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Our aim is to establish Hardy and Sobolev inequalities for Sobolev functions in Herz–Morrey spaces, which extend the classical Hardy inequalities in the Lp Lebesgue space.

This is a fundamental study of a non-destructive and contactless equipment to evaluate the chloride ion on concrete, with near infrared spectroscopy. Non-destructive measurements on Friedel’s salt, generated by ingress of chloride ion into concrete, have been studied; characteristic absorption unique to each substance was utilized to qualitative and quantitative analyses. However, there has been a difficulty in separating absorption peak of Friedel’ salt from that of other hydrates. This study investigates the method to extract the absorption peak of Friedel’s salt by Bayes’ theorem for quantitative evaluation, and its validity was confirmed using some conventional methods.

The electrodeposition of cobalt–antimony thermoelectric semiconductor films was investigated in a non-aqueous solution of ethylene glycol (EG)–CoCl 2 –SbCl 3 at 393 K. By controlling the bath composition and cathodic current density, Co–Sb alloys containing 0–94 mol% of Co were obtained at 50–300 Am − 2 . The resistance polarization caused by the formation of semiconductor film was observed in the polarization curve measured in the EG–CoCl 2 –SbCl 3 (90.0–9.3–0.7 mol%) bath. In this bath, the Co–Sb (23.6–76.4 mol%) alloy was obtained by maintaining the constant potential electrolysis at 0.1 V. This alloy included CoSb 3 and exhibited a p-type thermoelectric conversion by the given temperature difference.

This paper introduces the concept of a road input control system to coexist superior ride comfort performance with driving stability using an electric active stabiliser system. The specific road input control system studied, extends the skyhook theory in the roll direction to offer both ride comfort and driving stability. The predictions of performance achieved by this method have been confirmed through actual vehicle tests to offer superior ride comfort and tracing performance. Moreover, consumed power of the road input control was 7-25% of conventional steering input control because of the efficiency of the regenerated power in the active stabiliser system.

To understand better the thermal decomposition characteristics of organic peroxides, a C80 heat flux calorimeter was used and the decomposition pattern of cumene hydroperoxide and di-tert-butylperoxide were classified as auto-catalytic and nth order reaction, respectively. Based on the scanning results with the C80 at several differing rates of heating, the thermal decomposition behavior of organic peroxides under isothermal storage at lower temperature was simulated with a model-free simulation. Simulated results showed that the calculated conversion of cumene hydroperoxide as a function of time was in good agreement with experimental data obtained with the TAM-III high sensitivity thermal activity monitor.

We constructed the EUV microscope (EUVM) for actinic mask inspection which consists of Schwarzschild optics (NA 0.3, 30x) and X-ray zooming tube. Using this system, EUVL finished mask and Mo/Si coated glass substrates are inspected. EUVM image of 300-nm-wide pattern of finished mask was clearly observed. Resolution can be estimated to be 50nm or less from this pattern. The programmed phase defect on the glass substrate made by HOYA is also used for inspection. By using EUV microscope, programmed phase defect with dot patterns of over 90nm in size and over 4nm-height bump can be observed finely. And the programmed phase defect of 100-nm-wide and 2-nm-depth pit was also observed. Thus, in this research, observation of a programmed phase defect was advanced using the EUV microscope, in other words, it is succeeded in observation of the topological defect image inside a multilayer film. These results show that it is possible to detect internal reflectance distribution of multilayer under the EUV microscope, without being dependent on surface figure.

A lot of researchers have studied cell fusion and manipulation during the past decades, and this field was pursued low cost and small setup. There is a lot of ways that can manipulate cell such as optical tweezers and dielectrophoresis (DEP). Particularly, optical tweezers can manipulate cells with non-contact and non-invasive so this technique was noticed in biotechnology. In this paper we introduce three techniques based on DEP and optical tweezers: Distinction between viable cells and non-viable cells using DEP, Manipulating cells captured by positive DEP (pDEP) using optical tweezers and PEG fusion combining optical tweezers and DEP. About cell fusion, we would suggest efficient PEG fusion that can fuse cell in selective. We are considering a variety of system combined DEP and optical tweezers now. The systems will be useful to perform cell operation and other applications. Keywords-optical tweezers; dielectrophoresis; yeast;protoplast; fusion lab-on-chip system

