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Summary: Background: Primary hyperparathyroidism (pHPT) caused by a single benign parathyroid adenoma is a common endocrine disorder that is affected by regional differences. Living in different geographical regions reveals differences in the laboratory results and pathological findings, but studies on this subject are not sufficient. The article focuses on biochemical and pathological effects of geographical differences in parathyroid adenoma. In addition, the present study seeks to elaborate on treatment methods and effectiveness of screening in geographical area of Bulgaria and Turkey. Method: In this prospective study, 159 patients were included from 16 centres. Demographic characteristics, symptoms, biochemical markers and pathologic characteristics were analysed and compared between 8 different regions. Results: Patients from Turkish Black Sea had the highest median serum calcium (Ca) level, whereas patients from Eastern Turkey had the lowest median serum phosphorus (P) level. On the other hand, there was no significant difference between Ca, parathormone (PTH) and P levels according to regions. Patients from Eastern Turkey had the highest adenoma weight, while patients from Bulgaria had the lowest adenoma weight. The weight of adenoma showed statistically significant differences between regions (p

The article presents abstracts of the international Symposium "Diseases of bones, joints and age", which was held 9-11 March 2016 in Lviv.

The objective of this study was to assess the regeneration response of in vitro cultured Magnolia × soulangeana ‘Alexandrina’ and Magnolia liliiflora ‘Nigra’ to nutrient medium composition. In the primary culture (initiated from dormant axillary buds) combinations of Murashige and Skoog (MS) basal salts with 6-benzylaminopurine and α-naphthaleneacetic acid were tested. The primary explants of cv. ‘Alexandrina’ expressed higher regeneration rate than cv. ‘Nigra’. For both species, the regen eration was most strongly potentiated at addition of 0.25 mg dm−3 of the cytokinin alone. The auxin exerted undesir–able effects. Several basal salts media were applied in proliferation stage and their physiological effects were evaluated in reference to traditionally used MS. At culturing on Chée & Pool C2d Vitis Medium (VM) that is for the first time introduced to magnolia and on MS, M. liliiflora formed more but less elongated shoots than M. soulangeana. However, on VM, substantial increase (25-30%) of the number of axillary shoots and leaves, shoot length and fresh and dry weights over MS was established for both species. This suggested VM as promising composition of nutrients in multiplication stage. Microshoots obtained on MS, VM, Rugini Olive Medium and DKW Juglans Medium were successfully rooted in vitro and subsequently established ex vitro. The findings expand the information on magnolia response to culture conditions and contribute to elaboration of innovative elements of protocols for establishing tissue cultures with high regeneration capacity.

Abstract  Dislocation of hip arthroplasty due to false aneurysm formation is a rarity. Here, we report a case with false aneurysm of the deep femoral artery causing dislocation of bipolar hemiarthroplasty. The patient was first thought to have an infection but the diagnosis of false aneurysm was made during surgery and repaired. [ABSTRACT FROM AUTHOR]

Human serum paraoxonase contributes to the anti-atherogenic effect of high-density lipoprotein cholesterol (HDL-C) and has been shown to protect both low-density lipoprotein cholesterol (LDL-C) and HDL-C against lipid peroxidation. We investigated the effects of rosiglitazone on paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus [50 patients (30 males, 20 females); mean±SD age: 58.7±9.2 years, body mass index: 28.2±4.1'kg/m2], in whom glucose control could not be achieved despite treatment with metformin, sulphonylurea, and/or insulin. The patients were given 4'mg/day rosiglitazone for 3 months in addition to their usual treatment. Serum paraoxonase activity, malondialdehyde, homocysteine, and lipid profile were measured at the time of initiation and at the end of therapy with rosiglitazone. After rosiglitazone therapy, serum levels of HDL-C, apolipoprotein A-1, and paraoxonase activity increased significantly (P

