Search

Your search keyword '"Xu, Ling-Ling"' showing total 286 results
Start Over Author "Xu, Ling-Ling"
286 results on '"Xu, Ling-Ling"'

6. Characterization and pathogenicity of Alternaria species associated with leaf spot on Plantago lanceolata in Sichuan Province, China

Author

Xu, Zhi‐Ting, primary, Long, Jia‐Hui, additional, Liu, Jia‐Qi, additional, Zhang, Rui‐Zhen, additional, Xu, Ling‐Ling, additional, Wang, Jian‐Jun, additional, Wei, Xue‐Kai, additional, White, James F., additional, Kamran, Malik, additional, Cui, Hua‐Wei, additional, Xue, Long‐Hai, additional, Li, Chun‐Jie, additional, and Yue, Shang‐Kun, additional

Published
2024
Full Text
View/download PDF

11. Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data

Author

Zhou, Yu-Wei, primary, Ren, Yue, additional, Lu, Miao-Miao, additional, Xu, Ling-Ling, additional, Cheng, Wei-Xin, additional, Zhang, Meng-Meng, additional, Ding, Lin-Ping, additional, Chen, Dong, additional, Gao, Jian-Guo, additional, Du, Juan, additional, Jin, Ci-Liang, additional, Chen, Chun-Xiao, additional, Li, Yun-Fei, additional, Cheng, Tao, additional, Jiang, Peng-Lei, additional, Yang, Yi-Da, additional, Qian, Peng-Xu, additional, Xu, Peng-Fei, additional, and Jin, Xi, additional

Published
2024
Full Text
View/download PDF

12. Common key ingredient concluded in Baitouweng decoction, Gegen Qinlian decoction and Shaoyao decoction prevents radiation enteritis by regulating gut microbial network

Author

Liu, Tian-hao, primary, Sheng, Ying-yue, additional, Zhang, Chen-yang, additional, Zhang, Hang, additional, Li, Xue, additional, Yu, Li-hua, additional, Xu, Ling-ling, additional, Zhao, Lin, additional, Wei, Hong, additional, Zhou, Ya-hong, additional, and Xue, Yu-zheng, additional

Published
2024
Full Text
View/download PDF

16. TRPV1 and GABAB1 in the Cerebrospinal Fluid-Contacting Nucleus are Jointly Involved in Chronic Inflammatory Pain in Rats

Author

Xu,Ling-Ling, Yan,Yao, Yuan,Yu-Min, Li,Ying, Jiang,Jun, and Zhang,Li-Cai

Subjects
Anesthesiology and Pain Medicine, Journal of Pain Research
Abstract

Ling-Ling Xu,1– 4,* Yao Yan,1– 3,* Yu-Min Yuan,1– 3 Ying Li,1– 3 Jun Jiang,1– 3 Li-Cai Zhang1– 3 1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, People’s Republic of China; 3NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou, People’s Republic of China; 4Department of Anesthesiology, Nanjing Gaochun People’s Hospital, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li-Cai Zhang, Email licaizhang001@163.comObjective: To assess the receptors of TRPV1 and GABAB1 receptors that were colocalized in cerebrospinal fluid contacting nucleus (CSF-contact nucleus) of chronic inflammatory pain (CIP) rats bringing inspiration for reducing chronic pain.Methods: A rat model of CIP was constructed by plantar injection of complete Freund’s adjuvant (CFA), and the paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 1, 3, 5, 7, 10, and 14 days after plantar injection. In the first part of the experiment, rats with CIP were divided into the immunofluorescence group and the coimmunoprecipitation (Co-IP) group (n = 6). Rats in the immunofluorescence group were injected with the retrograde tracer CB conjugated with Alexa Fluor 594 into the lateral ventricle two days before the injection of CFA into the plantar surface of the left paw. Three days later, rats that exhibited hyperalgesia were perfused, and their brains were extracted and used for double immunofluorescence staining of the CSF-contacting nucleus. Rats in the Co-IP group were anesthetized and dissected 3 days after CFA injection, and fresh brain segments containing the CSF-contacting nucleus were collected for Co-IP to assess the colocalization of TRPV1 and GABAB1 in the CSF-contacting nucleus (n = 6). In the second part of the experiment, SD rats were divided into the normal saline group (control group) and the CFA group. Fresh CSF-contacting nucleus-containing tissues were collected for Western blot analysis 3 days after plantar injection to observe the changes in TRPV1 and GABAB1 expression in the CSF-contacting nucleus.Results: TRPV1 and GABAB1 were co-expressed in the CSF-contacting nucleus in rats with CIP, and their expression was upregulated.Conclusion: TRPV1 and GABAB1 in the CSF-contacting nucleus are jointly involved in CIP in rats, and there is a direct or indirect link between TRPV1 and GABAB1.Keywords: cerebrospinal fluid-contacting nucleus, TRPV1 receptor, GABAB1 receptor, chronic inflammatory pain