Ni/Cu nano-multilayers were fabricated by an electrodeposition technique. Ratio of the Ni:Cu layer thickness was kept at 1:1. By laminating nickel and copper layers at a very narrow spacing, we obtained highly-densified parallel interfaces which can give rise to high strength. Dependence of Vickers hardness and tensile deformation on individual layer thickness h was investigated on the Ni/Cu multilayers. The Vickers hardness increased with decreasing layer thickness for the multilayers of h≥ 10 nm. This change in the hardness was consistent with the Hall-Petch relation. At the 10 nm layer thickness, the hardness attained more than three times higher than that of the copper substrate. On the other hand, the hardness decreased rapidly with the layer thickness at h < 10 nm. The tensile deformation tests were also carried out at the substrates coated with the multilayer of h = 5, 20 and 100 nm. The SEM observations revealed that the slip lines of the deformed substrates were terminated by the multilayer at the multilayers of h = 20 and 100 nm. On the other hand, a lot of slip lines penetrated into the multilayer of h = 5 nm. These slip observations were compatible with the layer thickness dependence of the hardness.

Interspecific and intergeneric cross-pollination and subsequent ovule culture were carried out among 6 genotypes of Gloriosa spp., 1 genotype of L. modesta and 2 genotypes of S. aurantiaca in order to widen their variations and to develop novel cultivars. Ovules with placental tissues prepared from ovaries 14 days after pollination were cultured at 25°C in the dark on a medium containing 0.01 mg l -1 α α α α -naphthaleneacetic acid (NAA) and 0.01 mg l -1 benzyladenine (BA), on which rhizome-like structures were produced from the ovules in 49 out of 61 cross-combinations. Following transfer to a medium containing 0.25 mg l -1 NAA and 2.5 mg l -1 BA under a 16-h photoperiod, some of the rhizome-like structures produced shoots and/or root-like structures. These shoots developed into plantlets and produced tubers on a plant growth regulator-free medium. In some of the plantlets derived from intergeneric cross-pollination, early confirmation of the hybridity was accomplished by flow cytometry analysis of relative DNA content of nuclei.

症例は62歳男性.発症の直前に中国渡航歴がある.平成14年7月より胃潰瘍にて加療中であった。無症状ではあったが,同年12月の血液データにてcarcinoembryonic antigen(以下CEA)が7.6ng/mlと高値を示したため,精査目的にて平成15年4月大腸内視鏡検査を施行した.盲腸に浅い不整形潰瘍の多発が認められ,生検では多数の栄養型アメーバが検出されたためアメーバ腸炎と診断した.便培養は陰性,便虫卵検査は陰性で,血清アメーバ抗体が高値であった.診断確定後より14日間メトロニダゾール500mg/日の投与を行い,3カ月後の大腸内視鏡検査では盲腸の潰瘍は瘢痕化し,生検でもアメーバは検出されなかった.海外渡航後の大腸内視鏡検査で偶然発見されたアメーバ腸炎の一例を経験したので報告する.

Autoantibodies against heat shock protein 40 (HSP40) and their clinical significance in ulcerative colitis (UC) have not been evaluated before. Twenty-six tissue specimens of inflamed areas from patients with UC, 16 from patients with Crohn's disease (CD) and 16 endoscopically normal tissues were analysed for HSP40 expression. Sera from 47 patients with UC and 44 healthy volunteers were examined for the presence of autoantibodies against HSP40 by enzyme-linked immunosorbent assay test. Immunohistochemistry showed that 17 out of 26 specimens from UC patients, one specimen from a CD patient and one normal tissue specimen were positive for HSP40. Most HSP40-positive cells expressed CD68. Higher titres of anti-HSP40 autoantibodies were detected in sera from UC patients compared with healthy volunteers. In patients with inactive disease, those with proctitis or left-sided colitis had higher titres of anti-HSP40 autoantibodies than those with total colitis. Our study suggests that autoimmunity against HSP40 may have a beneficial effect in UC patients by limiting the extent of the disease.

