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Purpose: To investigate the internal training loads of a professional Spanish female futsal team throughout 26 weeks of training including preseason and in-season weeks and verify the impact of training period and/or training load magnitudes on heart-rate variability responses. Furthermore, we aimed to assess, intraindividually, the relationship between training load and the coefficient of variation (CV) of weekly natural log of the root mean square difference of successive normal interbeat (RR) intervals (lnRMSSDCV), obtained from ∼5 measures per week, and recorded in the seated position. Methods: A within-subject design involved 12 high-level outfield female futsal players (mean [SD] age: 23.9 [3.4] y). Results: lnRMSSD was significantly lower and lnRMSSDCV was significantly higher during the preseason (weeks 1–6) compared to in-season (weeks 7–26) (P moderate to large negative correlations between lnRMSSDCV and lnRMSSD during the 26 weeks of observation. Correlations ranged between rplayer4 = −.41 (95% CI, −.69 to −.02) and rplayer12 = −.55 (−.78 to −.18). Players also presented moderate to very large positive correlations between lnRMSSDCV and session rating of perceived exertion. Correlations ranged between rplayer7 = .41 (.04 to .71) and rplayer1 = .71 (.45 to .86). Conclusion: Professional female futsal players in this study presented increased lnRMSSD and reduced lnRMSSDCV during 20 weeks into the competitive season compared to 6 weeks of preseason. Furthermore, lnRMSSDCV was negatively associated with lnRMSSD on an intraindividual basis. Finally, higher internal training loads were positively correlated with lnRMSSDCV, indicating that heart-rate variability is responsive to weekly training loads.

We have developed a novel radiopaque tiltmeter (ROT) that can indicate patient tilt during a radiography examination and display it on X-ray images. This study evaluated the effect of variation of patient tilt on the reproducibility of Fowler's position for chest radiography and the accuracy of the ROT.We evaluated the reproducibility of Fowler's position based on changes from the first day in the central venous catheter (CVC) tip position and the cardiothoracic ratio (CTR) with and without a digital tiltmeter to verify its efficacy in patients who underwent mobile chest radiography. The ROT contains radiopaque liquid consisting of white barium sulfate solution and oil and has a scale bar of 15°-75° with increments of 15° to indicate ROT tilt. The ROT tilt was increased from 10° to 80° in increments of 10°. We then evaluated (1) the difference between the ROT tilt and the tilt measured with a digital tiltmeter, and (2) the ROT tilt displayed on the X-ray image.With regard to reproducibility in Fowler's position, changes in the CVC tip position were 2.8 ± 3.9 mm and 10.7 ± 10.6 mm with and without the tiltmeter, respectively (p 0.05) and the respective rates of change in the CTR were 0.7% ± 0.6% and 4.0% ± 2.1% (p 0.05). Differences between the ROT tilt and the tilt measured by the digital tiltmeter were within ±2.5°. All ROT tilts displayed on the X-ray images were recognized exactly as each tilt.Our novel ROT had the potential to accurately indicate patient tilt during chest radiography, which could be helpful in terms of reproducibility and precise follow-up.Use of the ROT for determination of patient tilt can improve reproducibility in Fowler's position, allowing more accurate serial X-ray imaging.

BACKGROUND: Optimal neuromuscular performance is essential for futsal athletes and it has been linked to body composition. AIM: The present study aimed to verify the relationship between absolute (total amount; kg) and relative (percentage; %) lower-limb and thigh lean and fat mass with isometric and dynamic maximal strength in professional futsal players. METHOD: Sixteen male elite futsal athletes participated in this study. Unilateral lower-limb and thigh lean and fat mass were evaluated using DXA (Dual-Energy X-ray Absorptiometry) and strength performance using unilateral isokinetic concentric-eccentric knee extension (KE) and flexion (KF) peak torque (PT), KE and KF isometric PT at 30° and 70°, and hamstrings-to-quadriceps ratios (H:Q). RESULTS: Unilateral lower-limb lean mass amount showed a significant positive correlation with concentric and isometric KE PT (60°/s: r=0.58; 30°: r=0.55; 70°: r=0.65), and with concentric (60°/s: r=0.61), eccentric (60°/s: r=0.67) and isometric (30°:r=0.79; 70°: r=0.70) KF PT. No significant relationship between lower-limb lean and fat mass percentage with isokinetic performance was verified. Thigh lean mass amount had a significant positive correlation with concentric and isometric KE PT (60°/s:r=0.52; 30°: r=0.51; 70°: r=0.84) and also with concentric (60°/s: r=0.75) and eccentric KF PT (60°/s:r=0.54), while thigh fat mass amount was only associated with eccentric KF PT (r=0.54). No significant correlation between lower-limb and thigh body composition with H:Q ratios was observed. CONCLUSION: In conclusion, contrary to the relative (%) values, absolute (kg) lower-limb and thigh fat and lean mass present a significant correlation with dynamic and isometric KE and KF performance in futsal players.

