Search

In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03-0.42, p 0.05) (fasting insulin: SMD 0.95; 9 5% CI 0.11-1.8, p 0.05) (GH: SMD - 0.25; 95% CI - 0.41 to - 0.08, p 0.05). IGF-1 and FPG levels did not differ significantly (IGF-1: SMD -0.03; 95% CI - 0.22 to 0.17, p 0.05) (FPG: SMD 0.14; 95% CI - 0.23 to 0.52, p 0.05). The systematic review results suggest no significant differences in hemoglobin A1C, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9, and α-fetoprotein levels, but serum Klotho levels.We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.

In mixture experiments, sometimes, there are some so-called collapse phenomena among its mixture components. In view of these collapse phenomena, we present a detailed discussion of the influence t...

Magnetic absorber in optical frequency can be fulfilled through metamaterials designing. Therein, magnetic resonance in metal-dielectric-metal metasurfaces can be manipulated conveniently, and studying the parameters impacts is the primary for applications. In this work, through changing the grating width and the thickness of silica, the magnetic resonance modes have been studied, the conditions of the phase change zone from magnetic resonance (MR) to Fabry-Perot (FP) are given out in Ag−SiO2−Ag grating magnetic metasurfaces. The results indicate that the MR mode in metal-dielectric-metal configuration is mainly decided on the dielectric duty factor other than the sole behaviors of the thickness of dielectric and size of nanostructures. The physical mechanism is elucidated through simulated electromagnetic field distributions using finite difference time domain (FDTD) solution, and numerical analysis of effective refraction index of Ag−SiO2−Ag magnetic metasurfaces. This study may prompt development of metamaterials in basic research in condensed physics and in optical devices applications.

Clot and thrombus formation on surfaces that come into contact with blood is still the most serious problem for blood contacting devices. Despite many years of continuous efforts in developing hemocompatible materials, it is still of great interest to develop multifunctional materials to enable vascular cell selectivity (to favor rapid endothelialization while inhibiting smooth muscle cell proliferation) and improve hemocompatibility. In addition, biomaterial-associated infections also cause the failure of biomedical implants and devices. However, it remains a challenging task to design materials that are multifunctional, since one of their functions will usually be compromised by the introduction of another function. In the present work, the gold substrate was first layer-by-layer (LbL) deposited with a multilayered polyelectrolyte film containing chitosan (positively charged) and a copolymer of sodium 4-vinylbenzenesulfonate (SS) and the "guest" adamantane monomer 1-adamantan-1-ylmethyl methacrylate (P(SS-co-Ada), negatively charged) via electro-static interactions, referred to as Au-LbL. The chitosan and P(SS-co-Ada) were intended to provide, respectively, resistance to bacteria and heparin-like properties. Then, "host" β-cyclodextrin derivatives bearing seven lysine ligands (CD-L) were immobilized on the Au-LbL surface by host-guest interactions between adamantane residues and CD-L, referred to as Au-LbL/CD-L. Finally, a versatile surface coating with fibrinolytic activity (lysis of nascent clots), vascular cell selectivity and antibacterial properties was developed.

We experimentally and theoretically investigate Fano-like resonance in a large-area Au/SiO2/Au nano-patches meta-structure, which originates from the coupling between Fabry–Perot resonance and magnetic dipole resonance modes. A highly sensitive refractive index sensor based on the lineshape analysis is obtained. The extracted wavelength shift with the amount of substance of Hg2+ changing from 10–3 pmol to 1 nmol has a linear dependence, and the sensitivity can reach to ultra-low limit of detection (LOD) as 10–3 pmol. This study may provide an approach for the development and modification in sensing.

With the increasing proportion of wind power in the power system, a significant threat is posed to the safe and stable operation of regional power grids and the consumption of the new energy by the harmonic interaction effects among wind farms. Aimed at the problem of mechanism for the harmonic interaction between wind farms and the degree of influence, an aggregation equivalence method of wind farms in harmonic power loss is proposed, where the complexity of wind farm equivalence calculation is reduced. Based on this, a harmonic impedance model of multiple wind farms grid-connected system is established, and the mechanism of harmonic interaction influence among the wind farms is revealed. The definition and calculation method of harmonic current interaction factor is presented, where the relationship between the harmonic current interaction and the potential factors, i.e., the coupling impedance, the dynamic reactive power compensation devices, and the number of wind turbines connected to the grid among multiple wind farms, is quantitatively analyzed. Finally, a typical wind farm of new energy base in Northwest China is used as a toy example to verify the effectiveness of the harmonic current interaction factor in the characterization of the interaction strength within multiple wind farms.

Magnetic photonic crystal slab with nanovoids buried in Ni films were fabricated using nanosphere lithography combined with electrochemical deposition. One featured structure was dominated the spectra of polar surface magneto-optical Kerr effect (MOKE) of samples with different voids depth. For the shallow ones, surface lattice resonance (SLR) was revealed through angle resolved spectra analysis, where the location of degeneracy points corresponded to that of the featured structure in MOKE signal. For the deeper ones, localized plasmons and degeneracy points were all demonstrated in angle resolved reflection spectra, where localized plasmons dominated the resonant MOKE signal, and the degeneracy points blue-shifted compared with that of shallow ones. Changing the lattice of samples, similar phenomena were presented. The physical mechanism of SLR could be attributed to the diffraction of surface plasmons by the reciprocity vector, and the localized plasmons were attributed to the Mie scattering. The featured structure in polar MOKE spectra demonstrated high sensitivity, which might pave the way to on-chip MO devices.