Search

Your search keyword '"YİLMAZ, Seher"' showing total 157 results
Start Over Author "YİLMAZ, Seher"
157 results on '"YİLMAZ, Seher"'

5. List of contributors

Author

Abramowitz, Matthew C., primary, Alluri, Prasanna, additional, Alyas, Tahira, additional, Arafat, Waleed, additional, Attar, Rukset, additional, Avnioglu, Seda, additional, Barnwal, Ravi Pratap, additional, Bellati, Filippo, additional, Benedetti Panici, Pierluigi, additional, Berardi, Rossana, additional, Bhatia, Alka, additional, Biray Avci, Cigir, additional, Breto, Adrian L., additional, Caruso, Giuseppe, additional, Caserta, Donatella, additional, Ceafalan, Laura C., additional, Cesmeli, Selin, additional, Corcoy, Rosa, additional, Di Bartolomeo, Gabrielle, additional, Di Donato, Violante, additional, Di Micco, Rosa, additional, Escolà-Gil, Joan Carles, additional, Fakhar, Maham, additional, Farmer, Madeline, additional, Farooqi, Ammad Ahmad, additional, Fuste, Victoria, additional, Gallo, Ryan, additional, Gasparri, Maria Luisa, additional, Gentilini, Oreste D., additional, Gherghiceanu, Mihaela, additional, Goel, Sumit, additional, Goker Bagca, Bakiye, additional, Hara, Daiki, additional, Hinescu, Mihail E., additional, Hu, Xiaoyu, additional, Ioghen, Octavian, additional, Iqbal, Muhammad Javed, additional, Jain, Srishti, additional, Julve, Josep, additional, Karasholakova, Lazzat, additional, Kaur, Indu Pal, additional, Khamis, Yomna, additional, Kryvenko, Oleksandr N., additional, Kusoglu, Alican, additional, Lerma, Enrique, additional, Mahmood, Naila Nasir, additional, Malik, Durr-e-shahwar, additional, Malkani, Naila, additional, Martinelli, Chiara, additional, Mato, Eugènia, additional, Mobeen, Iqra, additional, Moral, Antonio, additional, Mumtaz, Sidra, additional, Muzii, Ludovico, additional, Naureen, Humaira, additional, Niculae, Andrei M., additional, Ozbey, Ulku, additional, Paez Espinosa, Enma Veronica, additional, Palaia, Innocenza, additional, Pandit, Chitvan, additional, Papadia, Andrea, additional, Pérez, José Ignacio, additional, Perniola, Giorgia, additional, Pimentel, Tatiana Colombo, additional, Pollack, Alan, additional, Pra, Alan Dal, additional, Punnen, Sanoj, additional, Rashid, Muhammad Usman, additional, Redd, Kristina, additional, Revilla, Giovanna, additional, Rinaldi, Silvia, additional, Roberson, Tinsley, additional, Ruscito, Ilary, additional, Shi, Junwei, additional, Siconolfi, Arianna, additional, Singh, Aagamjit, additional, Singh, Gurpal, additional, Singh, Joga, additional, Smith, Metta, additional, Sohail, Muhammad Imran, additional, Soni, Udit, additional, Spohr, Tania Cristina Leite de Sampaio e, additional, Steed, Kayla Lewis, additional, Stoyanova, Radka, additional, Tanriover, Gamze, additional, Tao, Wensi, additional, Tutar, Yusuf, additional, Yaylim, Ilhan, additional, Yilmaz, Seher, additional, Youssef, Lara, additional, Yulaevna, Ishmuratova Margarita, additional, and Zuber, Veronica, additional

Published
2022
Full Text
View/download PDF

8. Investigation of Antitumor Activity of Fenugreek Paste Extracts.

Author

Alpa, Serife, Bozkurt, Ozlem, Yilmaz, Seher, Ertekin, Tolga, Nisari, Mehtap, Karatoprak, Gökce Seker, and Ulger, Harun

Subjects
CANCER chemotherapy, IN vitro studies, ABDOMEN, ASCITES, DATA analysis, ANTINEOPLASTIC agents, CELL proliferation, FLAVONOIDS, KRUSKAL-Wallis Test, IN vivo studies, DESCRIPTIVE statistics, MANN Whitney U Test, PLANT extracts, CELL lines, MICE, CELL culture, ANIMAL experimentation, PHENOLS, ANALYSIS of variance, STATISTICS, HISTOLOGICAL techniques, MEDICINAL plants, DATA analysis software, COMPARATIVE studies, PHARMACODYNAMICS
Abstract

Objective: Fenugreek paste, which contains fenugreek and spices, is a popular food in Kayseri and the surrounding region of Türkiye. This study aims to evaluate the antitumor effects of an extract derived from fenugreek paste in Balb/C mice bearing Ehrlich ascites tumor (EAT). Materials and Methods: In the in vivo experiments, fenugreek paste extract was administered at concent rations of 200 mg/kg or 400 mg/kg. For the in vitro study, extract concentrations of 250, 500, and 1000 µg/mL were used. At the end of the experiment, the volume of abdominal ascites fluid was measured, and cell counts were performed. Results: Fenugreek paste extract delayed weight gain due to EAT cell proliferation in the treatment groups and caused a significant decrease in the number of cells in the ascites fluid in the 400 mg/kg extract group (47.28×106) compared to the control group (67.60×106; p=0.041). Histopathological analysis revealed that EAT cells adhered intensely to tissues in the control group but adhered less in the treatment groups. The most significant decrease was observed in the 400 mg/kg fenugreek extract group. After 24 hours of culture, there was a substantial difference in EAT cell viability between the control group (5.9±0.2) and the treatment groups receiving 250, 500, and 1000 µg/mL of fenugreek paste extract (5.7±0.2, 5.7±0.2, and 5.6±0.1, respectively; p=0.013). Conclusion: The study results suggested that fenugreek paste extract had an antitumor effect on EAT cells. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. PI3K And mTOR Immunoreactivity In Testicular Tissue In Experimental Alcohol Addiction Model.

Author

ÖZTÜRK, Osman, OKAN, Aslı, KURT, Mustafa, EROĞLU, Ece, YILMAZ, Seher, UĞUZ, A. Cihangir, OCAK, Mert, and DOĞANYİĞİT, Züleyha

Subjects
PHOSPHATIDYLINOSITOL 3-kinases, MTOR protein, ALCOHOL-induced disorders, OXIDATIVE stress, DNA damage
Abstract

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

10. Role of melatonin in carcinogenesis and metastasis: From mechanistic insights to intermeshed networks of noncoding RNAs.

Author

Lin, Xiukun, Qureshi, Muhammad Zahid, Tahir, Fatima, Yilmaz, Seher, Romero, Mirna Azalea, Attar, Rukset, and Farooqi, Ammad A.

Subjects
NON-coding RNA, LINCRNA, MELATONIN, RNA regulation, CIRCULAR RNA
Abstract

In recent years, seminal studies have been devoted to unraveling the puzzling mysteries associated with the cancer preventive/inhibitory role of melatonin. Our current knowledge of the translational mechanisms and the detailed structural insights have highlighted the characteristically exclusive role of melatonin in the inhibition of carcinogenesis and metastatic dissemination. This mini‐review outlines recent discoveries related to mechanistic role of melatonin in prevention of carcinogenesis and metastasis. Moreover, another exciting facet of this mini‐review is related to phenomenal breakthroughs linked with regulation of noncoding RNAs by melatonin in wide variety of cancers. Significance statement: There has been a paradigm shift in our understanding related to metamorphosis of simplistic view about melatonin from a sleep inducer to mechanistic role of melatonin in cancer prevention. Furthermore, regulation of noncoding RNAs particularly long noncoding RNAs and circular RNAs is adding another layer of complexity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. The effect of ionizing radiation on the fetal bone development in pregnant rats: Role of melatonin.

