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8 results on '"Xu, Shitang"'

6. CsOH-Promoted Regiospecific Sulfenylation, Selenylation, and Telluration of Indoles in H2 O.

Author

Xu, Shitang, Yi, Rongnan, Zeng, Chunling, Cui, Yue, Wang, Xue-Qiang, Xu, Xinhua, and Li, Ningbo

Subjects
*WASTE recycling, *ORGANIC solvents, *SUSTAINABLE development, *FUNCTIONAL groups, *INDOLE compounds
Abstract

Various indole-containing compounds have shown impressive pharmaceutical activities against a variety of diseases. However, the functionalization of indoles usually relies on systems that use organic solvents, which do not meet the criteria for green and sustainable chemical development. To address this issue, regiospecific sulfenylation, selenylation, and telluration of indoles were developed using H2 O as solvent. The highly efficient chalcogenylation of indoles was achieved utilizing CsOH as a promoter, thus avoiding the use of expensive transition-metal catalysts. This newly developed protocol is characterized by its outstanding features including simple operation, mild conditions, wide substrate scope, excellent functional group tolerance, and recyclability, leading to the convenient synthesis of 3-chalcogenyl-indoles. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Ag2CO3-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones viaA3-coupling under solvent-free condition

Author

Li, Ningbo, Xu, Shitang, Wang, Xueyan, Xu, Li, Qiao, Jie, Liang, Zhiwu, and Xu, Xinhua

Abstract

Several simple, fast and practical protocols have been developed to synthesize internal or terminal propargylamines and chalcones viaA3-coupling reaction of aldehydes, amines, and alkynes catalyzed by an easily available catalyst Ag2CO3under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale preparation, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore, plausible mechanisms for the synthesis of different products have been proposed.

Published
2021
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