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5 results on '"Xuewei Xiong"'

1. Identification of hub genes and pathways of ferroptosis in Fusarium keratitis by bioinformatics methods

Author

Xingbo Teng, Xuewei Xiong, Xiaoyuan Sha, Yahui Lei, Yuyao Diao, Jiayan Liu, Yuan Tian, Lian Liu, and Jingxiang Zhong

Subjects
fungal keratitis, Fusarium keratitis, ferroptosis, bioinformatics, immune, Microbiology, QR1-502
Abstract

BackgroundFungal keratitis is a common blinding eye disease, and Fusarium is one of the main species that cause fungal keratitis. As is well known, oxidative stress plays an important role in Fusarium keratitis and it is also a significant initiating factor of ferroptosis. But the relationship between Fusarium keratitis and ferroptosis is currently unclear. This study aimed to speculate and validate potential ferroptosis-related genes in Fusarium keratitis using bioinformatics analysis, which provided ideas for further research on its specific mechanism and new targets for its treatment. MethodsThe microarray expression profiling dataset (GSE58291) came from Gene Expression Omnibus (GEO). The differentially expressed genes (DEGs) were obtained by the limma package of the R software. The DEGs were performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Then, the DEGs were intersected with the genes in the ferroptosis database. The top 5 hub genes were obtained by the protein-protein interaction (PPI) network analysis and the cytoHubba plug-in of Cytoscape software. The hub genes were subjected to GSEA analysis. Then we analyzed the immune infiltration of the samples by CIBERSORT and ssGSEA algorithm. Finally, we validated the mRNA of hub genes by qPCR.ResultsA total of 1,368 DEGs were identified and 26 ferroptosis-related DEGs were obtained. At the same time, ferroptosis-related pathways were enriched by GO and KEGG using DEGs. HMOX1, CYBB, GPX2, ALOX5 and SRC were obtained by the PPI network analysis and the cytoHubba plug-in of Cytoscape software. The iron metabolism and immune response related pathways were enriched using GSEA. They included hematopoietic cell lineage, lysosome and FC gamma R mediated phagocytosis. T cells follicular helper, monocytes, macrophages and mast cells might play an important role in Fusarium keratitis using analysis of immune infiltration. Finally, qPCR confirmed that the expression of HMOX1, CYBB, ALOX5 mRNA in the DON group was significantly elevated, while the expression of GPX2 were significantly decreased.ConclusionsFerroptosis may play an important role in Fusarium keratitis. HMOX1, CYBB, ALOX5 and GPX2 may be key ferroptosis-related genes in the pathogenesis of Fusarium keratitis.

Published
2023
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2. Selective Hydrogenation of CO2 to Ethanol over Sodium-Modified Rhodium Nanoparticles Embedded in Zeolite Silicalite-1

Author

Wei Zhou, Jincan Kang, Qinghong Zhang, Kang Cheng, Xuewei Xiong, Yuhao Wang, Ye Wang, and Fuyong Zhang

Subjects
Catalytic transformation, Ethanol, Sodium, Nanoparticle, chemistry.chemical_element, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Rhodium, chemistry.chemical_compound, General Energy, chemistry, Chemical engineering, Physical and Theoretical Chemistry, Zeolite
Abstract

Catalytic transformation of CO2 into chemicals in large demand such as ethanol has attracted much research attention under the background of establishing carbon-neutral societies. Supported Rh cata...

Published
2021

3. Effect of zeolite topology on the hydrocarbon distribution over bifunctional ZnAlO/SAPO catalysts in syngas conversion

Author

Ye Wang, Fuyong Zhang, Kang Cheng, Jincan Kang, Xuewei Xiong, Mengheng Wang, and Qinghong Zhang

Subjects
chemistry.chemical_classification, Materials science, Ethylene, Oxide, 02 engineering and technology, General Chemistry, Microporous material, 010402 general chemistry, 021001 nanoscience & nanotechnology, Topology, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Hydrocarbon, chemistry, 0210 nano-technology, Zeolite, Bifunctional, Syngas
Abstract

Recent studies demonstrate that bifunctional catalysts composed of metal oxide and zeolite can effectively control the hydrocarbon distribution in syngas conversion. In this effort, a set of eight silicoaluminophosphate (SAPO) zeolites with different topology structures are synthesized and integrated with a binary ZnAlO oxide for syngas conversion. The effects of micropore window size and cage size of SAPO zeolites, and reaction conditions on the hydrocarbon distribution are preliminarily investigated. It was found that the hydrocarbon distribution is primarily determined by the window size of SAPO zeolites, and a volcano trend was observed between the chain length of hydrocarbon products and the window sizes. The cage size of zeolites and reaction conditions only modifies the hydrocarbon distribution in a narrow range of chain length. The effect of zeolite topology on the hydrocarbon distribution in syngas conversion is overall in line with that in methanol conversion. These findings provide an efficient strategy to increase the selectivity of an individual hydrocarbon product in syngas conversion, such as ethylene, propylene, butenes, iso-butane and C5–C11 iso-paraffins.

Published
2021

5. In-situ confinement of ultrasmall palladium nanoparticles in silicalite-1 for methane combustion with excellent activity and hydrothermal stability

Author

Wei Zhou, Qinghong Zhang, Xuewei Xiong, Yuhao Wang, Jincan Kang, Ye Wang, Wangyang Wang, Kang Cheng, and Wei Li

Subjects
Materials science, Process Chemistry and Technology, Diffusion, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Combustion, 01 natural sciences, Catalysis, Methane, Hydrothermal circulation, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Chemical engineering, 0210 nano-technology, Zeolite, Water vapor, General Environmental Science, Palladium
Abstract

Maximizing the use of palladium without compromises in catalytic activity and stability in the combustion of methane is extremely challenging due to the harsh operation conditions. To achieve this goal, a series of core-shell-structured catalysts with different amounts of palladium nanoparticles confined in hydrophobic silicalite-1 (Pd@S-1) was designed. Unexpectedly, a volcanic trend between catalytic activity and palladium loading was found as the loading increased from 0.3 wt% to 1.6 wt%, among which the 0.6 wt%Pd@S-1 exhibited the highest catalytic activity with a complete combustion temperature of 380 °C. Besides, the 0.6 wt%Pd@S-1 showed an ultrahigh stability in the high temperature applications due to the spatial confinement of palladium inside the rigid zeolite matrix. Moreover, owing to the hydrophobicity of the pure silica zeolite, the Pd@S-1 could selectively hinder the diffusion of water vapor into the palladium sites, leading to the outstanding water-resistance ability.

Published
2020

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