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BackgroundUterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a cancer that include both carcinomatous and sarcomatous components, resembling endometrial carcinoma. A 55-year-old woman was admitted to the hospital with postmenopausal vaginal bleeding. Gross examination of the specimen revealed brittle tissue in the fundus and the left wall of the endometrium. Postoperative pathology revealed a mixture of well-differentiated endometrioid adenocarcinoma and osteosarcoma. The patient was never given birth, which may be relevant to the diagnosis. Literature review suggests that being nulliparous may be a significant risk factor for developing uterine carcinosarcoma.Case descriptionIn December 2023, a 55-year-old female patient was admitted to the hospital with postmenopausal vaginal bleeding. Hysteroscopic surgery was performed, and the postoperative pathology showed endometrial cancer accompanied by ossified tissue with necrosis. The immunohistochemical results indicated positive Estrogen receptors (ER), positive Progesterone receptors (PR), ki67 positivity at 70%, negative PTEN, mutated positive p53, focal positive Pax-8, positive SATB2, positive Cytokeratin 7 (CK7), positive EMA and positive Vimentin (Vim). The patient was diagnosed with Uterine carcinosarcoma. On December 18, 2023, the patient underwent partial vaginal resection, bilateral salpingo-oophorectomy, pelvic lymph node dissection, and a sub-extensive laparoscopic hysterectomy. Postoperatively, the patients received radiotherapy and four cycles of chemotherapy in the DC regimen. As of July 2024, laboratory and impact test results showed no tumor recurrence. The patient’s disease-free survival (DFS) was seven months.ConclusionThe rate of childless in patients with uterine carcinosarcoma is at a high level.

Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains a challenge. We here developed a chitosan-based sponge by integrating freeze-drying, chemical decoration of alkyl chains and phosphate groups, and physical loading of thrombin. The sponge exhibited high mechanical strength, self-elasticity, and rapid shape recovery. The sponge facilitated blood cell adhesion, aggregation, and activation through hydrophobic and electrostatic interactions, as well as accelerated blood clotting. The sponge exhibited higher efficacy than commercial gauze and gelatin sponge in managing uncontrolled hemorrhage from heparinized rat tail amputation, liver superficial injury, and liver perforating wound models. In addition, the sponge exhibited favorable biodegradability and biocompatibility. These findings revealed that the developed sponge holds great potential as a novel hemostat for effectively managing uncontrolled coagulopathic hemorrhage from superficial and perforating wounds.

Objective: To investigate the diagnostic utility of multimodal ultrasound for fetal bowel dilatation (FBD) in different parts of the bowel and to examine its prognostic potential in FBD. Methods: This retrospective study analyzed 86 fetuses with a dilated bowel identified via ultrasound in a 10-month postnatal follow-up. Both two- and three dimensional (2D and 3D, respectively) ultrasound volume imaging were used to characterize dilation across different bowel sections. The optimal intestinal diameter cut-off values for pathological bowel dilatation were determined and a predictive model for neonatal surgery was developed. Results: The 86 cases of dilatation were distributed as follows: duodenal (n = 36); jejunum/ileum (n = 35); and colonic (n = 15). Duodenal dilatations presented the earliest during pregnancy compared to the other 2 groups (24.4 versus [vs.] 29 vs. 33.7 weeks respectively; p

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Li-In alloys are widely used as reference materials in the research field of solid-state lithium-based batteries. Here, the authors report and discuss the instability of Li-In electrodes towards sulfide solid electrolytes in all-solid-state batteries.

Maize kernel growth is sensitive to heat stress, which is predicted to result in yield loss. However, the response of maize to short-term heat stress during different kernel-growth stages is still not clear. A 3-year field experiment, included two heat-stress treatments (LSH, lag-stage heat stress; FSH, effective-filling-stage heat stress), was conducted in 2019–2021. The results showed that LSH and FSH significantly reduced the grain yield by 8.7–14.9% and 11.6–17.6%, respectively, compared with the control (CK). LSH mainly reduced the kernel number per ear, and FSH mainly reduced the kernel weight. Heat stress reduced the SPAD and chlorophyll content during the effective-filling stage, but not in the lag stage. Photosynthesis was obviously reduced under heat stress during both stages; however, the photosynthesis rate during the lag stage was higher than during the effective-filling stage. The decreased amplitude of dry matter under LSH was higher than under FSH during the heating period. However, there was no difference between the CK and LSH samples in terms of dry-matter accumulation from the end of heat stress to harvest, which was significantly reduced under FSH. Additionally, decreased starch-synthesis-related enzyme activity, i.e., adenosine diphos-phoglucose pyrophosphprylase, contributed to the kernel number and kernel weight loss in LSH and FSH, respectively. The kernel-growth rate (per ear) was lowered, but the growth duration was not shortened in this study. Consequently, LSH mainly reduced the photosynthesis rate (Pn), resulting in kernel abortion and yield penalty. FSH mainly reduced the Pn and chlorophyll content, which reduced the kernel weight, and increased yield loss.

