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1,296 results on '"Xu, Jianmin"'

4. Identification the Causes of Negative Emotions in Smart Public Transportation Services Based on Social Media Data

Author

Shou, Yanfang, Xu, Jianmin, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Guo, Wei, editor, Qian, Kai, editor, Tang, Honggang, editor, and Gong, Lei, editor

Published
2024
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8. CACA guidelines for holistic integrative management of rectal cancer

Author

Wang, Guiyu, Fan, Daiming, Gu, Jin, Ding, Kefeng, Fang, Xuedong, Shen, Lin, Xu, Zhongfa, Xu, Jianmin, Cai, Jianchun, Cai, Lianming, Cai, Sanjun, Chen, Gong, Chen, Jiansi, Cheng, Longwei, Cheng, Yong, Chi, Pan, Cui, Binbin, Dai, Guanghai, Fu, Chuangang, Gu, Yanhong, He, Guodong, Hu, Junhong, Huang, Jing, Huang, Rui, Huang, Zhongcheng, Jiang, Zheng, Jie, Zhigang, Ju, Haixing, Li, Hai, Li, Jian, Li, Jun, Li, Ming, Li, Yaoping, Li, Yunfeng, Lin, Guole, Liu, Haiying, Liu, Ming, Liu, Qian, Pan, Zhizhong, Peng, Yifan, Qian, Niansong, Qiu, Meng, Ren, Li, Sun, Yueming, Tang, Jianqiang, Tang, Qingchao, Tang, Yuan, Tao, Kaixiong, Tao, Min, Wang, Haijiang, Wang, Meng, Wang, Zejun, Wang, Zhengguang, Wang, Ziqiang, Wang, Ziwei, Wei, Shaozhong, Xing, Baocai, Xiong, Bin, Xu, Ye, Yan, Su, Yang, Bin, Yang, Chunkang, Yao, Qinghua, Ye, Yingjiang, Yuan, Ying, Zhang, Guozhi, Zhang, Haizeng, Zhang, Hongmei, Zhang, Zhen, Zhong, Yunshi, Zhu, Ji, Zhu, Yuan, Zhu, Yuping, Zou, Shuangmei, Wang, Yuliuming, Lv, Jingfang, Liu, Enrui, Yang, Ming, Zhang, Qian, Zhang, Weiyuan, Zhang, Lin, Luo, Jun, Zheng, Zhaoxu, Zhao, Zhixun, Liu, Zheng, Tao, Jinhua, Huang, Haiyang, Chen, Tianli, and Wang, Xishan

Published
2023
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20. Preoperative chemotherapy prior to primary tumour resection for asymptomatic synchronous unresectable colorectal liver-limited metastases: The RECUT multicenter randomised controlled trial

Author

Lin, Qi, Ding, Kefeng, Zhao, Ren, Wang, Hao, Wei, Ye, Ren, Li, Ye, Qinghai, Cui, Yuehong, He, Guodong, Tang, Wentao, Feng, Qingyang, Zhu, Dexiang, Chang, Wenju, Wang, Xiaoying, Liang, Li, Zhou, Guofeng, Liang, Fei, Ye, Feng, Wang, Jianwei, Fan, Jia, and Xu, Jianmin

Published
2023
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24. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression

Author

Xu, Qixia, Long, Qilai, Zhu, Dexiang, Fu, Da, Zhang, Boyi, Han, Liu, Qian, Min, Guo, Jianming, Xu, Jianmin, Cao, Liu, Chin, Y Eugene, Coppé, Jean‐Philippe, Lam, Eric W‐F, Campisi, Judith, and Sun, Yu

