178 results on '"Y. Kohjimoto"'
Search Results
2. Screening of extended spectrum beta-lactamase is useful for preventing acute prostatitis after transrectal ultrasound guided prostate biopsy
- Author
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H. Kawabata, S. Yamashita, K. Kikkawa, Y. Kohjimoto, and I. Hara
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
- Full Text
- View/download PDF
3. Intraoperative measurements of urethral length and bladder neck diameter as predictors of urinary continence after robot-assisted radical prostatectomy
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Y. Kohjimoto, M. Higuchi, Y. Ueda, T. Iguchi, H. Koike, T. Wakamiya, S. Yamashita, K. Kikkawa, and I. Hara
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
- Full Text
- View/download PDF
4. Comparative study on stone retropulsion using pulse modulation mode in virtual ureter model
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Y. Maruyama, S. Yamashita, Y. Tasaka, T. Inoue, Y. Kohjimoto, T. Matsumura, and I. Hara
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Urology - Published
- 2023
5. Comparison of intrarenal pressure during retrograde intrarenal surgery using various single-use ureteroscopes: An in-vitro study
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S. Yamashita, R. Deguchi, Y. Iwahashi, M. Higuchi, T. Inoue, Y. Kohjimoto, and I. Hara
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Urology - Published
- 2023
6. Myosteatosis as a novel predictor of new-onset diabetes mellitus after kidney transplantation
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T. Wakamiya, S. Yamashita, K. Kikkawa, Y. Kohjimoto, and I. Hara
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Urology - Published
- 2023
7. Thermography-based comparison of irrigation temperatures between Moses Mode and Virtual Basket Mode: An in-vitro phantom study
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S. Yamashita, T. Inoue, S. Imai, Y. Kohjimoto, M. Fujisawa, and I. Hara
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Urology - Published
- 2022
8. Ureteroscopy-assisted versus conventional ultrasound-guided renal access for miniaturised endoscopic combined intrarenal surgery: A multicentre comparative study
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K. Taguchi, S. Yamashita, S. Hamamoto, R. Deguchi, K. Kawase, T. Okada, T. Sugino, R. Unno, T. Kato, R. Ando, A. Okada, Y. Kohjimoto, I. Hara, and T. Yasui
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Urology - Published
- 2021
9. HU above-below ratio is an useful preoperative factor for predicting impacted ureteral calculi
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K. Kikkawa, S. Yamashita, R. Deguchi, Y. Kohjimoto, and I. Hara
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medicine.medical_specialty ,business.industry ,Urology ,Medicine ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,business ,lcsh:RC254-282 - Published
- 2020
10. Automatic measurement of mean stone density by three-dimensional stone images for predicting shock wave lithotripsy success
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S. Yamashita, Y. Kohjimoto, Y. Iwahashi, T. Iguchi, A. Iba, and I. Hara
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Urology - Published
- 2018
11. How do urinary incontinence and PSA recurrence affect health related QoL after radical prostatectomy?
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H. Miyai, S. Ueno, Y. Iwahashi, Y. Ueda, T. Iguchi, T. Wakamiya, S. Yamashita, S. Nishizawa, A. Iba, Y. Kohjimoto, and I. Hara
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Urology - Published
- 2018
12. Oxalate-induced changes in renal epithelial cell function: role in stone disease
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C, Scheid, T, Honeyman, Y, Kohjimoto, L C, Cao, and J, Jonassen
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Time Factors ,Swine ,Sialoglycoproteins ,Phosphatidylserines ,Ceramides ,Kidney ,Antioxidants ,Phospholipases A ,Cell Line ,Proto-Oncogene Proteins c-myc ,Kidney Calculi ,Dogs ,Animals ,RNA, Messenger ,Glycoproteins ,Oxalates ,Arachidonic Acid ,Dose-Response Relationship, Drug ,Cell Membrane ,Epithelial Cells ,Blotting, Northern ,Sphingomyelins ,DNA-Binding Proteins ,Clusterin ,Osteopontin ,Cell Division ,Molecular Chaperones ,Signal Transduction ,Transcription Factors - Abstract
Many studies on the etiology of stone disease have focused on the properties of urine that affect crystal nucleation and growth. More recent studies have focused on the properties of the renal epithelium and the role of injury in crystal retention. The latter studies have shown that oxalate exposure per se can damage renal epithelial cells and enhance crystal binding. This overview summarizes findings of specific biochemical and genetic alterations observed in renal epithelial cells after exposure to oxalate. In LLC-PK1 and MDCK cells, oxalate exposure produces marked effects on membranes, causing a redistribution of phosphatidylserine and activation of two lipid signaling cascades, one involving phospholipase A(2) (PLA(2)) and one involving ceramide. Longer exposure to oxalate leads to membrane damage and cell death. Adaptive responses are also observed, including proliferation (for replacement of damaged cells) and induction of various genes (for cellular replacement and repair). Many or all of these responses are blocked by antioxidants, and many can be mimicked by PLA(2) agonists/products. This finding suggests links between oxalate-induced increases in oxidant stress, lipid signaling pathways, and subsequent molecular responses that may eventuate in renal cell damage or death. Whether such changes play a role in stone disease in vivo, and whether strategies to inhibit these changes would be beneficial therapeutically, is unknown.
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- 2001
13. Bikunin prevents adhesion of calcium oxalate crystal to renal tubular cells in human urine
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S, Ebisuno, M, Nishihata, T, Inagaki, M, Umehara, and Y, Kohjimoto
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Male ,Membrane Glycoproteins ,Serine Proteinase Inhibitors ,Calcium Oxalate ,Adhesiveness ,Kidney Calculi ,Dogs ,Kidney Tubules ,Animals ,Humans ,Trypsin Inhibitor, Kunitz Soybean ,Crystallization ,Cells, Cultured ,Glycoproteins - Abstract
Crystal-renal tubular cell interactions are important factors in crystal retention and development of kidney stones. It has been reported that human urine, especially its macromolecular fraction, distinctively prevented calcium oxalate monohydrate (COM) crystal adhesion to tubular cells. This study was designed to find and isolate a specific substance in human urine with a strong inhibitory effect against crystal adhesion. A protein from the urine was purified by two anion exchange chromatography columns and one gel filtration column. The inhibition activity for COM crystal adhesion to Madin-Darby canine kidney cells was determined quantitatively. Amino acid sequence of the protein was analyzed and then subjected to homology search in the GenBank protein database. A specific human urine protein that inhibited the COM crystal adhesion to the cells was isolated and identified. Molecular mass of the protein was approximately 35 kD. The first 20-amino acid sequence from the N-terminal of the purified protein was structurally homologous with the light chain of inter-alpha-trypsin inhibitor, also called bikunin. The isolated bikunin inhibited crystal adhesion at a minimum concentration of 10 ng/ml, and blocked completely at 200 ng/ml. It is concluded that bikunin may contribute to the regulation of crystal adhesion and retention within tubules during kidney stone formation.
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- 1999
14. The effects of human urine on the adhesion of calcium oxalate crystal to Madin-Darby canine kidney cells
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S, Ebisuno, M, Umehara, Y, Kohjimoto, and T, Ohkawa
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Dogs ,Calcium Oxalate ,Cell Adhesion ,Animals ,Humans ,Urine ,Crystallization ,Kidney ,Cells, Cultured - Abstract
To determine the effect of human urine on the adhesion of calcium oxalate monohydrate (COM) crystals to Madin-Darby canine kidney (MDCK) cells in a model system in vitro.MDCK cells were exposed to COM crystals in the presence of various human urine samples. COM crystals adhering on MDCK cells were quantified by measuring the calcium concentration using atomic absorption analysis. The inhibitory activities were estimated individually for various urine samples from healthy subjects and recurrent stone formers.Human urine inhibited the adhesion of COM crystals to MDCK cells, with some variations between individual samples. The most potent inhibition of crystal adhesion was expressed by the macromolecular fraction of the urine. Pretreatment of crystals with human urine before exposure to the cells significantly reduced crystal adhesion, suggesting that human urine altered the properties of the crystal surface but not the cell surface.Coating of the crystals by some component(s) of human urine might be an important physiological event in preventing adhesion or retention of crystals in the renal tubules. Although the mechanisms by which crystal adhesion is prevented are unknown, a low potential for inhibiting adhesion may be a risk factor in stone formation because it permits crystal adhesion and retention in the tubules.
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- 1999
15. [Advanced prostate cancer with normal serum prostate-specific antigen values]
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T, Komura, K, Yamagiwa, H, Ogura, Y, Kohjimoto, T, Ohkawa, T, Inagaki, S, Ebisuno, and A, Senzaki
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Aged, 80 and over ,Male ,Prostatectomy ,Reference Values ,Biomarkers, Tumor ,Humans ,Prostatic Neoplasms ,Adenocarcinoma ,Middle Aged ,Prostate-Specific Antigen ,Aged - Abstract
Although prostate-specific antigen (PSA) is a valuable marker of prostate cancer, some untreated patients with advanced prostate cancer have normal PSA values. Over a period of 5 years, we reviewed pretreatment serum PSA levels in 131 patients with advanced prostate cancer (stages C and D). Ten patients (7.6%) had normal PSA values. The histological type of prostate cancer associated with normal PSA values was variable and the prognosis was not so poor. Immunostaining for PSA was performed on the resected prostate tissue of the 10 patients. PSA staining was positive in 5 cases, negative in 3 cases, and equivocal in the remaining 2 cases. In conclusion, PSA is not always useful, especially for following patients with normal PSA values.
