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Your search keyword '"Xu, Houqiang"' showing total 205 results
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205 results on '"Xu, Houqiang"'

15. Conductive SiO2/HfO2 distributed Bragg reflector achieved by electrical breakdown and its application in GaN-based light emitters.

Author

Cui, Mei, Guo, Chenyu, Yang, Zhenhai, Chen, Li, Dai, Yijun, Xu, Houqiang, Guo, Wei, and Ye, Jichun

Subjects
ELECTRIC breakdown, CURRENT-voltage curves, ATOMIC force microscopy, METAL fibers, OPTICAL reflectors, OPTICAL properties, LIGHT emitting diodes
Abstract

Owing to the excellent optical reflectivity with wavelength tunability, dielectric distributed Bragg reflectors (DBRs) have attracted considerable interest in GaN-based light emitters. Yet, the non-conductive nature of the dielectric DBRs prevents current from passing through, leading to a current crowding effect and hampering dielectric DBRs from unlocking their full potential. In this paper, a conductive dielectric DBR was fabricated utilizing the electrical breakdown (EBD) technique. With the help of optical simulations, excellent optical properties were demonstrated by optimizing the structural designs with a high reflectivity of 98.3% at 450 nm based on 5.5 pairs SiO2/HfO2 DBRs. The outstanding electrical behaviors after the EBD process were verified by current–voltage curves and conductive atomic force microscopy characterization. Moreover, conductive mechanisms of this type of dielectric DBR were elaborated by comparing the EBD behaviors with different metal electrodes, suggesting that metal filaments play an important role in forming the conducting channels. Besides, 450 nm-emission with conductive 5.5 pairs SiO2/HfO2 DBR was successfully prepared, which proves that a conductive DBR can be successfully applied to GaN-based light-emitting devices. The conductive DBR presented in this work contributes to the acceleration of the development of high-power GaN-based solid-state light emitters. [ABSTRACT FROM AUTHOR]

Published
2022
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18. BLM promotes malignancy in PCa by inducing KRAS expression and RhoA suppression via its interaction with HDGF and activation of MAPK/ERK pathway.

Author

Guo, Yingchu, Xu, Houqiang, Huang, Mengqiu, and Ruan, Yong

Abstract

Prostate cancer (PCa) has long been the leading cause of cancer-associated deaths among male worldwide. Our previous studies have shown that Bloom syndrome protein (BLM) plays a vital role in PCa proliferation, yet the underlying molecular mechanism remains largely obscure. Mechanistically, BLM directly interacted with hepatoma-derived growth factor (HDGF). Functionally, BLM and HDGF knockdown resulted in the higher impairment of PC3 proliferation, clonogenicity, migration and invasion than that their counterpart with either BLM or HDGF knockdown exclusively. Of note, HDGF overexpression expedited, whereas its knockdown suppressed, PC3 proliferation, clonogenicity, migration and invasion. Additionally, the potentiation or attenuation was partially antagonized upon BLM depletion or overexpression. In line with the vitro data, the impact of BLM and HDGF on tumor growth was investigated in mouse xenograft models. ChIP-seq, dual-luciferase reporter and western blotting assays were employed to expound the regulatory network in PC3 cells. The results unveiled that HDGF activated KRAS and suppressed RhoA transcription, and that the function of HDGF was mediated, in part, by interaction with BLM. Accordingly, the MAPK/ERK pathway was activated. Moreover, the regulation of HDGF on KRAS and RhoA had a signal crosstalk. To recapitulate, BLM and HDGF may serve as novel prognostic markers and potential therapeutic targets in PCa. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Implementation of electron restriction layer in n-AlGaN toward balanced carrier distribution in deep ultraviolet light-emitting-diodes

Author

Liu, Kunzi, primary, Chen, Li, additional, Luo, Tian, additional, Zhao, Zihui, additional, Ouyang, Ping, additional, Zhang, Jiaxin, additional, Chen, Qiushuang, additional, Zhou, Biao, additional, Qi, Shengli, additional, Xu, Houqiang, additional, Yang, Zhenhai, additional, Guo, Wei, additional, and Ye, Jichun, additional

Published
2022
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25. Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells.

