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33 results on '"Xu, Mangmang"'

19. Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)—rationale and protocol for a prospective multicentre observational study

Author

Zhang, Shuting, primary, Wang, Zhetao, additional, Liu, Peng, additional, Tuo, Qingzhang, additional, Cheng, Yajun, additional, Xu, Mangmang, additional, Wu, Qian, additional, Lei, Peng, additional, Dai, Lunzhi, additional, Kwapong, William Robert, additional, Tan, Mingying, additional, and Liu, Ming, additional

Published
2022
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33. The association between hypertensive angiopathy and cerebral amyloid angiopathy in primary intracerebral hemorrhage.

Author

Zhu Y, Liu L, Zhong L, Cheng Y, Zhang S, Wu B, Wang D, and Xu M

Abstract

Objective: To determine the association between the burden of cerebral small vessel disease (CSVD) due to hypertensive angiopathy (HA) and cerebral amyloid angiopathy (CAA) on MRI in patients with primary intracerebral hemorrhage (ICH)., Methods: Patients with primary ICH admitted to our center from March 2012 to November 2021 were consecutively enrolled. We used multivariate binary and ordinal regression analyses to assess the association between HA-CSVD burden and CAA-CSVD burden. Lobar cerebral microbleeds (CMBs) were categorized into three level of severity: 0-1, 2-4, and ≥ 5 lobar CMBs. A high CAA-CSVD score was defined as a CAA-CSVD score of ≥3., Results: Overall, 222 participants (mean age 59.88 ± 13.56) were included into analysis. Age and ICH etiology differed among different lobar CMB severity and between the presence and absence of high CAA-CSVD score (all p  < 0.05). Positive associations between HA-related markers and both lobar CMB severity and high CAA-CSVD score ( p  < 0.05 for the presence of lacune, deep CMBs ≥5, the presence of WMH, and HA-CSVD score) were observed in univariate analysis. These associations remained significant after adjusting for age, sex, ICH etiology, and potential vascular risk factors. The distribution of CAA-CSVD score was significantly different between patients with and without CMBs ≥5 (adjusted OR 2.351, 95% CI 1.242-4.455, p  = 0.009) after correcting for age, sex, ICH etiology, and vascular risk factors., Conclusion: Our study provides evidence of an association between HA-CSVD and CAA-CSVD in patients with primary ICH, which needs to be verified in future studies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2023 Zhu, Liu, Zhong, Cheng, Zhang, Wu, Wang and Xu.)

Published
2023
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