Author

Tokpinar, Adem, Nisari, Mehtap, Yilmaz, Seher, Yay, Arzu, Yildiz, Oğuz Galip, Balcioğlu, Esra, Alişan, Pınar, Bilgici, Pınar, Uçar, Sümeyye, Ateş, Şükrü, and Bağci, Kezban

Abstract

Radiation has been widely used in many business sectors over the last century. Our study investigated the possible teratogenic effects of radiation on the bones of rat fetuses and the protective effect of melatonin against these effects. In this study, 15 pregnant female Wistar albino rats were used. These rats were divided into four groups: the control group, melatonin group (10 mg/kg/day), radiation group (0.5 gray), radiation (0.5 gray) + melatonin group (10 mg/kg/day), and sham group (1 mm hanks/day). The skeletal system development of fetuses was examined with double skeletal and scanning electron microscope (SEM), histopathological methods. In our study, fetal weight, placental weight, and fetal morphometric values were found to be statistically significantly decreased in the radiation group compared to the control group (p <.05). In immünohistochemistry (IHC) analysis, alkaline phosphatase, and tartrate‐resistant acid phosphatase) concentrations were found to be significantly lower in the radiation group compared to the other groups. In the SEM analysis, it was observed that the amount of calcium and sodium decreased when the radiation group was compared with the other groups. As a result, when exposed to ionizing radiation during pregnancy, melatonin has a protective feature against the negative effects of radiation on the bone development of fetuses. Research Highlights: In our study, fetuses obtained from pregnant rats exposed to ionizing radiation were examined.In this study, the effect of melatonin on bone development in fetuses exposed to gray ionizing radiation was investigated.There are few studies on our subject in the literature. We believe that our findings will contribute to other planned studies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Inhibition of Ehrlich ascites carcinoma growth by melatonin: Studies with micro-CT.

Author

YILMAZ, SEHER, DOĞANYIĞIT, ZÜLEYHA, OCAK, MERT, SÖYLEMEZ, EVRIM SUNA ARIKAN, OFLAMAZ, ASLI OKAN, UÇAR, SÜMEYYE, ATEŞ, ŞÜKRÜ, and FAROOQI, AMMAD AHMAD

Subjects
EHRLICH ascites carcinoma, X-ray computed microtomography, SERINE/THREONINE kinases, MELATONIN, PHOSPHATIDYLINOSITOL 3-kinases, PINEAL gland
Abstract

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling pathway. Melatonin has many benefits, such as organizing circadian rhythms and acting as a powerful hormone. We aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin (mTOR) signaling pathway and the Argyrophilic Nucleolar Regulatory Region (AgNOR), using the Microcomputed Tomography (Micro CT). Ehrlich ascites carcinoma (EAC) cells were administered into the mice by subcutaneous injection. Animals with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 days. Volumetric measurements for the taken tumors were made with micro-CT imaging, immunohistochemistry (IHC), real-time polymerase chain reaction (PCR) and AgNOR. Statistically, the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT images. In the IHC analysis, the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8 (F8) expression were compared with the control group. It was determined that there was a significant decrease (p < 0.05). Significant differences were found in the total AgNOR area/nuclear area (TAA/NA) ratio in the treatment groups (p < 0.05). Furthermore, there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase (PI3K), AKT Serine/Threonine Kinase (PKB/AKT) genes (p < 0.05). Cell apoptosis was evaluated with Annexin V in an in vitro study with different doses of melatonin; It was observed that 100 µg/mL melatonin dose caused an increase in the apoptotic cell death. In this study, we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice models. Comprehensive characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advancing our fundamental molecular understanding and translatability of pre-clinical findings to earlier phases of clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Rapid selection of a cefiderocol-resistantEscherichia coliproducing NDM-5 associated with a single amino acid substitution in the CirA siderophore receptor

Author

Jousset, Agnès B, primary, Poignon, Corentin, additional, Yilmaz, Seher, additional, Bleibtreu, Alexandre, additional, Emeraud, Cécile, additional, Girlich, Delphine, additional, Naas, Thierry, additional, Robert, Jérôme, additional, Bonnin, Rémy A, additional, and Dortet, Laurent, additional

Published
2023
Full Text
View/download PDF

18. Effects of Maternal Caffeine and Vitamin E Usage on Fetus

Author

TOKPINAR, ADEM, ARIKAN, EVRİM SUNA, GÖÇMEN, AYŞE YEŞİM, UÇAR, SÜMEYYE, YILMAZ, SEHER, KÖKLÜ, Betül, and ATEŞ, ŞÜKRÜ

Subjects
General Medicine
Abstract

The use of maternal caffeine has an important effect on the development of the fetus. We investigated the mechanism of oxidative damage induced by caffeine and the efficacy of vitamin E. Pregnant rats of Wistar-albino genus were used. Following groups of animals were defined: control, sham, caffeine (50 mg/kg), caffeine + vitamin E, vitamin E (60 mg/kg) all invasive applications were repeated daily for 20 days. Tumor necrosis factor alpha (TNF-α), interleukin 1β(IL-1β), interleukin 6 (IL-6) levels were measured in tissue homogenates by using Enzyme-Linked Immuno Sorbent Assay (ELISA) method. Thiobarbituric acid reactive acid substances (TBARS), Superoxide dismutase (SOD), Glutathione (GSH), Glutathione disulfide (GSSG), Total oxidant status (TOS), Total anti-oxidant status (TAS), Oxidative stress index (OSI), Calcium (Ca) and vitamin D (Vit D) parameters were measured by spectrophotometric assay. According to these data, caffeine used in pregnancy delayed ossification; It has been found that vitamin E, a powerful antioxidant, counteracts this effect.

Published
2022

27. Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study.

Author

Okan, Aslı, Doğanyiğit, Züleyha, Yilmaz, Seher, Uçar, Sümeyye, Arikan Söylemez, Evrim Suna, and Attar, Rukset

Subjects
RESVERATROL, SEPSIS, CELLULAR signal transduction, GENE expression, MESSENGER RNA, NEONATAL sepsis
Abstract

The development and progression of sepsis are multifactorial and influence the immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the key mechanisms involved in the pathogenesis of sepsis has expanded exponentially, yet this still needs to be translated into effective targeted therapeutic regimes. In the present study, we aimed to determine whether resveratrol has positive effects in the experimental sepsis rat model. Twenty‐eight male Spraque–Dawley rats were randomly divided into four groups (n = 7) as follows: control, lipopolysaccharide (LPS) (30 mg/kg dose), resveratrol, and LPS and resveratrol. After the experiment, liver and kidney tissues were collected for histopathological evaluation, blood serums were collected to measure malondialdehyde levels with enyzme‐linked immunosorbent assay, and Toll‐like receptor‐4 (TLR4), tumor necrosis factor‐α (TNF‐α), nuclear factor‐κB (NF‐κB) immunoreactivity density was evaluated immunohistochemically. In addition, messenger RNA expression levels for TLR4, TNF‐α, NF‐κB, interleukin‐1β, and interleukin 6 were measured. In addition, the damage observed in liver and kidney tissue was determined by AgNOR (argyrophilic nucleolar organizer regions) staining. LPS application caused severe tissue damage, oxidative stress, and increased the expressions of proinflammatory proteins and genes we evaluated, while resveratrol application eliminated these negativities. Resveratrol has been proven to suppress the TLR4/NF‐κB/TNF‐α pathway, a possible therapeutic signaling pathway that is important in initiating the inflammatory response in an animal model of sepsis. Significance Statement: Toll‐like receptors (TLRs) are potent activators of the inflammatory response. TLR4 is a potential therapeutic target for sepsis. Resveratrol has a protective role on liver and kidney functions in sepsis via the TLR4/nuclear factor‐κB/tumor necrosis factor‐α signaling pathway. AgNOR (argyrophilic nucleolar organizer regions) staining intensity, which quantifies tissue damage, increased in liver tissues in a lipopolysaccharide‐induced sepsis model. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

28. Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway.

