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The study aimed to explore the effects of psychological intervention on alleviating anxiety in patients in novel coronavirus (2019-nCoV) isolation wards.Between January 24th, 2020 and March 5th, 2020, 103 patients were studied. Among these, 32 were patients in the isolation ward of the Infectious Disease Department in Baoding Second Hospital with suspected 2019-nCoV, and 71 patients diagnosed with 2019-nCoV were in the Tangshan Infectious Disease Hospital. Of the 103 patients included, 97 cases were observed in isolation. Using a self-control study design, each patient's anxiety was scored on a self-rating anxiety scale before receiving the psychological intervention (on the 7th day of isolation) and after receiving the intervention (on the 14th day of isolation). The severity of anxiety was evaluated based on the anxiety score before receiving the intervention. The anxiety scores before and after receiving the intervention were then compared using the paired t-test, and p0.05 was considered statistically significant.After receiving the psychological intervention once or twice a week, the anxiety of the patients improved significantly after one week.The anxiety of patients with 2019-nCoV in isolation wards can be alleviated through psychological intervention. By alleviating patient anxiety, this intervention also helps patients maintain their psychological wellbeing, which promotes rehabilitation and helps with the control of 2019-nCoV.

Oral squamous cell carcinoma (OSCC) is one of the frequently occurring malignancies, but effective treatments are lacking. It is believed that exploring new molecular targets could help us to improve the treatment of OSCC. Therefore, we hope to find a new miRNA target to control OSCC.qPCR and Western blots were used to test the expressions of miR-802 and target gene in OSCC tissues and cell lines. Luciferase reporter assay was performed to check whether miR-802 could directly target MET. CCK-8, wound healing, cell invasion, colony formation, and tumor growth assays were used to determine the functions of miR-802 and MET in the malignant biological behavior of OSCC.The results suggested that miR-802 was low expressed in OSCC tissues and cell lines. Overexpression of miR-802 inhibited the cell viability, colony formation, migration and invasion of Tca8113 and SCC9 cells, and tumor growth in vivo. It was predicted that miR-802 might target the mRNA of proto-oncogene MET. Overexpressing miR-802 suppressed the expression of wild-type MET at both protein and mRNA levels in Tca8113 and SCC9 cells. Moreover, the expression of MET was high and significantly correlated with the low expression of miR-802 in OSCC tissues. Overexpression of MET in Tca8113 and SCC9 cells reduced the tumor-suppressive effects, which was induced by miR-802 overexpression.MiR-802 suppresses the malignant biological behavior of OSCC by targeting proto-oncogene MET. This work provides a new potential molecular target for treating OSCC.

Regeneration of the lens is an ideal strategy for cataract patients to restore their adjustable vision and to acquire excellent visual quality. However, mammalian lens regeneration is slow and incomplete, and functional lens regeneration cannot be achieved. The ability of lower amphibians (such as newts) to regenerate the lens provides the impetus for research on the regeneration of the lens of mammal. At present, the main form of mammalian lens regeneration is the differentiation of lens epithelial cells by capsular bag as a scaffold. In recent years, the continuous development of stem cell technology, tissue engineering and biological materials have made great progress in lens regeneration. This article describes the processes in the normal development of the lens, and reviews the research results of lens regeneration at home and abroad, and discusses the possibility of the new techniques and methods related to regenerative medicine applied to lens regeneration. It is hoped to help in the realization of rapid and complete regeneration of functional lens.晶状体再生是白内障患者恢复可调节视力、拥有优良视觉质量的理想策略。但哺乳动物晶状体再生速度慢且不完全，无法实现功能性晶状体再生。低等两栖动物（如蝾螈）强大的晶状体再生能力，为哺乳动物晶状体再生提供了动力。目前，哺乳动物晶状体再生主要的形式是以囊袋为支架由晶状体上皮细胞分化而成。近年来，随着干细胞技术、组织工程技术和生物材料的不断发展，哺乳动物晶状体再生研究取得了较大进展。本文拟总结晶状体的正常发育过程，回顾国内外晶状体再生的研究成果，探讨目前再生医学相关的新技术、新方法应用到晶状体再生的可能性，希望为功能性晶状体快速且相对完全再生研究提供参考。（中华眼科杂志，

