Search

Quantification of cardiac biomarkers from cine cardiovascular magnetic resonance (CMR) data using deep learning (DL) methods offers many advantages, such as increased accuracy and faster analysis. However, only a few studies have focused on the scan-rescan precision of the biomarker estimates, which is important for reproducibility and longitudinal analysis. Here, we propose a cardiac biomarker estimation pipeline that not only focuses on achieving high segmentation accuracy but also on improving the scan-rescan precision of the computed biomarkers, namely left and right ventricular ejection fraction, and left ventricular myocardial mass. We evaluate two approaches to improve the apical-basal resolution of the segmentations used for estimating the biomarkers: one based on image interpolation and one based on segmentation interpolation. Using a database comprising scan-rescan cine CMR data acquired from 92 subjects, we compare the performance of these two methods against ground truth (GT) segmentations and DL segmentations obtained before interpolation (baseline). The results demonstrate that both the image-based and segmentation-based interpolation methods were able to narrow Bland-Altman scan-rescan confidence intervals for all biomarkers compared to the GT and baseline performances. Our findings highlight the importance of focusing not only on segmentation accuracy but also on the consistency of biomarkers across repeated scans, which is crucial for longitudinal analysis of cardiac function., Comment: 11 pages, 3 figures, MICCAI STACOM 2024

Cardiac magnetic resonance (CMR) imaging and computed tomography (CT) are two common non-invasive imaging methods for assessing patients with cardiovascular disease. CMR typically acquires multiple sparse 2D slices, with unavoidable respiratory motion artefacts between slices, whereas CT acquires isotropic dense data but uses ionising radiation. In this study, we explore the combination of Slice Shifting Algorithm (SSA), Spatial Transformer Network (STN), and Label Transformer Network (LTN) to: 1) correct respiratory motion between segmented slices, and 2) transform sparse segmentation data into dense segmentation. All combinations were validated using synthetic motion-corrupted CMR slice segmentation generated from CT in 1699 cases, where the dense CT serves as the ground truth. In 199 testing cases, SSA-LTN achieved the best results for Dice score and Huasdorff distance (94.0% and 4.7 mm respectively, average over 5 labels) but gave topological errors in 8 cases. STN was effective as a plug-in tool for correcting all topological errors with minimal impact on overall performance (93.5% and 5.0 mm respectively). SSA also proves to be a valuable plug-in tool, enhancing performance over both STN-based and LTN-based models. The code for these different combinations is available at https://github.com/XESchong/STACOM2024., Comment: 13 pages, STACOM2024

Bell nonlocality is a valuable resource in quantum information processing tasks. Scientists are interested in whether a single entangled state can generate a long sequence of nonlocal correlations. Previous work has accomplished sequential tripartite nonlocality sharing through unsharp measurements. In this paper, we investigate the sharing of tripartite nonlocality using only projective measurements and sharing classical randomness. For the generalized GHZ state, we have demonstrated that using unbiased measurement choices, two Charlies can share the standard tripartite nonlocality with a single Alice and a single Bob, while at most one Charlie can share the genuine tripartite nonlocality with a single Alice and a single Bob. However, with biased measurement choices, the number of Charlies sharing the genuine tripartite nonlocality can be increased to two. Nonetheless, we find that using biased measurements does not increase the number of sequential observers sharing the standard tripartite nonlocality. Moreover, we provide the feasible range of double violation for the parameters of the measurement combination probability with respect to the state., Comment: 11 pages, 7 figures