Tin dioxide (SnO2) with multiple electron transport is considered as a potential substitute for graphite due to these advantages of natural abundance, environmental friendliness, and high theoretical capacity. However, the ineluctable volume change and structural crushing limit its practical application. Hence, SnO2 is coated by an N-doped graphite layer to form the flexible composite anode (SnO2@NG), which can provide a conductive network, increase the electronic conductivity, and effectively mitigate the irreversible volume expansion/contraction during the circulation process. Furthermore, the SnO2@NG anode shows a high specific capacity and stable cycle performance in lithium-ion batteries (677.7 mAh g−1 after 100 cycles) and sodium-ion batteries (169.7 mAh g−1 after 100 cycles). This excellent electrochemical performance illustrates that SnO2@NG has broad application prospects for high-performance energy storage systems.

The beach-bar sand reservoir of the Sha 4 Member of the Shahejie Formation in the Dongying Sag is the main oil-bearing formation in this area. In recent years, its proven reserves have been getting lower and lower, and the poor petrophysical properties of the reservoir have made water injection development difficult. In turn, it results in a rapid decline in elastic development productivity and low oil recovery. In this study, the experimental evaluation and numerical simulation research on the adaptability of CO2 flooding in beach-bar sand reservoirs are carried out on the basis of fully investigating the successful examples of CO2 flooding conducted by the previous. According to the geological characteristics of the reservoir in the CL area of the Dongying Sag, the reasonable reservoir engineering parameters and surface injection procedures for the CO2 flooding have been formulated. Experiments show that after the completion of water flooding, the recovery factor of the CO2 continuous flooding is 85.64%. It proves that the recovery factor of the CO2 flooding is higher than that of the water flooding. Field tests have shown that CO2 molecules in beach-bar sand reservoirs behave in a supercritical state underground, which is easier to being injected into the reservoir than water. In addition, the displacement distance of the CO2 is obviously larger than that of the water injection development. The gas-oil ratio variation of different flooding types is different, and CO2 flooding can effectively increase the formation energy, and improve the oil recovery and economic benefits of this type of reservoir.

Abstract Background During anterior cruciate ligament (ACL) reconstruction, different methods of harvesting hamstring tendon may lead to different degrees of injury to the inferior patellar branch of the saphenous nerve (IPBSN). Most of recent studies in the literature suggest that the classic oblique incision (COI) can reduce the incidence of IPBSN injury. We proposed a modified oblique incision (MOI) and compared it with the COI in terms of the resulting levels of injury and sensory loss and the clinical outcome. Methods Patients with ACL injury admitted to our hospital from April 2015 to July 2019 were randomly selected and included in our study. Thirty patients underwent the COI to harvest hamstring tendons, and the other 32 patients underwent the MOI. The pin prick test was performed to detect the sensation loss at 2 weeks, 6 months, and 1 year after the operation. Digital photos of the region of hypoesthesia area were taken, and then, a computer software (Adobe Photoshop CS6, 13.0.1) was used to calculate the area of the hypoesthesia. The length of the incision and knee joint functional score were also recorded. Results At the final follow-up, the incidence of IPBSN injury in COI and MOI were 33.3% and 9.4%, and the areas of paresthesia were 26.4±2.4 cm2 and 9.8±3.4 cm2 respectively. There was no significant difference in the incision length or knee functional score between the two groups. Conclusion The MOI can significantly reduce the risk of injury to the IPBSN, reduce the area of hypoesthesia, and lead to high subjective satisfaction. Therefore, compared with the COI, the MOI is a better method of harvesting hamstring tendons in ACL reconstruction.