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- 1998
16. The cytotoxic effect of fleroxacin and ciprofloxacin on transitional cell carcinoma in vitro
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S, Ebisuno, T, Inagaki, Y, Kohjimoto, and T, Ohkawa
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Carcinoma, Transitional Cell ,Mice ,Fleroxacin ,Anti-Infective Agents ,Dose-Response Relationship, Drug ,Urinary Bladder Neoplasms ,Cell Survival ,Ciprofloxacin ,Tumor Cells, Cultured ,Animals ,Humans ,Cell Count ,Cell Division - Abstract
There have been few reports concerning the cytotoxic effects of fluoroquinolone antibiotics on transitional cell carcinoma. This investigation was designed to study the cytotoxic effects of fleroxacin and ciprofloxacin on transitional cell carcinoma quantitatively in vitro.Two transitional cell carcinoma cell lines, MBT-2 and T24, were used in this study. The effects of fleroxacin and ciprofloxacin on cell proliferation were determined by counting the number of living cells and by colorimetric MTT assay.Two fluoroquinolones, fleroxacin and ciprofloxacin, significantly inhibited cell proliferation in a dose-dependent manner at a concentration of 50-800 microg/mL in both cell lines. Compared with the cytotoxic effects of the two antibiotics, the inhibitory activity of ciprofloxacin on cell proliferation significantly exceeded that of fleroxacin in the MBT-2 cell line. However, the two fluoroquinolones did not have significantly different effects on the T24 cell line.Fleroxacin and ciprofloxacin significantly affect cell proliferation in transitional cell carcinoma cell lines. The results encourage further study of the possibility of clinical application of some fluoroquinolones to prevent recurrence of urinary bladder tumors because the urinary excretions after oral administration of these drugs are quite high.
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- 1997
17. Neuroprotective effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the gerbil model of transient global cerebral ischemia
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M, Okada, H, Ueda, M, Kometani, K, Nakao, Y, Kohjimoto, I, Takahashi, and I, Tanaka
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Male ,Neurons ,Neuroprotective Agents ,2-Amino-5-phosphonovalerate ,Cell Survival ,Ischemic Attack, Transient ,Pipecolic Acids ,Animals ,Motor Activity ,Gerbillinae ,Excitatory Amino Acid Antagonists ,Receptors, N-Methyl-D-Aspartate - Abstract
Effect of the new competitive N-methyl-D-aspartate (NMDA) antagonist D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CAS 137424-81-8, CGP 40116) was examined in a mongolian gerbil model of global cerebral ischemia. Effect of CGP 40116 was compared to that of another competitive NMDA antagonist, (+/-)-cis-4-phosphonomethyl-piperadine-2-carboxylic acid (CAS 110347-85-8, CGS 19755) under the same conditions. Drugs were administered intraperitoneally 30 min before bilateral carotid artery occlusion. At 4 days after the ischemia, locomotor activity was significantly higher in ischemic control mongolian gerbils in comparison with sham-operated mongolian gerbils. CGP 40116 at the dose of 10 mg/kg and CGS 19755 at the doses of 10 and 30 mg/kg significantly suppressed the increase of the motility. Seven days after ischemia, ischemic control group was still hyperactive compared to sham-operated group. CGP 40116 at the dose of 10 mg/kg and CGS 19755 at the dose of 30 mg/kg significantly reversed it. The number of survived neurons of ischemic control group was significantly less than that of sham-operated group at 7 days after ischemia. CGP 40116 at the dose of 10 mg/kg and CGS 19755 at the dose of 30 mg/kg significantly increased the number of survived neurons. It is concluded that CGP 40116 is more potent for amelioration of global cerebral ischemic damage than CGS 19755.
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- 1997
18. Adhesion and endocytosis of calcium oxalate crystals on renal tubular cells
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Y, Kohjimoto, S, Ebisuno, M, Tamura, and T, Ohkawa
- Subjects
Male ,Calcium Oxalate ,Adhesiveness ,Kidney ,Endocytosis ,Rats ,Rats, Sprague-Dawley ,Kidney Calculi ,Dogs ,Kidney Tubules ,Animals ,Humans ,Crystallization ,Cells, Cultured ,Glycosaminoglycans - Abstract
The present investigation was designed to study interactions between Madin-Darby canine kidney (MDCK) cells and calcium oxalate monohydrate (COM) crystals and to clarify the significance of these crystal-cell interactions in stone pathogenesis. MDCK cells cultured in the presence of COM crystals showed a time-dependent uptake of crystals; this was specific for COM crystals. In the dynamic model system designed to study these phenomena under more physiological conditions, COM crystals adhered to the cell surface and were subsequently internalized. In this endocytotic process, the microvilli of the cell appeared to play an important role. The observation by scanning electron microscopy of complexes consisting of aggregated COM crystals and cell debris led us to speculate that adhesion and endocytosis of crystals might provide the calculus nidus for aggregation and retention of crystals in the renal tubule. Furthermore, glycosaminoglycans and the macromolecular fraction of human urine were shown to have the ability to inhibit the cellular uptake of crystals. Evidence that similar processes may also occur in vivo was obtained using an experimental stone model in rats. Our experiments revealed that most of the COM crystals adhered to the tubular cells and some crystals were endocytosed by the cell. Thus, these crystal-cell interactions might be one of the earliest processes in the formation of kidney stones. Further elucidation of the mechanism and the regulatory factors involved in this process may provide new insight into stone pathogenesis.
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- 1996
19. Extension of Surgical Indication for Gastric Cancer with Peritoneal Metastasis by Intraperitoneal Chemotherapy
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F. Imamura, Daisuke Makiura, Y. Goda, Y. Hashiguchi, M. Mizuta, N. Sugimoto, S. Fujita, Shinya Ueda, S. Ozaki, M. Kawayama, M. Niimi, Kojiro Futagami, N. Matsubara, T. Tamaki, M. Fukushima, K. Hirokaga, Won Seog Kim, A. Koyama, K. Matsumoto, H. Kusumoto, Y. Yoshida, T. Sasatomi, H. Akamatsu, A. Ohtsu, I. Sasaki, X. Liu, T. Ura, Chandra P. Belani, H. Yamamoto, K. Watanabe, N. Hokamura, H. Fukushima, H. Nishizaki, K. Yonesaka, Noriaki Ohuchi, S. Takao, H.-J. Tsai, Dimitri Pchejetski, K. Sunami, H. Fujimoto, J. Zhang, H. Samura, Tomoko Oku, M. Mori, Eiji Oki, T. Yano, N. Yamamoto, J. Tsukada, Yasutaka Sukawa, Kazuyoshi Yanagihara, A. Goy, J. Inoue, Kazuto Nishio, Y-C Chang, L. Wang, N. Kotani, M. Inomata, T. Nishimura, C.-C. Lin, N. Aisu, R. Saura, M. Makino, Hideki Shimodaira, Y. Fujishima, Satoshi Watanabe, H. Tanaka, Akiko Hisamoto, Koichi Akashi, J. E. Jang, T. Nobuoka, Chihiro Makimura, Taichi Isobe, T. Takahashi, C. Morizane, S.-M. Chang, N. Takigawa, F. Lv, N. Katagami, A. Kumagai, Takahide Komori, Koichi Hirata, N. Okamoto, A. Makiyama, Y. Takahashi, Hideyuki Hayashi, S. Iwasa, J.-C. Lin, J. S. Kim, K. Eguchi, A. Yokoyama, H. Kunimoto, M. Inoue, L. Sauer, H. Ueno, M. Nakano, A.-H. Kwon, Kiyoshi Ando, H. Nishimura, M. Kaibori, S. Arita, K. Tauchi, Erina Hatashita, H. Yoshioka, Ikuo Sekine, S. Iida, S.-F. Lin, J. Cao, H. Horinouchi, S. Atagi, H. Harashima, Hironori Ishigami, H. Isobe, Yoshimitsu Kobayashi, Shinichi Nishina, M. Motonaga, Tokuzo Arao, M. Edagawa, Kazuo Shirouzu, Kei Kawana, A. Kitamura, Emiko Sakaida, T. Ozaki, H. Fukada, Hiromichi Ishiyama, A. Tsuya, Manabu Muto, K. Takizawa, Satoru Kitazono, H. Uemura, T. Nakagawa, S. Kondo, Naoto Takahashi, Hisato Kawakami, M. D. Galsky, Shigeki Ito, Yoshihiko Maehara, S. Negoro, H. Matsushita, M. Kashiwa-Motoyama, Yoshinori Imamura, Kunio Okamoto, T. Ecke, Miyako Takahashi, T. Matsuno, K. Itoh, K. Tanaka, Kazuo Tamura, Y. Suzuki, A. Iwashima, K. Katayama, Tsuyoshi Shirakawa, M. Ohtsu, Ryohei Sasaki, M. Hayashi, M. Egyed, M. Tateyama, M. Munakata, T. Nomizu, T. Muta, T. Terauchi, Shin Takahashi, Y. Kohjimoto, I. Kawase, L. Qiu, Nozomi Niitsu, Y. Nishida, Hironori Yamaguchi, T. Sawai, T. Nakajima, Takanori Ishida, Tatsuo Oyake, M. Nagase, T. Yoshinami, Y. Sakata, Chiaki Imai, M. Kitazono, W. K. Oh, H. Kataoka, Y. Kakechi, Y. Terasaki, T. Miyagishima, Akira Yamada, A. Ono, R. Konno, M. Higashiguchi, Y. Namba, Hiroshi Kagamu, Eiki Ichihara, H. Nakasa, T. Yagi, Y. Tamaki, T. Onoe, N. Sonoda, Kazuhiko Nakagawa, H. Yamana, M. Sasaki, Yoji Ishida, K. Kaira, S. Yokoyama, W. Li, M. Tanioka, Eishi Baba, Hitoshi Kusaba, H. Suzuki, Sung Yong Oh, N. M. Hahn, Tomoko Kataoka, M. Mikami, Chikatoshi Katada, Y. Narita, J. Leach, T. Uehara, K. Miura, S. Yamamoto, O. Kobayashi, Kentaro Yamanaka, Katsuyuki Kiura, S. Hua, H. Miyao, Y. Kodama, Isamu Okamoto, K. Mikami, T. Hirashima, E. Konno, Naoko Chayahara, Junta Tanaka, Chang Fang Chiu, Hironobu Minami, Tadashi Hasegawa, Atsuo Okamura, T. Okusaka, K.