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Abstract CF2-containing compounds hold significant potential in drug discovery, organic synthesis, and materials science. However, synthesizing various CF2-containing building blocks from a single compound remains challenging. Here, we present a Cu-catalyzed, switchable defluoroborylation and hydrodefluorination of trifluoromethylated alkynes, yielding four types of CF2-containing compounds. The chemo- and regio-selective sp2/sp3 1,2-diborylation and sp2 monoborylation of 1-(trifluoromethyl)alkynes are controlled by adjusting the solvent and ligand quantity. Additionally, altering the base allows selective generation of gem-difluoroalkenes or difluoromethylalkenes. Notably, our method prevents over-defluorination of the CF3 group on unsaturated C-C bonds during nucleophilic additions, preserving the pharmaceutically valuable CF2 group. Experimental data and density functional theory (DFT) calculations elucidate the regioselectivities of Cu-Bpin addition and the regulatory role of the ligand in selective deborylation processes.

ObjectivesThis study aims to discuss the clinical manifestations and treatment of Familial hemophagocytic lymphohistiocytosis (FHL) caused by a mutation in the UNC13D gene.MethodsA 6-year-old female child presented with unexplained febricity, splenomegaly, pancytopenia, hemophagocytic lymphohistiocytosis in bone marrow, decreased NK cell activity, soluble CD25 levels > 44000ng/ml. Genetic sequencing revealed a mutation in the UNC13D gene. Additionally, the patient experienced intermittent fever with seizures characterized by involuntary twitching of the left upper limb. Head magnetic resonance imaging (MRI) showed white matter lesions.ResultsAccording to the HLH-2004 diagnostic criteria revised by the International Society of Histiocytosis the patient was diagnosed with FHL. Despite receiving HLH-2004 treatment, the disease relapsed. However, after a salvage allogeneic Hematopoietic Stem Cell Transplant (HSCT), febricity, abnormal blood cells, and neurological symptoms significantly improved.ConclusionsPrompt performance of allogeneic HSCT is crucial upon diagnosis of FHL, especially when neurological involvement is present.

Morphine is a widely used opioid for treatment of pain. The attendant problems including morphine tolerance and morphine dependence pose a major public health challenge. In recent years, there has been increasing interest in the gastrointestinal microbiota in many physiological and pathophysiological processes. The connectivity network between the gut microbiota and the brain is involved in multiple biological systems, and bidirectional communication between them is critical in gastrointestinal tract homeostasis, the central nervous system, and the microbial system. Many research have previously shown that morphine has a variety of effects on the gastrointestinal tract, but none have determined the function of intestinal microbiota in morphine tolerance. This study reviewed the mechanisms of morphine tolerance from the perspective of dysregulation of microbiota-gut-brain axis homeostasis, by summarizing the possible mechanisms originating from the gut that may affect morphine tolerance and the improvement of morphine tolerance through the gut microbiota.

Southwest Guizhou mining area is a typical karst development mining area in China. Under the influence of mining, the height of karst roof water conducting cracks is abnormally developed. During the rainy season, atmospheric precipitation is extremely easy to enter the underground working face through ultra-high water conducting channels, causing water inrush disasters at the working face, seriously affecting the normal production of the mine. Therefore, based on the analysis of the occurrence characteristics of karst caves in Xintian Coal Mine, the development rules of karst roof water conducting fracture zones during mining were studied by means of on-site measurement, indoor simulation, and theoretical analysis. The development mechanism of ultra-high water conducting fractures was revealed. The results show that: ①The roof karst caves in the study area have obvious zonation phenomenon from top to bottom in the layers such as the surface, the Yulongshan section, and the Changxing Formation. The surface water holes develop along the gullies, and the karst caves in the upper and middle parts of the strong aquifer in the Yulongshan section develop, presenting different forms of beads. The Changxing Formation only locally hosts karst caves with smaller diameters; ② Karst caves in karst aquifers have an important impact on water conducting fractures. Without karst caves, the development height of water conducting fractures is 43.1 m, and the fracture mining ratio is 14.4. Under karst caves, the development of water conducting fractures is abnormal, with a height of 173.1 m, and a fracture mining ratio of 57.7, which communicates with the strong limestone aquifer in the Yulong Mountain section; ③ Karst roof water conducting fissures consist of two parts: mining upward fissures and karst cave instability downward fissures. Under the influence of mining, karst caves become unstable under the combined action of concentrated stress and mining additional stress, and are prone to form downward fissures, which communicate with mining upward fissures, ultimately forming a special ultra-high water conducting fissure in southwestern Guizhou mining area.

