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Optical microscopy has long been the standard method for diagnosis in cytopathology. Whole slide scanners can image and digitize large sample areas automatically, but are slow, expensive and therefore not widely available. Clinical diagnosis of cytology specimens is especially challenging since these samples are both spread over large areas and thick, which requires 3D capture. Here, we introduce a new parallelized microscope for scanning thick specimens across extremely wide fields-of-view (54x72 mm^2) at 1.2 and 0.6 {\mu}m resolutions, accompanied by machine learning software to rapidly assess these 16 gigapixel scans. This Multi-Camera Array Scanner (MCAS) comprises 48 micro-cameras closely arranged to simultaneously image different areas. By capturing 624 megapixels per snapshot, the MCAS is significantly faster than most conventional whole slide scanners. We used this system to digitize entire cytology samples (scanning three entire slides in 3D in just several minutes) and demonstrate two machine learning techniques to assist pathologists: first, an adenocarcinoma detection model in lung specimens (0.73 recall); second, a slide-level classification model of lung smears (0.969 AUC).

Structured finance, which involves restructuring diverse assets into securities like MBS, ABS, and CDOs, enhances capital market efficiency but presents significant due diligence challenges. This study explores the integration of artificial intelligence (AI) with traditional asset review processes to improve efficiency and accuracy in structured finance. Using both open-sourced and close-sourced large language models (LLMs), we demonstrate that AI can automate the verification of information between loan applications and bank statements effectively. While close-sourced models such as GPT-4 show superior performance, open-sourced models like LLAMA3 offer a cost-effective alternative. Dual-agent systems further increase accuracy, though this comes with higher operational costs. This research highlights AI's potential to minimize manual errors and streamline due diligence, suggesting a broader application of AI in financial document analysis and risk management.

Diffuse Correlation Spectroscopy (DCS) allows the label-free investigation of microvascular dynamics deep within living tissue. However, common implementations of DCS are currently limited to measurement depths of $\sim 1-1.5cm$, which can limit the accuracy of cerebral hemodynamics measurement. Here we present massively parallelized DCS (pDCS) using novel single photon avalanche detector (SPAD) arrays with up to 500x500 individual channels. The new SPAD array technology can boost the signal-to-noise ratio by a factor of up to 500 compared to single-pixel DCS, or by more than 15-fold compared to the most recent state-of-the-art pDCS demonstrations. Our results demonstrate the first in vivo use of this massively parallelized DCS system to measure cerebral blood flow changes at $\sim 2cm$ depth in human adults. We compared different modes of operation and applied a dual detection strategy, where a secondary SPAD array is used to simultaneously assess the superficial blood flow as a built-in reference measurement. While the blood flow in the superficial scalp tissue showed no significant change during cognitive activation, the deep pDCS measurement showed a statistically significant increase in the derived blood flow index of 8-12% when compared to the control rest state.

We revisit and adapt the extended sequential quadratic method (ESQM) in [3] for solving a class of difference-of-convex optimization problems whose constraints are defined as the intersection of level sets of Lipschitz differentiable functions and a simple compact convex set. Particularly, for this class of problems, we develop a variant of ESQM, called ESQM with extrapolation (ESQM$_e$), which incorporates Nesterov's extrapolation techniques for empirical acceleration. Under standard constraint qualifications, we show that the sequence generated by ESQM$_e$ clusters at a critical point if the extrapolation parameters are uniformly bounded above by a certain threshold. Convergence of the whole sequence and the convergence rate are established by assuming Kurdyka-Lojasiewicz (KL) property of a suitable potential function and imposing additional differentiability assumptions on the objective and constraint functions. In addition, when the objective and constraint functions are all convex, we show that linear convergence can be established if a certain exact penalty function is known to be a KL function with exponent $\frac12$; we also discuss how the KL exponent of such an exact penalty function can be deduced from that of the original extended objective (i.e., sum of the objective and the indicator function of the constraint set). Finally, we perform numerical experiments to demonstrate the empirical acceleration of ESQM$_{e}$ over a basic version of ESQM, and illustrate its effectiveness by comparing with the natural competing algorithm SCP$_{ls}$ from [35].