Plasma β dependence of ion temperature gradient (ITG) driven turbulence is investigated using gyrokinetic simulations, where β is the normalized pressure. In our β scan, self-consistent magnetohydrodynamic (MHD) equilibrium state is numerically calculated for each value of β. It is found that the influence of the Shafranov shift cancels out the electromagnetic stabilizing effect on the ITG mode, and the growth rate of the ITG mode is accordingly unchanged as β increases. As a result, the turbulent energy transport does not decrease with β as suggested by the s − α model (Ishizawa et al 2019 Phys. Rev. Lett. 123 025003). A significant difference from the s − α model is the increase of the energy transport with β. It is also found that the critical onset β value for the kinetic ballooning mode is significantly increased by the influence of the Shafranov shift. The cancellation of the electromagnetic stabilization by the Shafranov shift is explained by the decrease of magnetic drift frequency in the dispersion relation of electromagnetic ITG modes obtained by using a fluid approximation.

El objetivo de este estudio fue analizar el valor de mercado (VM) de futbolistas profesionales de las 5 mejores ligas europeas de fútbol. Se analizó el efecto de las variables independientes sobre el VM de los futbolistas, mediante una ANOVA con un nivel de significación de p 30 años. Los delanteros y centrocampistas, mostraron mayor VM en comparación con los porteros y los laterales. Los futbolistas que representaron a sus países en partidos internacionales mostraron mayor VM en comparación con los que no lo hicieron. Los futbolistas de formación juvenil en clubes de la PL y La Liga (LL) mostraron mayor VM en comparación con los futbolistas de otros clubes. En conclusión, factores intrínsecos y extrínsecos afectan el VM de los futbolistas. Los resultados de esta investigación pueden ser útiles para los directores deportivos en el proceso de selección de futbolistas profesionales. The objective of this study was analysed to the market value (MV) of professional soccer players from Top-5 European Soccer Leagues. An ANOVA analysed the effect of the independent variables on the MV of the soccer players, with p30 years. Forward and midfielders showed greater MV compared to goalkeepers and backs. Soccer players that represented their countries at international matches showed greater MV compared to those that did not. The soccer players with a youth background formation in their clubs in the Premier League and La Liga showed greater MV compared to soccer players coming from other clubs. In conclusion, intrinsic and extrinsic factors affect the MV of soccer players. Research results may be useful to the sport managers in the selection of professional soccer players. O objetivo deste estudo foi analisar o valor de mercado (VM) de jogadores de futebol profissional das 5 melhores ligas europeias de futebol. O efeito das variáveis independentes sobre a VM dos futebolistas foi analisado por meio de uma ANOVA com nível de significância de p 30 anos. Os atacantes e meio-campistas mostraram maior VM em relação aos goleiros e laterais. Os jogadores de futebol que representaram seus países em jogos internacionais apresentaram maior MV em comparação com aqueles que não o fizeram. Jogadores de futebol em formação de jovens em clubes da PL e La Liga (LL) apresentaram maior VM em comparação com jogadores de futebol de outros clubes. Em conclusão, fatores intrínsecos e extrínsecos afetam a VM dos jogadores de futebol. Os resultados desta pesquisa podem ser úteis para dirigentes esportivos no processo de seleção de jogadores profissionais de futebol.