Idiopathic pulmonary aneurysm is a clinically rare condition characterized by an unknown etiology and episodic occurrence. Despite its rarity, idiopathic pulmonary artery aneurysm poses potential risks to patients. Currently, there is a lack of established clinical guidelines and consensus regarding its management, leading to ongoing controversies in treatment strategies. Particularly, the optimal approach for addressing the main pulmonary artery, its branches, and the pulmonary artery valve remains uncertain. A 57-year-old female patient presented with chest pain and tightness, leading to the diagnosis of idiopathic pulmonary artery aneurysm after excluding other potential causes. Subsequently, she underwent surgical treatment. However, during the surgery, the pulmonary artery wall was found to be extremely weak, prompting us to employ a surgical approach involving the utilization of autologous vessel wrapping with artificial grafts. By summarizing almost all surgical treatment strategies reported in recent years, including the management of pulmonary artery vessels and the pulmonary valve, we have developed a treatment flow chart. This flowchart serves as a valuable guide for the management of future cases presenting similar challenges, offering clinicians valuable insights and evidence-based recommendations.

Abstract Multipartite quantum steering, a unique resource for asymmetric quantum network information tasks, is very fragile to the inevitable decoherence, which makes it useless for practical purposes. It is thus of importance to understand how it decays in the presence of noise channels. We study the dynamic behaviors of genuine tripartite steering, reduced bipartite steering, and collective steering of a generalized three-qubit W state when only one qubit interacts independently with the amplitude damping channel (ADC), phase damping channel (PDC) or depolarizing channel (DC). Our results provide the region of decoherence strength and state parameters that each type of steering can survive. The results show that these steering correlations decay the slowest in PDC and some non-maximally entangled states more robust than the maximally entangled ones. Unlike entanglement and Bell nonlocality, the thresholds of decoherence strength that reduced bipartite steering and collective steering can survive depend on the steering direction. In addition, we find that not only one party can be steered by a group system, but also two parties can be steered by a single system. There is a trade-off between the monogamy relation involving one steered party and two steered parties. Our work provides comprehensive information about the effect of decoherence on multipartite quantum steering, which will help to realize quantum information processing tasks in the presence of noise environments.

In order to improve the tracking accuracy and robustness of the rotating mirror servo system, a modified sliding mode-active disturbance rejection control (MSM-ADRC) strategy is proposed. Firstly, the structure and working principle of the rotating mirror servo system are analysed, and its mathematical model is established to prepare for the design of the controller. Then, a MSM-ADRC is proposed to reduce the influence of unknown disturbance and improve the tracking accuracy. Among them, the modified sliding mode extended state observation (MSM-ESO) is designed by replacing the traditional nonlinear function with the designed optimal control function, which enhances the observation accuracy of the system state quantity and total disturbance. Meanwhile, an improved approach law is proposed, and an improved sliding mode nonlinear error feedback control law (MSM-NLSEF) is designed based on this approach law, which improves the convergence speed and accuracy of the control law. In addition, the stability of the designed MSM-ESO and MSM-NLSEF is proved. Finally, the proposed control method is validated by simulation and experimental comparison with other state-of-the-art controllers. Results reveal that the proposed control method has satisfying tracking performance and strong disturbance rejection ability.