Despite the significant advancements in natural language processing capabilities demonstrated by large language models such as ChatGPT, their proficiency in comprehending and processing spatial information, especially within the domains of 2D and 3D route planning, remains notably underdeveloped. This paper investigates the inherent limitations of ChatGPT and similar models in spatial reasoning and navigation-related tasks, an area critical for applications ranging from autonomous vehicle guidance to assistive technologies for the visually impaired. In this paper, we introduce a novel evaluation framework complemented by a baseline dataset, meticulously crafted for this study. This dataset is structured around three key tasks: plotting spatial points, planning routes in two-dimensional (2D) spaces, and devising pathways in three-dimensional (3D) environments. We specifically developed this dataset to assess the spatial reasoning abilities of ChatGPT. Our evaluation reveals key insights into the model's capabilities and limitations in spatial understanding.

Signal clipping is a classic technique for reducing peak-to-average power ratio (PAPR) in orthogonal frequency division multiplexing (OFDM) systems. It has been widely applied in consumer electronic devices owing to its low complexity and high efficiency. Although clipping reduces the nonlinear distortion caused by power amplifiers (PAs), it induces additional clipping distortion. Optimizing the joint system performance with consideration of both PA nonlinearity and clipping distortion remains an open problem due to the complex PA modeling. In this paper, we analyze the PA nonlinearity through the Bessel-Fourier PA (BFPA) model and simplify its power expression using inter-modulation product (IMP) analysis. We derive expressions of the receiver signal-to-noise ratio (SNR) and system symbol error rate (SER) for the nonlinear clipped OFDM system. With the derivations, we investigate the optimal system setting to achieve the SER lower bound in a practical OFDM system that considers both PA nonlinearity and clipping distortion. The methods and results presented in this paper can serve as a useful reference for the system-level optimization of clipped OFDM systems with nonlinear PA.

We report Tensorial tomographic Fourier Ptychography (ToFu), a new non-scanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in 3D. Built upon Fourier Ptychography, a quantitative phase imaging technique, ToFu additionally highlights the vectorial nature of light. The imaging setup consists of a standard microscope equipped with an LED matrix, a polarization generator, and a polarization-sensitive camera. Permittivity tensors of anisotropic samples are computationally recovered from polarized intensity measurements across three dimensions. We demonstrate ToFu's efficiency through volumetric reconstructions of refractive index, birefringence, and orientation for various validation samples, as well as tissue samples from muscle fibers and diseased heart tissue. Our reconstructions of muscle fibers resolve their 3D fine-filament structure and yield consistent morphological measurements compared to gold-standard second harmonic generation scanning confocal microscope images found in the literature. Additionally, we demonstrate reconstructions of a heart tissue sample that carries important polarization information for detecting cardiac amyloidosis.

Until recently, conventional biochemical staining had the undisputed status as well-established benchmark for most biomedical problems related to clinical diagnostics, fundamental research and biotechnology. Despite this role as gold-standard, staining protocols face several challenges, such as a need for extensive, manual processing of samples, substantial time delays, altered tissue homeostasis, limited choice of contrast agents for a given sample, 2D imaging instead of 3D tomography and many more. Label-free optical technologies, on the other hand, do not rely on exogenous and artificial markers, by exploiting intrinsic optical contrast mechanisms, where the specificity is typically less obvious to the human observer. Over the past few years, digital staining has emerged as a promising concept to use modern deep learning for the translation from optical contrast to established biochemical contrast of actual stainings. In this review article, we provide an in-depth analysis of the current state-of-the-art in this field, suggest methods of good practice, identify pitfalls and challenges and postulate promising advances towards potential future implementations and applications., Comment: Review article, 4 main Figures, 3 Tables, 2 supplementary figures

