), Workspace, computer.software_genre, Metadata, Work (electrical), Server, State (computer science), State information, business, computer
Abstract

This paper introduces a new design of disaster state presentation system using large size and ultra high definition displaying system to satisfy requirement of quick and wide collecting and sharing disaster state information from disaster areas to make decision by the officers as decision makers who work in the headquarters. The collected disaster state information are processed as workspace and interactively controlled using workspace controller to display on the Tiled Display Wall (TDW). We designed and implemented our system using current available technology as a prototype.

Published
2017
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48. P1548Impact of nutritional and inflammatory status on cardiovascular outcomes in patients with stable coronary artery disease

Author

T. Aoki, T. Kawamiya, K. Hirayama, Y. Negishi, D. Yamamoto, K. Kawashima, Toyoaki Murohara, Y. Tatami, Hideki Ishii, Takuya Sumi, Y. Shibata, Ken Harada, Susumu Suzuki, Tetsuya Amano, and Ayako Kunimura

Subjects
Coronary artery disease, medicine.medical_specialty, business.industry, Internal medicine, Cardiology, Medicine, In patient, Cardiology and Cardiovascular Medicine, business, medicine.disease, Cardiovascular outcomes
Published
2017
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49. Information Communication System Consisted of Multiple Unmanned Aerial Vehicles on Disaster

Author

Norifumi Tanaka, Noriki Uchida, and Y. Shibata

Subjects
Wireless mesh network, business.industry, Computer science, Real-time computing, Mesh networking, 020206 networking & telecommunications, Throughput, 02 engineering and technology, Communications system, Network topology, 0202 electrical engineering, electronic engineering, information engineering, Wireless, Mobile telephony, business, Telecommunications
Abstract

On large scale disasters, such as the Eastern Japan Great Earthquake and Kumamoto Earthquake, due to mud slides of cliff and floodwater of rivers, many disaster areas are physically isolated and relief and support activities of victims become quite difficult. The communication means are also destructed in those areas and cannot transmit the disaster information. In order to resolve those problems, we propose an information communication system which consisted of Multiple Unmanned Aerial Vehicles (UAV). In this system, multiple UAVs have wireless communication units and organize a wireless mesh network in the sky to transmit the information among the isolated areas. Its network configuration and architecture are explained. A prototype system is constructed to evaluate its function and performance.

Published
2017
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