Objective: The aim of this study was to determine the correlation between the number of FOXP3+ T cell in lesions and the disease activity of patients with oral lichen planus (OLP). Materials and Methods: The expression of FOXP3 was investigated using immunohistochemical staining and real-time RT-PCR in 23 OLP lesions and 12 controls. Changes of FOXP3+ Treg in peripheral blood from three patients’ pre and post-treatment were assessed using flow cytometry. Results: Few FOXP3+ cells were detected in controls, but an increased number of FOXP3+ cells were observed in lesions (n = 20, 40.99 ± 24.68 cells per high-power field – hpf). Furthermore, the frequency of FOXP3+ Treg in reticular OLP (n = 7, 63.6 ± 23.2 cells per hpf) was significantly higher than that in erythematous/erosive OLP (n = 13, 28.8 ± 16.8 cells per hpf, P = 0.001). In addition, negative correlation was found between the number of FOXP3+ Treg and disease activity (correlation oefficient = −0.557, P = 0.013). The proportion of FOXP3+ Treg showed remarkable increase in peripheral blood from patients after treatment (1.39 ± 0.71%vs 4.91 ± 1.59%). Conclusions: These data indicated that FOXP3+ Treg were involved in the pathogenesis of OLP and correlated with disease’s subtype and activity.

Summary Age is a key parameter to deduce the history of a plutonium material. An experimental method using both alpha spectrometry and thermal ionization mass spectrometry has been developed for the age determination of plutonium material. This method is based on the parent/daughter pair 241Pu/241Am ratio and has been validated using several plutonium source of known age. The results obtained are in good agreement with the last purification date of plutonium source.

Grid computing is a recently developed technology. Although the developmental tools and techniques for the grid have been extensively studied, grid reliability analysis is not easy because of its complexity. This paper is the first one that presents a hierarchical model for the grid service reliability analysis and evaluation. The hierarchical modeling is mapped to the physical and logical architecture of the grid service system and makes the evaluation and calculation tractable by identifying the independence among layers. Various types of failures are interleaved in the grid computing environment, such as blocking failures, time-out failures, matchmaking failures, network failures, program failures, and resource failures. This paper investigates all of them to achieve a complete picture about grid service reliability. Markov models, queuing theory, and graph theory are mainly used to model, evaluate, and analyze the grid service reliability. Numerical examples are illustrated

In this prospective, open-labeled study, 240 cancer patients were assigned to either a high-dose glucocorticoids (HDG) group that received chemotherapy containing HDG, or a control group that received chemotherapy without glucocorticoids. The Pittsburgh Sleep Quality Index (PSQI) was chosen to assess insomnia. The results of the study showed that dimensions of sleep latency, sleep duration, and sleep efficiency had the three largest differences in values and numbers of patients, with a score increase in the HDG group compared to the control group (p0.001). After chemotherapy in the HDG group, the PSQI score significantly increased in patients with stage II cancer (both p0.05), and patients diagnosed with lymphoma (p0.01), whereas the complete response and partial response rates (p0.05) had the smallest elevations. The average score of each dimension did not significantly decrease after hypnotics (p0.05). Our study suggests that the major clinical manifestations of insomnia in cancer patients receiving chemotherapy containing HDG include difficulty falling asleep, short sleep duration, and low sleep efficiency. however, we cannot definitively state that hypnotics can improve poor sleep quality.

The aim of this study was to determine the correlation between the number of FOXP3(+) T cell in lesions and the disease activity of patients with oral lichen planus (OLP).The expression of FOXP3 was investigated using immunohistochemical staining and real-time RT-PCR in 23 OLP lesions and 12 controls. Changes of FOXP3(+) Treg in peripheral blood from three patients' pre and post-treatment were assessed using flow cytometry.Few FOXP3(+) cells were detected in controls, but an increased number of FOXP3(+) cells were observed in lesions (n = 20, 40.99 +/- 24.68 cells per high-power field - hpf). Furthermore, the frequency of FOXP3(+) Treg in reticular OLP (n = 7, 63.6 +/- 23.2 cells per hpf) was significantly higher than that in erythematous/erosive OLP (n = 13, 28.8 +/- 16.8 cells per hpf, P = 0.001). In addition, negative correlation was found between the number of FOXP3(+) Treg and disease activity (correlation oefficient = -0.557, P = 0.013). The proportion of FOXP3(+) Treg showed remarkable increase in peripheral blood from patients after treatment (1.39 +/- 0.71%vs 4.91 +/- 1.59%).These data indicated that FOXP3(+) Treg were involved in the pathogenesis of OLP and correlated with disease's subtype and activity.