Author

Yilmaz, Seher, Doğanyiğit, Züleyha, Oflamaz, Aslı Okan, Ateş, Şükrü, Uçar, Sümeyye, and Söylemez, Evrim Suna Arıkan

Subjects
*SEPSIS, *PROTEIN synthesis, *CELLULAR signal transduction, *MELATONIN, *BIOMARKERS, *TRANSCRIPTION factors
Abstract

In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model. Twenty‐eight rats were randomly divided: Control, Melatonin, LPS and LPS + Melatonin. After LPS application, surgically remove kidney and liver tissues. The level of malondialdehyde (MDA) an oxidative stress marker and the immunoreactivity of Toll‐like receptor‐4 (TLR4), tumor necrosis factor‐α (TNF‐α), and transcription factor NF‐κB were evaluated immunohistochemically. Expression levels for TLR4, TNF‐α, NF‐kB, IL‐1β (interleukin 1 beta), and IL‐6 (interleukin 6) were evaluated. Additionally, Argyrophilic NOR staining was performed in tissues. Vacuolization and inflammation were more intense in the kidney and liver sections in the LPS group compared to the other groups. It was observed that vacuolization and inflammation were decreased in LPS + Melatonin applied groups. It was determined that glomerular damage was increased in the LPS and LPS‐melatonin groups, but the damage rate LPS‐Melatonin group was decrease in the LPS group. It was determined that the MDA level in tissues of the LPS group was importantly increased compared to other groups. Additionally, TAA/NA ratio statistically significant differences were discovered between the groups. This study supports the potential protective effects of 10 mg/kg melatonin by modulating critical markers of local immune reaction in a model of LPS‐induced sepsis. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Evaluation of antitumoral effect of mistletoe fruit extract on Ehrlich ascites tumor cells with muse cell analyzer and argyrophilic nucleolar organizer region staining method

Author

Ateş, Şükrü, primary, Ülger, Harun, additional, Yilmaz, Seher, additional, Karatoprak, Gökçe Şeker, additional, Al, Özge, additional, Uçar, Sümeyye, additional, Taştan, Mustafa, additional, Tokpinar, Adem, additional, Alpa, Şerife, additional, and Farooqi, Ammad Ahmad, additional

Published
2022
Full Text
View/download PDF

34. Effect of Acupressure on Senior Nursing Students' Anxiety during the COVID-19 Pandemic: A Randomized Controlled Clinical Trial.

Author

Yanik, Tugba Cam, Kanat, Canan, Karaman, Ahmet, Yilmaz, Seher Gurdil, and Ugras, Gulay Altun

Subjects
ANXIETY prevention, STATE-Trait Anxiety Inventory, ACUPRESSURE, INTERVIEWING, FISHER exact test, NURSING education, RANDOMIZED controlled trials, COMPARATIVE studies, SELF medication, CRONBACH'S alpha, T-test (Statistics), QUESTIONNAIRES, CHI-squared test, NURSING students, STATISTICAL sampling, COVID-19 pandemic, LONGITUDINAL method
Abstract

Background: The transition to distance learning in nursing education during the COVID-19 pandemic, where clinical practice is critical, may have caused senior nursing students to experience a sense of graduating without sufficient skills and experience anxiety in addition to the anxiety caused by the pandemic. Non-pharmacological methods such as acupressure may be helpful in reducing students' anxiety. Aim: This study was conducted to determine the effect of acupressure on senior nursing students' anxiety levels during the COVID-19 pandemic. Methodology: This prospective, two-armed (1:1), randomized controlled study included fifty-two senior nursing students at a university nursing department. While the experimental group (n=26) applied acupressure to the LI4, HT7, and EX-HN3 points three times a week for four weeks, acupressure was not applied to the control group (n=26). Data were collected at baseline and at the end of four weeks using the State-Trait Anxiety Inventory (STAI). Results: At the end of four weeks, there was no significant difference between the STAI-State and STAI-Trait scores of the experimental and control groups (p>0.05). The STAI-State score of the experimental group decreased significantly in the fourth week compared to the baseline (p<0.05). Conclusion: Research findings revealed that self-administered acupressure by senior nursing students was effective in reducing moderate state anxiety during the pandemic, but not trait anxiety. [ABSTRACT FROM AUTHOR]

