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112 results on '"Xu, Wenchang"'

1. CVAE-Based Hybrid Sampling Data Augmentation Method and Interpretation for Imbalanced Classification of Gout Disease

Author

Si, Xiaonan, Fu, Yifan, Liu, Xinran, Wang, Rulin, Xu, Wenchang, Wang, Lei, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Huang, De-Shuang, editor, Zhang, Qinhu, editor, and Guo, Jiayang, editor

Published
2024
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2. Proline Metabolism of Different Varieties of Hami Melon Fruits in Response to Low Temperature

Author

BI Ying, WANG Xinyu, LI Hui, HUANG Shuai, ZHANG Qi, LEI Yaxin, WANG Xue, WANG Fuxin, XU Wenchang, WANG Jing

Subjects
hami melon, chilling injury, proline metabolism, metabolomics, whole gene synthesis, Food processing and manufacture, TP368-456
Abstract

In order to investigate the change in proline metabolism of two varieties of Hami melon fruits during low-temperature storage, ‘Xizhoumi 25’ and ‘Gashi’ melons were pre-cooled for 24 h and then placed for up to 42 days in a mechanical cold storage at (3.0 ± 0.5) ℃. Chilling injury symptoms were recorded, and chilling injury index, free proline content and proline metabolism-related indexes were measured every seven days . The results showed that the symptoms of chilling injury in ‘Gashi’ melon were significantly milder than those in ‘Xizhoumi 25’ melon, and as the storage time increased, free proline content, Δ1-pyrrolidine-5-carboxylic acid synthase (P5CS) activity, ornithine transaminase (OAT) activity and their relative gene expression increased significantly for both varieties; all these indicators were significantly higher in ‘Gashi’ melon than ‘Xizhoumi 25’ melon. The activity and relative gene expression of proline dehydrogenase (ProDH) decreased, indicating that both varieties of Hami melon fruits could resist chilling injury by increasing the free proline content and the activities of P5CS and OAT, the key enzymes for proline synthesis, and decreasing the activity of ProDH, the key enzyme for proline degradation. The metabolomics study revealed that the amino acid content of ‘Xizhoumi 25’melon decreased when the chilling injury became more serious, while the amino acid content of ‘Gashi’ melon showed an opposite trend. Whole gene synthesis of CmP5CS, a key enzyme gene involved in the proline metabolic pathway of Hami melon fruits, revealed that the Hami melon CmP5CS gene had the closest relatedness to melon (LOC103485529) P5CS, indicating functional similarity between them.

Published
2024
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3. An Effective Iterated Two-stage Heuristic Algorithm for the Multiple Traveling Salesmen Problem

Author

Zheng, Jiongzhi, Hong, Yawei, Xu, Wenchang, Li, Wentao, and Chen, Yongfu

Subjects
Computer Science - Artificial Intelligence
Abstract

The multiple Traveling Salesmen Problem (mTSP) is a general extension of the famous NP-hard Traveling Salesmen Problem (TSP), that there are m (m > 1) salesmen to visit the cities. In this paper, we address the mTSP with both the minsum objective and minmax objective, which aims at minimizing the total length of the $m$ tours and the length of the longest tour among all the m tours, respectively. We propose an iterated two-stage heuristic algorithm called ITSHA for the mTSP. Each iteration of ITSHA consists of an initialization stage and an improvement stage. The initialization stage aims to generate high-quality and diverse initial solutions. The improvement stage mainly applies the variable neighborhood search (VNS) approach based on our proposed effective local search neighborhoods to optimize the initial solution. Moreover, some local optima escaping approaches are employed to enhance the search ability of the algorithm. Extensive experimental results on a wide range of public benchmark instances show that ITSHA significantly outperforms the state-of-the-art heuristic algorithms in solving the mTSP on both the objectives.

Published
2022

9. Histological and Single-nucleus Transcriptome Analyses Unveil the Specialized Functions of Ligular Sclerenchyma Cells and Key Regulators of Leaf Angle in Maize

Author

Wang, Qibin, primary, Guo, Qiuyue, additional, Shi, Qingbiao, additional, Yang, Hengjia, additional, Liu, Meiling, additional, Niu, Yani, additional, Quan, Shuxuan, additional, Xu, Di, additional, Chen, Xiaofeng, additional, Li, Laiyi, additional, Xu, Wenchang, additional, Kong, Fanying, additional, Zhang, Haisen, additional, Li, Pinghua, additional, Li, Bosheng, additional, and Li, Gang, additional