In the critical situation of energy shortage and environmental problems, Si has been regarded as one of the most potential anode materials for next-generation lithium-ion batteries as a result of the relatively low delithiation potential and the eminent specific capacity. However, a Si anode is subjected to the huge volume expansion–contraction in the charging–discharging process, which can touch off pulverization of the bulk particles and worsens the cycle life. Herein, to reduce the volume change and improve the electrochemical performance, a novel Si@SiOx/C anode with a core–shell structure is designed by spray and pyrolysis methods. The SiOx/C shell not only ensures the structure stability and proves the high electrical conductivity but also prevents the penetration of electrolytes, so as to avoid the repetitive decomposition of electrolytes on the surface of Si particle. As expected, Si@SiOx/C anode maintains the excellent discharge capacity of 1,333 mAh g−1 after 100 cycles at a current density of 100 mA g−1. Even if the current density reaches up to 2,000 mA g−1, the capacity can still be maintained at 1,173 mAh g−1. This work paves an effective way to develop Si-based anodes for high-energy density lithium-ion batteries.

The crustal structure in Myanmar can provide valuable information for the eastern margin of the ongoing Indo-Eurasian collision system. We successively performed H–k stacking of the receiver function and joint inversion of the receiver function and surface wave dispersion to invert the crustal thickness (H), shear wave velocity (VS), and the VP/VS ratio (k) beneath nine permanent seismic stations in Myanmar. H was found to increase from 26 ​km in the south and east of the study area to 51 ​km in the north and west, and the VP/VS ratio was complex and high. Striking differences in the crust were observed for different tectonic areas. In the Indo-Burma Range, the thick crust (H ​∼ ​51 ​km) and lower velocities may be related to the accretionary wedge from the Indian Plate. In the Central Myanmar Basin, the thin crust (H ​= ​26.9–35.5 ​km) and complex VP/VS ratio and VS suggest extensional tectonics. In the Eastern Shan Plateau, the relatively thick crust and normal VP/VS ratio are consistent with its location along the western edge of the rigid Sunda Block.

Due to the rapid development of bendable electronic products, it is urgent to prepare flexible anode materials with excellent properties, which play a key role in flexible lithium-ion batteries. Although carbon fibers are excellent candidates for preparing flexible anode materials, the low discharge specific capacity prevents their further application. In this paper, a hierarchical porous and silicon (Si)/nitrogen (N) co-doped carbon nanofiber anode was successfully prepared, in which Si doping can improve specific capacity, N doping can improve conductivity, and a fabricated hierarchical porous structure can increase the reactive sites, improve the ion transport rate, and enable the electrolyte to penetrate the inner part of carbon nanofibers to improve the electrolyte/electrode contacting area during the charging–discharging processes. The hierarchical porous and Si/N co-doped carbon nanofiber anode does not require a binder, and is flexible and foldable. Moreover, it exhibits an ultrahigh initial reversible capacity of 1737.2 mAh g−1, stable cycle ability and excellent rate of performance. This work provides a new avenue to develop flexible carbon nanofiber anode materials for lithium-ion batteries with high performance.

We report on 2 different types of left pulmonary artery sling (LPAS), types IA and IIB, diagnosed by fetal magnetic resonance imaging (MRI). We suggest that fetal MRI is an effective tool for accurately diagnosing LPAS and helping guide its perinatal management. Fetal MRI is relatively unaffected by the conditions that limit visualization by echocardiography. When prenatal ultrasound detects either a possible anomalous origin of the left pulmonary artery or a tracheobronchial anomaly, fetal MRI may provide additional information to confirm the LPAS diagnosis and classify its type. To our knowledge, these are the first reports of prenatally diagnosed LPAS by fetal MRI.