Published
2023

36. Poster presentations

Author

Aksu, Funda, Topacoglu, Hakan, Arman, Candan, Atac, Aytul, Tetik, Suleyman, Hasanovic, Aida, Kulenovic, Amela, Mornjakovic, Zakira, Pikula, Branko, Sarac-Hadzihalilovic, Aida, Voljevica, Alma, Bamac, Belgin, Colak, Tuncay, Alemdar, Murat, Dundar, Gulmine, Selekler, Macit, Dincer, Ozgur, Colak, Enis, Ozbek, Aydin, Kilic, Cenk, Kamburoglu, Kivanc, Ozen, Tuncer, Kavak, Vatan, Kirici, Yalcin, Oztas, Emin, Soysal, Handan Altinkaya, Unur, Erdogan, Ekinci, Nihat, Karaca, Omur, Malakhova, Olga, Kocaoglu, Murat, Toker, Serdar, Taser, Figen, Kilincoglu, Volkan, Yurtgun, Mustafa Fahri, Dalcik, Cannur, Zeybek, Ali, Baroncini, Marc, Peltier, Johann, Jissendi, Patrice, Pruvo, Jean-Pierre, Francke, Jean-Paul, Prevot, Vincent, Kosif, Rengin, Arifoglu, Yasin, Diramali, Murat, Sarsilmaz, Mustafa, Kose, Evren, Ogeturk, Murat, Akpinar, Burhan, Kus, Ilter, Meydan, Sedat, Kara, Alev, Kurtoglu, Zeliha, Tekdemir, Ibrahim, Elhan, Alaittin, Bas, Orhan, Odaci, Ersan, Mollaoglu, Hakan, Ucok, Kagan, Kaplan, Suleyman, Senoglu, Mehmet, Nacitarhan, Vedat, Kurutas, Ergul Belge, Senoglu, Nimet, Altun, Idris, Atli, Yalcin, Ozbag, Davut, Karakas, Sacide, Bilgin, M. Dincer, Tellioglu, Ayfer Metin, Ozlem, Sercin, Akcanal, Betul, Yildiz, Yuksel, Gunes, Hakki, Kose, Hayrullah, Uzum, Ibrahim, Gundogmus, Umit Naci, Caglayan, Cigdem, Pavlova, Velichka, Dimitrova, Mashenka, Georgieva, Lilia, Nikolova, Elena, Uzmansel, Deniz, Ozturk, Nail Can, Saylam, Canan Yurttas, Ozgiray, Erkin, Orhan, Mustafa, Cagli, Sedat, Zileli, Mehmet, Ozkan, Derya, Akkaya, Taylan, Comert, Ayhan, Balikci, Nilgun, Ozdemir, Esra, Gumus, Haluk, Ergul, Zafer, Kaya, Oskay, Altun, Serdar, Unlu, R. Erkin, Orbay, Hakan, Kim, Deog-Im, Han, Seung-Ho, Kim, Yi-Suk, Kim, Ho-Jeong, Lee, Kyu-Seok, Elcioglu, Omur, Ozden, Hilmi, Guven, Gul, Imre, Nurcan, Yalcin, Bulent, Ozan, Hasan, Akyer, Pinar, Guvencer, Mustafa, Karatosun, Vasfi, Sagoo, Mandeep Gill, Aland, Rachel Claire, Ustuner, Derya, Ustuner, M. Cengiz, Ai, Jafar, Ghazi, Seyed Reza, Mansouri, Seyed Hadi, Tuncer, Mehmet Cudi, Aluclu, Mehmet Ufuk, Karabulut, Ozlen, Hatipoglu, Eyup Savas, Nazaroglu, Hasan, Icke, Cigdem, Akbay, Emrah, Gunay, Turkan, Icke, Suleyman, Yildiz, Selda, Yazar, Fatih, Barlas, Barcin Orhan, Zahoi, Delia Elena, Kavakli, Ahmet, Tas, Ufuk, Dabak, Durrin Ozlem, Sapmaz, Hilal Irmak, Kocabiyik, Necdet, Ozer, Cenk Murat, Ozcan, Ayhan, Elevli, Levent, Desdicioglu, Kadir, Alanbay, Ibrahim, Govsa, Figen, Saylam, Canan Y., Akdogan, Ilgaz, Kiroglu, Yilmaz, Onur, Sule, Evcil, Emine Hilal, Cankara, Neslihan, Malas, Mehmet Ali, Kalcioglu, M. Tayyar, Duman, Serdar, Ulcay, Tufan, Uzun, Ahmet, Karabulut, Zulfu, Barut, Cagatay, Sevinc, Ozdemir, Yurdakan, Gamze, Kacar, Dundar, Erdogan, Ali Riza, Kurt, Hulyam, Demir, Bunyamin, Saltan, Mustafa, Burukoglu, Dilek, Ustuner, Mehmet Cengiz, Degirmenci, Irfan, Erdogan, Aliriza, Damar, Ozlem, Is, Merih, Bayramoglu, Gokhan, Kabay, Sahin, Uysal, Onur, Senturk, Hakan, Bayramoglu, Aysegul, Ozbayar, Cansu, Kutlu, Ali, Canbek, Mediha, Cevli, Salih Cenap, Hancerlioglu, Oguz, Koplay, Mustafa, Aksakalli, Elif, Dikici, Fatih, Kale, Aysin, Gayretli, Ozcan, Gurses, Ilke Ali, Ozdemir, Senem Turan, Ercan, Ilker, Baskan, Emel Bulbul, Yilmaz, Mediha, Ozkaya, Guven, Saricaoglu, Hayriye, Erturk, Mete, Kayalioglu, Gulgun, Uzel, Mehmet, Kahraman, Guler, Tanyeli, Ercan, Soyluoglu, Ali Ihsan, Tacar, Orhan, Demirant, Ayda, Bilgin, Murat, Karadede, Aziz, Aktas, Ayfer, Evcil, E. Hilal, Koyuncu, Esra, Sulak, Osman, Albay, Soner, Ozguner, Gulnur, Ozbek, Ahmet, Ozbek, Elvan, Ozturk, A. Hakan, Demirci, Tuba, Ciftcioglu, Engin, Demir, Mehmet Tevfik, Kopuz, Cem, Eroglu, Esra, Gedikli, Semin, Ozyurek, Hamit, Nural, Mehmet Selim, Incesu, Lutfi, Ogur, Gonul, Kara, Engin, Celebi, Baris, Yildiz, Altan, Altunkaynak, B. Zuhal, Kuvat, Samet Vasfi, Tagil, Suleyman Murat, Ertekin, Cumhur, Uysal, Hilmi, Bademkiran, Fikret, Albayrak, Nural, Esmer, Ali Firat, Coskun, Nigar Keles, Sindel, Muzaffer, Kizilay, Ferah, Yalin, Sevket, Karapinar, Nevin, Tokdemir, Mehmet, Karakurt, Lokman, Tumkaya, Levent, Korkmaz, Adnan, Ayas, Bulent, Ciftci, Nusret, Terzi, Yuksel, Baran, Ozlem, Nergiz, Yusuf, Akkus, Murat, Aluclu, Ufuk, Topal, Askin Ender, Yuksel, Dilek, Acar, Halil Ibrahim, Kendir, Simel, Hekimoglu, Emre, Basman, Deniz, Duman, Sunay, Ozener, Baris, Pelin, Can, Zagyapan, Ragiba, Kurkcuoglu, Ayla, Koc, Mustafa, Erdinc, Meral, Erdinc, Levent, Kelle, Ilker, Sancakdar, Enver, Cetin, Nil, Tunik, Selcuk, Yildirim, Ayse, Kaplanoglu, Iskender, Ayaz, Ercan, Ilhan, Necip, Okumus, Mehmet, Yuksel, Kasim Zafer, Ciralik, Harun, Yilmaz, Zeki, Gumusalan, Yakup, Gamsizkan, Mehmet, Kazkayasi, Mustafa, Dogan, Nadire Unver, Uysal, Ismihan Ilknur, Karalezli, Aylin, Fazliogullari, Zeliha, Buyukmumcu, Mustafa, Bozkurt, Mehmet Cem, Cicekcibasi, Aynur Emine, Demiryurek, Deniz, Ozsoy, M. Hakan, Bayramoglu, Alp, Tuccar, Eray, Baran, Ozlem Pamukcu, Soker, Sevda, Bahceci, Selen, Nasir, Yasemin, Yilmaz, Mehmet Tugrul, Cicekcibasi, Emine Aynur, Ulusoy, Mahinur, Gunaslan, Pervin, Bilge, Nuray, Akkaya, Muzaffer, Genc, Abdurrahman, Akcer, Sezer, Gonul, Yucel, Cosar, Emine, Koken, Gulengul, Ari, Ilknur, Bakirci, Sinan, Kafa, Ilker Mustafa, Uysal, Murat, Karabulut, Ahmet Kagan, Keles, Bahar, Emlik, Dilek, Uyar, Yavuz, Ozturk, Kayhan, Yilmaz, Neslihan Altuntas, Salbacak, Ahmet, Kacira, Burkay Kutluhan, Arazi, Mehmet, Demirci, Serafettin, Kiresi, Demet, Gumus, Serter, Seker, Muzaffer, Uyar, Mehmet, Astaneh, Mohammad Ebrahim, Khorshid, Alireza, Uygur, Ramazan, Songur, Ahmet, Sonmez, Osman