This article experimentally examines different configurations of a novel multi-camera array microscope (MCAM) imaging technology. The MCAM is based upon a densely packed array of "micro-cameras" to jointly image across a large field-of-view at high resolution. Each micro-camera within the array images a unique area of a sample of interest, and then all acquired data with 54 micro-cameras are digitally combined into composite frames, whose total pixel counts significantly exceed the pixel counts of standard microscope systems. We present results from three unique MCAM configurations for different use cases. First, we demonstrate a configuration that simultaneously images and estimates the 3D object depth across a 100 x 135 mm^2 field-of-view (FOV) at approximately 20 um resolution, which results in 0.15 gigapixels (GP) per snapshot. Second, we demonstrate an MCAM configuration that records video across a continuous 83 x 123 mm^2 FOV with two-fold increased resolution (0.48 GP per frame). Finally, we report a third high-resolution configuration (2 um resolution) that can rapidly produce 9.8 GP composites of large histopathology specimens.

We present a new Multimodal Fiber Array Snapshot Technique (M-FAST), based on an array of 96 compact cameras placed behind a primary objective lens and a fiber bundle array. which is capable of large-area, high-resolution, multi-channel video acquisition. The proposed design provides two key improvements to prior cascaded imaging system approaches: a novel optical arrangement that accommodates the use of planar camera arrays, and the new ability to acquire multi-modal image data acquisition. M-FAST is a multi-modal, scalable imaging system that can acquire snapshot dual-channel fluorescence images as well as d phase contrast measurements over a large 8x10mm^2 FOV at 2.2um full-pitch resolution.

We report Tensorial Tomographic Differential Phase-Contrast microscopy (T2DPC), a quantitative label-free tomographic imaging method for simultaneous measurement of phase and anisotropy. T2DPC extends differential phase-contrast microscopy, a quantitative phase imaging technique, to highlight the vectorial nature of light. The method solves for permittivity tensor of anisotropic samples from intensity measurements acquired with a standard microscope equipped with an LED matrix, a circular polarizer, and a polarization-sensitive camera. We demonstrate accurate volumetric reconstructions of refractive index, birefringence, and orientation for various validation samples, and show that the reconstructed polarization structures of a biological specimen are predictive of pathology.

Fast noninvasive probing of spatially varying decorrelating events, such as cerebral blood flow beneath the human skull, is an essential task in various scientific and clinical settings. One of the primary optical techniques used is diffuse correlation spectroscopy (DCS), whose classical implementation uses a single or few single-photon detectors, resulting in poor spatial localization accuracy and relatively low temporal resolution. Here, we propose a technique termed Classifying Rapid decorrelation Events via Parallelized single photon dEtection (CREPE)}, a new form of DCS that can probe and classify different decorrelating movements hidden underneath turbid volume with high sensitivity using parallelized speckle detection from a $32\times32$ pixel SPAD array. We evaluate our setup by classifying different spatiotemporal-decorrelating patterns hidden beneath a 5mm tissue-like phantom made with rapidly decorrelating dynamic scattering media. Twelve multi-mode fibers are used to collect scattered light from different positions on the surface of the tissue phantom. To validate our setup, we generate perturbed decorrelation patterns by both a digital micromirror device (DMD) modulated at multi-kilo-hertz rates, as well as a vessel phantom containing flowing fluid. Along with a deep contrastive learning algorithm that outperforms classic unsupervised learning methods, we demonstrate our approach can accurately detect and classify different transient decorrelation events (happening in 0.1-0.4s) underneath turbid scattering media, without any data labeling. This has the potential to be applied to noninvasively monitor deep tissue motion patterns, for example identifying normal or abnormal cerebral blood flow events, at multi-Hertz rates within a compact and static detection probe., Comment: Journal submission

This work demonstrates a multi-lens microscopic imaging system that overlaps multiple independent fields of view on a single sensor for high-efficiency automated specimen analysis. Automatic detection, classification and counting of various morphological features of interest is now a crucial component of both biomedical research and disease diagnosis. While convolutional neural networks (CNNs) have dramatically improved the accuracy of counting cells and sub-cellular features from acquired digital image data, the overall throughput is still typically hindered by the limited space-bandwidth product (SBP) of conventional microscopes. Here, we show both in simulation and experiment that overlapped imaging and co-designed analysis software can achieve accurate detection of diagnostically-relevant features for several applications, including counting of white blood cells and the malaria parasite, leading to multi-fold increase in detection and processing throughput with minimal reduction in accuracy.

