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225 results on '"Xu, Jiangyan"'

9. Bioinformatics Analysis on the Molecular Mechanism of Dragon’s Blood in Treating Diabetic Kidney Disease

Author

Chen, Zhanke, Yuan, Jie, Feng, Suxiang, Wang, Lujia, Qiu, Yue, Li, Yaoyang, Li, Chenyu, Liu, Yi, Xu, Jiangyan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Pei, Yan, editor, Chang, Jia-Wei, editor, and Hung, Jason C., editor

Published
2022
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25. Corrigendum to “Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ” [Biomed. Pharmacother. 124 (2020) 109886]

Author

Xie, Zhishen, primary, Zhao, Jianping, additional, Wang, Hui, additional, Jiang, Yali, additional, Yang, Qiaoling, additional, Fu, Yu, additional, Zeng, Huahui, additional, Hölscher, Christian, additional, Xu, Jiangyan, additional, and Zhang, Zhenqiang, additional

Published
2023
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27. On the Design and Implementation of Structured P2P VPNs

Author

Wolinsky, David Isaac, Abraham, Linton, Lee, Kyungyong, Liu, Yonggang, Xu, Jiangyan, Boykin, P. Oscar, and Figueiredo, Renato

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Centralized Virtual Private Networks (VPNs) when used in distributed systems have performance constraints as all traffic must traverse through a central server. In recent years, there has been a paradigm shift towards the use of P2P in VPNs to alleviate pressure placed upon the central server by allowing participants to communicate directly with each other, relegating the server to handling session management and supporting NAT traversal using relays when necessary. Another, less common, approach uses unstructured P2P systems to remove all centralization from the VPN. These approaches currently lack the depth in security options provided by other VPN solutions, and their scalability constraints have not been well studied. In this paper, we propose and implement a novel VPN architecture, which uses a structured P2P system for peer discovery, session management, NAT traversal, and autonomic relay selection and a central server as a partially-automated public key infrastructure (PKI) via a user-friendly web interface. Our model also provides the first design and implementation of a P2P VPN with full tunneling support, whereby all non-P2P based Internet traffic routes through a trusted third party and does so in a way that is more secure than existing full tunnel techniques. To verify our model, we evaluate our reference implementation by comparing it quantitatively to other VPN technologies focusing on latency, bandwidth, and memory usage. We also discuss some of our experiences with developing, maintaining, and deploying a P2P VPN.

Published
2010

31. Hydrazinocurcumin Induced Autophagy and Affected Cell Proliferation by Downregulating the JAK/STAT3 Signaling Pathway in Skin Squamous Cell Carcinoma.

Author

Mao, Qifen, Xia, Xufen, Luo, Hongbin, Jin, Li, Li, Ying, Zhu, Jinjun, Wang, Yuan, Shangguan, Zuifei, and Xu, Jiangyan

Subjects
JAK-STAT pathway, CELLULAR signal transduction, SQUAMOUS cell carcinoma, CELL proliferation, AUTOPHAGY, POLYMERASE chain reaction
Abstract

This study aims to investigate the relevant mechanism by which hydrazinocurcumin (HC) interferes with A431 cell autophagy by inhibiting the STAT3 signaling pathway. Different concentrations of HC are used to treat A431 cells to study the effects of HC on A431 cell proliferation and apoptosis. Real‐time fluorescent quantitative polymerase chain reaction (PCR) is used to further explore the relationship of HC with the JAK signaling pathway and autophagy. Double immunofluorescence staining is used to detect the fluorescence localization of LC3 and STAT3 after HC treatment. With increasing HC concentrations, A431 cell viability decreases in a dose‐dependent manner, and the apoptosis rate increases significantly. Laser confocal colocalization reveals that the fluorescence of labeled LC3 protein is significantly increased, and the fluorescence of labeled STAT3 is significantly reduced in this study. HC may induce autophagy in A431 cells and affect cell proliferation by downregulating the JAK/STAT3 signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Rapid removal of high-concentration Rhodamine B by peroxymonosulfate activated with Co3O4-Fe3O4 composite loaded on rice straw biochar.

