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9 results on '"Xuan-Hao Bui"'

1. α‐Glucosidase Inhibitory Cycloartanes from the Vietnamese Combretum quadrangulare

Author

Huu‐Hung Nguyen, Thuc‐Huy Duong, Huy Truong Nguyen, Thanh‐Sang Vo, Dinh‐Tri Mai, Huyen Nguyen Thi Thuong, Xuan‐Hao Bui, Ngoc‐Hong Nguyen, and Thi‐Hong‐Tuoi Do

Subjects
Molecular Structure, alpha-Glucosidases, Bioengineering, General Chemistry, General Medicine, Biochemistry, Triterpenes, Molecular Docking Simulation, Asian People, Humans, Combretum, Molecular Medicine, Glycoside Hydrolase Inhibitors, Molecular Biology
Abstract

Leaves of Combretum quadrangulare Kurz showed potent α-glucosidase inhibition. Two new cycloartane-type triterpenes, combretic acids D and E were isolated from the bioactive fraction. The chemical structures were determined using NMR and MS methods. Combretic acid D represents for the first cycloartane having a dihydrofuran ring in the side chain. Combretic acids D and E showed significant α-glucosidase inhibition, with IC

Published
2022

2. Cycloartanes from leaves of

Author

Thanh-Sang, Vo, Huu-Hung, Nguyen, Thi-Phuong, Nguyen, Thi-Minh-Dinh, Tran, Xuan-Hao, Bui, Minh-Hiep, Dinh, Nguyen-Kim-Tuyen, Pham, Jirapast, Sichaem, Van-Son, Dang, Ngoc-Hong, Nguyen, and Thuc-Huy, Duong

Abstract

Two new cycloartanes, combretic acid C (

Published
2022

3. Cycloartanes from leaves of Combretum quadrangulare growing in Vietnam

Author

Thanh-Sang Vo, Huu-Hung Nguyen, Thi-Phuong Nguyen, Thi-Minh-Dinh Tran, Xuan-Hao Bui, Minh-Hiep Dinh, Nguyen-Kim-Tuyen Pham, Jirapast Sichaem, Van-Son Dang, Ngoc-Hong Nguyen, and Thuc-Huy Duong

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Two new cycloartanes, combretic acid C (1) and combretanone I (3), were isolated from the leaves of Combretum quadrangulare Kurz, together with the previously-reported combretic acids A-B (2 and 5) and combretanone A (4). An extensive set of spectroscopic methods were used to elucidate the structures of these compounds. Cytotoxicity against the K562 cancer cell line was evaluated. Compound 1 showed strong activity, with an IC50 value of 9.7 µM. The other compounds showed moderate activity. Alpha-glucosidase inhibition was also evaluated. The isolated compounds showed moderate inhibition, with IC50 values in the range 102.2-194.7 µM.

Published
2022
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4. Norquandrangularic acid D, a new trinorcycloartane isolated from the leaves of

Author

Huu-Hung, Nguyen, Xuan-Hao, Bui, Thi-Minh-Dinh, Tran, Jirapast, Sichaem, Thi-Kim-Dung, Le, Ngoc-Hong, Nguyen, and Thuc-Huy, Duong

Subjects
Plant Leaves, Molecular Structure, Plant Extracts, Combretum, alpha-Glucosidases, Triterpenes
Abstract

Phytochemical investigation on the leaves of

Published
2021

5. Norquandrangularic acid D, a new trinorcycloartane isolated from the leaves of Combretum quadrangulare

Author

Jirapast Sichaem, Xuan-Hao Bui, Thuc-Huy Duong, Huu-Hung Nguyen, Thi-Minh-Dinh Tran, Ngoc-Hong Nguyen, and Thi-Kim-Dung Le

Subjects
Pharmacology, Combretaceae, biology, Traditional medicine, Organic Chemistry, Pharmaceutical Science, Positive control, General Medicine, biology.organism_classification, Analytical Chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Phytochemical, Betulinic acid, Drug Discovery, Apigenin, medicine, Molecular Medicine, Combretum quadrangulare, Luteolin, Acarbose, medicine.drug
Abstract

Phytochemical investigation on the leaves of Combretum quadrangulare growing in Vietnam afforded a new trinorcycloartane triterpenoid, norquandrangularic acid D (1), along with three known compounds, betulinic acid (2), luteolin (3), and apigenin (4). Their structures were elucidated using spectroscopic methods and comparison was made with reports in the literature. Compounds 1 and 3 were evaluated for α-glucosidase inhibition. Compound 3 showed significant activity, with an IC50 value of 11.39 µM, (acarbose, used as a positive control, had an IC50 of 367 µM).