-I. Nishiyama, M. Satouchi, Y. Maekawa, T. Kato, Rei Ono, F. Hongo, Mamoru Watanabe, T. Miki, M. Ogura, Masato Komoda, S. Natsugoe, Yuichi Takiguchi, I. Iwanaga, Hiroshi Soeda, Y. Fujiwara, M. Endo, H. Yasui, S. Katano, Satoshi Yuki, K. Nagai, H. Tsukuda, Jun Koshio, I. Hara, J. Tomomatsu, M. Kudo, Kenichi Yoshimura, T. Esaki, Satoshi Morita, R. Udagawa, M. Nakamura, S. Miura, K. Iwata, W. Su, N. Nonomura, S. J. Kim, Y. Omori, T. Shukuya, S. Y. Hyun, H. Hara, Yasunori Emi, M. Nezu, S. Tanimura, Koji Wada, Y. H. Min, D. Y. Hwang, Yoshito Komatsu, S. Takaishi, Kazuhiko Kobayashi, Mayumi Ono, K. Sato, Yuka Kato, T. Mine, S. Egawa, J. Li, N. Matsumura, Y. Tsuji, Hiroyuki Hata, Hirohisa Yoshizawa, S. Sogabe, Y. Guo, D. Kuroda, Chih-Cheng Chen, T. Takano, X. Hong, Y. D. Kim, K. Oda, Shoji Tokunaga, Masahiro Nozawa, Takeshi Sugawara, T. Fukui, Y. Saito, T. Fukuda, Yasuhisa Shinomura, Y. Yamashita, T. Minami, H. Mukai, Y. Ito, Ayumu Hosokawa, Hiroshi Nakatsumi, Y. Ohoka, S. Matsuyama, H. Takase, T. Akimoto, M. Ishizaki, T. Nakamura, Masahiro Tabata, T. Shimada, K. Shitara, Kimiharu Uozumi, T. Shiroyama, A. Umeta, N. Akakura, T.-Y. Chen, Kiyoko Kuwata, S. Emoto, Y. Naito, O. Muto, Cheolwon Suh, H. Oda, S. Fujii, Kenichiro Kudo, H. Hino, N. Morishita, Hiromichi Matsuoka, Y. Adachi, K. Minato, W.-Y. Kao, K. Hatake, Kosuke Ichikawa, Wataru Okamoto, S. H. Yoon, N. Wada, K. Uchida, U. Fujii, Ih-Jen Su, E. Vandendries, H. Ootsuka, Mitsuaki Tatsumi, K. Hatanaka, K. Matsui, M. Saijo, Fumihiko Fujita, W.-L. Hwang, Y. Negoro, M. Asanabe, Aya Kita, Hideo Baba, H. C. Chung, H. Igaki, J. Hashimoto, Yohei Funakoshi, Ukihide Tateishi, Masanori Toyoda, T. Feldman, Y. Kimura, T. Kondo, Yoshito Akagi, T. Kojima, A. Bamias, D. Takahari, Katsuyuki Hotta, K. Tobinai, K. Yamazaki, A. Volkert, T. Miyake, Hiroharu Yamashita, H. Iishi, Kazunori Murai, Y. Hata, M. Ri, H. Tomioka, S. Kato, M. Fukuoka, Y. Nakamura, Naomi Kiyota, Yee Soo Chae, T. Kimura, N. Gondo, Hiroshi Saeki, G. Sonpavde, H. S. Eom, K. Tane, Yasuo Ohashi, Yasuyuki Kawamoto, T. Beppu, T. Naito, M. Iwasaku, T. Ueda, R. Nakatake, Y. Umeyama, Takayasu Kurata, H. Kenmotsu, Hironori Ashinuma, Y. Miura, Ken-ichi Nibu, Y. Ogata, Toshihiro Miyamoto, N. Uike, K. Muro, S. Goya, Yasushi Takamatsu, Ichiei Narita, Chikashi Ishioka, T. Sueta, Satoshi Takeuchi, M.-C. Chang, Y. Iwanami, Yasuo Hamamoto, H. Kashihara, Yoshikazu Kotani, H. Daiko, Y. Kakugawa, J.-W. Cheong, T. Oochi, Joji Kitayama, K. Matsuo, M. Tamiya, Tzeon Jye Chiou, T. Sugiura, K. Kato, S. Krege, Masatomo Otsuka, A. Kitao, Y. Tanaka, Toru Mukohara, Masataka Taguri, Y. Hattori, T. Harada, Y. Hasegawa, S. Hoshino, K. Yoneyama, M. Ikeda, Shingo Tamura, H. Murakami, M. Kitada, K. Yanase, K. Nosho, and C. S. Chim
- Subjects
medicine.medical_specialty ,Chemotherapy ,medicine.diagnostic_test ,Colorectal cancer ,business.industry ,medicine.medical_treatment ,Cancer ,Hematology ,medicine.disease ,Gastroenterology ,Chemotherapy regimen ,Surgery ,Metastasis ,Oncology ,Pancreatic fistula ,Internal medicine ,medicine ,Gastrectomy ,business ,Laparoscopy - Abstract
Background The prognosis of gastric cancer with peritoneal metastasis is extremely poor. Neither systemic chemotherapy nor surgery alone prolongs survival of patients significantly. Methods Patients diagnosed with advanced gastric cancer underwent staging laparoscopy and received chemotherapy when peritoneal dissemination and/or cancer cells on peritoneal cytology were confirmed. The chemotherapy regimen consisted of S-1, weekly intravenous and intraperitoneal paclitaxel, which was verified in our phase II trial (Ann Oncol 2009). S-1 was administered at 80 mg/m2/day for 14 consecutive days, followed by 7 days rest. Paclitaxel was administered intravenously at 50 mg/m2 and intraperitoneally at 20 mg/m2 on days 1 and 8. Clinical response of chemotherapy was assessed by computed tomography, gastroendoscopy, peritoneal cytology and second-look laparoscopy. Radical gastrectomy was carried out when macroscopic curative resection was made achievable by chemotherapy. Chemotherapy was restarted after operation as soon as possible. Overall survival, relapse free survival, morbidity and mortality of gastrectomy were evaluated. Results Out of 100 patients with peritoneal metastasis who received chemotherapy, 60 patients underwent gastrectomy after response to chemotherapy, including 54 with macroscopic metastasis and 6 with positive peritoneal cytology only. A median of three courses were administered preoperatively (range 1–16). Total or distal gastrectomy with lymphnode dissection was carried out in 54 or 6 patients, respectively. The median survival time was 34.5 months. The median relapse-free survival was 16.7 months. The first site of relapse was the peritoneum in 24 patients and the other organ site in 17 patients. Postoperative complications included anastomotic leakage and pancreatic fistula in two patients each, which were healed conservatively. There were no treatment-related deaths. Conclusions Gastrectomy combined with S-1, intravenous and intraperitoneal paclitaxel is safe and active for gastric cancer patients with peritoneal metastasis.
- Published
- 2012
20. Suppressive effect of clenbuterol on citric acid-induced cough reflex in guinea pigs
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H, Horiuchi, T, Nonaka, M, Ito, T, Kaniwa, T, Kishimoto, J, Fuchikami, Y, Kohjimoto, and M, Kiyoki
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Male ,Serotonin ,Dose-Response Relationship, Drug ,Airway Resistance ,Guinea Pigs ,Citric Acid ,Bronchodilator Agents ,Cough ,Reflex ,Animals ,Clenbuterol ,Drug Interactions ,Citrates ,Serotonin Antagonists - Abstract
We previously demonstrated that clenbuterol suppressed bronchial hyperresponsiveness in acute bronchitic models. However the effect of clenbuterol on the cough reflex, the main symptom of acute bronchitis, is not clear. The present study was thus undertaken to investigate the influence of clenbuterol on the cough reflex. Oral administration of clenbuterol (3 and 10 micrograms/kg) to guinea pigs markedly inhibited the increase in the respiratory resistance in response to 5-HT in a dose-dependent manner. At doses of 10 micrograms/kg and above, clenbuterol significantly inhibited the cough reflex induced by citric acid in guinea pigs. These doses are comparable with those causing broncho-dilation as described above, suggesting that the suppressive effect of clenbuterol on the cough reflex in guinea pigs may result from mainly its broncho-dilative action via stimulation of beta-2 adrenoceptors in airway smooth muscles however, other mechanisms cannot be ruled out. These results indicate that this agent may be useful for treatment of cough, the main symptom of acute bronchitis.
- Published
- 1995
21. Preliminary Result of Calcium Oxalate Crystal Interaction With Madin-Darby Canine Kidney Cells in Culture
- Author
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M Uehara, T. Yoshida, T. Ohkawa, Y. Kohjimoto, and S. Ebisuno
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Kidney ,Primary culture ,Tubular cell ,urogenital system ,Chemistry ,Madin Darby canine kidney cell ,Calcium oxalate ,Cell biology ,chemistry.chemical_compound ,medicine.anatomical_structure ,Biochemistry ,Hyaluronic acid ,medicine ,Duct (anatomy) ,CALCIUM OXALATE MONOHYDRATE - Abstract
Recently, interactions of crystals and tubular cell of the kidney have been extensively examined on inner medullary collecting duct epithelial cells in primary culture by Wiessner et a11 and Riese et al2, 3. However, the exact and specific processes that mediate attachment of stone crystals to tubular epithelium are not yet known.
- Published
- 1994
22. [Adhesion of calcium oxalate crystal to Madin-Darby canine kidney cells: quantitative determination and effects of glycosaminoglycans (GAG) and cell injuries on adhesion]
- Author
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S, Ebisuno, T, Yoshida, Y, Kohjimoto, and T, Ohkawa
- Subjects
Dogs ,Calcium Oxalate ,Animals ,Crystallization ,Kidney ,Cells, Cultured ,Glycosaminoglycans - Abstract
The present investigation was designed to study adhesion of calcium oxalate crystals on the surface of intact MDCK cells quantitatively, and to estimate the effects of glycosaminoglycans (GAGs) and cell injuries on these adhesions. Calcium oxalate monohydrate (COM) crystals adhere to the cell surface by an active force, and the attachment is in a time and concentration dependency with plateau. Pre-treatments with low concentration of GAGs (chondroitin sulphate C, hyaluronic acid, heparan sulphate, heparin and sodium pentosan polysulphate) produce significant reductions of the adhesion. There are significant decreases of the adhesions with pre-treatments of Triton-X100, 0.1 N HCl and gentamicin. These phenomena might be induced by some alterations of cell surface structures or characters. The current quantitative system on MDCK cells should serve as a useful model for the investigations of interactions with crystals and tubular cells. Our studies may also support the hypothesis of attachment of microcrystals to the cellular membrane, which is one of the most important and the earliest process of the pathophysiology of kidney stone.