Based on the Riemann problem in compressible fluid dynamics, if the head of an unsteady jet acts as a physical piston for air compression, a higher-pressure field than that of the kinetic pressure from a steady jet can be generated. In this study, the pressure characteristics of this air compression method, referred to as “remote in-tube air compression,” were evaluated. The generated unsteady jet exhibited a high-pressure region in its central part that effectively acted as a physical piston (piston effect). Depending on the distance between the unsteady jet generator and a cylindrical test section, the overpressure inside the test section reached the maximum value when the cross section of the jet head and the test section were matched. This matching condition was consistent with the in-tube pressure characteristics, thereby yielding an effective method for the remote generation of a high-pressure region using a simple device.

Context Athletes' sleep is the most important recovery strategy and has received growing attention. However, athletes may experience sleep disruptions due to numerous factors, such as training and competition workloads, travel, changes in sleep-wake schedules, and sleeping environments. They often spend nights in unfamiliar hotels, and sharing a bed, room, or both with another person might affect sleep duration and quality. Objective To analyze the effect of sleeping in shared (SRs) versus individual (IRs) rooms on objective and subjective sleep and on slow-wave-sleep–derived cardiac autonomic activity during an official training camp in elite youth soccer players. Training and match workloads were characterized. Design Observational case study. Setting Hotel accommodations. Patients or Other Participants Thirteen elite male youth soccer players. Results Players slept longer in IRs than in SRs (+1:28 [95% CI = 1:18, 1:42] hours:minutes; P < .001). Sleep efficiency was higher in IRs than in SRs (+12% [95% CI = 10%, 15%]; P < .001), whereas sleep latency was shorter in IRs than in SRs (−3 [95% CI = −15, −4] minutes; P < .001). Subjective sleep quality was lower in IRs than in SRs (−2 [−3 to −2] arbitrary units; P < .001). No differences were found for slow-wave-sleep–derived cardiac autonomic activity or for training or match workloads between training camps. Conclusions During soccer training camps, sleep may be affected by whether the athlete is in an SR versus an IR.

International audience; The ground-state magnetic dipole moment of the neutron-rich O21 isotope has been measured via β-ray-detected nuclear magnetic resonance (β-NMR) spectroscopy by using a spin-polarized secondary beam of O21 produced from the Ne22 primary beam. From the present measurement, the g factor |gexp(Og.s.21)|=0.6036(14) has been determined. Based on the comparison of this value with Schmidt values, we unambiguously confirm the νd5/2 configuration with spin and parity assignments Iπ=5/2+ for the O21 ground state, suggested by previously reported studies. Consequently, the magnetic moment has been determined as μexp(Og.s.21)=(−)1.5090(35)μN. The obtained experimental magnetic moment is in good agreement with the predictions of the shell-model calculations using the USD, YSOX, and SDPF-M interactions as well as random phase approximation (RPA) calculations. This observation indicates that the O21 nucleus in its ground state does not manifest any anomalous structure and is not influenced by the proximity of the drip line.

This study aimed to examine the effects of quercetin glycoside-containing beverages on cognitive function and cerebral blood flow (CBF) in adult men and women aged between 60 and 75 years.Eighty healthy men and women with no cognitive impairment and aware of ageing-related forgetfulness underwent a placebo-controlled, randomized, double-blind, and parallel-group trial. They regularly consumed 500 mL of beverage containing 110 mg of quercetin glycoside as isoquercitrin for 40 weeks. Cognitive function assessment by Cognitrax was the endpoint of the study. The participants were assessed for CBF, health-related quality of life, as well as physical, biological, and hematological parameters, and lateral index.Cognitrax demonstrated that the reaction time significantly improved in the quercetin glycoside intake group. The CBF measurement suggested that quercetin glycoside intake could likely suppress the decrease in cerebral blood volume, CBF, and cerebral activity owing to stress alleviation and inhibition of the accumulation of amyloid β (Aβ), a waste product in the brain, although there were no significant differences between the groups.Quercetin glycoside intake as a beverage could improve reaction time and may potentially inhibit the decrease in CBF and suppress Aβ accumulation.