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Cancer, Aging, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, Good Health and Well Being, Amphiregulin, Animals, Antineoplastic Agents, B7-H1 Antigen, Cells, Cultured, Cellular Senescence, Drug Resistance, Neoplasm, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Stromal Cells, Tumor Microenvironment, aging, amphiregulin, cancer resistance, clinical biomarker, combinational treatment, programmed cell death 1 ligand, senescence-associated secretory phenotype, stroma, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Aging is characterized by a progressive loss of physiological integrity, while cancer represents one of the primary pathological factors that severely threaten human lifespan and healthspan. In clinical oncology, drug resistance limits the efficacy of most anticancer treatments, and identification of major mechanisms remains a key to solve this challenging issue. Here, we highlight the multifaceted senescence-associated secretory phenotype (SASP), which comprises numerous soluble factors including amphiregulin (AREG). Production of AREG is triggered by DNA damage to stromal cells, which passively enter senescence in the tumor microenvironment (TME), a process that remarkably enhances cancer malignancy including acquired resistance mediated by EGFR. Furthermore, paracrine AREG induces programmed cell death 1 ligand (PD-L1) expression in recipient cancer cells and creates an immunosuppressive TME via immune checkpoint activation against cytotoxic lymphocytes. Targeting AREG not only minimized chemoresistance of cancer cells, but also restored immunocompetency when combined with classical chemotherapy in humanized animals. Our study underscores the potential of in vivo SASP in driving the TME-mediated drug resistance and shaping an immunosuppressive niche, and provides the proof of principle of targeting major SASP factors to improve therapeutic outcome in cancer medicine, the success of which can substantially reduce aging-related morbidity and mortality.

Published
2019

26. Social Media-Based Analysis of Bus Service Satisfaction

Author

Wu, Yang, Xu, Jianmin, Lin, Yongjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, and Zhang, Zhenyuan, editor

Published
2022
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29. Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial

Author

Xu, Jianmin, Feng, Qingyang, Wei, Ye, He, Guodong, Liang, Fei, Yuan, Weitang, Sun, Zhenqiang, Li, Taiyuan, Tang, Bo, Gao, Linfeng, Jia, Baoqing, Li, Peng, Zhou, Yanbing, Liu, Xiaodong, Zhang, Wei, Lou, Zheng, Zhao, Ren, Zhang, Tao, Zhang, Cheng, Li, Da, Cheng, Longwei, Chi, Zhaocheng, Zhang, Xiaoqiao, and Yang, Guang

Published
2022
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34. Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification

Author

Zhang, Hua, Zhao, Lin, Jiang, Jingjing, Zheng, Jie, Yang, Li, Li, Yanyan, Zhou, Jian, Liu, Tianshu, Xu, Jianmin, Lou, Wenhui, Yang, Weige, Tan, Lijie, Liu, Weiren, Yu, Yiyi, Ji, Meiling, Xu, Yaolin, Lu, Yan, Li, Xiaomu, Liu, Zhen, Tian, Rong, Hu, Cheng, Zhang, Shumang, Hu, Qinsheng, Deng, Yangdong, Ying, Hao, Zhong, Sheng, Zhang, Xingdong, Wang, Yunbing, Wang, Hua, Bai, Jingwei, Li, Xiaoying, and Duan, Xiangfeng

Published
2022
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35. Robotic colorectal cancer surgery in China: a nationwide retrospective observational study

Author

Xu, Jianmin, Tang, Bo, Li, Taiyuan, Jia, Baoqing, Yao, Hongliang, Zhao, Ren, Yuan, Weitang, Zhong, Ming, Chi, Pan, Zhou, Yanbing, Yang, Xiongfei, Cheng, Longwei, He, Yulong, Li, Yongxiang, Tong, Weidong, Sun, Xuejun, Jiang, Zhiwei, Wang, Kang, Li, Xiaorong, Wang, Xin, Wei, Ye, Chen, Zongyou, Zhang, Xiaoqiao, Ye, Yingjiang, Han, Fanghai, Tao, Kaixiong, Kong, Dalu, Wang, Ziqiang, Zhang, Cheng, He, Guodong, and Feng, Qingyang

Published
2021
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36. Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.