Fikret, Dogan, Kamil Hakan, Kolcu, Giray, Iliescu, Madalina, Bordei, Petru, Iliescu, Dan, Ciobotaru, Camelia, Lucescu, Viorel, Covaleov, Anatoli, Ionescu, Constantin, Guirao, Miguel, Páramo, E., Mutuberria, R., Sánchez-Montesinos, I., Roda, O., Girón, F., Lopez-Soler, Miguel, Roda, Olga, Campos-López, Raúl, Guirao-Piñeiro, Miguel, Pascual-Morenilla, Maria Teresa, Sanchez-Montesinos, Indalecio, Pascual, Maria Teresa, Garzon, I., Serrato, D., Nieto-Aguilar, R., Sanchez-Montesinos, I., Sanchez-Quevedo, M., Ozdemir, M. Bulent, Ozean, R. Hakan, Bagdatli, Dilek, Adiguzel, Esat, Dogan, Zumrut, Aycan, Ozlem, Vardi, Nigar, Erkal, Haldun Sukru, Ozturk, Hakan, Mocanu, S., Stefanescu, C., Ionescu, A., Talpes, Raluca, Sapte, Elena, Dina, Constantin, Surdu, Loredana, Bulbuc, Ionut, Medina, M. T., Medina, J., López-Soler, M., Martin-Oviedo, Carlos, Lowy-Benoliel, Alejandro, Maranillo, Eva, Martinez-Guirado, Tomas, Sañudo, Jose, Scola, Bartolome, Vazquez, Teresa, Arráez-Aybar, L. A., Conejo-Menor, J. L., Gonzáles-Gómez, C. C., Torres-García, A. J., Nasu, Hisayo, Chiba, Shoji, Gutierrez-Semillera, M., Paksoy, Yahya, Kalaycioglu, Ahmet, Yildirim, Mehmet, Ozyasar, Ali, Ozdogmus, Omer, Cakmak, Yusuf Ozgur, Verimli, Ural, Cavdar, Safiye, Yildizhan, Begum, Aktan Ikiz, Z. Asli, Ucerler, Hulya, Ozgur, Zuhal, Yilmaz, Seher, Demirtas, Abdullah, Mavili, Ertugrul, Hacialiogullari, Mehtap, Susar, Hatice, Arslan, Seda, Aycan, Kenan, Ozkaya, Vecihi, Pilmane, Mara, Boka, Sarmite, Ortug, Gursel, Ramirez, Carlos, Pascual-Font, Aran, Valderrama-Canales, Francisco, Kucukalic, Abdulah, Kapur, Eldan, Talovic, Elvira, Baca, Vaclav, Grill, Robert, Horak, Zdenek, Kachlik, David, Dzupa, Valer, Konarik, Marek, Knize, Jakub, Veleminsky, Petr, Smrzova, Tereza, Otcenasek, Michal, Chmelova, Jana, Kheck, Michal, Kheck, Sr., Michal, Cupka, Tomas, Hnatek, Lukas, van der Meijs, Floris, Cech, Pavel, Musil, Vladimir, Ozkan, H. Mustafa, Muratli, S. Kivanc, Tayefi, Hamid, Ergur, Ipek, Kiray, Amac, Toktas, Muhsin, Alkoc, Ozan, Acar, Tolgahan, Uzun, Ibrahim, Ozen, Oguz Asian, Aycicek, Abdullah, Alkoc, Ozan Alper, Unlu, Mehmet, Corumlu, Ufuk, Ikiz, Ihsaniye Coskun, Oygucu, I. Hakan, Sendemir, Erdogan, Kaner, Tuncay, Caglar, Veli, Eser, Olcay, Demir, Mehmet T., Iyigun, Omer, Pirzirenli, Gokhan, Kaya, Ahmet Hilmi, Aydin, Mennan Ece, Celik, Fahrettin, True, Hakan, Ozkaya, Sevket, Ergur, Bekir Ugur, Zeybek, Gulsah, Bacakoglu, Kadir, Tadjalli, Mina, Poostpasand, Aghdas, Mansouiri, Seid Hadi, Allahvaisi, Ozra, Soleimanirad, Jafar, Nikkhoo, Bahram, Nagato, Yasukazu, Haruki, Yasuo, Yazawa, Komazo, Okazaki, Tutomu, Haida, Munetaka, Imai, Yutaka, Peirouvi, Thmineh, Mahzad-Sadaghiani, Mehrzad, Noroozinia, Farahnaz, Siamak, Salami, Farjah, Gholamhosseine, Mola, Sima, Biegaj, Ewa, Skadorwa, Tymon, Pawlewicz, Konrad, Kapolka, Robert, Chachulska, Agata, Zabicka, Joanna, Krasowska, Aleksandra, Prusik, Alicja, Jaczewski, Grzegorz, Kolesnik, Adam, Taghavi, M. Mohsen, Alavi, S. Hasan, Moallem, S. Adel, Safikhani, Zahed, Panahi, Marzieh, Dabiri, Shahriar, Shekaari, Majid Asadi, Latorre, Rafael, Soria, Federico, Lopez-Albors, Octavio, Sarria, Ricardo, Ayala, Inacio, Serrano, Inma, Perez-Cuadrado, Enrique, Musienko, Vladimir, Tkachenko, Dmitry, Colakoglu, Neriman, Kus, Murat Abdulgani, Jalali, Mahdi, Nikravesh, Mohammad Reza, Moeen, Abbas Ali, Karimfar, Mohammad Hassan, Rafighdoost, Houshang, Mohammadi, Shabnam, Korneeva, Marina, Rafighdoust, Houshang, Lovasova, Kvetuse, Bolekova, Adriana, Kluchova, Darina, Sulla, Igor, Kapitonova, Marina Yurievna, Syed Ahmad Fuad, Syed Baharom, Jayakaran, Flossie, Shams, Ali Reza, Aghaee, Fereshteh, Baqer, Zohreh, Faroki, Mohamad, Das, Srijit, Kassim, Normadiah, Latiff, Azian, Suhaimi, Frihah, Ghafar, Norzana, Hlaing, Khin Pa Pa, Maatoq, Israa, Othman, Faizah, Kiray, Muge, Bagriyanik, Husnu Alper, Pekcetin, Cetin, Ozogul, Candan, Fidan, Mustafa, Suhaimi, Farihah, Sun, Fei, Sanchez-Margallo, Francisco, Gil, Francisco, Crisostomo, Verónica, Uson, Jesus, Ramirez, Gegorio, Turamanlar, Ozan, Kirpiko, Oguz, Haktanir, Alpay, Climent, Salvador, Losilla, Sergio, Climent, Maria, Sarikcioglu, Levent, Senol, Yesim, Yildirim, Fatos B., Utuk, Arzu, Kunicki, Jacek, Pasbakhsh, Parichehr, Omidi, Negar, Omidi, Hamed, Nazhvani, Fatemeh Dehghani, Ghalebi, Seyed Razi, Javan, Nima, Mohagery, Akrami, Bideskan, Ali Reza Ebrahimzadeh, Taheri, Mohammad Mehdi Hassanzadeh, Fazel, Ali Reza, Tiengo, Cesare, Macchi, Veronica, Stecco, Carla, Porzionato, Andrea, Mazzoleni, Franco, De Caro, Raffaele, Clemente, Alberto, Morra, Aldo, Greco, Pietro, Pavan, Piero, Natali, Arturo, Demir, Mehmet, Dokur, Mehmet, Acer, Niyazi, Mavi, Ayfer, Matveeva, Niki, Lazarova, Dobrila, Korneti, Kostandina, Jovevska, Svetlana, Jurkovik, Dragica, Papazova, Meri, Havasi, Masoumeh, Alboghobeish, Naeim, Savari, Ahmad, Salamat, Negin, Sharifi, Mozafar, Kwak, Hyun-Ho, Hu, Kyung-Seok, Kim, Gyoo-Cheon, Park, Bong-Soo, Kim, Hee-Jin, Sinav, Ahmet, Gulati, Adarsh K., Gulati, Nidhi K., Alshammary, Hussien, Nazhvani, Seifollah Dehghani, Vafafar, Amir, Esmaeilpour, Tahereh, Bahmanpour, Soghra, Elyasi, Leila, Monabbati, Ahmad, Ghanadi, M., Paryani, Mohammad Reza, Gilanpour, Hassan, Amirsam, Banino, Omaña, Rodrigo Elizondo, López, Santos Guzmán, De la Garza Castro, Oscar, Vega, Edgar Urrutia, Lopez, Santos Guzman, Talebpour, Freshteh, Golmohammadi, Rahim, Dashti, Golamreza, Atlasi, Mohammad Ali, Mehdizadeh, Mehdi, Bahadori, Mohammad Hadi, Joghataei, Mohammad Taghi, Hatami, Leili, Boroujeni, Mandana