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Abstract Objective This study aimed to investigate the influence of injection rates of calibrating standard solution on monitoring pulse indicator continuous cardiac output (PICCO, made in Germany), and thereby to provide significant references for clinical practice. Methods A total of 108 critical patients in stroke intensive care unit were identified. All these participants received transesophageal cardiac color Doppler ultrasound, and within 15 min PICCO equipment was utilized to monitor the relevant parameters, by means of 0 °C calibrating standard solution, and the injection speeds were 2–4, 5–7, and 8–10 s. Besides, the monitoring indicators were as follows, cardiac index, global ejection fraction, global end diastolic volume index. The potential correlations were evaluated between PICCO and transesophageal cardiac color Doppler ultrasound. Results All the data was available, and the monitored parameters of PICOO at 2–4, 5–7, and 8–10 s were positively correlated with the parameters obtained from transesophageal cardiac color Doppler ultrasound (P

ABSTRACT Background: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of [...]

A novel bimetallic 4f-3d metal-isonicotinic acid inorganic-organic hybrid complex [{Eu(NC5H4COOH)3(H2O)2}(1.5ZnCl4)·(2H2O)]n (1) was synthesized via a hydrothermal reaction and structurally characterized by single- crystal X-ray diffraction. Complex 1 crystallizes in the space group C2/c of the monoclinic system with eight formula units in a cell: a = 23.878(8) Å, b = 20.573(6) Å, c = 15.358(5) Å, β = 127.276(5)°, V = 6003(3) Å3, C18H23Cl6EuN3O10Zn1.5, Mr = 904.11 g/mol, ñ = 2.001 g/cm3, S = 1.077, μ(MoKα) = 3.846 mm-1, F(000) = 3536, R = 0.0270 and wR = 0.0672. Complex 1 has a characteristic, one-dimensional polycationic chain-like structure. A photoluminescent investigation revealed that the title complex displays intense emissions in the orange and red regions. The luminescence spectra show that the red emission is stronger than the orange emission. Optical absorption spectra of 1 revealed the presence of an optical gap of 3.56 eV.

Background: Circulating long noncoding RNAs (lncRNAs) are considered a new class of biomarkers for the diagnosis and prognosis of various malignancies. We aimed to identify circulating lncRNAs as biomarkers for the diagnosis and prognosis of non‐small cell lung cancer (NSCLC). Methods: The expression of 14 candidate lncRNAs was measured in matched cancer and ipsilateral normal lung tissues of 20 patients with NSCLC using quantitative reverse‐transcription PCR. In plasma samples from training and testing sets, significantly and aberrantly expressed lncRNAs, TA73‐AS1 and CRNDE, were further analyzed. Receiver operating characteristic (ROC) curves were constructed, and the areas under the ROC curves (AUC) were obtained to assess diagnostic performance. The Kaplan–Meier survival analysis was used to assess the impact of plasma TA73‐AS1 and CRNDE expression on tumor‐free survival (TFS) of patients with NSCLC. The effect of TP73‐AS1 expression on NSCLC cells was investigated in vitro. Results: AUC values of plasma TA73‐AS1 and CRNDE were 0.822 and 0.815 in the training set and 0.843 and 0.804 in the testing set, respectively, to distinguish NSCLC from healthy controls. The combination of plasma TP73‐AS1, CRNDE, and two classical tumor markers, carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21‐1), showed excellent diagnostic performance for NSCLC (AUC =0.927 in the training set; AUC = 0.925 in the testing set). Furthermore, the high expression of the two plasma lncRNAs correlated with worse TFS in patients with NSCLC. In vitro cell model studies revealed that TP73‐AS1 overexpression facilitated NSCLC cell survival, invasion, and migration. Conclusion: Circulating TP73‐AS1 and CRNDE could be potential biomarkers for the diagnosis and prognostic prediction of NSCLC. [ABSTRACT FROM AUTHOR]