Published
2022

22. High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1

Author

Chen, Dong, primary, Lu, Miao-Miao, additional, Wang, Jin-Hai, additional, Ren, Yue, additional, Xu, Ling-Ling, additional, Cheng, Wei-Xin, additional, Wang, Sai-Sai, additional, Li, Xiao-Lin, additional, Cheng, Xiao-Fei, additional, Gao, Jian-Guo, additional, Kalyani, Farhin Shaheed, additional, and Jin, Xi, additional

Published
2022
Full Text
View/download PDF

23. Gut microbiota mediates methamphetamine-induced hepatic inflammation via the impairment of bile acid homeostasis

Author

Zhang, Kai-Kai, primary, Liu, Jia-Li, additional, Chen, Li-Jian, additional, Li, Jia-Hao, additional, Yang, Jian-Zheng, additional, Xu, Ling-Ling, additional, Chen, Yu-Kui, additional, Zhang, Qin-Yao, additional, Li, Xiu-Wen, additional, Liu, Yi, additional, Zhao, Dong, additional, Xie, Xiao-Li, additional, and Wang, Qi, additional

Published
2022
Full Text
View/download PDF

34. Antibiotics Attenuate Methamphetamine-Induced Hepatotoxicity by Regulating Oxidative Stress and TLR4/MyD88/Traf6 Axis

Author

Chen, Li-Jian, primary, He, Jie-Tao, additional, Pan, Ming, additional, Liu, Jia-Li, additional, Zhang, Kai-Kai, additional, Li, Jia-Hao, additional, Wang, Li-Bin, additional, Xu, Ling-Ling, additional, Chen, Yu-Kui, additional, Zhang, Qin-Yao, additional, Li, Dong-Ri, additional, Xu, Jing-Tao, additional, and Xie, Xiao-Li, additional

Published
2021
Full Text
View/download PDF

42. Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

Author

Zhang, Kai-Kai, primary, Wang, Hui, additional, Qu, Dong, additional, Chen, Li-Jian, additional, Wang, Li-Bin, additional, Li, Jia-Hao, additional, Liu, Jia-Li, additional, Xu, Ling-Ling, additional, Yoshida, Jamie Still, additional, Xu, Jing-Tao, additional, Xie, Xiao-Li, additional, and Li, Dong-Ri, additional

Published
2021
Full Text
View/download PDF

46. Additional file 1 of SGLT2 inhibitors and atrial fibrillation in type 2 diabetes: a systematic review with meta-analysis of 16 randomized controlled trials