Remote sensing is a non-contact, long-distance detection technology. The reflection characteristics of a seismic wave can be used to detect remote and non-contact targets. Based on the reflection characteristics of a seismic wave, the underground structure in Tengchong Volcanic Area is explored. In order to further study the deep structure and magmatic activity of the crust in the volcanic area, we carried out a one-year mobile seismic observation. In this paper, nine broadband seismic stations were set up in the Tengchong Volcanic Area, and 3350 receiver function waveforms were collected. The crustal thickness, average wave velocity ratio, and Poisson’s ratio below these stations were calculated by the receiver function method, and the velocity structure near the Moho below these stations was evaluated. Combined with topographic data from SRTM3 (Shuttle Radar Topography Mission 3), this study reveals the dynamic relationship among crustal structure, crustal magmatism, and regional tectonic movement. Mantle upwelling plays an important role on the Moho uplift in the northern Tengchong Volcanic Area, and there are interconnected intracrustal magma chambers in the upper platform. The evaluation results of the Moho transition zone also indicate that the Dayingjiang fault is closely related to the tectonic activity of the Tengchong Volcanic fault.

A very simple optical tunable device, which can realize multiple functions of frequency selection, reflection and slow light, is presented at the investigation. The proposed device is constructed by a periodic grating-like structure. There are two dielectrics (graphene and silicon) in a period of the equivalent grating. The incident light will strongly resonate with the graphene of electrostatic doping, forming an evanescent wave propagating along the surface of graphene, and this phenomenon is the surface plasmon. Under constructive interference of the polaritons, a unique plasmonic induced transparency phenomenon will be achieved. The induced transparency produced by this device can be well theoretically fitted by the bright and dark mode of optical equivalent cavity which can be called coupled mode theory. This theory can well analyze the influence of various modes and various losses between the function of this device. The device can use gate voltages for electrostatic doping in order to change the graphene carrier concentration and tune the optical performance of the device. Moreover, the length of the device in y -direction is will be much larger than the length of single cycle, providing some basis for realizing the fast tunable function and laying a foundation for the integration. Through a simulation and calculation, we can find that the group index and group delay of this device are as high as 515 and 0.257 picoseconds (ps) respectively, so it can provide a good construction idea for the slow light device. The proposed grating-like metamaterial structure can provide certain simulation and theoretical help for the optical tunable reflectors, absorbers, and slow light devices.

A magnetic field sensor with a new concentrating-conducting magnetic flux structure (CCMFS) is proposed in this paper, using a silicon-on insulator (SOI) Hall element fabricated by complementary metal oxide semiconductor (CMOS) technology as a magnetic sensitive unit. By fixing the CCMFS above the Hall element packaged on a printed circuit board (PCB) based on inner-connect wire bonding technology, a non-magnetized package can subsequently be obtained. To analyze the inner magnetic field vector distribution of the CCMFS, a simulation model was built based on a finite element software, where the CCMFS was processed using Ni-Fe alloys material by a low speed wire-cut electric discharge technology. The test results showed that the measurement of magnetic fields along a sensitive and a non-sensitive axis can be achieved when VDD = 5.0 V at room temperature, with magnetic sensitivities of 122 mV/T and 132 mV/T in a testing range from −30 mT to 30 mT, respectively. This study makes it possible to not only realize the detection of magnetic field, but also to significantly improve the sensitivity of the sensor along a non-sensitive axis.

NNK, formally known as 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanoe, is a potent chemical carcinogen prevalent in cigarette smoke and is a key contributor to the development of human lung adenocarcinomas. On the other hand, autophagy plays a complex role in cancer development, acting as a ''double-edged sword'' whose impact varies depending on the cancer type and stage. Despite this, the relationship between autophagy and NNK-induced lung carcinogenesis remains largely unexplored. Our current study uncovers a marked reduction in p62 protein expression in both lung adenocarcinomas and lung tissues of mice exposed to cigarette smoke. Interestingly, this reduction appears to be contingent upon the activity of extrahepatic cytochrome P450 (CYP450), revealing that NNK metabolic activation by CYP450 enzyme escalates its potential to induce p62 downregulation. Further mechanistic investigations reveal that NNK suppresses autophagy by accelerating the degradation of p62 mRNA, thereby promoting the malignant transformation of human bronchial epithelial cells. This degradation process is facilitated by the hypermethylation of the Human antigen R (HuR) promoter, resulting in the transcriptional repression of HuR - a key regulator responsible for stabilizing p62 mRNA through direct binding. This hypermethylation is triggered by the activation of ribosomal protein S6, which is influenced by NNK exposure and subsequently amplifies the translation of DNA methyltransferase 3 alpha (DNMT3a). These findings provide crucial insights into the nature of p62 in both the development and potential treatment of tobacco-related lung cancer.