This paper proposes an improved zero-mean normalization sum of squared differences (ZNSSD) algorithm to solve the problem of the inability of traditional structural measurement to extract high-frequency vibration signals. In the proposed technique, the high-speed image sequence of target vibration is captured by a high-speed camera. Then, the ZNSSD template matching algorithm with subpixel accuracy is introduced to process the captured images in the computer. Additionally, a modified search algorithm, the ZNSSD template matching algorithm based on image pyramid (ZNSSD-P), is proposed to significantly reduce the computation time and increase efficiency. Then, a jumping ZNSSD template matching algorithm based on image pyramid (J-ZNSSD-P) is proposed to further improve the efficiency of the ZNSSD-P algorithm. Vibration signals were extracted with Grating Ruler Motion Platform and sound barriers. Results show that the vibration signal extraction method has high precision and efficiency.

To achieve fast, accurate control of the position angle of the rotor of permanent magnet synchronous motor (PMSM), traditional auto disturbance rejection control often has many adjustable parameters and complex tuning problems. Sliding mode control technology is introduced into the extended state observer (ESO) part of the auto disturbance rejection controller, and a new sliding mode approach law is designed based on several typical sliding mode approaches, which simplifies parameter tuning while retaining the original anti-interference performance of auto disturbance. In addition, the nonlinear state error feedback control law in active disturbance rejection control is enhanced to improve the component order PID control law, which can improve the response speed and robustness of the system, and prove the stability of the controller. Finally, the simulation of the PMSM rotor position control system based on the sliding mode ESO is carried out, and the results verify the validity of the method.

Abstract Nonlocal quantum correlations, such as quantum entanglement, quantum steering, and Bell nonlocality, are crucial resources for quantum information tasks. How to protect these quantum resources from decoherence is one of the most urgent problems to be solved. Here, we investigate the evolution of these correlations in the correlated squeezed generalized amplitude damping (SGAD) channel and propose a scheme to protect them with weak measurement (WM) and quantum measurement reversal (QMR). Compared with the results of the uncorrelated SGAD channel, we find that when $$n=1$$ n = 1 , correlation and squeezing effects can prolong the survival time of quantum entanglement, Bell nonlocality, and quantum steering by about 152 times, 207 times, and 10 times, respectively. In addition, local WM and QMR can effectively recover the disappeared nonlocal quantum correlations either in uncorrelated or completely correlated SGAD channels. Moreover, we find that these initial nonlocal quantum correlations could be drastically amplified under the correlated channel. And the steering direction can be flexibly manipulated either by changing the channel parameters or the strength of WM and QMR. These results not only make a step forward in suppressing decoherence and enhancing quantum correlation in noise channels, but also help to develop relevant practical applications.

In order to ensure the voltage security of the receiving-end power grid under both steady state and N-1 faults, it is necessary to conduct an accurate dynamic reactive power reserve assessment to ensure its normal voltage operation range at steady state. In other words, it’s to determine the power grid voltage security region which is a transient stability constrained optimal power flow (TSCOPF) problem essentially. However, it needs to consider a large amount operational snapshots and corresponding transient constraints under each snapshot, which increases the computational burden heavily. To overcome this issue, this paper proposes a calculation method for the voltage security region of receiving-end power grid through the equivalence of the transient process. Firstly, based on the power grid partition and the matrix of graph theory, the different snapshots are selected to obtain typical snapshots, and then for the typical snapshots sought, the transient stability constraints under the fault are transformed into steady-state constraints. In other words, the form is consistent with the steady-state equation but the impedance matrix parameters are equivalently adjusted. In essence, it is equally to replace the constraints of the optimization problem under the premise of ensuring that the consistency of the boundary conditions, so as to greatly accelerate the solution speed under the premise of ensuring the accuracy of the solution, and the calculation cases made in the modified IEEE9 system and the modified IEEE39 system prove the effectiveness and reliability of the proposed method in this paper.