Author

Chen, Fei, Long, Qilai, Fu, Da, Zhu, Dexiang, Ji, Yan, Han, Liu, Zhang, Boyi, Xu, Qixia, Liu, Bingjie, Li, Yan, Wu, Shanshan, Yang, Chen, Qian, Min, Xu, Jianmin, Liu, Suling, Cao, Liu, Chin, Y, Lam, Eric, Coppé, Jean-Philippe, and Sun, Yu

Subjects
Biomarkers, Cell Line, Tumor, Cellular Senescence, DNA Damage, Drug Resistance, Neoplasm, Humans, NF-kappa B, Paracrine Communication, Phenotype, Transcriptome, Trypsin Inhibitor, Kazal Pancreatic, Tumor Microenvironment
Abstract

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 expression by engaging NF-κB and C/EBP, while paracrine SPINK1 promotes cancer cell aggressiveness particularly chemoresistance. Strikingly, SPINK1 reprograms the expression profile of cancer cells, causing prominent epithelial-endothelial transition (EET), a phenotypic switch mediated by EGFR signaling but hitherto rarely reported for a SASP factor. In vivo, SPINK1 is expressed in the stroma of solid tumours and is routinely detectable in peripheral blood of cancer patients after chemotherapy. Our study substantiates SPINK1 as both a targetable SASP factor and a novel noninvasive biomarker of therapeutically damaged TME for disease control and clinical surveillance.

Published
2018

39. Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial

Author

Xu, Lai, Su, Xiangqian, He, Zirui, Zhang, Chenghai, Lu, Junyang, Chen, Lei, Zhang, Guannan, Feng, Bo, Zang, Lu, Ma, Junjun, Sun, Yueming, Feng, Yifei, Ji, Dongjian, Du, Xiaohui, He, Changzheng, Fu, Ze, Chi, Pan, Huang, Ying, Jiang, Weizhong, Wang, Ziqiang, Wu, Qingbin, Zhong, Ming, Yu, Minhao, Wu, Aiwen, Chen, Pengju, Zhu, Anlong, Guan, Wenlong, Wu, Bin, Li, Fei, Li, Ang, Xu, Jianmin, He, Guodong, Kang, Liang, He, Xiaowen, Suo, Jian, Wang, Daguang, Deng, Haijun, Wang, Yanan, Ye, Yingjiang, Shen, Kai, Lin, Guole, Yao, Hongwei, Qiu, Huizhong, Ding, Kefeng, Xu, Tao, Liang, Zhiyong, Zhou, Weixun, Xue, Huadan, Li, Bin, Zhang, Zhongtao, Zheng, Minhua, and Xiao, Yi

Published
2021
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42. Genome-Wide Identification and Expression Analysis of Nitrate Transporter (NRT) Gene Family in Eucalyptus grandis.

Author

Li, Guangyou, Yang, Deming, Hu, Yang, Xu, Jianmin, and Lu, Zhaohua

Subjects
GENE expression, EUCALYPTUS grandis, GENE families, NITROGEN deficiency, PROMOTERS (Genetics), EUCALYPTUS
Abstract

Eucalyptus grandis is an important planted hardwood tree worldwide with fast growth and good wood performance. The nitrate transporter (NRT) gene family is a major core involved in nitrogen (N) absorption and utilization in plants, but the comprehensive characterization of NRT genes in E. grandis remains mostly elusive. In this study, a total of 75 EgNRT genes were identified from the genome of E. grandis that were distributed unevenly across ten chromosomes, except Chr9. A phylogenetic analysis showed that the EgNRT proteins could be divided into three classes, namely NRT1, NRT2 and NRT3, which contained 69, 4 and 2 members, respectively. The cis-regulatory elements in the promoter regions of EgNRT genes were mainly involved in phytohormone and stress response. The transcriptome analysis indicated that the differentially expressed genes of leaf and root in E. grandis under different N supply conditions were mainly involved in the metabolic process and plant hormone signal transduction. In addition, the transcriptome-based and RT-qPCR analysis revealed that the expression of 13 EgNRT genes, especially EgNRT1.3, EgNRT1.38, EgNRT1.39 and EgNRT1.52, was significantly upregulated in the root under low-N-supply treatment, suggesting that those genes might play a critical role in root response to nitrate deficiency. Taken together, these results would provide valuable information for characterizing the roles of EgNRTs and facilitate the clarification of the molecular mechanism underlying EgNRT-mediated N absorption and distribution in E. grandis. [ABSTRACT FROM AUTHOR]

