11 results on '"Xuewen Su"'
Search Results
2. Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats
- Author
-
Yu, Zhang, Wenyan, Tang, Xuewen, Su, Baixiang, Dong, Qian, Wang, Zhaoyan, Wang, Yinxiang, Yang, Suqing, Qu, and Zuo, Luan
- Published
- 2018
- Full Text
- View/download PDF
3. Clobetasol Attenuates White Matter Injury by Promoting Oligodendrocyte Precursor Cell Differentiation
- Author
-
Wanyu Feng, Yanyan Liang, Hua Zhu, Junlong Chen, Xuewen Su, Mingze Sui, Zhongxia Dou, Xiaomei Zhang, Yuxin Bai, and Haifeng Yuan
- Subjects
medicine.medical_specialty ,Oligodendrocyte progenitor ,Immunofluorescence ,Open field ,White matter ,Myelin ,Internal medicine ,medicine ,Animals ,Humans ,Myelin Sheath ,Oligodendrocyte Precursor Cells ,Clobetasol ,medicine.diagnostic_test ,biology ,business.industry ,White Matter Injury ,Infant, Newborn ,Cell Differentiation ,General Medicine ,White Matter ,Myelin basic protein ,Rats ,Oligodendroglia ,Endocrinology ,medicine.anatomical_structure ,Animals, Newborn ,Brain Injuries ,Pediatrics, Perinatology and Child Health ,biology.protein ,Surgery ,Neurology (clinical) ,business ,Infant, Premature - Abstract
Introduction: White matter injury (WMI) is the most common brain injury in preterm infants and can result in life-long neurological deficits. The main cause of WMI is damage to the oligodendrocyte precursor cells (OPC) in the brain that results in delayed myelin sheath formation, or the destruction of existing myelin sheaths. OPC undergo highly regulated and strictly timed developmental changes that result in their transformation to mature oligodendrocytes capable of myelin production. Objective: Studies have shown that clobetasol strongly promotes differentiation of OPC into myelin sheaths. Therefore, we hypothesized that clobetasol may be a therapeutic option for the treatment of preterm WMI. Methods: We induced a WMI rat model and observed white matter damage under an optical microscope. Rats subjected to WMI were injected intraperitoneally with clobetasol (2 or 5 mg/kg daily) from day 1 to day 5 in the early treatment groups, or from day 6 to day 10 in the late treatment groups. After 17 days, the rats were sacrificed and the expression of myelin basic protein (MBP) was visualized using immunofluorescence. In addition, we evaluated myelin sheath formation using electron microscopy. The rats were also subjected to the suspension test, ramp test, and open field test to evaluate neurobehavioral functions. Results: A rat model of WMI was successfully induced. It was found that clobetasol significantly induced MBP expression and myelin sheath formation and improved neurobehavioral function in the rats subjected to WMI. Conclusions: Our results indicate that clobetasol attenuates WMI by promoting OPC differentiation, and it may be an effective therapeutic agent for the treatment of preterm WMI.
- Published
- 2020
4. Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013
- Author
-
Wanyu Feng, Xiaomei Zhang, Hua Zhu, Yanyan Liang, and Xuewen Su
- Subjects
Cancer Research ,Pediatrics ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Age at diagnosis ,Articles ,General Medicine ,Inner mongolia ,medicine.disease ,Annual incidence ,03 medical and health sciences ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,030225 pediatrics ,Epidemiology ,medicine ,Kawasaki disease ,030212 general & internal medicine ,China ,business ,Epidemiologic survey - Abstract
The epidemiologic features of Kawasaki disease (KD) in the Inner Mongolia Autonomous Region of China has not been previously determined, to the best of our knowledge. Therefore, the aim of the present study was to investigate the epidemiology of KD in Inner Mongolia. Clinical data from 518 patients treated for KD in Inner Mongolia between January 2001 and December 2013 were analyzed. The results indicated that the mean annual incidence rate was 3.55±2.96 per 100,000 children under the age of 5 years between 2001 and 2013. The age at diagnosis ranged between 49 days and 14 years, while the disease occurred more frequently in the spring and summer. In addition, the incidence of coronary artery lesion (CAL) was reported to be 40.2% in the present survey. KD patients in the Han Chinese ethnic group were more likely to be complicated by CAL, whereas patients with incidence of KD in July were less likely to be complicated by CAL. In conclusion, the incidence of KD was observed to be increasing in Inner Mongolia, while the ethnic group and month of onset may be associated with the incidence of CAL in KD patients.