Author

Li, Wen-Jie, Xing-Qing Chen, Xu, Ling-Ling, Li, Yuan-Qing, and Luo, Bi-Hui

Abstract

Additional file 1: Figure S1: Forest plot and subgroup meta-analysis of atrial fibrillation/atrial flutter events. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S2. Forest plot and meta-analysis of heart failure. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S3. Forest plot and meta-analysis of cerebrovascular events. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S4. Forest plot and meta-analysis of myocardial infarction. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S5. Forest plot and meta-analysis of urinary tract infection rate. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S6: Forest plot and meta-analysis of adjusted mean HbA1c change from baseline for low dosage. Weights are from the random-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S7. Forest plot and meta-analysis of adjusted mean HbA1c change from baseline for high dosage. Weights are from the random-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S8. Forest plot and meta-analysis of adjusted mean body weight loss change from baseline for low dosage. Weights are from the random-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S9. Forest plot and meta-analysis of adjusted mean body weight loss change from baseline for low dosage. Weights are from the random-effect analysis. The solid line across the square represents the 95% confidence interval (CI). Figure S10. Forest plot and meta-analysis of adjusted mean SBP change from baseline for high dosage. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). SBP: systolic blood pressure. Figure S11. Forest plot and meta-analysis of adjusted SBP change from baseline for high dosage. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). SBP: systolic blood pressure. Figure S12. Forest plot and meta-analysis of adjusted DBP change from baseline for low dosage. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). DBP: diastolic blood pressure. Figure S13. Forest plot and meta-analysis of adjusted DBP change from baseline for high dosage. Weights are from the fixed-effect analysis. The solid line across the square represents the 95% confidence interval (CI). DBP: diastolic blood pressure. Figure S14. Random effect meta-regression for adjusted mean HbA1c (%) change from baseline with the following covariates: (A) female proportion (%) (B) duration of follow-ups (year), and (C) sample sizes.

Published
2020
Full Text
View/download PDF

49. Vascular and metabolic effects of metformin added to insulin therapy in patients with type 1 diabetes: A systematic review and meta-analysis.

Author

Liu, Ying‐Shan, Chen, Chu‐Na, Chen, Zhen‐Guo, Peng, Yu, Lin, Xiao‐Pu, Xu, Ling‐Ling, Liu, Ying-Shan, Chen, Chu-Na, Chen, Zhen-Guo, Lin, Xiao-Pu, and Xu, Ling-Ling

Subjects
TYPE 1 diabetes, CAROTID intima-media thickness, METFORMIN, GLYCEMIC control, META-analysis
Abstract

Background: The incidence of type 1 diabetes mellitus (T1DM) is increasing among youth worldwide, translating to an increased risk ofearly-onset cardiovascular disease (CVD). Mounting studies have shown that metformin may reduce maximal carotidintima-media thickness (cIMT), improve insulin resistance and metabolic control in subjects with T1DM, and thus, may extend cardioprotective benefits. This systematic review and meta-analysis was performed to assess the efficacy and safety of metformin added to insulin therapy on reducing CVD risks and improving metabolism in T1DM.Methods: PubMed, EMBASE, and the Cochrane Library were systematically searched for randomized controlled trials (RCTs) that compared metformin and insulin combination (duration ≥3 months) to insulin treatment alone in T1DM. Data were expressed as weighted/standardized mean differences (MDs/SMDs) for continuous outcomes and risk ratios (RRs) for dichotomous outcomes, along with 95% confidence intervals (CIs). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to evaluate the overall certainty of the evidence.Results: Nineteen RCTs (n = 1540) met the eligibility criteria. Metformin treatment significantly reduced carotid artery intima-media thickness (MD -0.06 mm [95% CI -0.88, -0.28], P < .001). Though no significant difference was found in insulin sensitivity (SMD 2.21 [95% CI -1.88, 6.29], P = .29), the total daily insulin dosage (SMD -0.81 [95% CI -1.25, -0.36], P < .001) along with traditional CVD risk factors showed improvement by better glycaemic control, partial lipid profiles, diastolic blood pressure, and limited weight gain, with neutral effect on diabetic ketoacidosis, lactic acidosis, and hypoglycaemia. However, metformin therapy increased the incidence of gastrointestinal adverse events.Conclusions: Metformin with insulin has the potential to retard the progression of atherosclerosis and provides better metabolic control in patients with T1DM, and thus, providing a potential therapeutic strategy for patients with T1DM on reducing CVD risks. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results