Published
2024
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43. KRAS genotypes predict metachronous colorectal cancer distant metastases after radical resections

Author

LIN Songbin, FENG Qingyang, XU Jianmin

Subjects
colorectal cancer, metachronous distant metastases, kras, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Surgery, RD1-811
Abstract

Objective To explore the relationship between KRAS genotype and metachronous distant metastases in patients with colorectal cancer after radical resections. Methods Patients were analyzed retrospectively with metachronous distant metastases group and non-metastases group. PCR and pyrosequencing were used to detect the genotype of KRAS. Clinicopathological data and the KRAS genotype were analyzed to find the predictor for metachronous distant metastases. Results A total of 186 patients were enrolled in this study: 93 cases in metachronous distant metastases group and 93 cases in non-metastases group. KRAS gene mutation type was significantly associated with preoperative CEA(P=0.015) and metachronous distant metastases (P

Published
2021
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46. Shanghai international consensus on diagnosis and comprehensive treatment of colorectal liver metastases (version 2019)

Author

Zhou, Aiping, Parvaiz, Amjad, Zhu, Andrew, Eng, Cathy, Lau, Chi-wai, Song, Chun, Tang, Chung-ngai, Lynch, Craig, Wan, Desen, Loyer, Evelyne, Aucejo, Federico, Wang, Feng, Chang, George J., Chen, Gong, Yang, Guang-zhong, Choi, Gyu-Seog, Wieshmann, Hulya, Tulina, Inna, Oh, Jae Hwan, Ngu, James CY., Wang, Jaw-Yuan, Zhou, Jian, Jin, Jing, Liang, Jin-Tung, Wang, Jiping, Kwak, Jung-myun, Okuda, Junji, Lee, Kang-Young, Ding, Kefeng, Kuo, Li-Jen, Ito, Masaaki, Ohue, Masayuki, Zeng, Mengsu, Valente, Michael, Miyoshi, Norikatsu, Bianchi, Paolo Pietro, Lan, Ping, Xu, Ruihua, Cai, Sanjun, Kim, Seon-Hahn, Wang, Shan, Zeng, Shan, Ng, Simon SM., Krishnamurthi, Smitha, Fenwick, Stephen, Akiyoshi, Takashi, Liu, Tianshu, Maughan, Tim, Konishi, Tsuyoshi, Law, Wai Lun, Zhang, Wei, Sun, Weijing, Chen, William Tzu-Liang, Wang, Yajie, Wang, Yi, Yuan, Ying, Sun, Yihong, Hou, Yingyong, You, YiQian Nancy, Lee, Yoon-Suk, Yao, Yunfeng, Liu, Yunpeng, Kinugasa, Yusuke, Zhang, Zhen, Yan, Zhiping, Pan, Zhizhong, Xu, Zhongfa, Zhou, Zongguang, Ren, Li, Zhu, Dexiang, Benson, Al B., III, Nordlinger, Bernard, Koehne, Claus-Henning, Delaney, Conor P., Kerr, David, Lenz, Heinz-Josef, Fan, Jia, Wang, Jianping, Gu, Jin, Li, Jin, Shen, Lin, Tsarkov, Petrv, Tejpar, Sabine, Zheng, Shu, Zhang, Suzhan, Gruenberger, Thomas, Qin, Xinyu, Wang, Xishan, Zhang, Zhongtao, Poston, Graeme John, and Xu, Jianmin

Published
2020
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