We report a theoretical study on molecular structure, vibrational spectra, nonlinear optical (NLO), and natural bond orbital (NBO) analysis of sarcosine-maleic acid (C7H11NO6) in the ground state calculated by using the Hartree-Fock (HF) and density functional method (DFT/B3LYP) with 6–31++G(d,p) basis set. We repeat NBO calculations with 6–31G(d,p) basis set so as to see the diffuse function impact on NBO analysis. Stability of the molecule arising from hyper conjugative interactions and charge delocalization has been analyzed using NBO analysis. NBO analysis shows that there is a O–H⋯O and N–H⋯O hydrogen bond in the title compound, which is consistent with the conclusion obtained by the analysis of molecular structure. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. Also, these results are supported by the NLO parameters. Finally, the calculated results were applied to simulate infrared and Raman spectra of the title compound which showed good agreement with experimental ones.

Surgery of lumbar disc herniation is still a problem since Mixter and Barr. Main trouble is dissatisfaction after the operation. Today there is a debate on surgical or conservative treatment despite spending great effort to provide patients with satisfaction. The main problem is segmental instability, and the minimally invasive approach via microscope or endoscope is not necessarily appropriate solution for all cases. Microsurgery or endoscopy would be appropriate for the treatment of Carragee type I and type III herniations. On the other hand in Carragee type II and type IV herniations that are prone to develop recurrent disc herniation and segmental instability, the minimal invasive techniques might be insufficient to achieve satisfactory results. The posterior transpedicular dynamic stabilization method might be a good solution to prevent or diminish the recurrent disc herniation and development of segmental instability. In this study we present our experience in the surgical treatment of disc herniations.

For multimode optical beams, field correlations at the receiver plane are found in underwater turbulence. Field correlations of single high order beams in underwater turbulence are special cases of our formulation. Variations of field correlations against the underwater turbulence parameters and the diagonal length from various receiver points are examined for different multimode and single high order beams. Stronger underwater turbulence is found to reduce the field correlations of multimode and single high order optical beams. The results will be of help in heterodyne detection analysis and fiber coupling efficiency in an underwater medium experiencing turbulence.

This joint feature issue in Applied Optics and JOSA A collects articles focused on the topic of propagation through and characterization of atmospheric oceanic phenomena. The papers cover a broad range of topics, many of which were addressed at the 2023 Propagation Through and Characterization of Atmospheric Oceanic Phenomena (pcAOP) Topical Meeting at the Optica Imaging Congress in Boston, Massachusetts, 14-17 August 2023. These papers are supplemented by numerous examples of the current state of research in the field. This is the first pcAOP feature issue, with the intention to produce an issue on this topic every two years.

Objective: Inflammation plays a key role in the pathogenesis of postoperative atrial fibrillation after coronary artery bypass graft surgery. In this study, we aimed to investigate the changes in mean platelet volume and platelet values during the spring and autumn seasons in patients who underwent isolated coronary artery bypass graft surgery and the possible effect of these occurrences on postoperative atrial fibrillation., Methods: Consecutive patients who underwent elective isolated coronary bypass surgery at our clinic in the spring and autumn months, between August 2020 and July 2022, were retrospectively included in this study. Variables were evaluated according to the spring and autumn seasons. Patients who did not develop in-hospital postoperative atrial fibrillation were identified as Group 1, and those who did constituted Group 2., Results: A total of 622 patients were included in the study. The patients were divided into two groups: those who were operated on in the spring (n=277, median age=62 years, male gender ratio=77.3%) and those who were operated on in the autumn (n=345, median age=61 years, male gender ratio=81.4%). There was no statistically significant difference between the patients operated on in both seasons in terms of age, gender, hypertension rates, and the frequency of chronic obstructive pulmonary disease. In multivariate analysis, being over 70 years old (OR: 1.934, 95% confidence interval (CI) 1.489-2.995, p<0.001), having a left ventricular ejection fraction below 30% (OR: 1.550, 95%CI 1.190-2.236, p=0.012), and having chronic obstructive pulmonary disease (OR: 1.663, 95%CI 1.339-2.191, p<0.001) were found to be independent predictors in predicting the development of postoperative atrial fibrillation., Conclusion: In this study, we first demonstrated that mean platelet volume and platelet mass index values were higher in patients in the autumn months. Additionally, for the first time in the literature, we showed that there is a significant relationship between platelet mass index value and the development of postoperative atrial fibrillation in patients who underwent isolated coronary artery bypass graft.

