436 results on '"Xu, Yungen"'
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2. Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors
3. Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
4. Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins
5. Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases
6. Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment
7. DCLK1 and its oncogenic functions: A promising therapeutic target for cancers
8. Discovery of novel dual Bruton’s tyrosine kinase (BTK) and Janus kinase 3 (JAK3) inhibitors as a promising strategy for rheumatoid arthritis
9. Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer
10. An overview of limonoid synthetic derivatives as promising bioactive molecules
11. Anti-inflammatory Effect of a Limonin Derivative In Vivo and Its Mechanisms in RAW264.7 Cells
12. Design, synthesis and biological evaluation of novel 4-aminopiperidine derivatives as SMO/ERK dual inhibitors
13. Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration
14. Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy
15. Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19
16. Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer
17. Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors
18. Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis
19. Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer
20. Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers
21. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs
22. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors
23. Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification
24. A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells
25. Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design
26. Targeting VEGF–neuropilin interactions: a promising antitumor strategy
27. Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy
28. DCLK1 and its oncogenic functions: A promising therapeutic target for cancers
29. Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia
30. Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors
31. A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway
32. Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors
33. Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease
34. Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease
35. Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1
36. Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors
37. Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors
38. Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c‑Met Overexpression.
39. Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.
40. Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.
41. Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation
42. Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists
43. Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors
44. Synthesis and Anti-inflammatory Evaluation of Novel 1,2,3-Triazole Derivatives
45. Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors
46. Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer
47. Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of dabigatran etexilate, intermediate metabolite and dabigatran in 50 μL rat plasma and its application to pharmacokinetic study
48. Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors
49. Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy
50. Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors
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