- Published
- 1993
23. [A case of retrovesical fibrosarcoma with severe hypoglycemia]
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A, Hirano, Y, Sawada, H, Aoshi, T, Komura, M, Matsumoto, Y, Kohjimoto, T, Inagaki, and T, Ohkawa
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Male ,Urinary Bladder Neoplasms ,Fibrosarcoma ,Humans ,Hypoglycemia ,Aged - Abstract
We report a case of retrovesical fibrosarcoma with severe hypoglycemia. A 67-year-old man was admitted to our hospital with second recurrence of the retrovesical tumor with hypoglycemia. The episodes of hypoglycemia were accompanied by the advance of tumor size. Complete tumor resection with total cystectomy was performed on December 21, 1989, and the tumor was diagnosed histopathologically as fibrosarcoma. Soon after removal of the tumor, hypoglycemia disappeared and the patient has been well without local recurrence or distant metastasis for more than 20 months.
- Published
- 1992
24. 3P-0911 Regression and stabilization of atherosclerosis by a cholesterol-lowering independent anti-inflammation effect of statin in cynomolgus monkeys
- Author
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S. Kitajima, Shiro Kitamoto, Y. Kohjimoto, K. Nakano, Kensuke Egashira, and Y. Hirouti
- Subjects
Statin ,business.industry ,medicine.drug_class ,Internal Medicine ,Medicine ,Cholesterol lowering ,Anti inflammation ,General Medicine ,Pharmacology ,Cardiology and Cardiovascular Medicine ,business - Published
- 2003
25. Effect of imipramine on high potassium evoked 3H-dopamine release in the rat striatum
- Author
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H, Kamiya, Y, Takano, Y, Sakurai, R, Saito, and Y, Kohjimoto
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Male ,Imipramine ,Nomifensine ,Cocaine ,Dopamine ,Potassium ,Animals ,Calcium ,Corpus Striatum ,Rats - Abstract
The effects of three different types of dopamine (DA) uptake inhibitor, imipramine, cocaine and nomifensine, were examined on high potassium evoked 3H-DA release using tissues obtained from rat striatum by a micropuncture technique. Imipramine caused an increase in 3H-DA efflux and this imipramine-induced efflux is Ca2+-independent. Moreover, imipramine reduced the high potassium evoked release, and at 50 microM, the release by potassium stimulation was entirely abolished. These results support that imipramine depletes vesicular DA which is released by potassium stimulation as well as an inhibitory effect on DA uptake. However, nomifensine dose not have such an effect.
- Published
- 1981
26. Comparative study of tiapride and neuroleptics with anti-dopamine activity on convulsive seizure in mice
- Author
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H, Satoh, H, Nakanishi, K, Shirakawa, Y, Kohjimoto, T, Kuwaki, T, Ono, and F, Shibayama
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Mice ,Mice, Inbred ICR ,Seizures ,Tiapamil Hydrochloride ,Benzamides ,Animals ,Dopamine Antagonists ,Anticonvulsants ,Female ,Electric Stimulation ,Antipsychotic Agents - Abstract
The effects of tiapride on the convulsive seizures induced by pentylenetetrazole, strychnine, picrotoxin and bemegride, and on electric seizure are reported and compared with those of sulpiride, chlorpromazine, haloperidol and reserpine. The number of deaths and intensity of convulsion increased dose-dependently and also with the increase in amplitude of electric shock. Tiapride and a similar compound, sulpiride, did not affect these seizures, whereas chlorpromazine potentiated strychnine-induced and electric seizure. Haloperidol and reserpine potentiated electric seizure, and chlorpromazine and reserpine tended to potentiate bemegride-induced seizure. Reserpine also tended to potentiate pentylenetetrazole-induced seizure. These results suggest that tiapride would be clinically safer than other drugs with anti-dopamine activity, except for sulpiride.
- Published
- 1987
27. Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol
- Author
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H, Satoh, T, Kuwaki, K, Shirakawa, Y, Kohjimoto, T, Ono, F, Shibayama, and Y, Nomura
- Subjects
Brain Chemistry ,Male ,Apomorphine ,Dopamine ,Tiapamil Hydrochloride ,Homovanillic Acid ,Rats, Inbred Strains ,Rats ,Receptors, Dopamine ,Antiparkinson Agents ,Spiperone ,Benzamides ,3,4-Dihydroxyphenylacetic Acid ,Animals ,Haloperidol ,Sulpiride - Abstract
The effects of long-term dosing with tiapride for 21 days on barin dopamine receptors and dopamine turnover were compared with those of sulpiride and haloperidol. Haloperidol caused an increase in both antagonist (3H-spiperone) labeled receptors and agonist (3H-N,n-propylnorapomorphine) labeled ones, whereas tiapride acted on the agonist binding sites and sulpiride acted on the antagonist binding sites. The increases induced by sulpiride were only observed in the striatum, while those induced by tiapride and haloperidol were observed in both the striatum and limbic area. Dopamine and dopamine metabolites in the brain tissues were measured at 2 hr and 3 days after long-term dosing with the drugs as an indicator of dopamine turnover. They were higher at 2 hr and lower at 3 days than those of the saline treated controls; however, the increase at 2 hr was much less than that after single acute dosing with drugs. This suggested that all drugs induced tolerance with regard to dopamine turnover. In these studies, tiapride and sulpiride were less active than haloperidol in the effects on brain dopamine receptors and dopamine turnover. This generally weaker activity of sulpiride and tiapride suggest that the benzamide drugs have fewer side effects such as a tardive dyskinesia, than does haloperidol, even after long-term dosing. Furthermore, a slight difference between the effects of tiapride and sulpiride on the dopamine receptor subtypes in the brain subdivision was suggested.
- Published
- 1987
28. Local extension findings on MRI compensate for the ability of pathological staging to predict oncological outcome.
- Author
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Wakamiya T, Kohjimoto Y, Yamashita S, and Hara I
- Abstract
Background: We investigated whether local extension findings on preoperative MRI and excisional pathology are associated with positive surgical margin and biochemical recurrence after robot-assisted radical prostatectomy., Methods: We identified 704 of our patients that underwent robot-assisted radical prostatectomy between 2012 and 2020, and extracted the 326 patients who had preoperative MRI scans and a radiologist reading. These patients were classified into groups according to the presence of local extension on MRI and pathological findings: ≤ cT2pT2 (195 cases), ≤ cT2pT3 (55 cases), cT3pT2 (31 cases), and cT3pT3 (45 cases). We compared positive surgical margin and biochemical recurrence between them., Results: Median age was 69 years, positive surgical margin rate was 20.2%, and five-year biochemical recurrence rate was 20.3%. Of the 226 patients without local invasion on excisional pathology, those with local extension on MRI (cT3pT2) had relatively higher positive surgical margin rate (29.0% vs. 14.4%, p = 0.05) and significantly higher five-year biochemical recurrence rate (25.8% vs. 9.3%, p = 0.01) than those without local extension on MRI (≤ cT2pT2). Similarly, among the 100 patients with local extension on excisional pathology, those with cT3pT3 had relatively higher positive surgical margin (37.8% vs. 21.8%, p = 0.08) and significantly higher five-year biochemical recurrence (53.3% vs. 29.3%, p = 0.01) than those with ≤ cT2pT3. In multivariate analysis, local extension on MRI was an independent predictor of biochemical recurrence (OR 2.1, 95%CI 1.1-3.9, p = 0.01)., Conclusions: Local extension on MRI is a prognostic factor independent of pathological stage. The use of MRI may complement the prognostic value of excisional pathology of prostate cancer., (© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.)
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- 2024
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29. Lower extremity pain and/or numbness after laparoscopic surgery and robot-assisted surgery in the lithotomy position combined with the Trendelenburg position.
- Author
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Yamasaki K, Fujii K, Kohjimoto Y, Matsuda K, Iwamoto H, Kawai M, Wan K, and Kawamata T
- Abstract
Purpose: The purpose of this study was to investigate the incidence and risk factors of lower extremity pain and/or numbness after laparoscopic colorectal surgery and robot-assisted laparoscopic radical prostatectomy in the lithotomy position combined with the Trendelenburg position. The relationship between creatine kinase (CK) levels and lower extremity pain and/or numbness was also investigated., Methods: We retrospectively reviewed adult patients who underwent laparoscopic colorectal surgery and robot-assisted laparoscopic radical prostatectomy in the lithotomy position combined with the Trendelenburg position between May 2015 and April 2020. Logistic regression analysis was used to identify risk factors of lower extremity pain and/or numbness. Preoperative and postoperative CK levels were compared in patients with and those without lower extremity pain and/or numbness., Results: Among 940 patients, 1.9% experienced lower extremity pain and/or numbness postoperatively. The incidences of lower extremity pain and/or numbness after laparoscopic colorectal surgery and after robot-assisted laparoscopic radical prostatectomy were 1.7% and 2.1%, respectively. Multivariate logistic regression analysis revealed that only duration of surgery > 4 h (odds ratio = 3.144, 95% CI: 1.102-8.969, p = 0.032) was a significant predictor of lower extremity pain and/or numbness. Postoperative median CK level in patients with lower extremity pain and/or numbness was significantly higher than that in patients without lower extremity pain and/or numbness., Conclusion: The incidence of lower extremity pain and/or numbness after laparoscopic colorectal surgery was comparable to that after robot-assisted laparoscopic radical prostatectomy. Prolonged duration of surgery contributed to lower extremity pain and/or numbness. Significantly elevated CK levels in patients with lower extremity pain and/or numbness suggest the involvement of muscle injury in these symptoms., (© 2024. The Author(s) under exclusive licence to Japanese Society of Anesthesiologists.)
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- 2024
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30. Japanese clinical practice guidelines for prostate cancer 2023.