Author

Sun, Jinkui, Ruan, Yong, Xu, Jiali, Shi, Pengfei, and Xu, Houqiang

Subjects
GENE expression, BOS, CELL cycle, APOPTOSIS, CELL proliferation
Abstract

Myocyte enhancer factor 2A (MEF2A) is a member of the myocyte enhancer factor 2 family. MEF2A is widely distributed in various tissues and organs and participates in various physiological processes. This study aimed to investigate the effect of MEF2A expression on the proliferation and apoptosis of bovine myoblasts. CCK8, ELISA, cell cycle, and apoptosis analyses were conducted to assess cell status. In addition, the mRNA expression levels of genes associated with bovine myoblast proliferation and apoptosis were evaluated using RT-qPCR. The results showed that the upregulation of MEF2A mRNA promoted the proliferation rate of myoblasts, shortened the cycle process, and increased the anti-apoptotic rate. Furthermore, the RT-qPCR results showed that the upregulation of MEF2A mRNA significantly increased the cell proliferation factors MyoD1 and IGF1, cell cycle factors CDK2 and CCNA2, and the apoptotic factors Bcl2 and BAD (p < 0.01). These results show that the MEF2A gene can positively regulate myoblast proliferation and anti-apoptosis, providing a basis for the analysis of the regulatory mechanism of the MEF2A gene on bovine growth and development. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Association Analysis of PRKAA2 and MSMB Polymorphisms and Growth Traits of Xiangsu Hybrid Pigs.

Author

Xu, Jiali, Ruan, Yong, Sun, Jinkui, Shi, Pengfei, Huang, Jiajin, Dai, Lingang, Xiao, Meimei, and Xu, Houqiang

Subjects
SWINE, HEART, LUNGS, STATURE, POLYMERASE chain reaction, BODY weight
Abstract

In this study, Xiangsu hybrid pig growth traits were evaluated via PRKAA2 and MSMB as candidate genes. Sanger sequencing revealed three mutation sites in PRKAA2, namely, g.42101G>T, g.60146A>T, and g.61455G>A, and all these sites were intronic mutations. Moreover, six mutation sites were identified in MSMB: intronic g.4374G>T, exonic g.4564T>C, exonic g.6378G>A, exonic g.6386C>T, intronic g.8643G>A, and intronic g.8857A>G. Association analysis revealed that g.42101G>T, g.60146A>T, g.61455G>A, g.4374G>T, g.4564T>C, g.6378G>A, g.6386C>T, g.8643G>A, and g.8857A>G showed different relationship patterns among body weight, body length, body height, chest circumference, abdominal circumference, tube circumference, and chest depth. Real-time polymerase chain reaction results revealed that the expression of PRKAA2 was highest in the longissimus dorsi muscle, followed by that in the heart, kidney, liver, lung, and spleen. The expression of MSMB was highest in the spleen, followed by that in the liver, kidney, lung, heart, and longissimus dorsi muscle. These results suggest that PRKAA2 and MSMB can be used in marker-assisted selection to improve growth related traits in Xiangsu hybrid pigs, providing new candidate genes for Pig molecular breeding. [ABSTRACT FROM AUTHOR]

Published
2023
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38. BLM interaction with EZH2 regulates MDM2 expression and is a poor prognostic biomarker for prostate cancer

Author

Ruan, Yong, Xu, Houqiang, Ji, Xinqin, and Zhao, Jiafu

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, urogenital system, nutritional and metabolic diseases, Original Article, macromolecular substances
Abstract

Prostate cancer (PCa) is one of the major causes of cancer death among males worldwide. Our previous studies indicated that the proliferation of prostate cancer cells was reduced after BLM knockdown, however, the mechanism is still not clear. In this study, we identified a direct interaction between BLM and EZH2, which had extremely significantly positive correlations (P

