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Diffusely infiltrating gliomas are known to cause alterations in cortical function, vascular disruption, and seizures. These neurological complications present major clinical challenges, yet their underlying mechanisms and causal relationships to disease progression are poorly characterized. Here, we follow glioma progression in awake Thy1-GCaMP6f mice using in vivo wide-field optical mapping to monitor alterations in both neuronal activity and functional hemodynamics. The bilateral synchrony of spontaneous neuronal activity gradually decreases in glioma-infiltrated cortical regions, while neurovascular coupling becomes progressively disrupted compared to uninvolved cortex. Over time, mice develop diverse patterns of high amplitude discharges and eventually generalized seizures that appear to originate at the tumors' infiltrative margins. Interictal and seizure events exhibit positive neurovascular coupling in uninfiltrated cortex; however, glioma-infiltrated regions exhibit disrupted hemodynamic responses driving seizure-evoked hypoxia. These results reveal a landscape of complex physiological interactions occurring during glioma progression and present new opportunities for exploring novel biomarkers and therapeutic targets.

To meet the lightweight requirements of advanced composite materials, the ultralightweight three‐dimensional (3D) braided spacer composites were designed and manufactured by ultra‐high molecular weight polyethylene (UHMWPE). The key structural effects of core column distances and core column heights on the static bending, compression, and low‐velocity impact properties of the composites were further investigated. Results indicated that the mechanical properties of 3D braided spacer composites was closely depended on their structural parameters. The flexure and compression of 3D braided spacer composites decreased with increasing core column distance and core column height. W1/H1 specimen showed the optimal bending and compressive performance. The maximum flexural strength and flexural modulus were approximately 54.77 MPa and 4.95 GPa, respectively. The low‐velocity impact properties were further investigated where the stiffness, energy absorption, and impact resistance of the composite decreased with increasing core column distance. The peak load and energy absorption of the W1 specimen were 2.39 kN and 7.99 J, respectively. While the low‐velocity impact properties increased with increasing core column distance. The H3 specimen exhibited the greatest stiffness, impact resistance and energy absorption with peak loads and energy absorption of 2.81 kN and 8.49 J, respectively. In addition, the macro morphology and scanning electron microscopy (SEM)micrographs were examined to investigate the damage morphology and failure mechanism of the composites. The main failure modes were matrix cracking, interface debonding, fiber buckling, and dislocation, as well as tilting, and failure of the core columns. This work provides guidance for structural design and engineering application of 3D lightweight braided spacer composite. [ABSTRACT FROM AUTHOR]

In this work, the poor fracture toughness of carbon fiber‐reinforced composites (CFRPs) was improved by the introduction of a graphene oxide/nanosilica (GOS) hybrid, and short carbon fibers (SCFs) were investigated through experimental and modeling methods. The effects of the SCF content, number of SCF layers, and introduction position on the mode I fracture toughness (GIC) and mode II fracture toughness (GIIC) of the composites were considered for epoxy resin (EP) modified by GOS. The results showed that GOS and SCF exhibited a synergistic toughening effect on CFRP. The GIC and GIIC of CFRP laminate with GOS content of 0.2 wt% and SCF content of 0.4 wt% reached 0.506 and 2.15 kJ/m2, increased by 72.2% and 53.6% compared to the unmodified composite, respectively. The number of layers and the lamination mode of GC10S5‐B specimens exhibited the optimal improvement of interlaminar fracture toughness. Similarly compared with those of the original. The GIC and GIIC of the CFRP laminates reached 0.662 and 0.506 kJ/m2 (enhanced by 125.9% and 95%, respectively). In addition, the stress propagation path and distribution, and progressive damage of the CFRP composites were obtained to further reveal the toughness mechanism. Highlights: Synergistic toughening of resin modification and short carbon fiber on modes I and II fracture toughness of composites were considered.Content of short carbon fiber and lay‐up methods on toughness performance were investigated thoroughly.Finite element models were established to reveal the stress progress and distribution and toughness mechanism. [ABSTRACT FROM AUTHOR]