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Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that: 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G2/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.

According to the characteristic of high-strength strip, the roll profile configuration and change of CVC tandem cold mill are analyzed. Through the establishment of FEM model, the influences of three representative forms of roll profile configuration on high-strength strip flatness control in CVC cold rolling mill are compared, which are conventional back-up roll / CVC intermediate roll, back-up roll with CVC compensation / CVC intermediate roll, VCL+ back-up roll / HVC intermediate roll. Compared with the other two roll profile configuration, the configuration of VCL+ back-up roll / HVC intermediate roll increases 26.74% in crown adjustment domain of roll gap and 22.09% in lateral stiffness of roll gap, decreases 27.43% in contact pressure peak values between rolls. The new roll profile configuration has obtained industrial applications. Production data indicate that the control accuracy of high-strength strip is improved, also the wear of back-up roll. Significant application results have been achieved.