Author

Liu, Haiyan, Deng, Shisi, Xu, Jiangyan, Liu, Li, Chen, Cheng, Lan, Yeqing, Li, Ying, and Li, Wei

Subjects
RHODAMINE B, RICE straw, PEROXYMONOSULFATE, REACTIVE oxygen species, POLLUTANTS, BIOCHAR
Abstract

In this study, rice straw biochar modified with Co3O4-Fe3O4 (RSBC@Co3O4-Fe3O4) was successfully prepared via calcinating oxalate coprecipitation precursor and employed as a catalyst to activate peroxymonosulfate (PMS) for the treatment of Rhodamine B (RhB)-simulated wastewater. The results indicated that RSBC@Co3O4-Fe3O4 exhibited high catalytic performance due to the synergy between Co3O4 and Fe3O4 doping into RSBC. Approximately 98% of RhB (180 mg/L) was degraded in the RSBC@Co3O4-Fe3O4/PMS system at initial pH 7 within 15 min. The degradation efficiency of RhB maintained over 90% after the fourth cycle, illustrating that RSBC@Co3O4-Fe3O4 displayed excellent stability and reusability. The primary reactive oxygen species (ROS) answerable for the degradation of RhB were 1O2, •OH, and SO4•−. Moreover, the intermediates involved in the degradation of RhB were identified and the possible degradation pathways were deduced. This work can provide a new approach to explore Co-based and BC-based catalysts for the degradation of organic pollutants. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

Author

Xu Jiangyan, Wang Pan, Qiao Yonghui, Gao Gai, Wang Hui, Xie Zhishen, Yuan Yong, Christian Hölscher, Er-Wen Li, Yu Fu, Zhenqiang Zhang, and Xiaowei Zhang

Subjects
Male, NF-E2-Related Factor 2, Pharmacology, GPX4, 01 natural sciences, Lipid peroxidation, Mice, chemistry.chemical_compound, Non-alcoholic Fatty Liver Disease, Malondialdehyde, Nonalcoholic fatty liver disease, medicine, Animals, Ferroptosis, Humans, S100 Calcium-Binding Protein A4, Luciferase, Triglycerides, Kelch-Like ECH-Associated Protein 1, biology, 010405 organic chemistry, Membrane Proteins, Glutathione, Phospholipid Hydroperoxide Glutathione Peroxidase, medicine.disease, KEAP1, Antioxidant Response Elements, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Cholesterol, HEK293 Cells, chemistry, Abietanes, biology.protein, Molecular Medicine, Lipid Peroxidation, Signal transduction, Reactive Oxygen Species, Heme Oxygenase-1, Signal Transduction, Peroxidase
Abstract

The accumulation of iron-dependent lipid peroxides is one of the important causes of NAFLD. The purpose of this study is to explore the effect of dehydroabietic acid (DA) on ferroptosis in nonalcoholic fatty liver disease (NAFLD) mice and its possible mechanisms. DA improved NAFLD and reduced triglycerides (TG), total cholesterol (TC), and lipid peroxidation level and inhibited ferroptosis in the liver of HFD-induced mice. DA binds with Keap1 to form 3 stable hydrogen bonds at VAL512 and LEU557 and increased nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elemen (ARE) luciferase activity. DA promoted the expression downstream of Nrf2 such as heme oxygenase-1 (HO-1), glutathione (GSH) and its peroxidase 4 (GPX4), so as to eliminate the accumulation of reactive oxygen species (ROS) and reduce lipid peroxides malondialdehyde (MDA) in the liver. DA inhibited ferroptosis and increased the expression of key genes such as ferroptosis suppressor protein 1 (FSP1) in vitro and vivo. In all, DA may bind with Keap1, activate Nrf2-ARE, induce its target gene expression, inhibit ROS accumulation and lipid peroxidation, and reduce HFD-induced NAFLD.

Published
2021

42. Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities

Author

Zhenqiang Zhang, Zhao Yinan, Tao Guo, Li-Min Wu, Xu Jiangyan, Xin-Guang Liu, Wang Pan, Ma Jinlian, Xu Ruizhu, Xie Zhishen, and Gao Gai

Subjects
Atractylodes macrocephala, 010404 medicinal & biomolecular chemistry, Traditional medicine, 010405 organic chemistry, Organic Chemistry, Plant Science, Biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Rhizome
Abstract

Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All ...

Published
2021

49. Evaluating Heavy Metals Contamination in Campus Dust in Wuhan, the University Cluster in Central China: Distribution and Potential Human Health Risk Analysis

Author

Liu, Shan, primary, Zhang, Xihao, additional, Zhan, Changlin, additional, Zhang, Jiaquan, additional, Xu, Jun, additional, Wang, Anglv, additional, Zhang, Huidi, additional, Xu, Jiangyan, additional, Guo, Jianlin, additional, Liu, Xianli, additional, Xing, Xinli, additional, Cao, Junji, additional, and Xiao, Yulun, additional

Published
2021
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