The study aimed to determine the association between cytotoxin-associated gene product (CagA), serum gastrin and pepsinogen levels in Japanese children infected with Helicobacter pylori. Three hundred children were enrolled in the study. H. pylori infection was assessed using an enzyme-linked immunosorbent assay, and CagA status was assessed using immunoblotting. Serum gastrin and pepsinogen concentrations were measured by radioimmunoassay. H. pylori seroprevalence was 12.3% (37/300) and CagA status was identified in 28/37 H. pylori-seropositive children (75.7%). Serum pepsinogen I and II levels were significantly higher in CagA-seropositive than CagA-seronegative children with H. pylori infection. There was no significant relationship between CagA seropositivity and serum gastrin levels. In conclusion, CagA status has a significant impact on serum pepsinogen levels, possibly through enhanced gastric mucosal inflammation.

The microbicidal activities of super-oxidized water (electrolysed strong acid water [ESAW] or electrolysed weak acid water [EWAW]), ozonated water, 0.05% chlorhexidine and 2% glutaraldehyde were tested against seven strains of clinical micro-organism isolates. Following incubation of bacterial suspensions in ESAW and EWAW for 10 s, the number of micro-organisms was reduced below the detection limit. The microbicidal activities of ESAW and EWAW were similar to that of glutaraldehyde, and superior to ozonated water and 0.05% chlorhexidine. The microbicidal activities of ESAW, EWAW and ozonated water were markedly diminished in the presence of albumin. Microbial contamination of upper gastrointestinal endoscopes was detected after 90 endoscopic procedures, but treatment of the endoscope with ESAW, EWAW or ozonated water eradicated the microbes. These results indicate that ESAW and EWAW are effective disinfectants after mechanical cleaning of upper gastrointestinal endoscopes, and can, therefore, be used in the endoscopy unit.

Summary Background : There is currently no optimal second-line treatment after failure of Helicobacter pylori triple therapy. Aim : To determine effective salvage therapy after failure of lansoprazole–amoxicillin–clarithromycin. Methods : After failure of lansoprazole–amoxicillin–clarithromycin 123 out-patients were randomized to receive either 2-week rabeprazole (20 mg b.d.) + amoxicillin (1000 mg b.d.) (RA group) or 1-week rabeprazole (10 mg b.d.) + amoxicillin (750 mg twice b.d.) + metronidazole (250 mg b.d.) (RAM group). Eradication was assessed by the 13C-urea breath test. We also evaluated cytochrome p450 (CYP) 2C19 genotype status, determined by polymerase chain reaction – restriction fragment length polymorphism, and susceptibility to clarithromycin and metronidazole. Results : On an intention-to-treat basis, H. pylori infection cure was achieved in 37 of 63 (59%) patients in the RA group and in 49 of 60 (82%) patients in the RAM group. Per protocol-based eradication rates in the RA and RAM groups were 66% (37/56) and 88% (49/56), respectively. In both analytic sets there were significant differences between the treatment groups (P

The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of sperm detection) through Day 7 of pregnancy using a mini-osmotic pump was found to delay the initiation of implantation by 1 or 2 days with no negative effects on embryonic viability. The Fad treatment delayed preimplantation embryo development and zona shedding by embryos. The treatment also delayed the period of maximum sensitivity to a decidualizing stimulus (intraluminal infusion of sesame oil) by 2 days. The results show that continuous treatment with Fad has multiple anti-implantation effects in rats.

We have performed muon spin rotation (μSR) measurements in polycrystalline Re 3 B to elucidate the structure of quasiparticle excitations which are related to the pairing symmetry. The temperature and magnetic field dependence of the penetration depth λ suggest an isotropic order parameter with the BCS mechanism.

The dislocation morphology and lattice distortion, including the tilting and twisting of lattice planes, at the Na-flux GaN/seed-GaN interface were investigated using transmission electron microscopy (TEM) and position-dependent nanobeam X-ray diffraction (nanoXRD). The results revealed that the dislocation morphology and lattice distortion in Na-flux GaN at the initial growth stage are strongly influenced by the seed-GaN surface morphology and the growth mode of Na-flux GaN. From the TEM results, one can observe that the formation of dislocation-related etch pits (DREPs) on the seed-GaN surface and the three-dimensional (3D) growth mode for Na-flux GaN give rise to the bending and lateral propagation of dislocations penetrating from the seed-GaN to the Na-flux GaN. This simultaneously results in homogenization of the GaN crystal domain structure as confirmed by nanoXRD. The mechanism responsible for the bending and lateral propagation of dislocations by the formation of DREPs and the 3D growth mode for t...