- Published
- 2016
- Full Text
- View/download PDF
5. Protective effect of miconazole on rat myelin sheaths following premature infant cerebral white matter injury
- Author
-
Xuewen Su, Yu Zhang, Xiue Wang, Wenyan Tang, Zhen Huang, Zuo Luan, Qian Wang, Lei Suo, Yinxiang Yang, Haifeng Yuan, and Zhaoyan Wang
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Necrosis ,Ischemia ,Corpus callosum ,premature infant cerebral white matter lesions ,miconazole ,Lesion ,03 medical and health sciences ,Myelin ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,Edema ,Internal medicine ,medicine ,biology ,business.industry ,Articles ,General Medicine ,myelin basic protein ,medicine.disease ,Hyperintensity ,Myelin basic protein ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,biology.protein ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
The aim of the present study was to investigate the protective effects of miconazole on myelin sheaths following cerebral white matter damage (WMD) in premature infant rats. Sprague Dawley rats (3-days-old) were randomly divided into four groups (n=30 each) as follows: Sham surgery group, WMD model group, 10 mg/kg/day treatment group and 40 mg/kg/day treatment group. A cerebral white matter lesion model was created by ligating the right common carotid artery for 80 min. Treatment groups were administered with 10 or 40 mg/kg miconazole at 4-8 days following birth (early treatment group) or 5-11 days following birth (late treatment group). Rats in the model group received the same concentration of dimethylsulfoxide. Myelin basic protein (MBP) immunohistochemical staining and western blotting were used to detect the expression of cerebral white matter-specific MBP, and changes in myelin structure were observed using transmission electron microscopy. No swelling or necrosis was observed in the corpus callosum of the sham group rats, whereas rats in the model group demonstrated edema, loose structure, fiber disorder, inflammatory gliocytes and selective white matter lesions. Following treatment with miconazole, MBP expression in the corpus callosum was significantly higher compared with the model group. Furthermore, in the model group, myelin sheaths in the corpus callosum were loose with small vacuoles, there was a marked decrease in thickness and structural damage was observed. Conversely, a marked improvement in myelination was observed in the treatment group. The results of the present study suggest that miconazole is able to promote formation of the myelin sheath to ameliorate premature cerebral white matter lesions caused by ischemia or hypoxia in rats.
- Published
- 2018
- Full Text
- View/download PDF
6. Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates
- Author
-
Hua Zhu, Wenyan Tang, Zu Luan, Xia Yun, Junlong Chen, Haifeng Yuan, Xuewen Su, and Cui Hongwei
- Subjects
0301 basic medicine ,Interleukin 2 ,Male ,Cancer Research ,medicine.medical_specialty ,Enzyme-Linked Immunosorbent Assay ,Biochemistry ,Severity of Illness Index ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Th2 Cells ,Downregulation and upregulation ,Internal medicine ,Genetics ,medicine ,Humans ,Molecular Biology ,Oncogene ,business.industry ,Gene Expression Profiling ,Infant, Newborn ,NF-kappa B ,T helper cell ,Th1 Cells ,Molecular medicine ,White Matter ,030104 developmental biology ,Endocrinology ,Real-time polymerase chain reaction ,medicine.anatomical_structure ,Oncology ,Brain Injuries ,Molecular Medicine ,Cytokines ,Premature Birth ,Tumor necrosis factor alpha ,Female ,business ,Transcriptome ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Incidence of white matter injury (WMI), which is featured as softening of white matter tissues, has recently increased. Previous studies have demonstrated a close correlation between T helper cell 1 and T helper cell 2 (Th1/Th2) imbalance and nuclear factor‑κB (NF‑κB) with brain disease. Their role in premature WMI, however, remains to be illustrated. Serum samples were collected from 60 premature WMI neonates, plus another control group of 60 premature babies without WMI. Patients were further divided into mild, moderate and severe WMI groups. Reverse transcription quantitative polymerase chain reaction was used to test mRNA expression levels of Th1/Th2 cytokines, including interleukin 2 (IL)‑2, tumor necrosis factor‑α (TNF‑α), IL‑4, IL‑10 and nuclear factor (NF)‑κB, whilst their serum levels were measured by ELISA. Their correlation with disease occurrence and progression were further analysed, to illustrate the effect of Th1/Th2 balance and NF‑κB on pathology of premature WMI. Serum levels of IL‑4 and IL‑10 were significantly decreased in premature WMI babies, whilst IL‑2, TNF‑α and NF‑κB were upregulated (P