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Kohjimoto Y, Uemura H, Yoshida M, Hinotsu S, Takahashi S, Takeuchi T, Suzuki K, Shinmoto H, Tamada T, Inoue T, Sugimoto M, Takenaka A, Habuchi T, Ishikawa H, Mizowaki T, Saito S, Miyake H, Matsubara N, Nonomura N, Sakai H, Ito A, Ukimura O, Matsuyama H, and Hara I
- Abstract
This fourth edition of the Japanese Clinical Practice Guidelines for Prostate Cancer 2023 is compiled. It was revised under the leadership of the Japanese Urological Association, with members selected from multiple academic societies and related organizations (Japan Radiological Society, Japanese Society for Radiation Oncology, the Department of EBM and guidelines, Japan Council for Quality Health Care (Minds), Japanese Society of Pathology, and the patient group (NPO Prostate Cancer Patients Association)), in accordance with the Minds Manual for Guideline Development (2020 ver. 3.0). The most important feature of this revision is the adoption of systematic reviews (SRs) in determining recommendations for 14 clinical questions (CQs). Qualitative SRs for these questions were conducted, and the final recommendations were made based on the results through the votes of 24 members of the guideline development group. Five algorithms based on these results were also created. Contents not covered by the SRs, which are considered textbook material, have been described in the general statement. In the general statement, a literature search for 14 areas was conducted; then, based on the general statement and CQs of the Japanese Clinical Practice Guidelines for Prostate Cancer 2016, the findings revealed after the 2016 guidelines were mainly described. This article provides an overview of these guidelines., (© 2024 The Japanese Urological Association.)
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- 2024
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31. Implication of KMT2C and TSC2 variants in the tumorigenesis of acquired cystic disease-associated renal cell carcinomas.
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Kojima F, Matsuzaki I, Musangile FY, Sagan K, Mikasa Y, Iwamoto R, Kohjimoto Y, Hara I, and Murata SI
- Abstract
In 2020, acquired cystic disease-associated renal cell carcinomas (ACD-RCCs) were reported to harbor KMT2C and TSC2 variants: however, their carcinogenic implication has not yet been reported. This study aimed to explore the variant features of KMT2C and TSC2 in ACD-RCC and their implication in ACD-RCC tumorigenesis. Eleven ACD-RCCs, 10 ACD-RCC-like cysts, and 18 background kidneys were retrieved. The background kidneys consisted of atrophic thyroid follicle-like tubules. They included four with clustered cysts, two with eosinophilic changes, and one each with clear cell changes and sieve-like changes in the renal tubules. First, DNA-targeted sequencing of KMT2C and TSC2 whole exons was performed on eight ACD-RCC samples. Subsequently, a custom DNA panel was designed to include the recurrent KMT2C and TSC2 variants based on the sequencing results. Second, DNA-targeted sequencing was performed on the remaining samples using a custom panel targeting the recurrent variants. Additionally, immunohistochemistry was performed for KMTC, H3K4me1, H3K4me3, TSC2, and GPNMB on the ACD-RCCs. Six of the 11 ACD-RCC cases harbored KMT2C and TSC2 variants, including nine likely pathogenic variants. In contrast to ACD-RCC, 1 of the 9 ACD-RCC-like cysts harbored both variants. Immunohistochemical analysis did not support the loss of function in ACD-RCCs harboring KMT2C and TSC2 variants. KMT2C and TSC2 variant frequencies were higher in ACD-RCC than in other renal cell carcinomas. However, KMT2C and TSC2 are unlikely to be the primary drivers of ACD-RCC development., Competing Interests: Declaration of competing interest The authors declare no competing financial interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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32. Significance of androgen-deprivation therapy for intermediate- and high-risk prostate cancer treated with high-dose radiotherapy: A literature review.
- Author
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Aizawa R, Ishikawa H, Kato M, Shimizu S, Mizowaki T, Kohjimoto Y, Hinotsu S, and Hara I
- Abstract
The real-world benefits of adding androgen-deprivation therapy (ADT) and its optimal duration when combined with current standard high-dose radiation therapy (RT) remain unknown. We aimed to assess the efficacy of and toxicities associated with ADT in the setting of combination with high-dose RT for intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). This article is a modified and detailed version of the commentary on Clinical Question 8 described in the Japanese Clinical Practice Guidelines for Prostate Cancer (ver. 2023). A qualitative systematic review was performed according to the Minds Guide. All relevant published studies between September 2010 and August 2020, which assessed the outcomes of IR or HR PCa treated with high-dose RT, were screened using two databases (PubMed and ICHUSHI). A total of 41 studies were included in this systematic review, mostly consisting of retrospective studies (N = 34). The evidence basically supports the benefit of adding ADT to high-dose RT to improve tumor control. Regarding IR populations, many studies suggested the existence of a subgroup for which adding ADT had no impact on either overall survival or the BF-free duration. On the other hand, regarding HR populations, several studies suggested the positive impact of adding ADT for ≥1 year on overall survival. Adding ADT increases not only the risk of sexual dysfunction but also that of cardiovascular toxicities or bone fracture. Although the benefit of adding ADT was basically suggested for both IR and HR populations, further investigations are warranted to identify subgroups of patients for whom ADT has no benefit, as well as the appropriate duration of ADT for those who do derive benefit., (© 2024 The Author(s). International Journal of Urology published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Urological Association.)
- Published
- 2024
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33. Verification of surgical factors affecting the efficiency of stone extraction with one-surgeon basketing technique using a f-URSL simulation model.
- Author
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Deguchi R, Yamashita S, Iwahashi Y, Kawabata H, Muraoka S, Wakamiya T, Kohjimoto Y, and Hara I
- Subjects
- Humans, Kidney Calculi surgery, Clinical Competence, Simulation Training, Models, Anatomic, Ureteroscopes, Ureteroscopy methods, Lithotripsy methods
- Abstract
Purpose: Stone extraction is an important treatment option when performing flexible ureteroscopic lithotripsy (f-URSL) for upper urinary stones. We used a f-URSL simulator model to investigate surgical factors affecting the efficacy of stone extraction with the one-surgeon basketing technique., Materials and Methods: This simulator-based study involved eight urologists and eight residents. These participants each performed two tasks, with Flexor (Cook Medical) and Navigator (Boston Scientific) ureteral access sheaths, with and without the M-arm (MC Medical) single-use basket holder, and with models representing both left and right kidneys. The two tasks were to touch each renal calix with the ureteroscope, and to extract stones. As outcomes, we recorded the number of times that the ureteroscope became stuck during insertion, the number of times a stone was dropped during removal, the number of times the basket forceps were opened and closed, and the time required to accomplish each task., Results: The ureteroscope became stuck significantly more often when Navigator was used compared with Flexor overall, and for both urologists and residents (all p<0.01). Stones were dropped significantly more often on the ipsilateral side (kidney on the same side as the operator's hand) than on the contralateral side overall (p=0.01), and the basket forceps were opened and closed significantly more often on the ipsilateral side than on the contralateral side both overall and by residents (all p<0.01)., Conclusions: The efficiency of stone extraction during f-URSL with the one-surgeon basketing technique was affected by differences in ureteral access sheath and the kidney side., Competing Interests: The authors have nothing to disclose., (© The Korean Urological Association.)
- Published
- 2024
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34. Poor performance status is a risk factor for higher detection of Gram positive coccus in stone-related pyelonephritis.
- Author
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Kawabata H, Iwahashi Y, Deguchi R, Muraoka S, Wakamiya T, Yamashita S, Kohjimoto Y, Koizumi Y, Shigemura K, and Hara I
- Subjects
- Humans, Retrospective Studies, Risk Factors, Escherichia coli, Pyelonephritis microbiology, Urinary Tract Infections drug therapy, Gram-Positive Cocci
- Abstract
Introduction: We aimed to investigate the detection rate of causative organisms in stone-related pyelonephritis and to compare their distribution according to patient backgrounds., Methods: We retrospectively identified patients with stone-related pyelonephritis. Clinical data were collected between November 2012 and August 2020 at Wakayama Medical University Hospital, including on patient backgrounds and causative organisms. Patients were categorized by Eastern Cooperative Oncology Group performance status (PS) as the good PS group (0, 1) and the poor PS group (2-4). Bacteria were divided into Gram-positive cocci (GPC) or non-GPC groups and logistic regression analysis was used to examine factors that predict detection of GPC., Results: Seventy-nine patients had stone-related pyelonephritis, 54 (68.4 %) in the good PS group and 25 (31.6 %) in the poor PS group. In the good PS group, Escherichia coli (67 %) was followed by Klebsiella species (9 %), while in the poor PS group, Escherichia coli (20 %) was followed by Enterococci and Staphylococci (12 %). GPC detection rate was significantly higher in the poor PS group than in the good PS group (40.0 % vs 14.8 %, p = 0.016), and multivariate logistic regression analysis showed that poor PS was an independent factor predicting detection of GPC (OR = 6.54, p = 0.02)., Conclusions: The distribution of the causative organisms in stone pyelonephritis was similar to that in common complicated urinary tract infections. Poor PS may be an independent predictor of GPC detection in patients with stone pyelonephritis., Competing Interests: Declaration of competing interest The authors declare conflict of interest., (Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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35. Association of lung immune prognostic index with survival outcomes in patients with metastatic renal cell carcinoma treated with nivolumab plus ipilimumab.