In this paper, the existing Displacement Discontinuity Method (DDM) for three-dimensional elastic analysis with boundary discretized into triangular elements, which is purely based on analytical integrals, is extended from the constant element to the square-root crack edge element. In order to evaluate the singular integral when the receiver point falls into the remitter element, i.e., the observed point (x,y) ∈Δ, a part analytical and part numerical integration procedure is adopted effectively. The newly developed codes prove valid in estimating the Stress Intensity Factor (SIF) KI. Furthermore, for the sake of keeping the advantages of high-speed and high-accuracy in developing the numerical system, a novel method to realize pure analytical integration of influence function is found by the aid of symbolic computation technology of Mathematica. Copyright © 2001 John Wiley & Sons, Ltd.

The relationship between the susceptibility to rapid temperature drop induced leaf injury, i.e. “leaf spot”, and the antioxidant capacities of several Saintpaulia (African violet) cultivars was examined. Cultivars ‘Ritali’ and ‘Tamiko’, that are more susceptible to leaf spot caused by a rapid drop in leaf temperature from 30 to 15°C than are cultivars ‘Maui’ and ‘New Jersey’. The susceptible cultivars were also more susceptible to oxidative stress caused by H2O2 and active chlorine than the tolerant cultivars. Reduction of available chlorine, considered to be accelerated by antioxidants of leaf tissue, was rapid in ‘Maui’ and ‘New Jersey’. Activity of the antioxidant enzymes superoxide dismutase and catalase were higher in the leaves of ‘Maui’ and ‘New Jersey’ than in the susceptible cultivars. These findings show a correlation between leaf spot injury and antioxidant capacity in Saintpaulia leaves.

Aim: To determine whether a 5-day regimen with rabeprazole, clarithromycin and amoxicillin (RCA) was as effective as a 7-day regimen. Methods: A total of 139 H. pylori-infected patients were randomized to receive either a 5-day or 7-day course of rabeprazole 10 mg b.d., clarithromycin 400 mg b.d. and amoxicillin 750 mg b.d. Eradication was assessed by CLO test, histology and 13C-urea breath test. Results: On the intention-to-treat basis, eradication rates were 66% (46 out of 70) and 84% (58 out of 69) for the 5- and 7-day regimens, respectively (P

Prostaglandins exert a protective effect on colonic mucosa in experimentally induced colitis. This study investigated the effect of enprostil, a prostaglandin E2(PGE2) analogue, on trinitrobenzenesulphonic acid (TNBS)-induced colitis in rats. Each rat received a rectal enema containing TNBS (30 mg), followed 24 h later by intrarectal once-daily enprostil (200 μg). Enprostil-treated and control rats were killed on day 3 (enprostil group, n = 5; control, n = 6) or day 10 (enprostil group, n = 5; control, n = 5) after TNBS treatment. The area of damaged mucosa of the colon was measured relative to the total colonic area. We also determined the macroscopic score of mucosal damage, and measured PGE2, 6-ketoprostaglandin F1α(6-keto-PGF1α) and thromboxane B2(TXB2) concentration in portal vein blood samples. Enprostil significantly reduced both the area of damaged mucosa (including the ulcer area) and the macroscopic score after 3 days' treatment compared with control. Similarly, enprostil significantly reduced plasma concentration of PGE2, 6-keto-PGF1αand TXB2during the acute phase at day 3 of treatment compared with control, but not at day 10. These results suggest that PGE2enema may have therapeutic potential for treating patients with proctitis or left-sided colitis.

大腸浸潤をきたした成人T細胞性白血病(ATL)の5症例を経験した.男性4例,女性1例で,平均58歳であった.病型は急性型が3例,リンパ腫型が2例であった.大腸浸潤の画像所見は,多発隆起性病変が4例,びまん浸潤型が1例であった.いずれも胃や小腸への浸潤も合併しており,4か月から1年9か月後に死亡した.自験5例を含む本邦報告31例の臨床的検討でも,大腸浸潤は多発する隆起性病変が18例,多発性潰瘍・びらんが5例と病変が多発するものが大半を占め,びまん浸潤型は6例のみであった.96%に胃や小腸への浸潤をきたしており,予後は平均7か月と不良であった.消化管の検索はATLの病態把握に有用と思われた.