Published
2021

40. Polarization isolation for GaN electronics

Author

Dai, Yijun, primary, Guo, Wei, additional, Chen, Li, additional, Xu, Houqiang, additional, AlQatari, Feras, additional, Guo, Chenyu, additional, Peng, Xianchuan, additional, Tang, Ke, additional, Liao, Che-Hao, additional, Li, Xiaohang, additional, and Ye, Jichun, additional

Published
2021
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41. Significantly boosted external quantum efficiency of AlGaN-based DUV-LED utilizing thermal annealed Ni/Al reflective electrodes

Author

Peng, Xianchun, primary, Guo, Wei, additional, Xu, Houqiang, additional, Chen, Li, additional, Yang, Zhenhai, additional, Xu, Liang, additional, Liu, Jianzhe, additional, Tang, Ke, additional, Guo, Chenyu, additional, Yan, Long, additional, Guo, Shiping, additional, Chen, Chongyi, additional, and Ye, Jichun, additional

Published
2021
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48. miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway

Author

Zhao,Jiafu, Xu,Houqiang, Duan,Zhiqiang, Chen,Xiang, Ao,Zheng, Chen,Yinglian, Ruan,Yong, and Ni,Mengmeng

Subjects
Cancer Management and Research
Abstract

Jiafu Zhao,1– 3 Houqiang Xu,1– 3 Zhiqiang Duan,2,3 Xiang Chen,2,3 Zheng Ao,2,3 Yinglian Chen,2,3 Yong Ruan,2,3 Mengmeng Ni2,3 1College of Life Science, Guizhou University, Guiyang 550025, People’s Republic of China; 2Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, People’s Republic of China; 3College of Animal Science, Guizhou University, Guiyang 550025, People’s Republic of ChinaCorrespondence: Houqiang XuCollege of Life Science, Guizhou University, No. 197, Huashi Road, Huaxi District, Guiyang City, Guizhou Province, People’s Republic of ChinaTel +86 13765056884Fax +86 851 88298005Email gzdxxhq@163.comIntroduction: Prostate cancer (PCa) is one of the most common malignancies, and almost all patients with advanced PCa will develop castration-resistant prostate cancer (CRPC) after receiving endocrine therapy. Effective treatment for patients with CRPC has not been established. Novel approaches are needed to identify therapeutic targets for CRPC.Purpose: Recent research studies have found that members of the 14-3-3 family play an important role in the development and progression of PCa. Previous results have shown that 14-3-3 ɛ is significantly upregulated in several cancers. This study aimed to identify novel miRNAs that regulate 14-3-3 ɛ expression and therapeutic targets for CRPC.Methods: In this study, we used computation and experimental approaches for the prediction and verification of the miRNAs targeting 14-3-3 ɛ, and investigated the potential roles of 14-3-3 ɛ in the survival and proliferation of 22RV1 cells.Results: We confirm that mir-31-5p is downregulated in 22RV1 cells and acts as a tumor suppressor by regulating 14-3-3 ɛ. Ectopic expression of miR-31-5p or 14-3-3 ɛ interference significantly inhibits cell proliferation, invasion, and migration in 22RV1 cells, as well as promotes cell apoptosis via the PI3K/AKT/Bcl-2 signaling pathway. Moreover, 14-3-3 ɛ is required for the miR-31-5p-mediated upregulation of the PI3K/AKT/Bcl-2 signaling pathway.Conclusion: Our findings provide information on the underlying mechanisms of miR-31-5p/ 14-3-3 ɛ in 22RV1 cell proliferation and apoptosis through the PI3K/AKT/Bcl-2 signaling pathway. These results suggest that miR-31-5p and 14-3-3 ɛ may potentially be utilized as novel prognostic markers and therapeutic targets for PCa treatment.Keywords: prostate cancer, miR-31-5p, 14-3-3 ϵ, PI3K/AKT/Bcl-2 pathway, cell proliferation, cell apoptosis

Published
2020

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