Published
2021
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6. Two novel diterpenes from the roots of Phyllanthus acidus (L.) Skeel

Author

Pierre Le Pogam, Thi-Thuan Tran, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Joël Boustie, Thuc-Huy Duong, Thi-Anh-Tuyet Nguyen, Xuan-Hao Bui, Warinthorn Chavasiri, Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), B2016-SPS-04, MICYT, Ministerio de Ciencia y Tecnología, Nantes Université (NU)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes 1 (UR1), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Biosynthetic considerations, Spruceanol, Phyllanthus, Stereochemistry, Cytotoxicity, High resolution, Moderate activity, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Drug Discovery, Ic50 values, [CHIM]Chemical Sciences, Organic chemistry, Phyllanthus acidus, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hepg2 cells, Diterpene, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

International audience; Two novel diterpenes, phyllanes A and B, were isolated from the roots of Phyllanthus acidus, along with the cleistanthane diterpene, spruceanol. Their chemical structures were unambiguously elucidated by extensive 1D and 2D NMR analyses and high resolution mass spectroscopic data, as well as by comparison with literature data. While phyllanes A and B are respectively reminiscent of amphilectane and serrulatane diterpenoids, their highly unusual substitution patterns and their co-occurrence with spruceanol led us to assume that they might correspond to an unprecedented type of re-arranged cleistanthane-diterpenoid precursors, resulting in final products that display a unique scaffold among terrestrial diterpenoids. Accordingly, a possible biosynthetic route to the two new compounds from the readily accessible spruceanol is proposed herein. These two compounds were evaluated for their cytotoxic activities against two cancer cell lines. Only phyllane B exerted a moderate activity against K562 and HepG2 cell line with IC50 values of 28.90 and 45.23 μg/mL, respectively. © 2017

Published
2017

7. A new cardenolide glycoside from the roots of

Author

Xuan-Hao, Bui, Phu Hoang, Dang, Tuan Trong, Vo, Nhi Y Thi, Nguyen, Minh-Duc, Nguyen, and Quan Le, Tran

Subjects
Apocynaceae, Cardenolides, Lung Neoplasms, Cell Death, Carcinoma, Non-Small-Cell Lung, Proton Magnetic Resonance Spectroscopy, MCF-7 Cells, Humans, Carbon-13 Magnetic Resonance Spectroscopy, Antineoplastic Agents, Phytogenic, Plant Roots, HeLa Cells
Abstract

From remaining aqueous fraction of the roots of

Published
2019

8. A new cardenolide glycoside from the roots of Streptocaulon juventas (lour.) merr. (Asclepiadaceae)

Author

Phu Hoang Dang, Nhi Y Thi Nguyen, Xuan-Hao Bui, Quan Le Tran, Minh Duc Huu Nguyen, and Tuan Trong Vo

Subjects
chemistry.chemical_classification, Traditional medicine, 010405 organic chemistry, Streptocaulon juventas, Organic Chemistry, Glycoside, Plant Science, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Periplogenin, chemistry, Cardenolide, medicine, Cardiac glycoside, medicine.drug
Abstract

From remaining aqueous fraction of the roots of Streptocaulon juventas, one new cardiac glycoside named periplogenin 3-O-β-gentiobioside (1) together with six known ones (2–7) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Compound 1 showed moderate cytotoxicity against non-small cell lung carcinoma NCI-H460 and ovarian cancer HeLa cells. Moreover, compounds 2 and 3 exhibited remarkable cytotoxicity against NCI-H460 cell with the IC50 values of 0.34 and 0.068 μM, respectively.

Published
2019
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9. Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus

Author

Mehdi A. Beniddir, Pierre Le Pogam, Warinthorn Chavasiri, Thammarat Aree, Jean-François Gallard, Dinh Hung Mac, Van-Kieu Nguyen, Xuan-Hao Bui, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Thuc-Huy Duong, Joël Boustie, Ho Chi Minh city University of Technology and Education, Chulalongkorn University [Bangkok], Molécules bioactives, conception, isolement et synthèse (MBCIS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Nguyen Tat Thanh University [Vietnam] (NTTU), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Chulalongkorn University, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Phyllanthus, Magnetic Resonance Spectroscopy, Chemical structure, Pharmaceutical Science, Sulfonic acid, 01 natural sciences, Plant Roots, Analytical Chemistry, chemistry.chemical_compound, X-Ray Diffraction, Drug Discovery, Organic chemistry, [CHIM]Chemical Sciences, Pharmacology, chemistry.chemical_classification, Flavonoids, biology, 010405 organic chemistry, Plant Extracts, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Isoflavones, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Molecular Medicine, Sulfonic Acids, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

International audience; Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5- O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of the roots of Phyllanthus acidus. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data, single-crystal X-ray diffraction analysis, and comparison to the literature data. These new structures represent the first examples of sulfonic acid-containing flavanones, auronols, aurones, and isoflavones.

Published
2018

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