- Published
- 2016
7. The Influencing Factors of Aggregation Behavior of Tree-of-Heaven Trunk Weevil, Eucryptorrhynchus brandti (Harold) (Coleoptera: Curculionidae)
- Author
-
Xuewen Sun, Wei Song, Wenjuan Guo, Shujie Wang, and Junbao Wen
- Subjects
coleoptera ,pest weevil ,aggregation ,conspecific communication ,environment factors ,Science - Abstract
The tree-of-heaven trunk weevil, Eucryptorrhynchus brandti (Harold) (Coleoptera: Curculionidae), is one of the most harmful pests that damage the tree of heaven, Ailanthus altissima Swingle (Sapindales: Simaroubaceae). Aggregation behavior tests of E. brandti adults were conducted in laboratory conditions. The effects of temperature and light on the aggregation behavior of adults were tested, and the effect of sex and host was conducted with binomial choice experiments. The results showed that (1) the adults aggregate in both light and dark environments but preferred the dark environment, (2) temperature can drive the aggregation of E. brandti adults, (3) host plants could trigger E. brandti adults’ aggregation behavior, which is probably related to phytochemicals and insect feeding and localization, (4) there was mutual attraction of males and females and chemical attraction of crude intestinal extracts of males and females, and (5) aggregation behavior of E. brandti adults may also be related to the mediating of physical signals in insects. In this study, aggregation behavior can help us understand conspecific interactions and discover some strategies for effective control.
- Published
- 2023
- Full Text
- View/download PDF
8. Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013.
- Author
-
XIAOMEI ZHANG, YANYAN LIANG, WANYU FENG, XUEWEN SU, and HUA ZHU
- Subjects
MUCOCUTANEOUS lymph node syndrome ,COMMUNICABLE diseases in children ,ARTERITIS ,ARTERIAL diseases ,ETHNIC groups - Abstract
The epidemiologic features of Kawasaki disease (KD) in the Inner Mongolia Autonomous Region of China has not been previously determined, to the best of our knowledge. Therefore, the aim of the present study was to investigate the epidemiology of KD in Inner Mongolia. Clinical data from 518 patients treated for KD in Inner Mongolia between January 2001 and December 2013 were analyzed. The results indicated that the mean annual incidence rate was 3.55±2.96 per 100,000 children under the age of 5 years between 2001 and 2013. The age at diagnosis ranged between 49 days and 14 years, while the disease occurred more frequently in the spring and summer. In addition, the incidence of coronary artery lesion (CAL) was reported to be 40.2% in the present survey. KD patients in the Han Chinese ethnic group were more likely to be complicated by CAL, whereas patients with incidence of KD in July were less likely to be complicated by CAL. In conclusion, the incidence of KD was observed to be increasing in Inner Mongolia, while the ethnic group and month of onset may be associated with the incidence of CAL in KD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
9. Optimization of Molecular Composition Distribution of Slurry Oil by Supercritical Fluid Extraction to Improve the Structure and Performance of Mesophase Pitch
- Author
-
Xiaoyu Dai, Yuanen Ma, Linzhou Zhang, Zhiming Xu, Xuewen Sun, and Suoqi Zhao
- Subjects
slurry oil ,supercritical fluid extraction ,mesophase pitch ,Technology - Abstract
