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A temperature-compensated MZI-based optical sensor using few-mode concentric multilayer-core fiber (CMCF) was designed, and surrounding refractive index (SRI) sensing via interference spectra was successfully proposed and experimentally demonstrated. This sensor with sandwich structure generated lots of resonance dips in the interference spectra, which had differentiated sensitivities to SRI and temperature. The homemade CMCF only supported few mode groups, and variability of the resonance drift could be influenced by different mode excitation and sensitivity. For the two selected dips of this proposed sensor, the SRI sensitivities experimentally achieved were −76.88 and −50.51 nm per refractive index unit (RIU), and the temperature ones were 80.2 and 50.1 pm/°C, respectively. The experimental mechanism and results have been analyzed in brief. The standard matrix inversion method could be used for simultaneous two parameter determination. Therefore, the SRI detection could show good accuracy and sensitivity by temperature compensation.

OBJECTIVE: To evaluate the effectiveness and safety of Ginkgo biloba extract (GBE50) in the treatment of dizziness caused by cerebral arteriosclerosis. METHODS: This was a multi-center, double-blind, double-dummy, positive -controlled, parallel randomized controlled clinical trial with 1∶1 allocation. We recruited 404 patients with dizziness caused by cerebral arteriosclerosis (blood stasis symptom pattern) in 10 hospitals in China. GBE50 group received GBE50 and Naoxinqing tablet (NXQ) of mimetic agent, control group received NXQ and GBE50 of mimetic agent. The main outcome was Traditional Chinese Medicine (TCM) symptom pattern score of blood stasis after 6 weeks. The secondary outcomes were changes in the dizziness handicap inventory (DHI) score, vertigo visual analogue scale (VAS) score, the university of California vertigo questionnaire (UCLA-DQ) score and single-item symptom score of TCM from baseline to 2, 4 and 6 weeks. Safety indicators included the incidence of adverse events, severe adverse events and laboratory examination including blood routine, liver function, renal function, and so forth. RESULTS: The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group, the difference in rate was statistically significant (92.67% vs 83.07%, P = 0.004). Compared with the control group, there was no difference in the incidence of adverse reactions (9.95% vs 14.85%, P = 0.136). CONCLUSION: The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective, safe and reliable.