Aeromonas sobria hemolysin is important in the pathogenesis of diarrhoea caused by this enteropathogenic bacterium. By immunoprecipitation analysis using hemolysin and anti-hemolysin antibody, a 66 kDa protein (p66) was identified as a receptor for A. sobria hemolysin on Intestine 407 cells. Treatment of p66 with N-glycosidase F reduced the apparent sized of p66 to 60 kDa on SDS-polyacrylamide gels. p66, released from Intestine 407 cells following incubation with phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, bound A. sobria hemolysin. Thus treatment of Intestine 407 cells with PI-PLC resulted in the remarkable decrease of the sensitivity to A. sobria hemolysin. These results are consistent with the hypothesis that p66, the binding protein for A. sobria hemolysin, is a glycosylphosphatidylinositol-anchored glycoprotein expressed on the surface of Intestine 407 cells and probably plays a role as a receptor for A. sobria hemolysin on the intestinal cells.

Although the pathogenesis of gastric xanthoma (GX) remains unclear, an association of GX with atrophic gastritis has been reported. Helicobacter pylori is closely related to atrophic gastritis. The aim of this study was to investigate the relationship among GX, H. pylori, and atrophic gastritis.Sixty-seven patients with GX were assessed for H. pylori infection by serum anti-H. pylori IgG antibody, in addition to the rapid urease test, culture, and histologic examination using biopsy specimens of the antrum and corpus. The findings were compared with 67 age- and sex-matched control subjects without GX. The distribution of atrophic gastritis was assessed endoscopically. The severity of atrophic gastritis was determined endoscopically and histologically. Serum pepsinogen (PG) levels were also measured. Immunohistochemical staining of GX samples for H. pylori antigen was performed. H. pylori clinical isolates from patients with GX and controls were assessed for cagA by means of polymerase chain reaction.The prevalence of H. pylori was significantly higher in patients with GX than in controls (94% and 72%, respectively). A significantly more extensive atrophic gastritis was present in patients with GX, as determined endoscopically and histologically, than in controls. Serum PG-I levels and the PG-I/PG-II ratio were significantly lower in the GX group than in the control group. H. pylori antigens were frequently identified in the cytoplasm of xanthoma cells in H. pylori-positive specimens of GX (54 of 63 specimens, 86%), whereas no immunoreactivity for H. pylori antigens was detected in H. pylori-negative specimens of GX. There was no significant difference in the positive rate of cagA between the two groups.Our results identified a close relationship among H. pylori infection, GX, and atrophic gastritis. A proportion of GXs may be provoked by H. pylori infection.

A wind tunnel study was conducted to examine the aerodynamic stability of concrete stress-ribbon pedestrian bridges with special reference to the Jomon Bridge. Not popular triangular fairings but half-circular and half-elliptic modified edges on both sides of decks were examined as a fundamental study prior to the Jomon deck model test. The modifications are found to be effective in increasing the critical flutter speed VF as well as suppressing vortex excitation. It was found in the Jomon deck model test that VF was below the design speed for the deck with a conventional cross-section and that VF was greatly increased by the similar edge modifications and a pair of half-circular cylindrical fairings as well. Based on the test results and for some reasons, the half-circular fairing was applied to the actual bridge.

A total of 44 patients with long-standing ulcerative colitis were studied to elucidate changes over time in colonoscopic and histological inflammatory activity. More than two years of symptomatic remission without melena or bloody diarrhea was achieved in 63.6% (28/44). All patients underwent total colonoscopic examinations. Compared with findings of the previously involved area, 70.5% (31/44) showed a reduction or disappearance of the inflammatory area on endoscopic and histological examinations; however, the rectal inflammation disappeared in 31.8% (14/44) of patients. Moreover, it became apparent that the remaining active inflammatory area tended to show discontinuous spread with patchy inflammatory foci. Thus, the mucosal inflammation in long-standing ulcerative colitis may be characterized by a reduction in both extent and degree.

A transmission x-ray tube super-miniature in size is described. The x-ray tube is 5mm in diameter, and comprised of a built-in electron-emitter assembly and a grounded planar target. The key component of the emitter assembly is a Kovar pipe 2mm in diameter, inside which carbon nanofibers aligned on an electro-polished molybdenum tip are loaded to serve as the electron emitter. This type of electron emitter is highly robust in non-ultrahigh vacuum, continuing to field emit electrons for 100h or longer at pressures in the 10−5Pa region. This x-ray tube provides clear x-ray images.