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OBJECTIVE: We previously established a descriptive dietary record method that accurately quantifies habitual water intake from food and beverages, to ascertain the relationship between water intake and health. Here, we verified the validity of a selective recall method, which is easy for users to answer and analyze. PATIENTS AND METHODS: Japanese men and women aged 20-44 years (n = 16) and 45-64 years (n = 16) participated over three working days and one non-working day. The day following each of the surveyed days, participants collected their first morning urine for urinalysis and completed a selective recall and descriptive dietary record questionnaire. RESULTS: The two methods of determining water intake were positively correlated (r = 0.94, p < 0.0001). Water intake volumes from non-alcoholic beverages (r = 0.94, p < 0.0001), alcoholic beverages (r = 1.00, p < 0.0001), and food (r = 0.72, p < 0.0001), calculated using the two methods, exhibited strong correlation. No correlation was observed between urinalysis parameters and total water intake. A significant, negative correlation was observed between urine osmolarity and total water intake in men (r = -0.55, p = 0.0011) and women (r = -0.51, p = 0.0032) aged 20-44 years. CONCLUSIONS: Selective recall is a valid method for assessing water intake from food and beverages.

Objectives The aim of this AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial subgroup analysis was to examine rivaroxaban monotherapy benefits and their relation to the time between stenting and enrollment among patients after coronary stenting. Background Of 2,215 patients with atrial fibrillation and stable coronary artery disease in the AFIRE trial, rivaroxaban monotherapy was noninferior to rivaroxaban plus antiplatelet therapy (combination therapy) in terms of efficacy and superior for safety endpoints. However, thrombotic risk after antiplatelet therapy cessation remained a concern among 1,444 patients who had undergone coronary stenting >1 year before enrollment. Methods The benefits of rivaroxaban monotherapy in coronary stenting subgroups were assessed for efficacy (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death of any cause), safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria), ischemic endpoints, net adverse clinical event, and time between stenting and enrollment. Results Efficacy and safety endpoints for monotherapy were superior to combination therapy, with HRs of 0.70 for efficacy (95% CI: 0.50-0.98; P = 0.036) and 0.55 for safety (95% CI: 0.33-0.92; P = 0.019). For ischemic endpoints, the HR was 0.82 (95% CI: 0.58-1.15; P = 0.240). The HR became smaller with longer time between stenting and enrollment (efficacy, P for interaction = 0.158; safety, P = 0.097). Conclusions In patients with atrial fibrillation after coronary stenting, the benefits of rivaroxaban monotherapy for efficacy and safety endpoints were consistent with those in the whole AFIRE trial population. The benefits became apparent with longer time between stenting and enrollment. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study [AFIRE]; UMIN000016612 , NCT02642419 )

Andes Large-area PArticle detector for Cosmic-ray physics and Astronomy (ALPACA) is an international experiment that applies southern very-high-energy (VHE) gamma-ray astronomy to determine the origin of cosmic rays around the knee energy region ($10^{15}\, {\rm eV} - 10^{16}\, {\rm eV}$). The experiment consists of an air shower (AS) array with a surface of $83, 000\, {\rm m}^2$ and an underground water Cherenkov muon detector (MD) array covering $5, 400\, {\rm m}^2$. The experimental site is at the Mt. Chacaltaya plateau in La Paz, Bolivia, with an altitude of $4, 740\, {\rm m}$ corresponding to $572\, {\rm g}/{\rm cm}^2$ atmospheric thickness. As the prototype experiment of ALPACA, the ALPAQUITA experiment aims to begin data acquisition in late 2021. The ALPAQUITA array consists of a smaller AS array ($18, 450\, {\rm m}^2$) and underground MD ($900\, {\rm m}^2$), which are now under construction. ALPAQUITA's sensitivity to gamma-ray sources is evaluated with Monte Carlo simulations. The simulation finds that five gamma-ray sources observed by H.E.S.S. and HAWC experiments will be detected by ALPAQUITA beyond 10 TeV and one out of these five - HESS J1702-420A - above 300 TeV in one calendar year observation. The latter finding means that scientific discussions can be made on the emission mechanism of gamma rays beyond 100 TeV from southern sources on the basis of the observational results of this prototype experiment., This is the manuscript accepted by Experimental Astronomy. For the published article, see https://doi.org/10.1007/s10686-021-09796-8

