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The emergence of business intelligence and analytics(BI&A) 3.0 and the broadening application scenarios of information fusion enhance the importance of data fusion in the business intelligence.More and more researches in the fields of economy,finance and management use the idea and methods of fusion,and the application of data fusion in these fields shows characteristics different from the traditional information fusion.Considering the concepts of information fusion and BI&A,this paper puts forward the new connotation of BI&A based on the perspective of data fusion under the background of multi-source and heteroge-neous big data,highlighting the importance of data fusion in BI&A.In addition,the paper constructs the fusion framework of ‘data,information and knowledge’ for BI&A based on WSR system methodology,so that the data fusion can be better applied in the fields of economy,finance and management.It provides scientific basis for acquiring knowledge from massive multi-source and heterogeneous data,and is beneficial to the development and implementation of a more effective business intelligence system.

Hematologic and neurological expression 1 (HN1) has been reported to involved in certain cancers, but its role in hepatocellular carcinoma (HCC) is largely unknown. The contribution of HN1 to HCC progression was investigated in the present study. We found that HN1 was significantly up‐regulated in HCC tissues, compared with normal tissues, by analyzing the Oncomine and Human Protein Atlas database; and found that high expression of HN1 was markedly associated with worse overall survival, relapse‐free survival, progression‐ free survival and disease‐specific survival in HCC patients via exploring the Kaplan‐Meier plotter database. Functional assays revealed that HN1 knockdown by siRNA induced G1 cell cycle arrest, and inhibited the growth and migration of HCC cells; accordingly, HN1 over‐expression promoted HCC cells proliferation and migration. Further studies indicated that HN1 knockdown reduced the expression of cyclin D1 and CDK4, while upregulated the cell cycle inhibitor p21WAF1/Cip1. Moreover, HN1 knockdown decreased c‐Met (receptor tyrosine kinase of hepatocyte growth factor) expression, and suppressed ERK activation, which is a common downstream signaling pathway triggered by c‐Met; consistently, HN1 over‐expression reversed these effects. Meanwhile, down‐regulation of c‐Met partly eliminated the effect of HN1 over‐expression in HCC cells. Thus, the present findings suggested that HN1 promotes the progression of HCC to some extent by up‐regulating the expression of c‐Met, and may act as a potential biomarker and therapeutic target for the treatment of HCC. [ABSTRACT FROM AUTHOR]

Renal tubulointerstitial injury induced by albumin overload is a critical stage during the progression of renal interstitial fibrosis and progression of chronic renal diseases. Inosine‑5'‑monophosphate dehydrogenase inhibitor mycophenolate mofetil (MMF), a pro‑drug of mycophenolic acid (MPA), is known to attenuate the progression of renal interstitial fibrosis; however, the underlying molecular mechanisms of the anti‑fibrotic effects of derivatives of MMF have not yet been studied. The present study assessed the effects of the MPA on renal tubular epithelial cells. Transforming growth factor beta 1 (TGF‑β1) has been indicated to have a central role in the underlying molecular mechanisms of renal fibrosis; furthermore, nuclear transcription factor‑κB (NF‑κB) is a transcription factor associated with the production of inflammatory cytokines, cell proliferation and apoptosis. In addition, the Akt signaling pathway has important roles in cell proliferation, differentiation, metabolism and apoptosis. The present study subjected the NRK52E rat kidney epithelial‑derived cell line to albumin overload, which resulted in an increase in TGF‑β1 production as well as phosphorylation of Akt and the binding activity of NF‑κB to the promoter region of the TGF‑β1 gene, which was, however, reduced following pre‑incubation of the cells with MPA. In addition, the effects of albumin were partially blocked by Ly294002, a specific inhibitor of Akt. In conclusion, the results of the present study suggested that MPA may exert its anti‑fibrotic effects by inhibiting the upregulation of TGF‑β1 and the activation of NF‑κB following albumin overload, which may be partly dependent on the Akt pathway.

The effect feature of greenbelt on flow field and pollutant dispersion in urban street canyon was researched. The greenbelt was assumed as uniform porous media and its aerodynamics property defined by the pressure loss coefficient. Subsequently, the pollutant dispersion in the street canyon of which there was greenbelt in the middle was simulated with the steady-state standard kappa-epsilon turbulence model and species transport equation. The simulated results agreed well with the wind-tunnel data. Compared with the treeless case, it finds that the street canyon contain a clockwise vortex, the pollutant concentration of the leeward was several times than the windward and the growth rate of pollutant concentration was 46.0%. The further simulation for the impact of tree crown position on the airflow and pollutant dispersion finds that the height of major vortex center in the street canyon increases with the height of tree crown and gradually closes the top of windward building This causes that the average wind speed in the street canyon decreases. Especially when the top of tree crown over the roof and hinder the air flow above the street canyon, the average pollutant concentration increases with the height of tree crown rapidly.