Internet-based companies such as Amazon, Facebook, and Tencent hold an enormous amount of consumer data that are utilized to create business value via big data analytics. Although some companies use big data to provide professional services, such as targeted advertising and product recommendations, according to the current CAS, IFRS, and U.S. GAAP accounting standards, these assets are not recognized as assets since they are generated internally. This paper starts with a discussion of how Amazon, Facebook, Tencent, and Walmart use big data to create value for their businesses and then argues why it makes sense to recognize big data as intangible assets. Possible methods of data asset evaluation and their implications for business managers are also explored.

Recent developments in technology have introduced dramatic changes to the practice of the accounting profession. This paper provides a comprehensive review of current developments in big data, machine learning, artificial intelligence, and blockchain utilized in general business practice and by specialized practitioners in the accounting profession worldwide. This paper explores the evolution of the accounting profession following these recent technological developments and assesses the impact of future developments. Inherent challenges and opportunities posed by these new technologies pertaining to accounting professionals and accounting educators are also examined, including an increased demand for IT professionals with accounting experience as opposed to accounting major graduates. Considering the dramatic changes and developments of AI applications in accounting, this paper reflects how all these technologies and the associated requirements of job candidates will affect the desired capabilities of accounting graduates and provides further discussion regarding what higher institutions and their accounting graduates can do to adopt such changes.

There are a large number of karst caves in the limestone rock strata in the karst mining area, and the karst water in rock strata seriously restricts the safe and efficient recovery of coal resources. In order to reveal the influence law of karst caves of rock strata on the evolution of water-conducting fissures in coal seam mining, the numerical simulation method in UDEC software is employed to analyze the development characteristics of water-conducting fissures in coal seam mining under the conditions of karst caves of different sizes. By comparing and analyzing the development characteristics of overlying fissures in rock strata and the displacement fields in coal seam mining under the conditions of different karst caves, the evolution law of water-conducting fissures in coal seam mining is obtained. The research results show that the size of karst cave directly affects the maximum height of the water-conducting fissures in the overlying rock strata in coal seam mining; when the thickness of the coal seam is 3.0 m, the larger the radius of karst cave is, the higher the development height of water-conducting fissures in the overlying rock strata is, and the greater the overall sinking displacement in the Yulongshan limestone is. When the radius of karst cave is between 10 m and 15 m, a through-type water-conducting channel is formed between the working face and the karst cave after the coal seam is mined, and the numerical simulation results are consistent with the field monitoring results. The research results provide an important reference for the prevention and treatment for water inrush disaster in karst mining areas.

This study aimed to develop and apply a closed-loop medication administration system in a hospital in order to reduce medication administration errors (MAEs).

The sequential quantum random access code (QRAC) allows two or more decoders to obtain a desired message with higher success probability than the best classical bounds by appropriately modulating the measurement sharpness. Here, we propose an entanglement-assisted sequential QRAC protocol which can enable device-independent tasks. By relaxing the equal sharpness and mutually unbiased measurement limits, we widen the sharpness modulation region from a one-dimensional interval to a two-dimensional triangle. Then, we demonstrate our scheme experimentally and get more than 27 standard deviations above the classical bound even when both decoders perform approximately projective measurements. We use the observed success probability to quantify the connection among sequential QRAC, measurement sharpness, measurement biasedness, and measurement incompatibility. Finally, we show that our protocol can be applied to sequential device-independent randomness expansion and our measurement strategy can enhance the success probability of decoding the entire input string. Our results may promote a deeper understanding of the relationship among quantum correlation, quantum measurement, and quantum information processing.