- Author
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Yamashita S, Hamamoto S, Furukawa J, Fujita K, Takahashi M, Miyake M, Ito N, Iwamoto H, Kohjimoto Y, and Hara I
- Subjects
- Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Prognosis, Adult, Aged, 80 and over, Neutrophils, Carcinoma, Renal Cell drug therapy, Carcinoma, Renal Cell mortality, Carcinoma, Renal Cell secondary, Carcinoma, Renal Cell immunology, Ipilimumab administration & dosage, Ipilimumab therapeutic use, Nivolumab administration & dosage, Nivolumab therapeutic use, Kidney Neoplasms drug therapy, Kidney Neoplasms pathology, Kidney Neoplasms mortality, Kidney Neoplasms immunology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lung Neoplasms drug therapy, Lung Neoplasms mortality, Lung Neoplasms secondary, Lung Neoplasms pathology, Lung Neoplasms immunology
- Abstract
Objective: Lung immune prognostic index is based on derived neutrophil-to-lymphocyte ratio and lactate dehydrogenase level. Lung immune prognostic index has reported association with survival outcomes in patients with various malignancies undergoing treatment with immune checkpoint inhibitors. However, the prognostic impact of pre-treatment lung immune prognostic index in patients with metastatic renal cell carcinoma receiving nivolumab plus ipilimumab treatment remains unclear. This study examines the association between lung immune prognostic index and outcomes in this setting., Methods: We retrospectively evaluated 156 patients with metastatic renal cell carcinoma treated with nivolumab plus ipilimumab at eight institutions. We assessed the associations between pre-treatment lung immune prognostic index and survival outcomes including progression-free survival, second progression-free survival (PFS2), cancer-specific survival and overall survival., Results: Patients were classified into good (n = 84, 54%), intermediate (n = 52, 33%) and poor (n = 20, 13%) lung immune prognostic index groups. Progression-free survival did not significantly differ between lung immune prognostic index groups, but there was significant difference in PFS2, cancer-specific survival and overall survival. In multivariable Cox proportional hazard analyses, high pre-treatment lung immune prognostic index was a significant predictor of poor PFS2 (vs. good group, intermediate group: P = 0.01 and poor group: P = 0.04) and poor overall survival (vs. good group, intermediate group: P = 0.01 and poor group: P < 0.01). Moreover, the patients with poor lung immune prognostic index had significantly poorer cancer-specific survival than those with good LIPI (P < 0.01)., Conclusions: High pre-treatment LIPI is suggested by our results to be a significant independent predictor of poor prognosis in patients receiving nivolumab plus ipilimumab for metastatic renal cell carcinoma., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
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36. Impact of postoperative sexual function on health-related quality of life after robot-assisted radical prostatectomy.
- Author
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Iwahashi Y, Deguchi R, Muraoka S, Wakamiya T, Yamashita S, Kikkawa K, Kohjimoto Y, and Hara I
- Abstract
Background: We investigated potential disparities in health-related quality of life, particularly concerning urinary function, between patients with preserved and those with impaired sexual function after robot-assisted radical prostatectomy (RARP)., Materials and Methods: Between December 2012 and April 2020, 704 men underwent RARP in our hospital. This study included 155 patients with a preoperative 5-item International Index of Erectile Function (IIEF-5) of ≥12 points and an assessable IIEF-5 at 12 months postoperatively. Health-related quality of life was assessed using the 8-item Short-Form Health Survey and Expanded Prostate Cancer Index Composite (EPIC) preoperatively and at 3, 6, and 12 months postoperatively. A logistic regression analysis and Wilcoxon rank sum tests were performed., Results: Patients were grouped according to the median IIEF-5 score 12 months after surgery: those with preserved sexual function (n = 71) and those with impaired sexual function (n = 84). The mental component summary of the 8-item Short-Form Health Survey was better in the group with preserved sexual function at 6 months postoperatively than in the group with impaired sexual function ( p < 0.01). In the EPIC, the group with preserved sexual function performed better not only in the sexual domain but also in the urinary domain at all time points compared with the group with impaired sexual function ( p < 0.01). In the comparison of the urinary subdomains of the EPIC, there were no significant differences in urinary function or incontinence, but there were significant differences in urinary distress and irritative/obstructive scores ( p < 0.01)., Conclusions: Patients with preserved postoperative sexual function after RARP showed better urinary function than those with impaired sexual function. Hence, preserved sexual function is closely associated with urinary function., Competing Interests: The authors declare that they have no conflict of interest., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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37. Prognostic impact of FAN score in patients receiving nivolumab plus ipilimumab for metastatic renal cell carcinoma.
- Author
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Yamashita S, Hamamoto S, Furukawa J, Fujita K, Takahashi M, Miyake M, Ito N, Iwamoto H, Kohjimoto Y, and Hara I
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Prognosis, Retrospective Studies, Adult, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Progression-Free Survival, Neoplasm Metastasis, Nivolumab therapeutic use, Nivolumab administration & dosage, Ipilimumab administration & dosage, Ipilimumab therapeutic use, Carcinoma, Renal Cell drug therapy, Carcinoma, Renal Cell mortality, Carcinoma, Renal Cell pathology, Kidney Neoplasms drug therapy, Kidney Neoplasms pathology, Kidney Neoplasms mortality
- Abstract
FAN score is reportedly associated with prognostic outcomes in patients with urothelial carcinoma being treated with immune check point inhibitors. However, the prognostic impact of pre-treatment FAN score in patients with metastatic renal cell carcinoma (RCC) treated with nivolumab plus ipilimumab remains unclear. We retrospectively evaluated the association between pre-treatment FAN score and prognostic outcomes in 154 patients with metastatic RCC treated with nivolumab plus ipilimumab. The pre-treatment FAN score was '0' in 56 patients (36%), '1' in 60 patients (40%), '2' in 37 patients (24%) and '3' in one patient (1%). Progression-free survival was not significantly different between patients with different FAN scores, but second progression-free survival (PFS2), cancer-specific survival (CSS) and overall survival (OS) were significantly different. In multivariable Cox proportional hazard analyses, FAN score ≥ 2 was a significant predictor of poor PFS2 (vs. FAN score 0, HR: 2.43, 95% CI 1.21-4.87, P = 0.01), poor CSS (vs. FAN score 0, HR: 2.71, 95% CI 1.13-6.47, P = 0.02) and poor OS (vs. FAN score 0, HR: 2.42, 95% CI 1.11-5.25, P = 0.02). High pre-treatment FAN score could be a significant independent predictor of poor prognosis in patients receiving nivolumab plus ipilimumab for metastatic RCC., (© 2024. The Author(s).)
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- 2024
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38. Effect of nephrostomy sheath size on renal pelvic pressure during endoscopic combined intrarenal surgery: artificial kidney model study.
- Author
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Iguchi T, Yamashita S, Kohjimoto Y, Tanioku T, Kawamata T, and Hara I
- Subjects
- Humans, Ureteroscopy methods, Kidney Pelvis surgery, Kidney surgery, Ureteroscopes, Nephrotomy, Kidneys, Artificial, Ureter surgery, Kidney Calculi surgery
- Abstract
Background: This study aimed to evaluate the intrarenal pelvic pressure in endoscopic combined intrarenal surgery using an artificial kidney model., Methods: An artificial kidney model was created using the Urovac evacuator™. Four sizes of nephrostomy sheaths (MIP-L: 25/26 Fr, MIP-M: 16.5/17.5 Fr, MIP-S: 11/12 Fr, MIP-XS: 8.5/9.5 Fr) and two sizes of ureteral access sheaths (12/14 Fr and 10/12 Fr) were installed into the model. For each combination of nephrostomy and ureteral access sheath, renal pelvic pressure was measured with and without insertion of the retrograde flexible ureteroscope. Irrigation from the nephroscope was adjusted to 40-160 mmHg using an automatic irrigation device, and the irrigation of the ureteroscope was by spontaneous dripping at 80 cmH
2 O. Conditions were measured six times, and the renal pelvic pressure was compared in different conditions., Results: Without ureteroscope insertion through the ureteral access sheath, the renal pelvic pressure never exceeded 30 mmHg. Meanwhile, when the ureteroscope was inserted, the renal pelvic pressure increased as the nephrostomy sheath and ureteral access sheath became narrower and as the irrigation pressure increased. Intrarenal pelvic pressure exceeded 30 mmHg when the irrigation pressure was increased in 12/14 Fr ureteral access sheath when MIP-XS was used, and in 10/12 Fr ureteral access sheath when MIP-XS and MIP-S were used., Conclusions: The use of a thin nephrostomy sheath in endoscopic combined intrarenal surgery can lead to increased intrarenal pelvic pressure. Although our results are from an artificial kidney model, special care is suggested to be required when using a retrograde flexible ureteroscope simultaneously in treatment of patients., (© 2024. The Author(s).)- Published
- 2024
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39. Area of hydronephrosis is a useful predictive factor of impacted ureteral stones.
- Author
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Iwahashi Y, Kohjimoto Y, Deguchi R, Wakamiya T, Yamashita S, and Hara I
- Subjects
- Humans, Retrospective Studies, Kidney Pelvis, Ureteral Calculi complications, Ureteral Calculi therapy, Hydronephrosis etiology, Lithotripsy
- Abstract
Ureteroscopic lithotripsy for impacted stones is challenging, but it is important to predict impacted stones preoperatively. Hydronephrosis, which is evaluated by a grading system, is often apparent in impacted stones. However, the currently used grading system is a qualitative evaluation. We, therefore, focused on a quantitative evaluation: the area of hydronephrosis. The aim of this study was to investigate whether the area of hydronephrosis could predict impacted stones more accurately than Society for Fetal Urology grade. We retrospectively identified 160 patients who underwent ureteroscopic lithotripsy for ureteral stones at our hospital between January 2014 and April 2022. Impacted stones were defined as stones fixed to the ureteral wall that could not be moved by means of ureteroscopic manipulation or water pressure. Of the 160 patients, 54 (33.8%) had impacted stones. Comparing patient characteristics, there were significant differences in stone size, ureteral wall thickness, Society for Fetal Urology grade, renal pelvic width and area of hydronephrosis (all P < 0.01). Receiver operating characteristic analysis showed that area of hydronephrosis was the more significant predictive value (area under the curve 0.781) compared with Society for Fetal Urology grade (area under the curve 0.676, P < 0.01). Multivariate analysis revealed that significant independent predictive factors of impacted stones were thicker ureteral wall thickness and larger area of hydronephrosis (both P < 0.01). The area of hydronephrosis and ureteral wall thickness were significant predictors of impacted stones in patients undergoing ureteroscopic lithotripsy for ureteral stones. These factors may be useful for selecting the treatment and preoperative settings., (© 2024. The Author(s).)
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- 2024
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40. hinotori TM vs. da Vinci ® : propensity score-matched analysis of surgical outcomes of robot-assisted radical prostatectomy.