Postoperative pain after cardiac surgery plays an important role in the patient's recovery process. In particular, pain at the chest tube site can negatively affect the comfort and recovery of these patients. Effective pain control minimizes the risk of many complications. Oral and intravenous analgesics, epidural anesthesia, paravertebral block, and intercostal nerve blockade are used in chest tube pain control. We routinely use the surgical cryoablation method in the presence of atrial fibrillation in the preoperative period of cardiac surgery in our clinic. Here we aimed to describe our method of using the cryoablation catheter for intercostal nerve blockade.

Background: Acute limb ischemia (ALI) is an emergency vascular pathology in which perfusion is disrupted in the lower extremity and threatens extremity viability. The admission blood glucose (ABG)/estimated average glucose (eAG) value has recently been shown as a prognostic marker in acute cardiovascular events. In this study, we aimed to investigate the predictive role of an ABG/eAG value in predicting development of early postoperative major amputation after emergency thromboembolectomy operations in patients presenting with ALI., Method: Patients who admitted to our hospital with ALI between November 01, 2016 and September 01, 2021 and underwent surgical thromboembolectomy were retrospectively included in the study. Patients who did not undergo postoperative limb amputation were recorded as Group 1, and patients who underwent major amputation in the early postoperative period (in-hospital), were recorded as Group 2., Results: The median age of the 226 patients included in Group 1 and 72 patients in Group 2 were 58 (34-86) years and 69 (33-91) years, respectively ( p <0.001). In univariate analysis, in-hospital amputation was found to significantly correlate with age>70 years (odds ratio [OR]: 1.914, 95% confidence interval [CI]: 1.351-2.319, p <0.001), PAD (OR: 1.698, 95% CI: 1.270-1.992, p = 0.002 re-embolectomy (OR: 2.184, 95% CI: 1.663-3.085, p < 0.001), admission Rutherford class (OR: 0.762, 95% CI: 0.591-0.859, p = 0.032), admission time>6 h (OR: 1.770, 95% CI: 1.480-1.152, p = 0.009), ABG (OR: 1.275, 95% CI: 1.050-1.790, p < 0.001), and ABG/eAG (OR: 1.669, 95% CI: 1.315-2.239, p < 0.001)., Conclusion: According to our study, we can predict patient groups with a high risk of major amputation with the ABG/eAG value calculated from the blood values of the patients at the time of admission., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Although underwater wireless optical communication (UWOC) has the advantages of high speed, low latency, and high confidentiality, the transmission of light in water will be affected by the absorption and scattering of particles, which will lead to the aggravation of channel path loss as well as channel pulse spreading, finally causing false codes. Therefore, how to analyze the channel impulse response (CIR) effectively is a key task in channel modeling. In this paper, we consider a two-way underwater vertical line-of-sight (LOS) communication system model, based on the inherent optical property (IOP) model of chlorophyll, using the Kopelevich phase function containing water depth information, the CIR curves under different water types and transceiver configurations are plotted using the Monte-Carlo Simulation (MCS). The obtained simulation results are fitted with the double gamma function (DGF) model and the Gaussian model, respectively. The Gaussian model exhibits better properties than the DGF model in each water condition. Based on the closed-form expression of the CIR obtained from the Gaussian model, we solve for the bit error rate (BER) and 3-dB bandwidth of the system under different settings. The conclusions obtained can be used for the design and optimization of underwater vertical channels.