Objective: This study reviews the development of rhubarb processing and the current status of pharmacological research. We summarized the effects of different processing methods on the active compounds, pharmacological effects, and toxicity of rhubarb, as well as the clinical application of different concoctions, providing reference for further pharmacological research and clinical application of rhubarb. Methods: A comprehensive literature review was conducted using databases such as Pubmed, Embase, National Science and Technology Library, Web of science, CNKI, China Science and Technology Journal Database, SinoMed, and the Pharmacopoeia of the People's Republic of China. Search terms included "rhubarb", "raw rhubarb", "wine rhubarb", "cooked rhubarb", "rhubarb charcoal", "herbal processing", "compounds", "pharmacological effects", "inflammation", "gastrointestinal bleeding", and "tumor". Results: Historical records of rhubarb processing date back to the Han Dynasty, with continual innovations. Currently, the types of rhubarb used in traditional Chinese medicine have stabilized to three species: Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. and Rheum officinale Baill. Common concoctions include raw rhubarb, wine rhubarb, cooked rhubarb and rhubarb charcoal. The active compounds of rhubarb are known to defecation, exhibit antibacterial and anti-inflammatory properties, regulate coagulation, protect the digestive system, and possess anti-tumor activities. Guided by Chinese medicine theory, the use of different rhubarb concoctions can enhance specific effects such as purgation to eliminate accumulation, clearing heat and toxins, cooling blood to stop hemorrhages, activating blood circulation to remove blood stasis, and inducing dampness to descend jaundice, thereby effectively treating various diseases. The therapeutic impact of these concoctions on diseases reflects not only in the changes to the active compounds of rhubarb but also in the formulations of traditional Chinese medicine. Processing has also shown advantages in reducing toxicity. Conclusion: Different processing methods alter the active compounds of rhubarb, thereby enhancing its various pharmacological effects and meeting the therapeutic needs of diverse diseases. Selecting an appropriate processing method based on the patient's specific conditions can maximize its pharmacological properties and improve clinical outcomes. [ABSTRACT FROM AUTHOR]

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia.sup.1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour.sup.2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatin-reader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome. The histone-acetylation-reader protein ENL is mutated in a paediatric kidney cancer in such a way that it clusters at target genes, increasing the recruitment of the transcriptional machinery, enhancing transcription and deregulating cell fate during development., Author(s): Liling Wan [sup.1] [sup.15] , Shasha Chong [sup.2] [sup.3] , Fan Xuan [sup.4] , Angela Liang [sup.1] , Xiaodong Cui [sup.5] , Leah Gates [sup.1] , Thomas S. Carroll [...]

Light quark matter (i.e., udQM) comprised of up and down quarks might be stable with respect to nuclear matter and strange quark matter (SQM). In this work we investigate the stability of nuggets made of such types of matter, which shows that udQM nuggets at certain sizes are more stable than others if a large symmetry energy is adopted. In such cases, there may be compact dwarfs comprised entirely of udQM nuggets and electrons, i.e., udQM dwarfs. We then examine the structure of such udQM dwarfs and consider their possibility of being covered by normal matter crusts. It is found that udQM dwarfs typically have smaller radii, and those covered by normal matter can explain the recently observed white dwarfs with unusually small radii. [ABSTRACT FROM AUTHOR]

This study investigated the antimony (Sb) adsorption behavior on newly prepared montmorillonite (Mt)-immobilized nanoscale zero-valent iron (nZVI) (hereafter Mt-nZVI) in aqueous solution. Mt-nZVI showed the highest Sb adsorption capacity (71-76 mg·Sb·g-1 adsorbent) at pH 4-8. The pseudo-first-order and pseudo-second-order kinetic models fitted well (R2 3 0.992) with the experimental data on Sb adsorption onto Mt-nZVI. The Langmuir isotherm model (R² = 0.99) was more suitable than the Freundlich isotherm model (R² = 0.95) for describing the adsorption of Sb on Mt-nZVI. Mt-nZVI had an almost 7 times higher theoretical Sb adsorption capacity than nZVI when calculated in terms of Fe. Neither 0.01 M phosphate nor 0.01 M sulfate had a significant effect the Sb adsorption capacity of Mt-nZVI, and more than 80% of the Sb adsorption capacity remained in the presence of 0.001-0.1 M NaCl or 1-30 mg·L-1 humic acid. However, the presence of 0.01 M silicate or carbonate or 0.0001 M arsenate significantly affected the Sb adsorption capacity of Mt-nZVI. [ABSTRACT FROM AUTHOR]

