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Neurodegenerative disorders such as Alzheimer's disease (AD) present a significant global health challenge, characterized by cognitive decline, functional impairment, and other debilitating effects. Current AD clinical trials often assess multiple longitudinal primary endpoints to comprehensively evaluate treatment efficacy. Traditional methods, however, may fail to capture global treatment effects, require larger sample sizes due to multiplicity adjustments, and may not fully exploit multivariate longitudinal data. To address these limitations, we introduce the Longitudinal Rank Sum Test (LRST), a novel nonparametric rank-based omnibus test statistic. The LRST enables a comprehensive assessment of treatment efficacy across multiple endpoints and time points without multiplicity adjustments, effectively controlling Type I error while enhancing statistical power. It offers flexibility against various data distributions encountered in AD research and maximizes the utilization of longitudinal data. Extensive simulations and real-data applications demonstrate the LRST's performance, underscoring its potential as a valuable tool in AD clinical trials.

Data mixing methods play a crucial role in semi-supervised learning (SSL), but their application is unexplored in long-tailed semi-supervised learning (LTSSL). The primary reason is that the in-batch mixing manner fails to address class imbalance. Furthermore, existing LTSSL methods mainly focus on re-balancing data quantity but ignore class-wise uncertainty, which is also vital for class balance. For instance, some classes with sufficient samples might still exhibit high uncertainty due to indistinguishable features. To this end, this paper introduces the Balanced and Entropy-based Mix (BEM), a pioneering mixing approach to re-balance the class distribution of both data quantity and uncertainty. Specifically, we first propose a class balanced mix bank to store data of each class for mixing. This bank samples data based on the estimated quantity distribution, thus re-balancing data quantity. Then, we present an entropy-based learning approach to re-balance class-wise uncertainty, including entropy-based sampling strategy, entropy-based selection module, and entropy-based class balanced loss. Our BEM first leverages data mixing for improving LTSSL, and it can also serve as a complement to the existing re-balancing methods. Experimental results show that BEM significantly enhances various LTSSL frameworks and achieves state-of-the-art performances across multiple benchmarks., Comment: This paper is accepted to CVPR 2024. The supplementary material is included

We present a hardware-efficient architecture of convolutional neural network, which has a repvgg-like architecture. Flops or parameters are traditional metrics to evaluate the efficiency of networks which are not sensitive to hardware including computing ability and memory bandwidth. Thus, how to design a neural network to efficiently use the computing ability and memory bandwidth of hardware is a critical problem. This paper proposes a method how to design hardware-aware neural network. Based on this method, we designed EfficientRep series convolutional networks, which are high-computation hardware(e.g. GPU) friendly and applied in YOLOv6 object detection framework. YOLOv6 has published YOLOv6N/YOLOv6S/YOLOv6M/YOLOv6L models in v1 and v2 versions.

The YOLO community has been in high spirits since our first two releases! By the advent of Chinese New Year 2023, which sees the Year of the Rabbit, we refurnish YOLOv6 with numerous novel enhancements on the network architecture and the training scheme. This release is identified as YOLOv6 v3.0. For a glimpse of performance, our YOLOv6-N hits 37.5% AP on the COCO dataset at a throughput of 1187 FPS tested with an NVIDIA Tesla T4 GPU. YOLOv6-S strikes 45.0% AP at 484 FPS, outperforming other mainstream detectors at the same scale (YOLOv5-S, YOLOv8-S, YOLOX-S and PPYOLOE-S). Whereas, YOLOv6-M/L also achieve better accuracy performance (50.0%/52.8% respectively) than other detectors at a similar inference speed. Additionally, with an extended backbone and neck design, our YOLOv6-L6 achieves the state-of-the-art accuracy in real-time. Extensive experiments are carefully conducted to validate the effectiveness of each improving component. Our code is made available at https://github.com/meituan/YOLOv6., Comment: Tech Report. arXiv admin note: text overlap with arXiv:2209.02976

Vision Transformer (ViT) suffers from data scarcity in semi-supervised learning (SSL). To alleviate this issue, inspired by masked autoencoder (MAE), which is a data-efficient self-supervised learner, we propose Semi-MAE, a pure ViT-based SSL framework consisting of a parallel MAE branch to assist the visual representation learning and make the pseudo labels more accurate. The MAE branch is designed as an asymmetric architecture consisting of a lightweight decoder and a shared-weights encoder. We feed the weakly-augmented unlabeled data with a high masking ratio to the MAE branch and reconstruct the missing pixels. Semi-MAE achieves 75.9% top-1 accuracy on ImageNet with 10% labels, surpassing prior state-of-the-art in semi-supervised image classification. In addition, extensive experiments demonstrate that Semi-MAE can be readily used for other ViT models and masked image modeling methods.

For years, the YOLO series has been the de facto industry-level standard for efficient object detection. The YOLO community has prospered overwhelmingly to enrich its use in a multitude of hardware platforms and abundant scenarios. In this technical report, we strive to push its limits to the next level, stepping forward with an unwavering mindset for industry application. Considering the diverse requirements for speed and accuracy in the real environment, we extensively examine the up-to-date object detection advancements either from industry or academia. Specifically, we heavily assimilate ideas from recent network design, training strategies, testing techniques, quantization, and optimization methods. On top of this, we integrate our thoughts and practice to build a suite of deployment-ready networks at various scales to accommodate diversified use cases. With the generous permission of YOLO authors, we name it YOLOv6. We also express our warm welcome to users and contributors for further enhancement. For a glimpse of performance, our YOLOv6-N hits 35.9% AP on the COCO dataset at a throughput of 1234 FPS on an NVIDIA Tesla T4 GPU. YOLOv6-S strikes 43.5% AP at 495 FPS, outperforming other mainstream detectors at the same scale~(YOLOv5-S, YOLOX-S, and PPYOLOE-S). Our quantized version of YOLOv6-S even brings a new state-of-the-art 43.3% AP at 869 FPS. Furthermore, YOLOv6-M/L also achieves better accuracy performance (i.e., 49.5%/52.3%) than other detectors with a similar inference speed. We carefully conducted experiments to validate the effectiveness of each component. Our code is made available at https://github.com/meituan/YOLOv6., Comment: technical report

This paper proposes a unified approach for dynamic modeling and simulations of general tensegrity structures with rigid bars and rigid bodies of arbitrary shapes. The natural coordinates are adopted as a non-minimal description in terms of different combinations of basic points and base vectors to resolve the heterogeneity between rigid bodies and rigid bars in three-dimensional space. This leads to a set of differential-algebraic equations with a constant mass matrix and free from trigonometric functions. Formulations for linearized dynamics are derived to enable modal analysis around static equilibrium. For numerical analysis of nonlinear dynamics, we derive a modified symplectic integration scheme which yields realistic results for long-time simulations, and accommodates non-conservative forces as well as boundary conditions. Numerical examples demonstrate the efficacy of the proposed approach for dynamic simulations of Class-1-to-$k$ general tensegrity structures under complex situations, including dynamic external loads, cable-based deployments, and moving boundaries. The novel tensegrity structures also exemplify new ways to create multi-functional structures., Comment: 25 pages, 19 figures; examples are substantially revised