Introduction: Chronic venous insufficiency (CVI) is a common disease affecting millions worldwide. Age, obesity, female gender, sedentary life, and long-standing at work causing orthostasis have been identified as predisposing factors., Objective: The visceral adiposity index (VAI) is an important indicator of abdominal obesity. Various studies in the cardiovascular field have shown that it may be more predictive than body mass index (BMI)., Methods: A total of 171 consecutive patients diagnosed with low-grade (C0-C3) superficial primary CVI in our clinic, between November 2021 and December 2022, were included in this prospective study. Venous Clinical Severity Score (VCSS) values were calculated. The patients were divided into two groups according to their VCSS values (Group 1: VCSS ≤6 and Group 2: VCSS >6)., Results: There were 110 patients in Group 1 with a median age of 42 (18-50) years. There was no difference between the groups in terms of gender, smoking, hypertension frequency, height, weight, body mass index, hemoglobin values, lymphocyte, neutrophil, mean platelet volume, urea, creatinine, high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol values ( p > .05). Multivariate logistic regression analysis was performed to reveal the predictive factors of high VCSS values in patients. As a result of the analysis, VAI (Odds Ratio (OR): 1.775; 95% Confidence Interval (CI): 1.389-2.269; p < .001) and CRP (OR: 2.641; 95% CI: 1.431-4.875; p = .002) values were identified as independent predictors in predicting high VCSS values., Conclusion: This current study showed that high VAI values affect clinical complaints in patients with low-grade CVI. In line with our results, clinical recommendations can be made to reduce VAI values in low-stage CVI patients., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

In a turbulent biological tissue, field correlations at the observation plane are found when a multimode optical incidence is used. For different multimode structures, variations of the multimode field correlations are evaluated against the biological tissue turbulence parameters, i.e., the strength coefficient of the refractive-index fluctuations, fractal dimension, characteristic length of heterogeneity, and the small length-scale factor. Using a chosen multimode content, for specific biological tissue types of liver parenchyma (mouse), intestinal epithelium (mouse), upper dermis (human), and deep dermis (mouse), field correlations are evaluated versus the strength coefficient of the refractive-index fluctuations and small length-scale factor. Again, with a chosen multimode content, behavior of the field correlations is studied against the strength coefficient of the refractive-index fluctuations for various diagonal lengths and the transverse coordinate at the observation plane. Finally, the field correlation versus the strength coefficient of the refractive-index fluctuations is reported for different single modes, which are special cases of multimode excitation. This topic is being reported in the literature for the first time, to our knowledge, and the presented results can be employed in many important biological tissue applications.

We read with interest the article entitled "The Role of Systemic Immune Inflammation Index for Predicting Saphenous Vein Graft Disease in Patients with Coronary Artery Bypass Grafting." We congratulate the authors for their contribution. We would like to discuss some points about the late development of saphenous vein graft disease.

Multimode field correlations are evaluated in atmospheric turbulence. High order field correlations are special cases of the results that we obtained in this paper. Field correlations are presented for various numbers of multimodes, various multimode contents of the same number of modes, and various high order modes versus the diagonal distance from various receiver points, source size, link length, structure constant, and the wavelength. Our results will be of help especially in the design of heterodyne systems operating in turbulent atmosphere and fiber coupling efficiency in systems employing multimode excitation.

The calculation of optical system performance for laser beam propagation in optical turbulence, such as bit error rate (BER), signal-to-noise ratio, and probability of fade, requires the knowledge of scintillation. In this paper, we show the analytical expressions of the aperture-averaged scintillation using a new recently introduced power spectrum of the refractive index fluctuations for underwater turbulence, the oceanic turbulence optical power spectrum (OTOPS). In addition, we use this main result to investigate the impact of weak oceanic turbulence on free-space optical system performance for a propagating Gaussian beam wave. Similar to the atmospheric turbulence case, results show that aperture averaging can reduce the mean BER and the probability of fade several orders of magnitude if the receiver aperture is chosen with a diameter larger than the Fresnel zone, L / k . Being valid for weak turbulence regime in any natural waters, results present the variations of irradiance fluctuations and the performance of underwater optical wireless communication systems depending on the practical values of average temperature and average salinity concentration that can be encountered in any world's waters.