Beigi, Estakhr, Jasem, Esfandiary, Ebrahim, Marzban, Mohsen, Bakhtiary, Mehrdad, Modiry, Navid, Jafarpur, Mokhtar, Mofidpur, Hassan, Alavi, S. Hassan, Mahmoudian, Alareza, Taghavi, Mohmmad Mohsen, Jafarpour, Mokhtar, Mahmoudian, Ali Reza, Sanjarmousavi, Nasrin, Doassans, Ines, Sorrenti, Natalia, Decuadro, German, Saibene, Andres, Poumayrac, Marie, Laza, Sebastian, Almiron, Carina, Vergara, Maria Elena, Soria, Victor, Lasa, Sebastian, Perez, Adolfo, Castro, Gabriela, Maria, Ana Santa, Soleimani, Mansoureh, Katebi, Majid, Bakhshayesh, Masoomeh, Oner, Mithat, Halici, Mehmet, Yikilmaz, Ali, Guney, Ahmet, Turk, Yildirim, Edizer, Mete, Beden, Umit, Icten, Nihal, Afshar, Mohammad, Hasanzadeh Taheri, Mohammad Mehdi, Moalem, Adel, Golalipour, Mohammad Jafar, Tamizi, Azadeh, Ahi, Mohammad, Mohammadpour, Shahram, Maiery, Ardeshir, Acikel, Cengiz, Ulkur, Ersin, Karagoz, Huseyin, Celikoz, Bahattin, Bedi, Kuldip, Ginus, Partadiredja, Golalipoor, Mohammad Jafar, Mohammadi, Mohammad Reza, Jhand, Poya, Mansourian, Azad Reza, Hosseinpoor, Kanizreza, Keshtkar, Abbas Ali, Alsaffar, Raith, Balajadeh, Babak Kabiri, Ghafari, Soraya, Azarhosh, Ramin, Fazeli, Seyyed Amirhossein, Jahanshahi, Mehrdad, Gharravi, Annen Mohammad, Alicioglu, Banu, Karakas, Hakki Muammer, Harma, Ahmet, Yang, Hun-Mu, Won, Sung-Yoon, Lee, Jae-Gi, Lee, Ju-Young, Lee, Jeong-Yong, Kim, Yoo-Ri, Song, Wu-Chul, Koh, Ki-Seok, Hwang, Eu-Na, Choi, Hyun-Gon, Kim, Soon-Heum, Kim, Soo-Young, Hur, Mi-Sun, Ulucam, Enis, Celbis, Osman, Kim, Da-Hye, Hong, Hee-Suk, Kim, Hyun-Joo, Choi, Jong-Hoon, Park, Jong-Tae, Kim, Hyeon-Cheol, Abbasi, Hamed, Hosseinipanah, Seyed Mohammad, Hosseini, Mohammad, Amani, A., Ashrafi, H. R., Sadeghimehr, Mohsen, Kim, Hyun-Ju, Sheverdin, Vadim, Amani, Zahra, Ashrafi, Alireza, Ashrafi, Ali Reza, Javad, Hami, Kachap, Mokhtar Jafarpoor, Laza, Sebastián, Poumayrac, Marie Catherine, Doassans, Inés, Vergara, María Elena, Almirón, Carina, Soria, Víctor, Rivara, Alvaro, Sirilo, Angela, Freire, Diego, Cirillo, Angela, Veragara, Maria Elena, Krmek, Vlado, Krmek, Nikola, Jo-Osvatic, Ana, Nikolic, Vasilije, Radic, Radivoje, Tubbs, R. Shane, Loukas, Marios, Fogg, Quentin, Ashwood, Neil, Cilingiroglu, Serpil, Ozbakir, Cemal, Mazoochi, Tahereh, Sabanciogullari, Vedat, Gumus, Cesur, Erdil, F. Hayat, Cimen, Mehmet, Moodi, Hesam, Ghiasi, Fateme, Akbari, Asghar, Hami, Javad, Khazei, Majid, Haghparast, Elham, Mitsakis, Ioannis, Anastasiou, Aikaterini, Mitsakis, Menelaos, Sianou, Kyriaki, Hainoglou, Roxani, Francisco, Margarida, Mitsaki, Charikleia, Konstantinidi, Maria, Prapa, Stamatia, Leksan, Igor, Mrcela, Tomislav, Selthofer, Robert, Kermanian, Fatemeh, Mahmoudian, Alireza, Ahmadpoor, Mahmood Erfanian, Dalili, Naser, Elian, Amir Hossein, Moaiery, Ardesheer, Jamalpour, Zahra, Nourani, Mohammad Reza, Asgari, Alireza, Hassanzadeh Taheri, Mohammad Mehdi, Ebrahimzadeh, Alireza, Eftekharvaghefi, Seyed Hasan, Mohammadi, Abbas, Sheibani, Vahid, Nematollahi-Mahani, Seyed Noureddin, Latifpour, Mastafa, Deilami, Masood, Soroure-Azimzadeh, Behzad, Nabipour, Fatemeh, Najafipour, Hamid, Nakhaee, Nouzar, Yaghoobi, Mohammad, Eftekharvaghefi, Rana, Salehinejad, Parvin, Azizi, Hasan, Riasi, Hamid Reza, Nobakht, Maliheh, Asalgoo, Sara, Rahbar, Roshanak, Najafzadeh, Norooz, Moosavizadeh, Kazem, Ezzatabadypour, Massood, Majidi, Masoud, Malekpor-Afshar, Reza, Karimzade, Fariba, Hoseini, Mahmood, Bayat, Mohamad, Gorgi, Ali, Nezhadi, Akram, Bakhtiari, Mehrdad, Jazi, Homa Rasooli, Jafaryan, Maryam, Haghir, Hosein, Hosseini, Mahmood, Rahimi, Sadegh, Rassouli, Fatemeh Behnam, Gorji, Ali, Habibi, Aliasghar, Pouya, Fatemeh, Dabiri, Shahryar, Mousavi, A., Rajabalian, Saeed, Abolidokht, A., Khanlarkhani, Neda, Naderian, Homayoun, Berjis, Nezamedin, Namavar, Mohamad Reza, Talaei, Tahereh, Mazaheri, Zohreh, Monabati, Ahmad, Kosar, Mehmet Ilkay, Karacan, Kezban, Chegini, Hamidreza, Nikzad, Hossein, Ayhan, Egemen, Ustundag, Sinan, Akkin, Salih Murat, Ogut, Tahir, Rayegan, Parviz, Meibodi, Mohamad Ali Emami, Ghaem, Reza Montazer, Zargarpoor, Rosa, Eftekhar Vaghefi, Seyd Hasan, Moshkdanian, Ghazale, Poya, Fateme, Kohestani, Hamid, Abarghoeai, Roozbeh Rayegan, Abarghoeai, Parviz Rayegan, Eftekhar Vaghefi, Seyed Hasan, Mahmodi, Abolghasem Amir, Poraboli, Ali, Kohestani, Hamid Reza, Vaghefi, Raena Eftekhar, Eftekhar Vaghefy, Seyed Hasan, Vaghefy, Raena Eftekhar, Abarghoeai, Parviz Raygan, Saba, Mohamad, Gharravi, Anneh Mohammad, Javadnia, Fatemeh, Zhaleh, Mohsen, Nezhad, Dariush Bijan, Gholami, Mohammad Reza, Piagkou, Maria, Aikaterini, Vassiliki Kouki, Piagkos, Giannoulis, Douvetzemis, Stergios, Skandalakis, Panagiotis, Anagnostopoulou, Sophia, Papadopoulos, Nikolaos, Celik, H. Hamdi, Tatar, Ilkan, Tatar, Emel Cadalli, Mocan, Burce Ozgen, Sargon, Mustafa F., Denk, C. Cem, Rasoolijazi, Homa, Joghataie, Mohammad Taghi, Roghani, Mehrdad, Akkin, Salin Murat, Dinc, Gulten, Kurklu, Mustafa, Ozboluk, Sener, Komurcu, Mahmut, Koebke, Jürgen, Balioglu, Mehmet Bulent, Kaygusuz, Mehmet Akif, Bozkus, Ferdi Sefa, Korkmaz, Ozgur, Bayram, Sule Biyik, Can, Mehmet Ali, Nasiri, Ebrahim, Jafar-Kazemi, Koroush, Hosseini, Melina, Maghoul, Shahin, Soleimani, Mansooreh, Amini, Abdollah, Hassanzade, Mohamad Mahdi, Davari, Mohammad Hossein, Van Hoof, Tom, Gomes, Germano T., Audenaert, Emmanuel, Verstraete, Koenraad, Kerckaert, Ingrid, D’Herde, Katharina, Benninger, Brion, Hedley, Gil, Filipoiu, Florin Mihail, Tarta, Eugen, Enyedi, Mihali, Pantu, Cosmin, Stanciulescu, Razvan, Skobowiat, Cezary, Calka, Jaroslaw, Majewski, Mariusz, Rezaian, Maryam, Yaghoobfar, Akbar, Hamedi, Somayeh, and Shomali, T.

