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Electrical address circuits developed for driving fast-switching ferroelectric liquid-crystal spatial light modulators (SLM) can be programmed to increase the speed of much slower responding nematic liquidcrystal SLMs. Using an addressing circuit that can switch as fast as 0.164 ms, voltages are programmed for values of phase that exceed the desired phase, and when the phase reaches the desired value, the voltage is switched to the required steady-state voltage. For a SLM that has a phase range of 3.5[pi] and that is programmed over a 2[pi] range, switching speed is reduced from 400 ins to between 71 and 77 ms. The speedup algorithm is applied to each pixel of the SLM together with a digital correction for a spatially nonuniform phase. OCIS codes: 230.6120, 230.3720, 050.1970, 070.2580.

A new 512 x 512 pixel phase-only spatial light modulator (SLM) has been found to deviate from being flat by several wavelengths. Also, the retardation of the SLM relative to voltage varies across the device by as much as 0.25 wavelength. The birefringence of each pixel as a function of address voltage is measured from the intensity of the SLM between crossed polarizers. To these responses are added a reference spatial phase measured by phase shifting interferometry for a single address voltage. Fits to the measured data facilitate the compensation of the SLM to a root-mean-square wave-front error of 0.06 wavelength. The application of these corrections to flatten the full aperture of the SLM sharpens the focal plane spot and reduces the distortion of computer-designed diffraction patterns. OCIS codes: 230.6120, 050.1970, 070.2580, 120.5050, 120.3180.

Previously we described a method for estimating the thermal conductivity of magneto-optic recording media. The method relies on identifying the laser power that brings the maximum temperature of the TbFeCo layer to as high as the Curie temperature. We extensively use a similar method to estimate the heat capacity of a dielectric layer, a TbFeCo layer, and an aluminum alloy layer of magneto-optic recording media. Measurements are conducted on static disks with a beam of light focused on a TbFeCo layer. The method has the advantage of thermal diffusion depending on a multilayer structure and irradiation time.

We present the results of crystallization studies in thin-film samples of amorphous and crystalline [Ge.sub.x][Sb.sub.y][Te.sub.z]. The experiments, conducted at moderately elevated temperatures, are based on measurements of the first-order diffraction efficiency from a two-dimensional periodic array of recorded marks. When the samples are slowly heated above room temperature, changes in the efficiencies of various diffracted orders give information about the on-going crystallization process within the sample. Two different compositions of the GeSbTe alloy are used in these experiments. Measurements on [Ge.sub.2][Sb.sub.2.3][Te.sub.5] films show crystallization dominated by nucleation. For the Sb-rich eutectic composition Ge-(SbTe), crystallization is found to be dominated by growth from crystalline boundaries. We also show that crystalline marks written by relatively high-power laser pulses are different in their optical properties from the regions crystallized by slow heating of the sample to moderate temperatures. OCIS code: 210.4810.

We have conducted measurements of scattered light from bare polycarbonate and glass substrates and from complete optical disks using a He-Ne laser beam in different polarization states and at different angles of incidence. The results are compared with the measured media noise obtained from the same disks on a dynamic tester. Both the scattered light and the media noise originate from the jaggedness and other imperfections of the groove structure, the roughness of the substrate's surface, and the inhomogeneities of the bulk of the substrate. Although some sources of media noise manifest themselves in the scattered light distribution, others cannot be easily detected by this type of measurement.

We describe a method to estimate the thermal conductivity of the substrate, the dielectric layer, and the magneto-optic (MO) layer of MO recording media. The method relies on the disappearance of the polar Kerr rotation above the Curie temperature of the MO layer. We obtain the thermal conductivities by taking into account the differences in the heat diffusion behavior under different sized focused spots. The results are reliable to better than 5% accuracy. [C] 2000 Optical Society of America OCIS codes: 210.3820, 210.4770, 120.6810.