Although optical wave propagation is investigated based on the absorption and scattering in biological tissues, the turbulence effect can also not be overlooked. Here, the closed-form expressions of the wave structure function (WSF) and phase structure function (PSF) of plane and spherical waves propagating in biological tissue are obtained to help with future research on imaging, intensity, and coherency in turbulent biological tissues. This paper presents the effect of turbulent biological tissue on optical wave propagation to give a perception of the performance of biomedical systems that use optical technologies. The behavior of optical waves in different types of turbulent biological tissues such as a liver parenchyma (mouse), an intestinal epithelium (mouse), a deep dermis (mouse), and an upper dermis (human) are investigated and compared. It is observed that turbulence becomes more effective with an increase in the characteristic length of heterogeneity, propagation distance, and the strength of the refractive index fluctuations. However, an increase in the fractal dimension, wavelength, and small length scale factor has a smaller turbulence effect on the propagating optical wave. We envision that our results may be used to interpret the performance of optical medical systems operating in turbulent biological tissues.

Tomato brown rugose fruit virus (ToBRFV; genus, Tobamovirus , family, Virgaviridae) was first reported in 2015 infecting tomatoes grown under protected cropping in the Jordan Valley. Since then, ToBRFV has been detected in tomatoes grown in both protected and open fields across Jordan. The increased incidence of ToBRFV prompted this investigation of the potential role of natural weed hosts in the dissemination of ToBRFV. A survey was conducted in the Jordan Valley and highlands to determine possible reservoir hosts of ToBRFV in fields and greenhouse complexes in which tomatoes were grown. Detection of ToBRFV infection was made by double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) and further confirmation by reverse-transcription polymerase chain reaction (RT-PCR), followed by DNA cloning and sequencing, and bioassays. Thirty weed species belonging to twenty-six genera from sixteen families were tested. Twelve species belonging to eight families were infected of which ten species are newly reported hosts for ToBRFV. Seed transmission of ToBRFV in Solanum nigrum was confirmed in a grow-out experiment. To our knowledge, this is the first report of the natural occurrence of ToBRFV on weed hosts. Identification of natural reservoirs of ToBRFV can help to develop management practices focused on weed plant species to prevent ToBRFV transmission. The extent to which ToBRFV survives in diverse alternate weed host species outside tomato growing seasons in different world regions requires further research in order to establish the risk associated with the possible contribution of weeds as a reservoir for primary infections in tomato crops.

Purpose: Diabetes mellitus (DM) plays a key role in the formation and prognosis of cardiovascular diseases. In this study, we aimed to investigate the effects of DM and glycemic control on left internal thoracic artery (LITA) Doppler flow in patients scheduled to undergo coronary artery bypass graft (CABG) surgery., Methods: Patients who were hospitalized with a planned isolated CABG operation to our clinic between October 1, 2019 and March 1, 2020 were consecutively included in this prospective study. The patients were divided into three groups as those without DM (Group 1), those with DM and HbA1c values of below 7.5 (Group 2), and those with DM and HbA1c values of 7.5 and above (Group 3). The differences between the LITA Doppler flow patterns of the patients were analyzed., Results: The mean ages of Group 1 (n = 103), Group 2 (n = 42), and Group 3 (n = 47) were 59.8 ± 9.6 years, 60.5 ± 9.3 years, and 61.9 ± 8.1 years, respectively. The groups differed in terms of diameter, volume, Vmax, pulsality index (PI), and resistive index (RI) values, both when the groups were compared among themselves (P < .001, for all), and when they were compared between those with (Groups 2 and 3) and without DM (Group 1) (P < .001, for all). Volume (R = -0.627, P < .001) and Vmax (R = -.450, P < .001) were moderately negatively correlated, while PI (R = .523, P < .001) and RI (R = 0.598, P < 0.001) were moderately positively correlated with HbA1c levels., Conclusion: In this study, we showed that increased HbA1c levels may be associated with significant functional and structural changes of LITA., (© 2022 Wiley Periodicals LLC.)

