4 results on '"Y. Al-Zaman"'
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2. Subject Index Vol. 68, Suppl. 5, 2007
- Author
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Bessie E. Spiliotis, Mary P. Gillam, Klaus Mann, Barney Harrison, Anthony P. Heaney, Wiebke Arlt, Ieuan A. Hughes, F. Péter, V. Radonsky, D. Damiani, Felix Casanueva, Wim Van Hul, Elena Livadariu, H. Cabral de Menezes Filho, E. Sólyom, Allan E. Herbison, Peter J Trainer, M. C. Burlacu, Felix Beuschlein, Sabine M.P.F. de Muinck Keizer-Schrama, Amar Agha, Ulla Feldt-Rasmussen, Stanko Skrtic, Wayne S. Cutfield, Annette Grüters, David R. Clemmons, Francis H. Glorieux, J. Sudagani, A. Muzsnai, Patrick Wilton, Robert C. Tasker, Dana S. Hardin, Paul Czernichow, Friedhelm Raue, Hans Lennernäs, S. Aylwin, Georgios Karagiannis, Sadaf Farooqi, M.B. Ranke, Maithé Tauber, Karin Frank-Raue, Mehul T. Dattani, H. Kuperman, S. Dewan, Michael Buchfelder, A. Mukherjee, Feyza Darendeliler, C. Taylor, David B. Dunger, Gudmundur Johannsson, Christian J. Strasburger, Gerard S. Conway, I.M. Holdaway, A. Lecka, Adrian F. Daly, Heiko Krude, T. Della Manna, Paraic McGrogan, I. Ilyés, J. Prague, Lauri A. Aaltonen, Daniel Kelberman, V. Dichtchekenian, Claus Højbjerg Gravholt, J.M. Rodrigues, Günter K. Stalla, Helmuth G. Dörr, Jens Sandahl Christiansen, Kees Noordam, Kirstine Stochholm, Ragnhildur Bergthorsdottir, T. Kearney, A. McGregor, Kenji Fujieda, Martin O. Savage, K. Gnanalingham, J. Kovács, Helena Filipsson, Michael Droste, Hans P.F. Koppeschaar, Clifford J. Rosen, J. Miell, Dominique Simon, Mitchell E. Geffner, Ezio Ghigo, Torben Laursen, Lucy Ann Behan, L. Steinmetz, Akira Shimatsu, Jarod S.C. Wong, Andy Toogood, Carlo L. Acerini, Theo J. Visser, Aldo Pinchera, Berthold P. Hauffa, Niki Karavitaki, T. Niederland, N. Setian, Albert Beckers, Phyllis W. Speiser, Nils Krone, Mark E. Molitch, Mauro Bozzola, S Faisal Ahmed, D. Kannappan, J. Sólyom, V. Oguntolu, J.P.H. Shield, Y. Al-Zaman, Beverly M. K. Biller, and Bernhard Saller
- Subjects
Endocrinology ,Index (economics) ,Endocrinology, Diabetes and Metabolism ,Pediatrics, Perinatology and Child Health ,Statistics ,Subject (documents) ,Psychology - Published
- 2007
- Full Text
- View/download PDF
3. Emerging concepts in the medical and surgical treatment of obesity.
- Author
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Aylwin S and Al-Zaman Y
- Subjects
- Adipose Tissue pathology, Amyloid therapeutic use, Anticonvulsants therapeutic use, Antidepressive Agents therapeutic use, Anxiety complications, Appetite Regulation physiology, Bariatric Surgery adverse effects, Bariatric Surgery methods, Body Mass Index, Bupropion therapeutic use, Cholecystokinin therapeutic use, Ciliary Neurotrophic Factor therapeutic use, Clinical Trials as Topic, Cyclobutanes therapeutic use, Depression complications, Diabetes Mellitus, Type 2 therapy, Female, Fluoxetine therapeutic use, Fructose analogs & derivatives, Fructose therapeutic use, Ghrelin therapeutic use, Humans, Intra-Abdominal Fat pathology, Islet Amyloid Polypeptide, Isoxazoles therapeutic use, Lactones therapeutic use, Leptin therapeutic use, Metabolic Syndrome drug therapy, Metformin therapeutic use, Obesity classification, Obesity epidemiology, Obesity prevention & control, Obesity, Morbid complications, Obesity, Morbid therapy, Orlistat, Oxyntomodulin therapeutic use, Peptide YY therapeutic use, Piperidines therapeutic use, Polycystic Ovary Syndrome therapy, Pyrazoles therapeutic use, Rimonabant, Sertraline therapeutic use, Sleep Apnea, Obstructive therapy, Surgical Procedures, Operative, Topiramate, Zonisamide, Obesity surgery, Obesity therapy
- Abstract
The relentless rise in the prevalence of obesity predicts an exponential increase in the incidence of obesity-related complications. Medical and surgical treatments are necessary to prevent and treat obese co-morbidities, thereby avoiding disability and premature death. Interventions for obesity should be evaluated not by weight loss alone but against the new incidence in obesity-related co-morbidities, their remission or improvement. In combination with lifestyle measures, currently available pharmacological therapies -- rimonabant, orlistat and sibutramine -- achieve 5-10% weight loss, although a return to baseline is the norm after cessation of medication. All these agents demonstrate approximately 0.5% reduction in HbA1c in diabetic subjects; orlistat also reduces the new incidence of type 2 diabetes. Modest improvement in lipid profiles and reduced calculated cardiovascular risk is observed, but data on improvement of other co-morbidities are sparse. In contrast, surgical procedures that restrict food ingestion and/or curtail the absorptive surface area of the gut consistently achieve substantial weight loss, typically 20-35%, effect resolution of co-morbid conditions and improve quality of life. Although mortality is low, complications and hospitalisation are not uncommon after bariatric surgery. Intriguingly, surgical patients experience a reduction in appetite and report changes in food preference. Accentuation of the normal gastrointestinal hormonal response to food intake and possible changes in vagal afferent signalling are proposed to induce satiety. Increased understanding of body weight homeostasis and appetite regulation has provided an impressive list of potential targets for drug development, with the promise that single or combination therapy may ultimately challenge the supremacy of bariatric surgery.
- Published
- 2008
- Full Text
- View/download PDF
4. Adult growth hormone replacement using a fixed graded initiation phase followed by an individualised titration phase: a single centre experience.
- Author
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Prague J, Taylor C, Al-Zaman Y, Lecka A, Oguntolu V, Miell J, McGregor A, and Aylwin S
- Subjects
- Adult, Age of Onset, Humans, Retrospective Studies, Titrimetry, Hormone Replacement Therapy methods, Human Growth Hormone deficiency, Human Growth Hormone therapeutic use, Metabolism, Inborn Errors drug therapy
- Published
- 2007
- Full Text
- View/download PDF
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