- Author
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Kohjimoto Y, Yamashita S, Iwagami S, Muraoka S, Wakamiya T, and Hara I
- Subjects
- Male, Humans, Propensity Score, Treatment Outcome, Prostatectomy methods, Robotic Surgical Procedures methods, Robotics
- Abstract
hinotori™ is a recently developed surgical robot system. The present study aims to compare intraoperative and postoperative outcomes of robot-assisted radical prostatectomy (RARP) by the hinotori™ system compared with those of the longer-established da Vinci
® system. This study includes 100 consecutive patients who underwent RARP by da Vinci® and 60 patients who underwent RARP by hinotori™. To minimize imbalances of patient demographics between the two groups, 1:1 propensity score-matching was performed, and 43 patients each were assigned to the da Vinci® and hinotori™ groups after matching. In the propensity score-matched cohort, we could not find significant differences in patient demographics between the two groups. Surgical outcomes, operative time, and console time in the hinotori™ group were significantly longer than those in the da Vinci® group. Meanwhile, we could not find significant differences in other outcomes between the two groups, such as estimated blood loss, intraoperative complications, major postoperative complications (Clavien-Dindo grade 3 or 4) or length of hospital stay after surgery. The rate of positive cancer margin in the hinotori™ group was higher than that in the da Vinci® group, but significant difference could not be found between the two groups. Moreover, we could not find significant differences in urinary continence rates after surgery between the da Vinci® and hinotori™ groups. Our results suggest that the hinotori™ surgical robot system could provide comparable surgical outcomes to that of the da Vinci® system for patients undergoing RARP., (© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)- Published
- 2024
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41. Laparoscopic Nephrectomy Via the Retroperitoneal Approach for Autosomal Dominant Polycystic Kidney Disease After Renal Transplant: A Case Report.
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Kikkawa K, Yamamoto H, Kohjimoto Y, and Hara I
- Subjects
- Male, Humans, Middle Aged, Kidney, Nephrectomy, Retrospective Studies, Polycystic Kidney, Autosomal Dominant diagnosis, Polycystic Kidney, Autosomal Dominant diagnostic imaging, Kidney Transplantation adverse effects, Laparoscopy
- Abstract
We report a case of laparoscopic nephrectomy via the retroperitoneal approach for autosomal dominant polycystic kidney disease after renal transplant. A 54-year-old male patient with end-stage renal failure because of autosomal dominant polycystic kidney disease underwent a living donor renal transplant and right nephrectomy via open surgery through a median abdominal incision 5 years previously. However, the left kidney gradually became enlarged. We performed laparoscopic left nephrectomy via the retroperitoneal approach. After dissecting the renal vessels, we performed cyst puncture and aspiration to decrease the kidney volume. The patient's symptoms improved after operation. Laparoscopic nephrectomy for enlarged kidneys with multiple cysts can be safely performed, and the retroperitoneal approach can be preferred if the patient has a history of abdominal surgery or an enlarged polycystic kidney.
- Published
- 2024
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- View/download PDF
42. Efficacy of Bisphosphonate for Urolithiasis Complicated by Osteogenesis Imperfecta.
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Deguchi R, Kohjimoto Y, Maruyama Y, Iwahashi Y, Muraoka S, Wakamiya T, Yamashita S, and Hara I
- Subjects
- Male, Humans, Adult, Diphosphonates therapeutic use, Kidney, Calcium Oxalate analysis, Calcium, Osteogenesis Imperfecta complications, Osteogenesis Imperfecta drug therapy, Urolithiasis complications, Urolithiasis drug therapy
- Abstract
A 44-year-old man with osteogenesis imperfecta presented with left renal colic. Non-contrast computed tomography revealed a stone (10×9 mm) in the left upper ureter. Ureteroscopic lithotripsy was performed twice and stone-free status was achieved. An analysis of the stone revealed a mixed composition including calcium oxalate and calcium phosphate. Postoperatively, we administered bisphosphonates to prevent recurrence of urolithiasis, as 24-hour urine collection revealed marked hypercalciuria. Eighteen months after surgery, the urinary calcium levels had normalized, and there was no recurrence of urolithiasis. Osteogenesis imperfecta can be complicated by urolithiasis, but bisphosphonates may be useful in preventing recurrence of this disease.
- Published
- 2024
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43. In vitro comparison of simulated intrapelvic pressure in an artificial kidney model during retrograde intrarenal surgery among various single-use ureteroscopes.
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Yamashita S, Tanioku T, Deguchi R, Iwahashi Y, Higuchi M, Maruyama Y, Inoue T, Kikkawa K, Kohjimoto Y, Kawamata T, and Hara I
- Subjects
- Humans, Ureteroscopes, Ureteroscopy, Pressure, Equipment Design, Kidney Calculi surgery, Kidneys, Artificial, Ureter surgery
- Abstract
Objectives: This study compares intrapelvic pressure (IPP) during retrograde intrarenal surgery with various single-use flexible ureteroscopes (f-URS) in an artificial kidney model., Methods: We created an artificial kidney model with a pressure sensor using a bladder evacuation device. The model was completely closed and the only backflow was on the side of the ureteroscope inside the ureteral access sheath (UAS). We tested five single-use f-URSs (LithoVue, Wiscope, PU3022A, PU3033A, and AXIS) with six different types of UAS (9.5/11.5-14/16 Fr). Using the automatic irrigation system, 30 s of irrigation was performed at various pressures (40-180 mmHg) and steady-state IPP was recorded. IPP was compared between the five single-use f-URSs. IPP cutoff value was determined at 30 mmHg. The diameter of the endoscope tip and the curved and shaft parts were also measured and recorded., Results: The diameters of all parts were significantly different between single-use f-URSs. The maximum IPP tended to be higher in ureteroscopes with larger diameters of the proximal parts (curved part/shaft part). In LithoVue and Uscope PU3022A f-URSs, the maximum IPP did not exceed 30 mmHg when UAS ≥12/14 Fr was used. In AXIS and Wiscope f-URSs, it did not exceed the cutoff value when the UAS ≥11/13 Fr was used. In Uscope PU3033A f-URS, it did not exceed 30 mmHg when the UAS ≥10/12 Fr was used., Conclusions: Maximum IPP tended to be higher in f-URSs with larger diameters of the proximal part and the appropriate size of the UAS differed between various single-use f-URSs., (© 2023 The Japanese Urological Association.)
- Published
- 2024
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44. Clinicopathological and molecular features of renal cell carcinomas with haemangioblastoma-like features distinct from clear cell renal cell carcinoma.
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Kojima F, Matsuzaki I, Musangile FY, Kinoshita Y, Otani T, Abe K, Asai A, Kohjimoto Y, Kondo T, Hara I, and Murata SI
- Subjects
- Humans, Kidney pathology, Mutation, Carcinoma, Renal Cell genetics, Carcinoma, Renal Cell pathology, Kidney Neoplasms genetics, Kidney Neoplasms pathology, Hemangioblastoma
- Abstract
Aims: Haemangioblastomas arise in the central nervous system. Rarely, haemangioblastomas may develop in extra-neural sites, such as the kidneys. A few reported cases of renal cell carcinomas (RCCs) with haemangioblastoma-like features have exhibited both clear cell renal cell carcinoma (CCRCC)- and haemangioblastoma-like components. The clinicopathological and molecular characteristics of RCCs with haemangioblastoma-like features were analysed, focusing on VHL alterations, in comparison with CCRCCs partially resembling haemangioblastoma., Methods and Results: Four RCCs with haemangioblastoma-like features and five CCRCCs partially resembling haemangioblastoma were included. The RCCs with haemangioblastoma-like features were indolent and lacked adverse prognostic factors. All RCCs with haemangioblastoma-like features had a well-circumscribed appearance and a thick fibromuscular capsule, with fibromuscular bundles extending into the tumour to varying degrees in the three tumours. Each RCC with haemangioblastoma-like features exhibited CCRCC-like areas with indistinct tubular structures and foci of haemangioblastoma-like areas, in which vessels and short spindle cells overwhelmed tumour cells. Whereas haemangioblastoma-like areas in the CCRCCs partially resembling haemangioblastoma exhibited sparse vessels and spindle cells and distinct clear cells. The RCCs with haemangioblastoma-like features exhibited a unique immunohistochemical profile, with positive staining for inhibin-α, S100, carbonic-anhydrase-9, keratin7, and high molecular weight keratin and negative staining for (alpha-methylacyl-CoA racemase) AMACR. RCC with haemangioblastoma-like features did not display any VHL alterations, including VHL mutation, 3p LOH, and methylation of the VHL promoter region, and the two tumours harboured a likely oncogenic missense variant of MTOR (c.7280T>G)., Conclusion: The histopathological, immunohistochemical, and molecular findings suggest that RCC with haemangioblastoma-like features is a distinct entity from CCRCC., (© 2023 John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
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45. Myosteatosis as a novel predictor of new-onset diabetes mellitus after kidney transplantation.
- Author
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Wakamiya T, Fujimoto T, Endo T, Nishioka S, Yokoyama N, Yamashita S, Kikkawa K, Hyodo Y, Ishimura T, Kohjimoto Y, Hara I, and Fujisawa M
- Subjects
- Humans, Male, Female, Muscle, Skeletal, Psoas Muscles diagnostic imaging, Psoas Muscles pathology, Retrospective Studies, Sarcopenia diagnostic imaging, Sarcopenia epidemiology, Sarcopenia etiology, Glucose Intolerance etiology, Glucose Intolerance complications, Kidney Transplantation adverse effects, Diabetes Mellitus epidemiology, Diabetes Mellitus etiology
- Abstract
Objectives: We evaluate the effect of myosteatosis on new-onset diabetes mellitus after kidney transplantation., Methods: Consecutive patients who had renal transplant between 2006 and 2021 were reviewed, and 219 patients were finally included. Psoas muscle index was used to evaluate sarcopenia and average total psoas density (calculated by computed tomography before surgery) for myosteatosis. We used Cox proportional regression analyses in investigation of whether skeletal muscle depletion before surgery inclusive of sarcopenia and myosteatosis is a new additional predictor of new-onset diabetes mellitus., Results: Median recipient age and body mass index were 45 years and 21.1 kg/m
2 , respectively, and 123 patients (56%) were male. Preoperative impaired glucose tolerance was present in 58 patients (27%) and new-onset diabetes mellitus in 30 patients (14%), with median psoas muscle index of 6 cm2 /m2 and average total psoas density of 41 Hounsfield Unit. In multivariate analysis, significant risk factors were body mass index ≥25 kg/m2 (p < 0.01), impaired glucose tolerance (p < 0.01), and average total psoas density < 41.9 Hounsfield Unit (p = 0.03). New-onset diabetes mellitus had incidence rates of 3.7% without risk factors, 10% with a single risk factor, 33% with two, and 60% with three. Patients with new-onset diabetes mellitus were effectively stratified by the number of risk factors (p < 0.01)., Conclusions: Myosteatosis could be a new risk factor used to predict new-onset diabetes mellitus., (© 2023 The Japanese Urological Association.)- Published
- 2024
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- View/download PDF
46. AI prediction of extracorporeal shock wave lithotripsy outcomes for ureteral stones by machine learning-based analysis with a variety of stone and patient characteristics.