Published
2009
Full Text
View/download PDF

41. Effect of Curcumin on Testis in Mice with Ehrlich Ascites Tumor

Author

YİLMAZ, Seher, GÖÇMEN, Yeşim, TOKPINAR, Adem, ATEŞ, Şükrü, NİSARİ, Mustafa, CANİKLİOĞLU, Aysen, and ÖZTEKİN, Ünal

Subjects
Androloji, Testis,EAT,Mice,Curcumin,Antioxidant, Andrology
Abstract

In the current work, the effects of curcumin on testicular tissues in Ehrlich Ascites Tumor (EAT) model developed in Balb/C mice. EAT cells (1x106) received from stock of animals were injected intraperitoneally to animals. 25mg/kg and 50mg/kg of curcumin was administered intraperitoneally. Testicular tissues obtained after all the experiment were evaluated for histopathological and biochemical parameters. Histopathological results showed that 50 mg/kg curcumin group had less EAT cells around testicular tissues than tumor control group. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH), oxide glutathione (GSSG), total antioxidant status (TAS), total oxidant status (TOS), interleukin-1beta (IL-1β), interleukin-6, interleukin-17, tumor necrosis factor-alfa (TNF-α) levels were measured in testis tissues. Oxidative stress index (OSI) and GSH/GSSG ratio were calculated. Findings clearly suggested that antioxidant parameters (except CAT and GPx) had higher value in animal models treated with 25 and 50 mg curcumin groups associated to tumor control group. There was a statistically noteworthy variance between the groups in all parameters. Antitumor effect of curcumin on ascites tumor cells produced by EAT cells evidenced with histopathological while antioxidant and anti-inflammatory biochemical parameters evidenced with biochemical parameters.

Published
2020

42. Effect of Cornus Mas L. Extract on Organs in Rats Given Nicotine

Author

YİLMAZ, Seher, TOKPINAR, Adem, ATEŞ, Şükrü, ÖZTEKİN, Ünal, ALPA, Serife, and GÖÇMEN, Yeşim

Subjects
Anatomy and Morphology, Oxidative stress,Cornus mas L,Nicotine,Cornelian cherry, Anatomi ve Morfoloji
Abstract

Nicotine plays an important role in oxidative stress formation. For this purpose, to reveal the antioxidant effect of cornelian cherry plant, the effects of nicotine-induced oxidative stress.28 adult Wistar Albino (180-220 g) male rats were used in the study. Rats were divided into four groups as control group (n = 6), cornelian cherry group (n = 7), nicotine group (n = 7) and nicotine + cornelian cherry group (n = 8). While nicotine extract was applied to the experimental group, cornelian cherry extract was applied to the treatment group as well as nicotine. TBARS, SOD, GSH, GSSG, TOS, TAS, Redox potential values were measured by spectrophotometric analysis in lung, brain, kidney, heart and liver tissues. OSI and GSH / GSSG values were calculated as TOS / TAS and GSH / GSSG rates, respectively.When the experimental groups are examined, it is seen that there is a significant difference between the nicotine-treated group and the other groups (p

Published
2020

44. HUMERUS ÜZERİNDE ANATOMİK YAPILARIN MORFOMETRİK OLARAK İNCELENMESİ Morphometric Investigation of Anatomic Structures on Humerus

Author

YILMAZ, Seher, TOKPINAR, Adem, TAŞTAN, Mustafa, ATEŞ, Şükrü, ÜNALMIŞ, Demet, and PATAT, Dilara

Subjects
Health Care Sciences and Services, HUMERUS ÜZERİNDE ANATOMİK YAPILARIN MORFOMETRİK OLARAK İNCELENMESİ Morphometric Investigation of Anatomic Structures on Humerus, Sağlık Bilimleri ve Hizmetleri
Abstract

ÖZETGiriş: Humerus; scapula, radius ve ulna arasında bulunan üst ekstremitenin en uzun ve kalın kemiğidir. Humarusüzerindeki anatomik yapılar morfoloji ve antropolojide cinsiyet ayrımını tespitte kullanılır.Gereç ve yöntem: Bu çalışma 80 adet (56 sol, 24 sağ) humerus kuru kemik numunesinde 0,01 milimetre(mm) hassasiyetli dijital kumpas kullanılarak yapıldı. Kemik örneklerinde yaş ve cinsiyet ayrımı belli değildi.Humerus üzerinde 21 anatomik yapı ölçüldü.Bulgular: Çalışmanın sonuçlarına göre humerusun maksimum uzunluğu solda ortalama 31.16±2.44 mm,sağda 29.85±3.08 mm’dir. Humerusun minimum gövde çapı solda 17.62 ±2.18 mm, sağda 17.84 ±1.82 mm,maksimum çapı solda 21.41 ±1.95mm ve sağda 21.29 ±1.77mmdir.Sonuç: Humerus kemiğinin normal anatomik yapısını bilmek ve bu bölgedeki cerrahi prosedürleri ve protezuygulamalarını yönlendirmek için bu kemikteki anatomik yapıların ortalama değerlerini hesaplamak çokönemlidir.

