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Autophagy, a process that isolates intracellular components and fuses them with lysosomes for degradation, plays an important cytoprotective role by eliminating harmful intracellular substances and maintaining cellular homeostasis. Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the capacity for self-renewal that can give rise to a subset of tissues and therefore have potential in regenerative medicine. However, a variety of variables influence the biological activity of MSCs following their proliferation and transplantation in vitro. The regulation of autophagy in MSCs represents a possible mechanism that influences MSC differentiation properties under the right microenvironment, affecting their regenerative and therapeutic potential. However, a deeper understanding of exactly how autophagy is mobilized to function as well as clarifying the mechanisms by which autophagy promotes MSCs differentiation is still needed. Here, we review the current literature on the complex link between MSCs differentiation and autophagy induced by various extracellular or intracellular stimuli and the molecular targets that influence MSCs lineage determination, which may highlight the potential regulation of autophagy on MSCs’ therapeutic capacity, and provide a broader perspective on the clinical application of MSCs in the treatment of a wide range of diseases.

In the construction industry, the professional evaluation of construction schemes represents a crucial link in ensuring the safety, quality and economic efficiency of the construction process. However, due to the large number and diversity of construction schemes, traditional expert review methods are limited in terms of timeliness and comprehensiveness. This leads to an increasingly urgent requirement for intelligent check of construction schemes. This paper proposes an intelligent compliance checking method for construction schemes that integrates knowledge graphs and large language model (LLM). Firstly, a method for constructing a multi-dimensional, multi-granular knowledge graph for construction standards is introduced, which serves as the foundation for domain-specific knowledge support to the LLM. Subsequently, a parsing module based on text classification and entity extraction models is proposed to automatically parse construction schemes and construct pathways for querying the knowledge graph of construction standards. Finally, an LLM is leveraged to achieve an intelligent compliance check. The experimental results demonstrate that the proposed method can effectively integrate domain knowledge to guide the LLM in checking construction schemes, with an accuracy rate of up to 72%. Concurrently, the well-designed prompt template and the comprehensiveness of the knowledge graph facilitate the stimulation of the LLM's reasoning ability. This work contributes to exploring the application of LLMs and knowledge graphs in the vertical domain of text compliance checking. Future work will focus on optimizing the integration of LLMs and domain knowledge to further improve the accuracy and practicality of the intelligent checking system. [ABSTRACT FROM AUTHOR]

Phosphogypsum (PG) is a byproduct of the phosphate fertilizer industry that can be used in cement mortar. However, PG mortar is known to have high water absorption. This paper proposes a new method to address this issue by using superhydrophobic phosphogypsum (SPG). PG was modified using stearic acid and sodium metasilicate. The hydrophobic mortar (H-mortar) was obtained by replacing a portion of the cement with SPG powder. The optimum water contact angle of the H-mortar was measured at 108.3°. Results from the experiment show that the water absorption of H-mortar was 19% lower than that of the reference mortar (Ref-M). Furthermore, the mechanical strength of H-mortar increased compared to Ref-M, as observed through strength testing. The study also investigated the impact of SPG addition rate on mortar corrosion resistance, and found that the addition of SPG reduces water migration and enhances resistance to chloride ion corrosion. The proposed method has the potential to utilize PG waste while improving mortar strength and corrosion resistance, making it suitable for use in marine mortar structures. [ABSTRACT FROM AUTHOR]