A miniature x-ray tube is described. The tube is made of Kovar, inside which a grounded target is located close to a field-electron emitter consisting of aligned carbon nanofibers, which continues to work for around 100 h in the 10−6 Pa region unless arcing is induced between the electrodes. The resolution of the contact x-ray images provided by the tube would be impossible using the existing techniques of conventional x-ray radiography, whether the sample is biological or nonbiological.

In order to both experimentally and numerically investigate nonlinear femtosecond ultrabroadband-pulse propagation in a silica fiber, we have extended the finite-difference time-domain (FDTD) calculation of Maxwell's equations with nonlinear terms to that including all exact Sellmeier-fitting values. We have compared results of this extended FDTD method with experimental results, as well as with the solution of the generalized nonlinear Schrodinger equation by the split-step Fourier method with a slowly varying-envelope approximation. To the best of our knowledge, this is the first comparison between FDTD calculation and experimental results for nonlinear propagation of a very short (12 fs) laser pulse in a silica fiber.

AFPが著明な高値を示した直腸癌症例を経験したので,AFP1000ng/ml以上を示した本邦報告例8例をもとに若干の考察を加え報告した.症例は58例の男性,主訴は下血であった.諸検査にて直腸癌の肝転移と診断したが,AFPが200万以上と高値を示した.人工肛門を造設し抗癌剤による治療を行ったが約3カ月後に肝不全にて死亡した.直腸の腫瘍部と転移巣である肝腫瘍部,ともに酵素抗体法によるAFP染色にて陽性所見を示し,ともにAFPを産生していることがあきらかとなった.

Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD).Employing in house radioimmunoassay, we examined concentrations of the major forms alpha-defensins, human neutrophil peptides (HNP) 1-3 and human beta-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn's disease (CD) and 57 controls.The circulating HNP 1-3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1-3 concentrations in CD patients significantly correlated with Crohn's disease activity index, peripheral white blood cell counts, serum CRP values and TNF-alpha levels.Elevation of circulating alpha-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1-3 concentrations may be an indicator for CD activity and their association with CRP and TNF-alpha supports a possible association with the inflammatory process.

To evaluate bone formation on porous ceramic baiomaterials, such as hydroxy- apatite (HA) and apatite-wollastonite glass ceramic (AW-GC), a micro-focus X-ray CT method was employed to image and recostruct the 3-dimensional (3-D) structures of the ceramic specimens. The 100 CT cross section images of the specimens, composed of 512 x 512 pixels, formed one solid 3-D CT image of the specimen. The 3-D porous structures of the ceramics were analyzed by usig a bone-analyzing software, which gave the distribution of pore sizes and path sizes between pores for various specimens with different porosities. Some ceramic specimens soaked in simulated body fluid and those implanted in rat for in-vivo tests were investigated. After a few weeks in-vivo experiments, bone formation could be clearly observed and the amount of the formation could be estimated by the CT images.

内科的治療に抵抗し, 外科的切除を行った回盲部単純性潰瘍の3例を経験した。症例1は33歳, 男性.口腔内アフタと右下腹部痛を主訴とし, 回盲弁直上に深い潰瘍を認めた.症例2は39歳男性、口腔内アフタと右下腹部痛, 皮疹を主訴とし, 回盲弁肛門側に深い潰瘍を認めた.症例3は55歳男性で, 右下腹部痛と口内炎および外陰部潰瘍を主訴とし, 回盲部狭窄と潰瘍を認めた.いずれも組織学的に単純性潰瘍と診断されたが, 一連の臨床症状の経過から腸管ベーチェットとの強いかかわりが考えられた.いわゆる狭義の単純性潰瘍は一つの疾患単位として確立されるには至っていない。本病変は他の様々な回盲部疾患との鑑別診断が重要で, 長期観察により腸管ベーチェットとの関連が考えられ, 難治性で全身性の強い炎症反応を伴い, 術後の再発率も高く治療が困難である事, などの問題点をあげることができる.今後も臨床経過の十分な観察と内科的治療の試みが必要と思われた.