Lu, Qi, Wu, Xian, Zhu, Yanhui, Yang, Junzhe, Wang, Xingmeng, Ye, Chaoran, Cai, Ruyu, Zhang, Kai, Xu, Tingyu, Wang, Bing, Veeramootoo, Jordee S, Xia, Tiansong, and Liu, Xiaoan
Qi Lu,1,* Xian Wu,2,* Yanhui Zhu,2,* Junzhe Yang,2 Xingmeng Wang,2 Chaoran Ye,2 Ruyu Cai,2 Kai Zhang,2 Tingyu Xu,3 Bing Wang,3 Jordee S Veeramootoo,2 Tiansong Xia,2 Xiaoan Liu2 1Department of Thyroid and Breast Surgery, The Second People’s Hospital of Kunshan, Kunshan Jiangsu 215300, People’s Republic of China; 2Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, People’s Republic of China; 3Department of Information, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tiansong Xia; Xiaoan LiuThe First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People’s Republic of ChinaTel/fax +86-25-68308152Email liuxiaoan@126.comPurpose: Chemotherapy is a comprehensive therapy for breast cancer; nevertheless, its associated adverse effects are drawing increasing attention with the continuous improvement of the efficacy. The changes in serum lipids of breast cancer patients caused by chemotherapy have been reported by previous studies, whereby the former increase the incidence rate of cardiovascular disorders. However, the variations in the changes of serum lipids with different chemotherapy regimens have seldom been reported.Methods: From January 2011 to December 2017, 1740 breast cancer patients treated with chemotherapy were recruited at the First Affiliated Hospital of Nanjing Medical University. The chemotherapy regimens included anthracycline-based, taxane-based, and anthracycline-plus-taxane-based regimens, dose-dense and standard-interval regimens. Lipid profiles that contained TG (triglyceride), TC (total cholesterol), HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol) and Lpa (lipoprotein a) levels were collected prior to the first, second and last cycles of chemotherapy. The changes of serum lipids with the same or different chemotherapy regimens were analyzed and compared.Results: It was observed that the levels of TG, TC, LDL-C and Lpa increased significantly while that of HDL-C decreased after adjuvant chemotherapy in breast cancer patients (P< 0.05). Besides, dose-dense regimens had more influence in TG and HDL-C and less influence in TC and LDL-C than standard-interval regimens. HDL-C was more sensitive to anthracycline-based regimens than taxane-based regimens. The level of TG with anthracycline-plus-taxane-based regimens was higher than that with only anthracycline-based or taxane-based regimens, and the level of HDL-C with anthracycline-plus-taxane-based regimen showed lower than that with taxane-based regimen.Conclusion: In summary, this study proposed that dyslipidemia was strongly associated with chemotherapy in Chinese breast cancer patients after operative treatment. Furthermore, the changes in levels of serum lipids varied among patients with different chemotherapy regimens and taxane had less effect on dyslipidemia than anthracycline.Keywords: breast cancer, serum lipids, dyslipidemia, chemotherapy, treatment