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Amaç: Hipoksikiskemikensefalopati (HİE), perinatal dönemde hipoksiye bağlı olarak görülen ağır morbidite ve mortalite ile sonuçlanabilen klinik bir durumdur. Bu çalışmanın amacı, hipoksik iskemik ensefalopatide kardiyak biyomarkerlerden N-Terminal pro Brain Natriüretik Peptid (NTproBNP) ve Troponin I’nın rolünü değerlendirmektir. Yöntemler: Bu çalışmada, Ocak 2019 ve Mayıs 2021 tarihleri arasında Yenidoğan Yoğun Bakım Ünitesinde HİE tanısı ile takip ve tedavileri yapılmış olan hastaların Troponin I ve NTproBNP düzeyleri geriye dönük olarak incelendi. Bulgular: Bu çalışma %44,5 (45)’i kız ve %55.5(56)’sı erkek olmak üzere 101 olgudan oluştu. Normal spontan vajinal yol ile doğum oranı %57,8 (63) iken Sezaryenle doğum oranı %42,2 (46) idi. Olgularda HİE evre 1 oranı %31.7 (32), HİE evre2 oranı %31,7 (32) ve HİE evre 3 oranı%36,6 (37) olarak bulundu. Ortalama doğum ağırlığı 3139.95±499.02 g, ortalama gestasyon haftası 38.39±1.69 hafta bulundu. NTproBNP; ortalama 10099.49±12023.03 pg/mL ve Troponin I; 122.575±188.5287 ng/L bulundu. Hipoksik iskemik ensefalopatinin şiddetinin artması ile Troponin I arasında istatistiksel olarak anlamlı bir fark bulunurken, NTproBNP ile HİE’nin şiddeti arasında herhangi bir farklılık bulunmadı. Sonuç: Yenidoğan HİE’li bebeklerde NTproBNP ve Troponin I düzeylerinde artış vardır. Ayrıca, Troponin I düzeyleri ile yenidoğan hipoksik iskemik ensefalopati şiddeti arasında anlamlı ilişki olduğu bulundu. Objective: Hypoxic ischemic encephalopathy (HIE) is a clinical condition that can result in severe morbidity and mortality due to hypoxia in the perinatal period. The aim of this study is to evaluate the role of cardiac biomarkers NTerminal pro Brain Natriuretic Peptide (NTproBNP) and Troponin I in hypoxic ischemic encephalopathy. Methods: In this study, Troponin I and NTproBNP levels of patients who were followed up and treated with the diagnosis of HIE in the Neonatal Intensive Care Unit between January 2019 and May 2021 were evaluated retrospectively. Results: This study consisted of 101 subjects, 44.5% (45) female and 55.5% (56%) male. While the rate of normal spontaneous vaginal delivery was 57.8% (63), the rate of cesarean delivery was 42.2% (46). In the cases, the rate of HIE stage 1 was 31.7% (32), the rate of HIE stage 2 was 31.7% (32) and the rate of HIE stage 3 was 36.6% (37). Mean birth weight was 3139.95±499.02 g, mean gestational week was 38.39±1.69 weeks. NTproBNP; mean 10099.49±12023.03 pg/mL and Troponin I; 122.575±188.5287 ng/L was found. While there was a statistically significant difference between the increase in the severity of hypoxic ischemic encephalopathy and Troponin I, there was no difference between the severity of NTproBNP and HIE. Conclusion: There is an increase in NTproBNP and Troponin I levels in infants with neonatal HIE. In addition, a significant correlation was found between Troponin I levels and the severity of neonatal hypoxic ischemic encephalopathy.