Published
2024
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15. Reciprocal versus Parasocial Relationships in Online Social Networks

Author

Gong, Neil Zhenqiang and Xu, Wenchang

Subjects
Computer Science - Social and Information Networks, Physics - Physics and Society
Abstract

Many online social networks are fundamentally directed, i.e., they consist of both reciprocal edges (i.e., edges that have already been linked back) and parasocial edges (i.e., edges that haven't been linked back). Thus, understanding the structures and evolutions of reciprocal edges and parasocial ones, exploring the factors that influence parasocial edges to become reciprocal ones, and predicting whether a parasocial edge will turn into a reciprocal one are basic research problems. However, there have been few systematic studies about such problems. In this paper, we bridge this gap using a novel large-scale Google+ dataset crawled by ourselves as well as one publicly available social network dataset. First, we compare the structures and evolutions of reciprocal edges and those of parasocial edges. For instance, we find that reciprocal edges are more likely to connect users with similar degrees while parasocial edges are more likely to link ordinary users (e.g., users with low degrees) and popular users (e.g., celebrities). However, the impacts of reciprocal edges linking ordinary and popular users on the network structures increase slowly as the social networks evolve. Second, we observe that factors including user behaviors, node attributes, and edge attributes all have significant impacts on the formation of reciprocal edges. Third, in contrast to previous studies that treat reciprocal edge prediction as either a supervised or a semi-supervised learning problem, we identify that reciprocal edge prediction is better modeled as an outlier detection problem. Finally, we perform extensive evaluations with the two datasets, and we show that our proposal outperforms previous reciprocal edge prediction approaches., Comment: Social Network Analysis and Mining, Springer, 2014

Published
2013

16. Evolution of Social-Attribute Networks: Measurements, Modeling, and Implications using Google+

Author

Gong, Neil Zhenqiang, Xu, Wenchang, Huang, Ling, Mittal, Prateek, Stefanov, Emil, Sekar, Vyas, and Song, Dawn

Subjects
Computer Science - Social and Information Networks, Computer Science - Computers and Society, Physics - Physics and Society
Abstract

Understanding social network structure and evolution has important implications for many aspects of network and system design including provisioning, bootstrapping trust and reputation systems via social networks, and defenses against Sybil attacks. Several recent results suggest that augmenting the social network structure with user attributes (e.g., location, employer, communities of interest) can provide a more fine-grained understanding of social networks. However, there have been few studies to provide a systematic understanding of these effects at scale. We bridge this gap using a unique dataset collected as the Google+ social network grew over time since its release in late June 2011. We observe novel phenomena with respect to both standard social network metrics and new attribute-related metrics (that we define). We also observe interesting evolutionary patterns as Google+ went from a bootstrap phase to a steady invitation-only stage before a public release. Based on our empirical observations, we develop a new generative model to jointly reproduce the social structure and the node attributes. Using theoretical analysis and empirical evaluations, we show that our model can accurately reproduce the social and attribute structure of real social networks. We also demonstrate that our model provides more accurate predictions for practical application contexts., Comment: 14 pages, 19 figures. will appear in IMC'12

Published
2012

23. Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury

Author

Mei, Tingfang, primary, Wu, Jinwen, additional, Wu, Keling, additional, Zhao, Minglei, additional, Luo, Jingyi, additional, Liu, Xinqi, additional, Shang, Bizhi, additional, Xu, Wenchang, additional, Yang, Zeqiu, additional, Lai, Yuhua, additional, Liu, Chujun, additional, Gong, Haijun, additional, Gao, Xinbo, additional, Zhuo, Yehong, additional, Lin, Mingkai, additional, and Zhao, Ling, additional

Published
2023
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26. Differentially Private Continual Monitoring of Heavy Hitters from Distributed Streams

Author

Chan, T. -H. Hubert, Li, Mingfei, Shi, Elaine, Xu, Wenchang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Fischer-Hübner, Simone, editor, and Wright, Matthew, editor

Published
2012
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27. Enabling Efficient Browsing and Manipulation of Web Tables on Smartphone

Author

Xu, Wenchang, Shi, Yuanchun, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Jacko, Julie A., editor

Published
2011
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31. Managing Workplace Resources in Office Environments through Ephemeral Social Networks

Author

Zhu, Lijun, Chin, Alvin, Zhang, Ke, Xu, Wenchang, Wang, Hao, Zhang, Li, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Yu, Zhiwen, editor, Liscano, Ramiro, editor, Chen, Guanling, editor, Zhang, Daqing, editor, and Zhou, Xingshe, editor

Published
2010
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32. Enabling Interactive Access to Web Tables

Author

Yang, Xin, Xu, Wenchang, Shi, Yuanchun, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Jacko, Julie A., editor

Published
2009
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33. Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.

