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176 results on '"Xu, Xin-Ya"'

3. Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544.

Author

Zhang, Geng-Si, Li, Hai-Yan, Liang, Li-Fen, Fu, Chun-Qing, Yu, Qin, Liu, Kai, Su, Zhi-Wei, Zhou, Dong-Mei, Gao, Cheng-Hai, Xu, Xin-Ya, and Liu, Yong-Hong

Subjects
ANTIFUNGAL agents, ALKALOIDS, MICROBIAL sensitivity tests, FUNGI, PLANT extracts, PHYSICAL & theoretical chemistry, FERMENTATION, ASPERGILLUS, MOLECULAR structure, MEDICINAL plants, MOLECULAR biology, PHARMACODYNAMICS
Abstract

A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Ultraviolet A Enhances Cathepsin L Expression and Activity via JNK Pathway in Human Dermal Fibroblasts.

Author

Xu, Qing-Fang, Zheng, Yue, Chen, Jian, Xu, Xin-Ya, Gong, Zi-Jian, Huang, Yun-Fen, Lu, Chun, Lai, Wei, and Maibach, Howard

Subjects
Anthracenes, Cathepsin L, Cells, Cultured, Child, Child, Preschool, Enzyme Inhibitors, Extracellular Signal-Regulated MAP Kinases, Fibroblasts, Humans, Imidazoles, MAP Kinase Signaling System, Oncogene Proteins v-fos, Proto-Oncogene Proteins c-jun, Pyridines, Skin, Ultraviolet Rays
Abstract

BACKGROUND: Cathepsin L (CatL) is a cysteine protease with strong matrix degradation activity that contributes to photoaging. Mannose phosphate-independent sorting pathways mediate ultraviolet A (UVA)-induced alternate trafficking of CatL. Little is known about signaling pathways involved in the regulation of UVA-induced CatL expression and activity. This study aims to investigate whether a single UVA irradiation affects CatL expression and activity and whether mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway is involved in the regulation of UVA-induced CatL expression and activity in human dermal fibroblasts (HDFs). METHODS: Primary HDFs were exposed to UVA. Cell proliferation was determined by a cell counting kit. UVA-induced CatL production and activity were studied with quantitative real-time reverse transcription polymerase chain reaction (RT-PCR), Western blotting, and fluorimetric assay in cell lysates collected on three consecutive days after irradiation. Time courses of UVA-activated JNK and p38MAPK signaling were examined by Western blotting. Effects of MAPK inhibitors and knockdown of Jun and Fos on UVA-induced CatL expression and activity were investigated by RT-PCR, Western blotting, and fluorimetric assay. Data were analyzed by one-way analysis of variance. RESULTS: UVA significantly increased CatL gene expression, protein abundance, and enzymatic activity for three consecutive days after irradiation (F = 83.11, 56.14, and 71.19, respectively; all P < 0.05). Further investigation demonstrated phosphorylation of JNK and p38MAPK activated by UVA. Importantly, inactivation of JNK pathway significantly decreased UVA-induced CatL expression and activity, which were not affected by p38MAPK inhibition. Moreover, knockdown of Jun and Fos significantly attenuated basal and UVA-induced CatL expression and activity. CONCLUSIONS: UVA enhances CatL production and activity in HDFs, probably by activating JNK and downstreaming AP-1. These findings provide a new possible molecular approach for antiphotoaging therapy.

Published
2016

26. In Vitro and in Vivo Antitumor Effects of Plant-Derived Miliusanes and Their Induction of Cellular Senescence

Author

Xu, Xin-Ya, primary, Tsang, Siu Wai, additional, Guan, Yi-Fu, additional, Liu, Kang-Lun, additional, Pan, Wen-Hui, additional, Lam, Chu Shing, additional, Lee, Kwan Ming, additional, Xia, Yi-Xuan, additional, Xie, Wen-Jian, additional, Wong, Wing Yan, additional, Lee, Magnolia Muk Lan, additional, Tai, William Chi Shing, additional, and Zhang, Hong-Jie, additional

Published
2019
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27. New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015.

Author

Amin, Muhammad, Zhang, Xiao-Yong, Xu, Xin-Ya, and Qi, Shu-Hua

Subjects
CLADOSPORIUM, MARINE fungi, FUNGI, CIRCULAR dichroism, BIOACTIVE compounds
Abstract

During the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A–D (1–4) were isolated from a culture broth of the deep-sea-derived fungus Cladosporium sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of 1–3 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds 1–4 showed weak toxicity towards brine shrine naupalii with LC50 values of 72.0, 81.7, 49.9 and 81.4 μM, respectively. And 4 also showed significant antioxidant activity against ɑ,α-diphenyl-picrylhydrazyl (DPPH) radicals with an IC50 value of 16.4 μM. [ABSTRACT FROM AUTHOR]

Published
2020
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