Plenty of volatile organic compounds, inert gases, oxygen, carbon dioxide and other gases which are called as gas mixtures exist and mix in the upper space of liquid cargo tank owing to sloshing of oil tanker and heating of the crude oil in the liquid cargo tank. There will be potential risks of fires or explosions, air pollution and personnel poisoning in the oil tanker when gas mixtures escape from the liquid cargo tank and diffuse somewhere in oil tanker unusually. At the same time, potential risks of fires, explosions, collisions, groundings and oil spills et al. will also take place when operation of the tanker or work of the liquid cargo tank is carried out wrongly etc.. Once these potential risks are controlled improperly, the serious accidents will occur, resulting in huge losses and damages to oil tanker. In consideration of these potential risks existed in oil tanker, methods of VOCs processing are summarized, the current method of VOCs processing in the sloshing liquid cargo tank and its problems or deficiencies are analysed, the system diagram of the sloshing liquid cargo tank including 13 basic elements is established based on the theory of Man-Machine-Environment-Management System Engineering. Escaping and diffusion of the gas mixtures, VOCs fires and explosions, air pollution, personnel poisoning, collisions or groundings of oil tanker and oil spills of the main risks in the sloshing liquid cargo tank in ship are concluded from operation processes of loading, unloading and washing of crude oil in the system of the sloshing liquid cargo tank in oil tanker. What’s more, the formation process of these risks and hazards caused by risks are analysed too. Keywords-oil tanker; the sloshing liquid cargo tank; volatile organic compounds; risk; risk hazard.