Search

Your search keyword '"Xu, Hongyao"' showing total 511 results
Start Over Author "Xu, Hongyao"
511 results on '"Xu, Hongyao"'

28. Tripterygium drug-loaded liposome alleviates renal function by promoting vascularization and inhibiting fibrosis.

Author

Chen, Ziwei, Wang, Jiajia, Zhou, Jianyu, Yu, Haifeng, Zheng, Lu, Chen, Yuan, Wan, Xiaoqing, Zhang, Wei, Zhang, Hongbo, Xu, Zimeng, and Xu, Hongyao

Subjects
TRIPTERYGIUM wilfordii, CHINESE medicine, LIPOSOMES, FIBROSIS, TRANSMISSION electron microscopy
Abstract

Introduction: Tripterygium species have been traditionally used in Chinese medicine for treating various conditions. The aim of the study was to construct a drug-modified renal infarction targeting liposome (rTor-LIP) containing Tripterygium in order to improve the therapeutic effect on renal injury. Methods: rTor-LIP was prepared using the extruder method containing Tripterygium solution. The preparation was characterized by transmission electron microscopy, Marvin laser particle size analyzer, and Western blotting. In vitro experiments were conducted to verify the biocompatibility of rTor-LIP, and in vivo experiments were conducted to verify the therapeutic effect of rTor- LIP on renal injury. Results and discussion: The surface of rTor-LIP was regular and oval. In vitro results showed that after co-incubation with rTor-LIP, endothelial cells did not show significant apoptosis, and there were no significant abnormalities in the mitochondrial metabolism. The in vivo results showed that the morphology of endothelial cells in the rTor-LIP group was uniform and the cytoplasmic striations were clear, but the local striations had disappeared. Thus, rTor-LIP nano-targeted liposomes can effectively target hypoxic kidney tissue, providing a new idea for the treatment of renal infarction. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Synthesis of novel copolymer hybrid modifiers (MMA-MAH-MAPOSS and ST-MAH-MAPOSS) based on POSS nanoplatform and study on its thermal properties

Author

Zhang, Kezhen, Li, Wenqing, Guang, Shanyi, and Xu, Hongyao

Subjects
Methyl methacrylate -- Usage, Organosilicon compounds -- Usage, Engineering and manufacturing industries, Science and technology
Abstract

Maleic anhydride is often used as a modifier to improve the thermal performance of the material due to its unique structure and properties. However, in order to meet higher demands, it is often imperative to have better heat resistance and thermal stability. Currently, the traditional method is physically blend inorganic nanoparticles to further improve thermal performance. Unfortunately, inorganic nanoparticles have a fatal problem in that they are not uniformly dispersed in the system, which severely limits their application. Here, we used organic-inorganic molecule, MAPOSS (methyl methacrylate-based cage oligomeric silsesquioxane), to chemically modify the copolymer. And considering the unique structure of MAPOSS, we used two monomers with different polarities to study its influence on the thermal properties of the copolymerization system (MMA-MAH-MAPOSS and ST-MAH-MAPOSS), and discussed the interaction mechanism, respectively. As a result, MAPOSS introduced can not only be evenly distributed in the polymerization system via chemical bonding and physical interactions but also effectively improve the thermal stability and high-temperature resistance of the polymers. Thereinto, the Tg of MMA-MAH copolymer is increased to above 130[degrees]C, and the carbon residue rate is up to 7.3%. The carbon residue rate is increased to 15.6% without affecting the Tg of the ST-MAH copolymer. KEYWORDS chemical bonding, maleic anhydride, MAPOSS, organic-inorganic hybrid, thermal properties, 1 | INTRODUCTION With the rapid development of society, traditional single materials can no longer meet the higher specific demands. For instance, inorganic materials possess outstanding mechanical properties, excellent heat [...]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results