The Beer-Lambert-Bouguer law characterizes attenuation of an optical plane wave resolved in terms of absorption and scattering of a medium it passes through. However, the optical turbulence present in a medium may also cause severe local attenuation in beam-like light fields. This study aims to incorporate the effects of absorption and scattering with that of optical turbulence in Earth's natural waters. To do so, expression for the turbulence induced local attenuation coefficient is developed first for the on-axis position of the lowest-order Gaussian beam, being dependent on the source's wavelength, width, and propagation distance. We present a comparison among turbulence, absorption, and scattering effects for different Jerlov water types. Our results show that underwater turbulence can cause attenuation quantitatively comparable to that of absorption. This study enables a direct comparison of absorption, scattering, and turbulence effects and will benefit the diagnostics of imaging, sensing, and communication systems operating underwater.

Expressions for the temporal covariance function and temporal frequency spectrum for a plane wave propagation in an underwater turbulent medium are developed analytically. Temporal correlation in moving natural water is presented, which is shown to be dependent upon the moving velocity, the delay between two instants of time, propagation distance, average temperature, and average salinity concentration. Coherence time and zero crossing time also are calculated. The results show that the velocity of the moving natural water has a significant impact on the temporal correlation of irradiance fluctuations. Additionally, the propagation distance, average temperature, average salinity concentration, and temperature-salinity gradient ratio also impact the temporal correlation up to a certain level.

Background: There are opinions that telangiectasis and reticular veins are asymptomatic and constitute a cosmetic problem only. However, it has been proven that telangiectasis and reticular veins also affect the quality of life and are symptomatic., Methods: Ninety consecutive female patients who were admitted to our outpatient clinic and did not have insufficiency in deep, superficial and perforating veins were included in this study. All participants were divided into three groups as the compression group (Group 1), medical treatment group (Group 2), and sclerotherapy group (Group 3). The initial complaint severities of all patients were noted. Except for patient compliance assessment, baseline, 1st month (T1), 3rd month (T2) and 6th month (T3) evaluation records were kept in all three groups., Results: The study began with a total of 90 patients, 30 patients in each group. The mean ages of Groups 1, 2 and 3 were 39.73 ± 8.51 years, 39.30 ± 8.67 years, and 40.77 ± 9.45 years, respectively. The rates of decrease in pain, itching, restless leg, and muscle cramps were similar among the patient groups at all times (P > 0.05). The rate of reduction in swelling was similar between the groups at T1 and T2 (P > 0.05), while there was a significant difference between the groups at T3 (P = 0.009). The groups significantly differed in terms of appearance concern at all times (P = 0.002 for T1, P < 0.001 for T2 and T3)., Conclusion: We showed that symptoms such as swelling and heaviness in leg can be improved with medical treatment, but the patient's cosmetic satisfaction can increase with sclerotherapy.

Wave structure function, coherence length, and angle-of-arrival variance are derived analytically for a Gaussian beam propagating in an underwater turbulent medium. The recently introduced oceanic turbulence optical power spectrum model [J. Opt. Soc. Am. A37, 1614 (2020)JOAOD60740-323210.1364/JOSAA.399150] is used, and results are obtained for the case of large separations. The effect of temperature, salinity, rates of dissipation of mean-squared temperature and energy, temperature-salinity gradient ratio, wavelength, and aperture diameter, is presented. Further, a Gaussian beam is compared with the plane and spherical waves in terms of their effect on wave structure function, coherence length, and angle-of-arrival fluctuations. The presented results can be beneficial to set the parameters of imaging and communication systems using a Gaussian beam in an underwater turbulent medium and can be used for the optimization of the design of these systems.