The composition distribution of slurry oil has a significant impact on the structure and performance of the mesophase. In this study, supercritical fluid extraction oil (SFEO) and extraction components were extracted from two slurry oils (SLOs) using the supercritical fluid extraction (SFE) technique. The fundamental properties and composition distribution of two SLOs and associated SFEOs were thoroughly investigated. Electron microscopy and spectroscopic techniques were employed to study the morphology and structures of mesophase pitch produced by carbonizing SLOs and their extraction components under the same conditions. The findings revealed that, compared to SLO–LH, SLO–SH has a higher proportion of 4–5 aromatic rings and a narrower hydrocarbon distribution range. In SLO–LH, O1, N1, and N1O1 molecules with long side chains and poor flatness make up the majority of the heterocyclic aromatic hydrocarbons. The distribution of CH compounds can be narrowed by using supercritical fluid extraction to efficiently separate various heteroatom-containing compounds with a higher condensation degree. After supercritical extraction, the mesophase content, texture distribution, and graphitization degree of the mesophase were improved. Polycyclic aromatic hydrocarbons with high planarity help polymer macromolecules stick together and build up in an orderly way. Heterocyclic aromatic hydrocarbons with high condensation and low planarity, on the other hand, play an important role in the formation of mosaic structures.
- Published
- 2022
- Full Text
- View/download PDF
10. Thermo-Structural Behaviour Prediction of the Nose Cap of a Hypersonic Vehicle Based on Multifield Coupling
- Author
-
Xuewen Sun, Haibo Yang, and Tao Mi
- Subjects
Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
The analysis of thermo-structural behaviour is crucial to the nose cap of a hypersonic vehicle under aerothermodynamic loads. Considering chemical nonequilibrium of the flow field, heat transfer, and deformation of the structure, a fluid-thermal-structural coupling model of the typical nose cap was established. The coupling relation between the flow field and nose cap was analyzed. The results show that the fluid-thermal-structural model can effectively predict the response of the nose cap under a hypersonic environment. The highest temperature and the peak of maximum principal stress appear at the front of the nose cap at an initial stage. As time goes on, the highest temperature increases gradually and the peak of maximum principal stress decreases after reaching a certain value. The position of the peak of maximum principal stress gradually moves to the inside of the nose cap and eventually stabilizes. With the increase in the Mach number, the highest temperature and the peak of maximum principal stress of the nose cap increase. The fluid-thermal-structural coupling model can provide guidance for the optimal design of the nose cap of a hypersonic vehicle.
- Published
- 2020
- Full Text
- View/download PDF
11. Heat Transfer and Ablation Prediction of Carbon/Carbon Composites in a Hypersonic Environment Using Fluid-Thermal-Ablation Multiphysical Coupling
- Author
-
Xuewen Sun, Haibo Yang, and Tao Mi
- Subjects
Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
Carbon/carbon composites are usually used as a thermal protection material in the nose cap and leading edge of hypersonic vehicles. In order to predict the thermal and ablation response of a carbon/carbon model in a hypersonic aerothermal environment, a multiphysical coupling model is established taking into account thermochemical nonequilibrium of a flow field, heat transfer, and ablation of a material. A mesh movement algorithm is implemented to track the ablation recession. The flow field distribution and ablation recession are studied. The results show that the fluid-thermal-ablation coupling model can effectively predict the thermal and ablation response of the material. The temperature and heat flux in the stationary region of the carbon/carbon model change significantly with time. As time goes on, the wall temperature increases and the heat flux decreases. The ablation in the stagnation area is more serious than in the lateral area. The shape of the material changes, and the radius of the leading edge increases after ablation. The fluid-thermal-ablation coupling model can be used to provide reference for the design of a thermal protection system.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.