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Your search keyword '"Xu, Zhengxin"' showing total 106 results
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106 results on '"Xu, Zhengxin"'

2. Research and Application of Real-Time Measurement Method of Engine Oil Consumption

Author

Liu, Zhiyong, Li, Xiao, Zhao, Zhijun, Zhu, Weijian, Xu, Zhengxin, Wang, Yue, Zhang, Lin, China Society of Automotive Engineers, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, and Zhang, Junjie James, Series Editor

Published
2023
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31. Inhibitory Effects of Nobiletin on Voltage-Gated Na + Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method.

Author

Gu, Youwei, Wang, Jieru, Li, Mengting, Zhong, Fei, Xiang, Jie, and Xu, Zhengxin

Subjects
MOLECULAR docking, ARRHYTHMIA, VENTRICULAR arrhythmia, ELECTROPHYSIOLOGY, VENTRICULAR fibrillation, MUSCLE cells, VENTRICULAR tachycardia
Abstract

Nobiletin (NOB) has attracted much attention owing to its outstanding bioactivities. This study aimed to investigate its anti-arrhythmic effect through electrophysiological and molecular docking studies. We assessed the anti-arrhythmic effects of NOB using aconitine-induced ventricular arrhythmia in a rat model and the electrophysiological effects of NOB on rat cardiomyocytes utilizing whole-cell patch-clamp techniques. Moreover, we investigated the binding characters of NOB with rNav1.5, rNav1.5/QQQ, and hNaV1.5 via docking analysis, comparing them with amiodarone and aconitine. NOB pretreatment delayed susceptibility to ventricular premature and ventricular tachycardia and decreased the incidence of fatal ventricular fibrillation. Whole-cell patch-clamp assays demonstrated that the peak current density of the voltage-gated Na+ channel current was reversibly reduced by NOB in a concentration-dependent manner. The steady-state activation and recovery curves were shifted in the positive direction along the voltage axis, and the steady-state inactivation curve was shifted in the negative direction along the voltage axis, as shown by gating kinetics. The molecular docking study showed NOB formed a π-π stacking interaction with rNav1.5 and rNav1.5/QQQ upon Phe-1762, which is the homolog to Phe-1760 in hNaV1.5 and plays an important role in antiarrhythmic action This study reveals that NOB may act as a class I sodium channel anti-arrhythmia agent. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Gene Therapy for Hemophilia B With Liver-specific Element Mediated by Rep-RBE Site-specific Integration System

Author

Linjun Xie, Juan Ye, Xu Zhengxin, Qi Shen, Jing-Lun Xue, Amin Zhang, and Chen Jinzhong

Subjects
viruses, Transgene, Genetic enhancement, Genetic Vectors, Mice, Transgenic, Biology, Hemophilia B, DNA-binding protein, Virus, Factor IX, Mice, Viral Proteins, Plasmid, medicine, Animals, Humans, Promoter Regions, Genetic, Cells, Cultured, Pharmacology, Expression vector, Gene Transfer Techniques, Genetic Therapy, Transfection, Dependovirus, Molecular biology, DNA-Binding Proteins, Liver, Cardiology and Cardiovascular Medicine, Chromosomes, Human, Pair 19, Plasmids, medicine.drug
Abstract

Adeno-associated virus (AAV) is a nonpathogenic virus capable of targeting human chromosome 19 for integration at AAVS1 site, and a 16 bp Rep binding element (RBE) sequence of AAV was sufficient for mediating this specific integration in the presence of AAV regulation proteins (Rep). Previously, we cotransduced 2 plasmids, pRBE-CMV-hFIX and pRC, into the AAVS1 transgenic mice by hydrodynamic injection, and a long-term expression of human coagulation Factor IX (hFIX) was observed. The corresponding AAVS1 locus site-specific integrations were verified by nested polymerase chain reaction. In this study, we established a novel hFIX expression plasmid, pRBE-HCR-hAAT-hFIX, driven by a liver-specific promoter by replacing the CMV promoter of pRBE-CMV-hFIX with a humanized promoter consisting of HCR-hAAT. The expression of hFIX in vitro was almost the same in transient transfection of pRBE-CMV-hFIX or pRBE-HCR-hAAT-hFIX. AAVS1-specific integrations were identified both in mice transfected with pRC/pRBE-CMV-hFIX cocktail and pRC/pRBE-HCR-hAAT-hFIX cocktail. However, the expression of hFIX of pRBE-HCR-hAAT-hFIX mice was higher and persisted longer. It achieved more than 1% of normal plasma hFIX concentration and maintained for 240 days. The result suggested that RBE-HCR-hAAT element could improve the expression of hFIX and present potential usage of Rep-RBE site-specific integration in gene therapy for hemophilia B.

Published
2015

41. Experimental investigation on the urea injection and mixing module for improving the performance of urea‐SCR in diesel engines.

Author

Xu, Zhengxin, Liu, Jingping, and Fu, Jianqin

Subjects
DIESEL motors, NITROGEN oxides
Abstract

Abstract: In a urea selective catalytic reduction (urea‐SCR) system for diesel engines, the atomization, evaporation, and mixing conditions of urea water solution (UWS) play a crucial role for NOX conversion and ammonia slip in the SCR process. In this paper, a series of novel mixing modules were proposed to improve UWS evaporation, mixing, and distribution for NOX reduction in the SCR system. Experimental investigations were conducted on the performances of the existing and developed mixing modules under various engine test conditions, including particle size test, NOX conversion efficiency, flow bench tests, etc. To determine ammonia slip, the urea and ammonia distribution patterns were constructed and the non‐uniformity index was then calculated. Compared with the baseline (without mixing module) and existing mixing module, the NOX conversion efficiency of the SCR system with a developed mixing module is improved by 37.7 and 14.1 % at maximum, respectively. Furthermore, ammonia slip and distribution are ameliorated significantly with low‐pressure drops simultaneously. Among the mixing modules, Concept 3 design exhibits superior performance under the engine test conditions. [ABSTRACT FROM AUTHOR]

Published
2018
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