Author

Xu, Wenchang, Liu, Xinqi, Han, Wenjuan, Wu, Keling, Zhao, Minglei, Mei, Tingfang, Shang, Bizhi, Wu, Jinwen, Luo, Jingyi, Lai, Yuhua, Yang, Boyu, Zhuo, Yehong, Lu, Lin, Liu, Yizhi, Tian, Xiao-li, and Zhao, Ling

Subjects
*RETINAL degeneration, *MACULAR degeneration, *AGING, *VISION disorders, *TRANSGENIC mice, *CELLULAR aging
Abstract

Background: Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE senescence is an important contributor to AMD and has become a potential target for AMD therapy. HTRA1 is one of the most significant susceptibility genes in AMD, however, the correlation between HTRA1 and RPE senescence hasn't been investigated in the pathogenesis of AMD. Methods: Western blotting and immunohistochemistry were used to detect HTRA1 expression in WT and transgenic mice overexpressing human HTRA1 (hHTRA1-Tg mice). RT-qPCR was used to detect the SASP in hHTRA1-Tg mice and ARPE-19 cells infected with HTRA1. TEM, SA-β-gal was used to detect the mitochondria and senescence in RPE. Retinal degeneration of mice was investigated by fundus photography, FFA, SD-OCT and ERG. The RNA-Seq dataset of ARPE-19 cells treated with adv-HTRA1 versus adv-NC were analyzed. Mitochondrial respiration and glycolytic capacity in ARPE-19 cells were measured using OCR and ECAR. Hypoxia of ARPE-19 cells was detected using EF5 Hypoxia Detection Kit. KC7F2 was used to reduce the HIF1α expression both in vitro and in vivo. Results: In our study, we found that RPE senescence was facilitated in hHTRA1-Tg mice. And hHTRA1-Tg mice became more susceptible to NaIO3 in the development of oxidative stress-induced retinal degeneration. Similarly, overexpression of HTRA1 in ARPE-19 cells accelerated cellular senescence. Our RNA-seq revealed an overlap between HTRA1-induced differentially expressed genes associated with aging and those involved in mitochondrial function and hypoxia response in ARPE-19 cells. HTRA1 overexpression in ARPE-19 cells impaired mitochondrial function and augmented glycolytic capacity. Importantly, upregulation of HTRA1 remarkably activated HIF-1 signaling, shown as promoting HIF1α expression which mainly located in the nucleus. HIF1α translation inhibitor KC7F2 significantly prevented HTRA1-induced cellular senescence in ARPE-19 cells, as well as improved the visual function in hHTRA1-Tg mice treated with NaIO3. Conclusions: Our study showed elevated HTRA1 contributes to the pathogenesis of AMD by promoting cellular senescence in RPE through damaging mitochondrial function and activating HIF-1 signaling. It also pointed out that inhibition of HIF-1 signaling might serve as a potential therapeutic strategy for AMD. F6p4cFd4Xy8hC-VtNmT8Qx Video Abstract [ABSTRACT FROM AUTHOR]

Published
2023
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35. PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

Author

Luo, Jingyi, primary, Lian, Qing, additional, Zhu, Deliang, additional, Zhao, Minglei, additional, Mei, Tingfang, additional, Shang, Bizhi, additional, Yang, Zeqiu, additional, Liu, Chujun, additional, Xu, Wenchang, additional, Zhou, Lan, additional, Wu, Keling, additional, Liu, Xinqi, additional, Lai, Yuhua, additional, Mao, Fuxiang, additional, Li, Weihua, additional, Zuo, Chengguo, additional, Zhang, Kang, additional, Lin, Mingkai, additional, Zhuo, Yehong, additional, Liu, Yizhi, additional, Lu, Lin, additional, and Zhao, Ling, additional

Published
2022
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39. Defect of LSS Disrupts Lens Development in Cataractogenesis

Author

Zhao, Minglei, primary, Mei, Tingfang, additional, Shang, Bizhi, additional, Zou, Bin, additional, Lian, Qing, additional, Xu, Wenchang, additional, Wu, Keling, additional, Lai, Yuhua, additional, Liu, Chujun, additional, Wei, Lai, additional, Zhu, Jie, additional, Zhang, Kang, additional, Liu, Yizhi, additional, and Zhao, Ling, additional

Published
2021
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