Quantification of behaviors in macaques provides crucial support for various scientific disciplines, including pharmacology, neuroscience, and ethology. Despite recent advancements in the analysis of macaque behavior, research on multi-label behavior detection in socially housed macaques, including consideration of interactions among them, remains scarce. Given the lack of relevant approaches and datasets, we developed the BehaviorAware Relation Network (BARN) for multi-label behavior detection of socially housed macaques. Our approach models the relationship of behavioral similarity between macaques, guided by a behavior-aware module and novel behavior classifier, which is suitable for multi-label classification. We also constructed a behavior dataset of rhesus macaques using ordinary RGB cameras mounted outside their cages. The dataset included 65 913 labels for 19 behaviors and 60  367 proposals, including identities and locations of the macaques. Experimental results showed that BARN significantly improved the baseline SlowFast network and outperformed existing relation networks. In conclusion, we successfully achieved multilabel behavior detection of socially housed macaques with both economic efficiency and high accuracy. [ABSTRACT FROM AUTHOR]

The Bohai Bay Basin, as a super oil-rich basin in the world, is characterized by cyclic evolution and complex regional tectonic stress field, and its lifecycle tectonic evolution controls the formation of regional source rocks. The main pre-Cenozoic stratigraphic system and lithological distribution are determined through geological mapping, and the dynamics of the pre-Cenozoic geotectonic evolution of the Bohai Bay Basin are investigated systematically using the newly acquired high-quality seismic data and the latest exploration results in the study area. The North China Craton where the Bohai Bay Basin is located in rests at the intersection of three tectonic domains: the Paleo-Asian Ocean, the Tethys Ocean, and the Pacific Ocean. It has experienced the alternation and superposition of tectonic cycles of different periods, directions and natures, and experienced five stages of the tectonic evolution and sedimentary building, i.e. Middle–Late Proterozoic continental rift trough, Early Paleozoic marginal-craton depression carbonate building, Late Paleozoic marine–continental transitional intracraton depression, Mesozoic intracontinental strike-slip–extensional tectonics, and Cenozoic intracontinental rifting. The cyclic evolution of the basin, especially the multi-stage compression, strike-slip and extensional tectonics processes in the Hercynian, Indosinian, Yanshan and Himalayan since the Late Paleozoic, controlled the development, reconstruction and preservation of several sets of high-quality source rocks, represented by the Late Paleozoic Carboniferous–Permian coal-measure source rocks and the Paleogene world-class extra-high-quality lacustrine source rocks, which provided an important guarantee for the hydrocarbon accumulation in the super oil-rich basin.

Abstract Electromagnetic fields (EMFs) have emerged as an effective treatment for osteoporosis. However, the specific mechanism underlying their therapeutic efficacy remains controversial. Herein, we confirm the pro-osteogenic effects of 15 Hz and 0.4-1 mT low-frequency sinusoidal EMFs (SEMFs) on rat bone marrow mesenchymal stem cells (BMSCs). Subsequent miRNA sequencing reveal that miR-34b-5p is downregulated in both the 0.4 mT and 1 mT SEMFs-stimulated groups. To clarify the role of miR-34b-5p in osteogenesis, BMSCs are transfected separately with miR-34b-5p mimic and inhibitor. The results indicate that miR-34b-5p mimic transfection suppress osteogenic differentiation, whereas inhibition of miR-34b-5p promote osteogenic differentiation of BMSCs. In vivo assessments using microcomputed tomography, H&E staining, and Masson staining show that miR-34b-5p inhibitor injections alleviate bone mass loss and trabecular microstructure deterioration in ovariectomy (OVX) rats. Further validation demonstrates that miR-34b-5p exerts its effects by regulating STAC2 expression. Modulating the miR-34b-5p/STAC2 axis attenuate the pro-osteogenic effects of low-frequency SEMFs on BMSCs. These studies indicate that the pro-osteogenic effect of SEMFs is partly due to the regulation of the miR-34b-5p/STAC2 pathway, which provides a potential therapeutic candidate for osteoporosis.