To eliminate the back wall defect of external canal and opened mastoid cavity which was remained from radical mastoidectomy.We performed the operation on 17 cases after radical mastoidectomy by using reconstruction of the canal wall and fill-in opened mastoid cavity and ossicular replacement prostheses made of homograft costal cartilage. The tympanoplasty had been made operated for all patients, 8 ears were PORP, the others were TORP.All cases were followed-up for 6 months-2 years. The external canal of all patients are normal in appearance. The total effective rate of gain (15 dB) was 14 ears (82.4%). Only one patient whose tympanic membrane was perforated postoperation 3 months.Reconstruction of acusticus back wall and hearing after radical mastoidectomy with homograft costal cartilage is effective to prevent mastoid cavity infection and improve hearing.

A potential molluscicidal extract, obtained from the indigenous Chinese plant Solanum xanthocarpum (Schrad. and Wendl), was tested for toxicity against snails and fish in static, acute-toxicity tests. The extract had a significant effect on mature and young snails of the amphibious Asian freshwater prosobranch Oncomelania hupensis (Gredler) and also on mature specimens of the freshwater pulmonate snails Biomphalaria glabrata (Say) and Lymnaea stagnalis (Linnaeus). The minimum dose that produced 100% mortality of snails exposed for 48h, 4.321mg/litre, is much less than the threshold, of 100mg/litre, set for a potential molluscicide by the World Health Organization. In contrast, the minimum concentration producing 100% mortality in the fish Gobiocypris rarus (Ye and Fu) was 17.28mg/litre. The extract also limited the extent of water-leaving by snails exposed to it, an important feature for the control of amphibious snails. This extract thus represents a promising plant-derived molluscicide which is worthy of further investigation.

The Three Gorges dam, under construction on the Yangtze River in China, might affect the transmission of Schistosoma japonicum on the Jiang Han plain, which is downstream of the dam. To study this possibility, the prevalence of schistosomiasis was investigated in relation to a range of malacological, hydrological and meteorological factors. The general water level in the Yangzte over a year had a marked effect on the distribution of the intermediate host (Oncomelania hupensis) and the prevalence of human schistosomiasis in that year. Disease prevalence showed significant correlations with the density of the snail hosts, the level of the water table, annual rainfall, yearly evaporation, and altitude. Once the dam is complete, the flow of water downstream will probably be maintained at a level between those currently occurring in flood and dry weather, and this may have implications for schistosome transmission. Systematic monitoring is necessary to investigate the impact of the environmental changes brought about by the dam on transmission.

With the construction of the Three Gorges high dam on the Yangtze River in China in mind, a serious of ecological environmental factors that might affect the transmission of Schistosoma japonicum in Jian Han Plain were investigated by means of data collection, field surveys and observation in Hubei Province. Several ecological factors including water level of the Yangtze River; riparian water table, annual rainfall and yearly evaporation were investigated in relation to the prevalence of schistosomiasis. The results suggest that after the dam construction, middle water level flows (ie between flood flows and dry-weather flows) will persist in the flood season due to a rise in the water table. The investigation indicated that snail distribution and human schistosomiasis prevalence differed significantly between years which had typically high, middle and low typical water levels in the Yangzte. Moreover, the prevalence of the disease showed a significant linear regression relationship with density of snail intermediate hosts, water table, annual rainfall, yearly evaporation and ground altitude in the survey area. Systematic and careful monitoring and surveillance is necessary to investigate the impact of the environmental changes brought about by the dam construction on schistosomiasis transmission.

A flexible Ge-on-polyimide photodetector is demonstrated. The single crystalline thin film of Ge was transferred on the polyimide by adhesive wafer bonding and smart-cut techniques. A simple tunneling metal-oxide-semiconductor structure is fabricated for the detector applications. Due to the transparency of the polyimide, the responsivity of the detector is sensitive to the environments. At −2 V, the photodetector on the stainless steel has responsivities of 220, 200, and 140 mA/W at wavelength of 850, 1310, and 1550 nm, respectively.

The development and present approach to training doctors at the Peking Union Medical College, the only medical school in the country with an 8-year curriculum, is described.