This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier ptychography, which is a synthetic aperture-based imaging approach to improve resolution with phaseless measurements, to additionally account for the vectorial nature of light. After images are acquired using a standard microscope outfitted with an LED illumination array and two polarizers, our vectorial Fourier Ptychography (vFP) algorithm solves for the complex 2x2 Jones matrix of the anisotropic specimen of interest at each resolved spatial location. We introduce a new sequential Gauss-Newton-based solver that additionally jointly estimates and removes polarization-dependent imaging system aberrations. We demonstrate effective vFP performance by generating large-area (29 mm$^2$), high-resolution (1.24 $\mu$m full-pitch) reconstructions of sample absorption, phase, orientation, diattenuation, and retardance for a variety of calibration samples and biological specimens.

Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, we utilize a single-photon avalanche diode (SPAD) array camera to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. We then apply a deep neural network to convert the acquired single-photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. We demonstrate the ability to reconstruct images of transient (0.1-0.4s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter-scale resolution, and highlight how our model can flexibly extend to monitor flow speed within buried phantom vessels.

In this paper, we propose first-order feasible methods for difference-of-convex (DC) programs with smooth inequality and simple geometric constraints. Our strategy for maintaining feasibility of the iterates is based on a "retraction" idea adapted from the literature of manifold optimization. When the constraints are convex, we establish the global subsequential convergence of the sequence generated by our algorithm under strict feasibility condition, and analyze its convergence rate when the objective is in addition convex according to the Kurdyka-Lojasiewicz (KL) exponent of the extended objective (i.e., sum of the objective and the indicator function of the constraint set). We also show that the extended objective of a large class of Euclidean norm (and more generally, group LASSO penalty) regularized convex optimization problems is a KL function with exponent $\frac12$; consequently, our algorithm is locally linearly convergent when applied to these problems. We then extend our method to solve DC programs with a single specially structured nonconvex constraint. Finally, we discuss how our algorithms can be applied to solve two concrete optimization problems, namely, group-structured compressed sensing problems with Gaussian measurement noise and compressed sensing problems with Cauchy measurement noise, and illustrate the empirical performance of our algorithms., Comment: To appear in Advances in Computational Mathematics

Few-shot text classification is a fundamental NLP task in which a model aims to classify text into a large number of categories, given only a few training examples per category. This paper explores data augmentation -- a technique particularly suitable for training with limited data -- for this few-shot, highly-multiclass text classification setting. On four diverse text classification tasks, we find that common data augmentation techniques can improve the performance of triplet networks by up to 3.0% on average. To further boost performance, we present a simple training strategy called curriculum data augmentation, which leverages curriculum learning by first training on only original examples and then introducing augmented data as training progresses. We explore a two-stage and a gradual schedule, and find that, compared with standard single-stage training, curriculum data augmentation trains faster, improves performance, and remains robust to high amounts of noising from augmentation., Comment: To appear at NAACL 2021

Traditional data augmentation aims to increase the coverage of the input distribution by generating augmented examples that strongly resemble original samples in an online fashion where augmented examples dominate training. In this paper, we propose an alternative perspective -- a multi-task view (MTV) of data augmentation -- in which the primary task trains on original examples and the auxiliary task trains on augmented examples. In MTV data augmentation, both original and augmented samples are weighted substantively during training, relaxing the constraint that augmented examples must resemble original data and thereby allowing us to apply stronger levels of augmentation. In empirical experiments using four common data augmentation techniques on three benchmark text classification datasets, we find that the MTV leads to higher and more robust performance improvements than traditional augmentation., Comment: Accepted to EACL 2021