- Author
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Nakamae Y, Deguchi R, Nemoto M, Kimura Y, Yamashita S, Kohjimoto Y, and Hara I
- Subjects
- Humans, Retrospective Studies, Artificial Intelligence, Treatment Outcome, Machine Learning, Ureteral Calculi diagnostic imaging, Ureteral Calculi therapy, Lithotripsy methods
- Abstract
We propose an artificial intelligence prediction method for extracorporeal shock wave lithotripsy treatment outcomes by analysis of a wide variety of variables. We retrospectively reviewed the records of 171 patients from between January 2009 and November 2019 that underwent shock wave lithotripsy at Wakayama Medical University, Japan, for ureteral stones shown on preoperative non-contrast computed tomography. This prediction method consisted of stone area extraction, stone analyzing factor extraction from non-contrast computed tomography images, and shock wave lithotripsy treatment result prediction by a non-linear support vector machine for analysis of 15 input and automatic measurement factors. Input factors included patient age, skin-to-stone distance, and maximum ureteral wall thickness, and the automatic measurement factors included 11 non-contrast computed tomography image texture factors in the stone area and stone volume. Permutation feature importance was also applied to the artificial intelligence prediction results to analyze the importance of each factor relating to estimate decision grounds. The prediction performance was evaluated by five-fold cross-validation, it obtained 0.742 of the mean area under the receiver operating characteristic curve. The proposed method is shown by these results to have robust data diversity and effective clinical application. As a result of permutation feature importance, some factors that showed high p-values in the significant difference tests were thought to have a high contribution to the proposed prediction method. Future issues include validation using a larger volume of high-resolution clinical non-contrast computed tomography image data and the application of deep learning., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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47. Increasing age predicts adverse pathology including intraductal carcinoma of the prostate and cribriform patterns in deferred radical prostatectomy after upfront active surveillance for Gleason grade group 1 prostate cancer: analysis of prospective observational study cohort.
- Author
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Tohi Y, Ishikawa R, Kato T, Miyakawa J, Matsumoto R, Mori K, Mitsuzuka K, Inokuchi J, Matsumura M, Shiga K, Naito H, Kohjimoto Y, Kawamura N, Inoue M, Akamatsu S, Terada N, Miyazawa Y, Narita S, Haba R, and Sugimoto M
- Subjects
- Male, Humans, Aged, Prostate pathology, Watchful Waiting, Prostatectomy, Neoplasm Grading, Carcinoma, Intraductal, Noninfiltrating pathology, Prostatic Neoplasms pathology
- Abstract
Background: In men undergoing upfront active surveillance, predictors of adverse pathology in radical prostatectomy specimens, including intraductal carcinoma of the prostate and cribriform patterns, remain unknown. Therefore, we aimed to examine whether adverse pathology in radical prostatectomy specimens could be predicted using preoperative patient characteristics., Methods: We re-reviewed available radical prostatectomy specimens from 1035 men prospectively enrolled in the PRIAS-JAPAN cohort between January 2010 and September 2020. We defined adverse pathology on radical prostatectomy specimens as Gleason grade group ≥3, pT stage ≥3, pN positivity or the presence of intraductal carcinoma of the prostate or cribriform patterns. We also examined the predictive factors associated with adverse pathology., Results: All men analyzed had Gleason grade group 1 specimens at active surveillance enrolment. The incidence of adverse pathologies was 48.9% (with intraductal carcinoma of the prostate or cribriform patterns, 33.6%; without them, 15.3%). The addition of intraductal carcinoma of the prostate or cribriform patterns to the definition of adverse pathology increased the incidence by 10.9%. Patients showing adverse pathology with intraductal carcinoma of the prostate or cribriform patterns had lower biochemical recurrence-free survival (log-rank P = 0.0166). Increasing age at active surveillance enrolment and before radical prostatectomy was the only predictive factor for adverse pathology (odds ratio: 1.1, 95% confidence interval: 1.02-1.19, P = 0.0178; odds ratio: 1.12, 95% confidence interval: 1.02-1.22, P = 0.0126)., Conclusions: Increasing age could be a predictive factor for adverse pathology. Our findings suggest that older men could potentially derive advantages from adhering to the examination schedule in active surveillance., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
- Published
- 2023
- Full Text
- View/download PDF
48. The Importance of Follow-Up and Evaluation of Intraoperative Findings to Determine Surgical Indications for Retractile Testis.
- Author
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Kikkawa K, Ueda Y, Yamashita S, Kohjimoto Y, and Hara I
- Abstract
Objectives: Ascending testis or acquired undescended testis develops in approximately 30% of cases of retractile testis, and orchiopexy is recommended for these cases. This study aimed at assessing the intraoperative anatomical findings of ascending testis and acquired undescended testis in search of better management for retractile testis., Methods: We retrospectively collected data of patients with confirmed diagnosis of retractile testis between February 2012 and November 2021. Orchiopexy was performed for cases with ascending testis and for patients with increasing difference of right and left testicular volume. The site of gubernaculum attachment and patent processus vaginalis were evaluated during surgery., Results: A total of 119 testes in 71 patients with retractile testis were included in this study. Sixteen retractile testes in 12 patients (17%) underwent orchiopexy. The weight at birth was significantly higher, and bilateral retractile testes were significantly more common in the follow-up group than in the surgical intervention group. In the surgical intervention group, the abnormal site of gubernaculum attachment was found in 12 out of 16 testes (75%), and patent PV was found in nine out of sixteen testes (56%). Sites of gubernaculum attachment in testes with patent PV were significantly higher than in sites with closed processus vaginalis, and all testes with patent processus vaginalis had abnormal site of gubernaculum attachment., Conclusion: Patients with ascending testis and acquired undescended testis have clinical features and intraoperative abnormal findings similar to a cryptorchidism. Therefore, our surgical indication for retractile testis is considered appropriate., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Kazuro Kikkawa et al.)
- Published
- 2023
- Full Text
- View/download PDF
49. Prognostic significance of pre-treatment albumin-bilirubin grade in metastatic urothelial carcinoma receiving pembrolizumab.
- Author
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Yamashita S, Wada T, Deguchi R, Mashima N, Higuchi M, Miyai H, Koike H, Kohjimoto Y, and Hara I
- Abstract
Background: Pre-treatment albumin-bilirubin grade is a useful biomarker for predicting prognosis in patients receiving immune checkpoint inhibitors for advanced malignancies. We evaluated the prognostic impact of pre-treatment albumin-bilirubin grade in patients receiving pembrolizumab for metastatic urothelial carcinoma., Methods: In this multicenter retrospective study, we calculated pre-treatment albumin-bilirubin scores of 96 patients who received pembrolizumab for metastatic urothelial carcinoma between January 2018 and March 2022. Patients were classified according to albumin-bilirubin grade. Progression-free survival and cancer-specific survival were compared between the groups. To evaluate the prognostic impact of pre-treatment albumin-bilirubin grade, we also performed Cox proportional regression analyses for progression-free survival and cancer-specific survival., Results: The median pre-treatment albumin bilirubin score was -2.52 (quartile: -2.76 to -2.10), and albumin-bilirubin grade was grade 1 in 37 patients (39%), grade 2a in 30 patients (31%), 2b in 22 patients (23%) and grade 3 in 7 patients (7%). The median progression-free survival and cancer-specific survival were 2 and 7 months, respectively. Progression-free survival and cancer-specific survival were significantly different between the albumin-bilirubin grade groups (P < 0.01 and P < 0.01, respectively) and prognosis became poorer as albumin-bilirubin grade increased. High albumin-bilirubin grade was shown in multivariable Cox proportional analyses to be independently associated with both poor progression-free survival and poor cancer-specific survival., Conclusions: High pre-treatment albumin-bilirubin grade could be a significant independent predictor of poor prognosis in patients receiving pembrolizumab for advanced urothelial carcinoma., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
- Published
- 2023
- Full Text
- View/download PDF
50. Dynamic Changes in Fluid Temperatures during Laser Irradiation Using Various Laser Modes: A Thermography-Based In Vitro Phantom Study.
- Author
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Yamashita S, Inoue T, Imai S, Maruyama Y, Iwahashi Y, Deguchi R, Kohjimoto Y, Fujisawa M, and Hara I
- Abstract
The differences in dynamic thermal changes during laser lithotripsy between various laser pulse modes are unclear. We used thermography to evaluate the temporal changes in high-temperature areas during laser activation in order to compare different laser pulse modes. An unroofed artificial kidney model was used for the experiments. The laser fired for 60 s with a laser setting of 0.4 J/60 Hz in the following four different laser pulse modes without saline irrigation: short pulse mode (SPM), long pulse mode (LPM), virtual basket mode (VBM) and Moses mode (MM). Using the first 30 s of moving images, we compared the ratio of a high-temperature area of >43 °C to the total area every 5 seconds. The dynamic changes in fluid temperatures were shown to be different between the laser pulse modes. The extent of the high-temperature areas during the laser activation was large in the LPM and MM compared with the SPM and VBM. While the high-temperature areas expanded in an anterior direction in the early laser irradiation period using the LPM, they spread in a posterior direction in the early laser activation period using the MM. Although only the temperature profile in one specific plane was investigated, these results are considered useful for preventing thermal injuries during retrograde intrarenal surgeries.
- Published
- 2023
- Full Text
- View/download PDF
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