We conducted comprehensive clinical and molecular characterization of claudin 18.2 expression (CLDN18.2) in advanced gastric or gastroesophageal junction cancer (GC/GEJC).Patients with advanced GC/GEJC who received systemic chemotherapy from October 2015 to December 2019 with available tumor specimens were analyzed. We evaluated clinicopathological features of CLDN18.2 expression with four molecular subtypes: mismatch repair deficient, Epstein-Barr virus-positive, human epidermal growth factor receptor 2-positive, and others. In addition, programmed death-ligand 1 (PD-L1) combined positive score (CPS), genomic alterations, and the expression of immune cell markers were assessed. Clinical outcomes of standard first- or second-line chemotherapy and subsequent anti-programmed cell death protein 1 (anti-PD-1) therapy were also investigated according to CLDN18.2 expression.Among 408 patients, CLDN18.2-positive (moderate-to-strong expression in ≥75%) was identified in 98 patients (24.0%) with almost equal distribution in the four molecular subtypes or CPS subgroups. CLDN18.2-positive was associated with Borrmann type 4, KRAS amplification, low CD16, and high CD68 expression. Overall survival with first-line chemotherapy was not significantly different between CLDN18.2-positive and -negative groups [median 18.4 versus 20.1 months; hazard ratio 1.26 (95% confidence interval 0.89-1.78); P = 0.191] regardless of stratification by PD-L1 CPS ≥5. Progression-free survival and objective response rates of first- and second-line chemotherapy, and anti-PD-1 therapy also showed no significant differences according to CLDN18.2 status.CLDN18.2 expression in advanced GC/GEJC was associated with some clinical and molecular features but had no impact on treatment outcomes with chemotherapy or checkpoint inhibition. CLDN18.2-positive also had no impact on overall survival. This information could be useful to interpret the results from currently ongoing clinical trials of CLDN18.2-targeted therapies for advanced GC/GEJC and to consider a treatment strategy for CLDN18.2-positive GC/GEJC.

SUMMARYCancers often display immune escape, but the mechanisms and potential for reversibility are incompletely understood. Epigenetic dysregulation has been implicated in the immune escape of various cancer types. We have identified the epigenetic modifier SET and MYND-domain containing protein 3 (SMYD3) as a mediator of immune escape in human papilloma virus (HPV)- negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor prognosis and low response to immunotherapy with pembrolizumab, a programmed-death-1 (PD-1) targeting antibody. SMYD3 loss increased the sensitivity of HNSCC cancer cells to IFN-β, resulting in upregulation of type I IFN response and antigen presentation machinery genes. We found that SMYD3 regulates the transcription of Ubiquitin-Like PHD And RING Finger Domain- Containing Protein 1 (UHRF1), a key epigenetic reader of trimethylated lysine 9 on histone H3 (H3K9me3), which binds to H3K9me3-enriched promoters of key immune-related genes and silences their expression. SMYD3 further maintains the repression of immune-related genes through the deposition of H4K20me3 within the gene body regions of these genes. In an anti-PD-1 immune checkpoint resistant syngeneic mouse model of HPV-negative HNSCC, Smyd3 depletion induced influx of CD8+ T-cells, upregulated PD-L1 and MHC class I molecules, and increased sensitivity to anti-PD-1 therapy. SMYD3 overexpression was associated with decreased CD8 T-cell infiltration in tumor samples from patients with HPV-negative HNSCC, and was associated with poor response to pembrolizumab. Overall, these data highlight a previously unreported function of SMYD3 as a master epigenetic regulator of anti-tumor immune response in HPV-negative HNSCC and provide a rationale for translational approaches combining SMYD3 depletion strategies with checkpoint blockade to overcome anti-PD-1 resistance in this devastating disease.

Helical distortion in the core region and its formation mechanism in weakly reversed magnetic shear tokamak plasmas are investigated using three-dimensional magnetohydrodynamic (MHD) equilibrium calculations and MHD stability analysis. It is found that there are two different types of helical equilibrium states: one is a rigid-body shift in the core region on a poloidal cross-section, while the other is a local advection only around the magnetic axis. Linear stability analysis of the corresponding axisymmetric equilibrium is carried to understand the origin of these two types of helical equilibrium states. The analysis shows that the former is related to the current-driven internal-kink instability, while the latter is linked to the pressure-driven quasi-interchange instability. The kink-mode-driven helical equilibrium state appears when the minimum value of the safety factor q m i n is close to unity, while the quasi-interchange-driven helical equilibrium state appears when q m i n is below unity. The appearance of the quasi-interchange state is attributed to the weak magnetic shear at the inner q = 1 rational surface and finite β.