Published
2020

45. ABDOMİNAL CERRAHİ UYGULANAN HASTALARDA NORMOTERMİ SAĞLANMASININ GASTROİNTESTINAL SİSTEM FONKSİYONLARI ÜZERİNE ETKİSİ

Author

Gürdil Yilmaz, Seher, Başer, Mürüvvet, and Hemşirelik Anabilim Dalı

Subjects
Nursing, Hemşirelik
Abstract

ABDOMİNAL CERRAHİ UYGULANAN HASTALARDA NORMOTERMİ SAĞLANMASININ GASTROİNTESTINAL SİSTEM FONKSİYONLARI ÜZERİNE ETKİSİSeher GÜRDİL YILMAZErciyes Üniversitesi, Sağlık Bilimleri Enstitüsü Hemşirelik Anabilim Dalı Cerrahi Hastalıkları Hemşireliği Doktora ProgramıDoktora Tezi, Mayıs 2020Danışman: Prof. Dr. Mürüvvet BAŞERÖZETAraştırma; abdominal cerrahi geçiren hastalarda normotermi sağlanmasının gastrointestinal sistem fonksiyonları üzerine etkisini incelemek amacıyla yapıldı. Nonrandomize kontrol gruplu deneysel türde yapılan araştıma Şubat 2018 ve Aralık 2019 tarihleri arasında bir üniversite ve bir özel hastanede ameliyatı aynı hekim tarafından gerçekleştirilen, araştırmaya alınma ölçütlerine uyan toplam 54 hasta ile gerçekleştirildi. Araştırmanın verilerinin toplanmasında, hasta tanıtım formu, hasta değerlendirme formu ve hastanın bulantısını değerlendirmek için görsel analog skala kullanıldı. Müdahale grubuna ameliyat öncesi pasif ısıtma ve ameliyat sonrası aktif ısıtma uygulanırken, kontrol grubunun rutin ameliyat öncesi ve sonrası bakımına müdahale edilmedi. Hastalar vücut sıcaklığı, bağırsak sesleri, gaz ve gaita çıkarımı, bulantı ve kusma açısından 3 gün izlendi. Verilerin analizinde; tanımlayıcı istatistikler, bağımsız iki örnek t testi, Mann-Whitney U testi, tekrarlı ölçümlerde iki yönlü varyans analizi, Friedman analizi ve Pearson kikare testi kullanıldı. Ameliyattan hemen önce ve ameliyattan sonra yoğun bakımda 0. dakikada ölçülen vücut sıcaklık değerleri gruplara göre benzerlik gösterirken (p=0.255; p=0.408), ameliyat sonrası 20. dakikada müdahale grubu hastalarının vücut sıcaklıkları istatistiksel olarak kontrol grubundan daha yüksek bulundu (p0.05). Abdominal cerrahi geçiren hastalarda normotermi sağlanmasının gastrointestinal sistem fonksiyonları üzerine etkisinin incelendiği çalışmada uygulanan ısıtmanın hastaların vücut sıcaklığı üzerine anlamlı bir etkisinin olduğu ancak gastrointestinal sistem fonksiyonları üzerine etkisinin olmadığı belirlendi. Anahtar kelime: Hipotermi, ısıtma, bulantı, kusma, bağırsak sesleri. THE EFFECT OF PROVIDING NORMOTHERMY ON GASTROINTESTINAL SYSTEM FUNCTIONS IN PATIENTS WITH ABDOMINAL SURGERYHealth Sciences Institute Erciyes University, Nursing DepartmentDoctoral Program in Nursing of Surgical DiseasesDoctorate Thesis, May 2020Supervisor: Prof. Dr. Mürüvvet BAŞERABSTRACTThe aim of this study was to examine the effect of providing normothermia on gastrointestinal system functions in patients undergoing abdominal surgery. The research was performed as a non-randomized experimental studies. The study was conducted in a university and a private hospital during February 2018 and December 2019 with a total of 54 patients which were performed by the same physician and meeting the criteria for inclusion in the research.Patient information form, patient evaluation form and Visual Analogue Scale to evaluate the nausea of the patient, was used to collect the data of the study. While the preoperatif passive heating and postoperative active heating were applied to the intervention group, the routine preoperatif and postoperative care of the control group was not interfered. Patients were follow up for 3 days in terms of body temperature, bowel sounds, flatus, defecation, nausea and vomiting. In the analysis of the data; descriptive statistics, independent two sample t test, Mann-Whitney U test, bidirectional variance analysis in repeated measurements, Friedman analysis and Pearson chi-square test were used. Body temperature values measured before operation and at the 0th minute in the intensive care unit immediately after the operation were similar compared to the groups (p=0.255; p=0.408). The body temperature of the patients in the 20th minute postoperatively was higher than the control group (p0.05). In the study, in which the effect of providing normothermia on gastrointestinal system functions in patients undergoing abdominal surgery was examined, it was determined that the heating applied had a significant effect on the body temperature of the patients, but not on the functions of the gastrointestinal system.Keywords: Hypothermia, warming, nausea, vomiting, bowel sounds. 102

Published
2020

46. Rapid selection of a cefiderocol-resistant Escherichia coli producing NDM-5 associated with a single amino acid substitution in the CirA siderophore receptor.

Author

Jousset, Agnès B, Poignon, Corentin, Yilmaz, Seher, Bleibtreu, Alexandre, Emeraud, Cécile, Girlich, Delphine, Naas, Thierry, Robert, Jérôme, Bonnin, Rémy A, and Dortet, Laurent

Subjects
ESCHERICHIA coli, GENOMICS, FRAMESHIFT mutation, ANTIBIOTICS, GENE expression, AMINO acids
Abstract

In previous studies, cefiderocol resistance in I E. coli i has been mainly attributed to the increased copy number and expression of the I bla i SB NDM sb -like gene.[2] Thus, we first investigated the gene copy number of I bla i SB NDM sb using the average coverage of reads generated from WGS data normalized to the average coverage of several intrinsic chromosomal genes used as reference ( I bla i SB EC sb -like, I gyrB i , I tonB i , I rpoB i ). Cefiderocol is a novel siderophore-conjugated cephalosporin that is very promising for the treatment of infections caused by MDR bacteria. [Extracted from the article]

Published
2023
Full Text
View/download PDF

47. Investigating cardiac morphological alterations in a pentylenetetrazol-kindling model of epilepsy

Author

Akyuz, E, Polat, K, Ates, S, Unalmis, D, Tokpinar, A, Yilmaz, S, Kaymak, E, Doganyigit, Z, Villa, C, Akyuz, Enes, Polat, Kristina, Ates, Sukru, Unalmis, Demet, Tokpinar, Adem, Yilmaz, Seher, Kaymak, Emin, Doganyigit, Zuleyha, Villa, Chiara, Akyuz, E, Polat, K, Ates, S, Unalmis, D, Tokpinar, A, Yilmaz, S, Kaymak, E, Doganyigit, Z, Villa, C, Akyuz, Enes, Polat, Kristina, Ates, Sukru, Unalmis, Demet, Tokpinar, Adem, Yilmaz, Seher, Kaymak, Emin, Doganyigit, Zuleyha, and Villa, Chiara

Abstract

Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic patients. SUDEP patients displayed an increased cardiovascular (CV) risk, probably due to an impaired autonomic control of CV functions, but the underlying mechanisms need to be explored yet. Therefore, we aimed to examine the cardiac morphological alterations in a pentylenetetrazol (PTZ)-kindled rat model, a well-established tool for studying chronic epilepsy. To complete this, the distance between the atria, between the atrium and ventricle were measured, the heart was weighed, and the pathological morphology of dissected hearts was analyzed by histological assessment with hematoxylin and eosin staining. A significantly decreased distance between atria and a significant increase in heart weight were observed in PTZ-kindled rats which interestingly also displayed increased hemorrhagic content when compared with controls. Our findings provided evidence that changes in cardiac morphology may be related to autonomic CV dysfunctions occurring during SUDEP while also opening up more avenues to better develop novel drugs for the treatment of this disorder.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results