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There are a huge of number people with liver tumors. The main method of treatment of this pathology is surgery, in some cases, impossible without prior stimulation of liver regeneration. For these purposes in recent years increasingly used embolization and/or chemoembolization of liver vessels. One of the most common ways - portal vein embolization (PVE). Identification of the benefit - risk ratio for PVE agents is very actually aim of studies in preclinical fields. The aim of this study was to evaluate the methods of administration of the microspheres in the portal vein of the rabbit. As means embolic microspheres used a polyvinyl alcohol with a size 0,1÷0,3 mm. In the course of this work was reproduced method of rabbit’s PVE.