We present the results of crystallization and amorphization studies on a thin-film sample of [Ge.sub.2][Sb.sub.2.3][Te.sub.5], encapsulated in a quadrilayer stack as in the media of phase-change optical disk data storage. The study was conducted on a two-laser static tester in which one laser, operating in pulsed mode, writes either amorphous marks on a crystalline film or crystalline marks on an amorphous film. The second laser, operating at low power in the cw mode, simultaneously monitors the progress of mark formation in terms of the variations of reflectivity both during the write pulse and in the subsequent cooling period. In addition to investigating some of the expected features associated with crystallization and amorphization, we noted certain curious phenomena during the mark-formation process. For example, at low-power pulsed illumination, which is insufficient to trigger the phase transition, there is a slight change in the reflectivity of the sample. This is believed to be caused by a reversible change in the complex refractive index of the [Ge.sub.2][Sb.sub.2.3][Te.sub.5] film in the course of heating above the ambient temperature. We also observed that the mark-formation process may continue for as long as 1 [micro]s beyond the end of the write laser pulse. This effect is especially pronounced during amorphous mark formation under high-power, long-pulse illumination. OCIS codes: 210.0210, 210.4810, 210.4770, 210.4590.

We have designed and built a static tester around a commercially available polarized light microscope. This device employs two semiconductor laser diodes (at 643- and 680-nm wavelengths) for the purpose of recording small marks on various media for optical data storage and for the simultaneous monitoring of the recording process. We use one of the lasers in the single-pulse mode to write a mark on the sample and operate the other laser in the cw mode to monitor the recording process. The two laser beams are brought to coincident focus on the sample through the objective lens of the microscope. The reflected beams are sent through a polarizing beam splitter and thus divided into two branches, depending on whether they are p or s polarized. In each branch the beam is further divided into two according to the wavelength. The four beams thus produced are sent to four high-speed photodetectors, and the resulting signals are used to monitor the reflectance as well as the polarization state of the beam on reflection from the sample. We provide a comprehensive description of the tester's design and operating principles. We also report preliminary results of measurements of phase-change, dye-polymer, and magneto-optical samples, which are currently of interest in the areas of writable and rewritable optical data storage. [C] 1999 Optical Society of America OCIS codes: 210.4770, 120.4640.

Objective: Due to the tumor immune microenvironment (TIME) complexity and cancer heterogeneity, the clinical outcomes of hepatocellular carcinoma (HCC) are barely elicited from the conventional treatment options, even from the promising anti-cancer immunotherapy. As a suppressive TIME-related marker, the role played by cyclooxygenase-2 (COX-2) in HCC TIME, and its potential effects on anti-cancer T cell immune response remains unknown. In our study, to investigate the COX-2-dependent immune regulation pathway, we verified that the macrophages phenotypes were correlated to COX-2/PGE2 expressions among HCC patients. A multi-cellular co-culture platform containing HCC cells, macrophages, and T cells were established to mimic HCC TIME in vitro and in animal model. M2 macrophage polarization and activated CD8 + T cells exhaustion were observed under high COX-2 levels in HCC cells, with further evaluation using CRISPR/Cas9-based PTGS2 knocking out and COX-2 blockade (celecoxib) treatment controls. PGE2, TGF-β, Granzyme B, and IFN-γ levels were testified by flow cytometry and ELISA to fully understand the mechanism of COX-2 suppressive effects on T cell-based anti-HCC responses. The activation of the TGF-β pathway evaluated by auto-western blot in T cells was confirmed which increased the level of phosphorylated Smad3, phosphorylated Samd2, and FoxP1, leading to T cell de-lymphotoxin. In conclusion, high COX-2-expressing HCC cell lines can induce anti-tumor abilities exhaustion in activated CD8 + T cell through M2 TAMs polarization and TGF beta pathway. COX-2 inhibitors may reduce the inhibitory effect on CD8 + T cells through regulating TAMs in TIME, thus enhance the T cell-based cytotoxicity and improve the prognosis of HCC patients., Competing Interests: None., (AJTR Copyright © 2021.)