COVID-19 pandemisi dünya çapında yayılmaya devam ederken, risk altındaki popülasyonları belirlememiz ve onları korumak için uygun klinik bakım politikaları geliştirmemiz çok önemlidir. Yenidoğan SARS-CoV-2 enfeksiyonunun insidansı ve sonuçlarına ilişkin veriler ortaya çıkmaya devam etse de, öğrenilecek daha çok şey vardır. Şimdiye kadar ki kanıtlar, yenidoğanda dikey bulaşmanın nadir olduğunu ve daha büyük bir oranın doğum sonrası solunum damlacıkları yoluyla veya enfekte anne veya bakıcılarla temas yoluyla enfeksiyon kaptığını göstermektedir. Yenidoğanların çoğunda SARS-CoV-2'ye bağlı semptom gelişmez, ancak prematüreliğe bağlı morbiditeler yoğun bakım ve destek gerektirebilir. Semptomların varlığına bakılmaksızın, COVID-19 enfeksiyonundan şüphelenilen veya teyit edilen annelerden doğan tüm yenidoğanlar test edilmelidir. Yenidoğanda COVID-19 durumu hakkında farkındalık, enfeksiyon önleme ve kontrol önlemleri uygulama yöntemleri teşvik edilmelidir. As the COVID-19 pandemic continues to spread worldwide, it is critical that we identify populations at risk and develop appropriate clinical care policies to protect them. While data on the incidence and outcomes of neonatal SARS-CoV-2 infection continue to emerge, there is much more to learn. Evidence to date indicates that vertical transmission in the neonate is rare, with a greater proportion contracting postnatally via respiratory droplets or through contact with infected mothers or caregivers. Most newborns do not develop symptoms due to SARS-CoV-2, but morbidities due to prematurity may require intensive care and support. Regardless of the presence of symptoms, all newborns born to mothers with suspected or confirmed COVID-19 infection should be tested. Awareness of the COVID-19 situation in the newborn and methods of implementing infection prevention and control measures should be encouraged.

Platelet parameters such as platelet count (PLT), mean platelet volume (MPV) and platelet mass index (PMI) are associated with physiological and pathological functions in various inflammatory diseases. The aim of the present study was to investigate whether platelet parameters were related to retinopath y of prematurity (ROP) in premature newborns. We retrospectively evaluated the platelet count, platelet mass index, and MPV parameters measured on the first day and 28th day, which belonged to patients, who were examined for retinopathy of prematurity at n eonatal intensive care unit. Among 343 patients enrolled by the study, 52.8 % (181) were male and 47.2 %(162) were female. The PLT level studied on the first day was 231.6±84(x1000/mm3) in the ROP group and 207.8±81.6(x1000/mm3) in the non ROP group, and t he PLT level studied on the 28th day was 409.9±179.4(x1000/mm3) in the ROP group and 350.7±140.4(x1000/mm3) in the non ROP group. There was a significant difference between the two groups regarding both PLT levels (p=0.007, p=0.006, respectively). The PMI level studied on the first day was 1854.1±774.7 in the ROP group and 1638.2±753.3 in the non ROP group, and the PMI level studied on the 28th day was 3784.5±1797.4 in the ROP group and 3302.8±1452.9 in the non ROP group. This study showed that platelet count and platelet mass index measured on the first and 28th days are important parameters in patients who undergo ROP examination, and these parameters measured prior to examination will guide clinicians in diagnostic process.

PMID: 33819976 Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal corticosteroid treatment in both the patient and the control group on the 28th day and, for a second time, after treatment termination in the patient group. Results: There were significant differences between the measured GFAP, MAPT, and NSE values of the BPD and control groups on the 28th day, whereas there was no significant difference between the measured S100B values of the two groups. There were a statistically significant difference between the NSE values measured on the 28th day and after the treatment within the BPD group, whereas no significant difference existed between the GFAP, MAPT, and S100B values. Conclusion: NSE levels, which indicate brain damage in the early period, increased in preterm babies with BPD who had been administered postnatal dexamethasone.

Objectives Amniotic band syndrome and osteogenesis imperfecta are two distinct diseases that develop due to structural defects of the collagen protein. In our paper, we report the concurrence of these two diseases rarely seen in the newborn period. Case presentation A female infant born at 33rd gestational week was found to have constrictive bands in her right lower extremity and flexion contractures in distal joints of lower and upper extremities due to amniotic bands in postnatal physical examination. While being treated for respiratory difficulty, she was diagnosed with osteogenesis imperfecta and treated with bisphosphonates upon being found to suffer bilateral humeral fractures on the sixth day of life. She received respiratory support with mechanical ventilation due to respiratory tract complications related to osteogenesis imperfecta and died on the 384th day of life. Conclusions One should bear in mind that other collagen tissue diseases may accompany the amniotic band syndrome; this possibility should be definitely pursued if clinical suspicion exists.