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350 results on '"Xu, Hong‐yu"'

13. Chitosan composite hydrogel loaded with TGF-β3 promotes the repair of meniscus defects in rabbits

Author

WANG Yun, XU Hong-yu, PAN Zong-you, NI Li-cheng, WANG Gang-xiang, ZHAO Yong, ZHENG Qiang

Subjects
chitosan composite hydrogel, transforming growth factor beta 3, meniscus defect, type ⅱ collagen, proteoglycan, Medicine
Abstract

Objective To study the effect of bone marrow mesenchymal stem cells(BM-MSCs) combined with chitosan composite hydrogel loaded with transforming growth factor beta 3 (TGF-β3) to repair meniscus defects. Methods A full-thickness defect model of the anterior horn of the meniscus was developed in 60 New Zealand white rabbits. They were randomly divided into: the control group which did not implant any materials. The repair group Ⅰ in which chitosan composite hydrogel and bone marrow mesenchymal stem cells composite were injected into the defect group, and in group Ⅱ,the chitosan composite hydrogel loaded with TGF-beta 3 and bone marrow mesenchymal stem cells complex were repaired. After 12 weeks of operation, the samples were taken for radiology, gross and histological observation. Western blot was used to detect type Ⅱ collagen and proteoglycan protein. Results In the control group, the full-thickness defect of the meniscus anterior horn was not obviously repaired; in the repair group Ⅰ,most of the defects were filled with repaired tissue; in the repair group Ⅱ, the defects were completely filled with repaired tissue. The expression level of type Ⅱ collagen and proteoglycan protein in repair group Ⅱ was higher than that in control group (P＜0.05). Conclusions Bone marrow mesenchymal stem cells combined with chitosan hydrogel loaded with TGF-beta 3 can promote the repair of meniscus defects in rabbits.

Published
2020

17. Microstructure and mechanical properties of Al2O3/AZ31 composites prepared by multi-pass hot extrusion

Author

WEI Shuai-hu, HU Mao-liang, JI Ze-sheng, XU Hong-yu, and WANG Ye

Subjects
hot extrusion, magnesium matrix composite, mechanical property, dynamic recrystalli-zation, microstructure, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Multi-pass hot extrusion was used to prepare the Al2O3/AZ31 composite.The microstru-cture was characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy, and mechanical properties were tested by Vickers hardness tester and electron universal strength tester. The results show that Al2O3 particles are uniformly distributed in AZ31 magnesium matrix by multi-pass hot extrusion. The grain refining effect of Al2O3 particles on the matrix is enhanced, and the grain size of the composite decreases significantly with the increase of the pass. During the hot extrusion process, the dislocation density around the Al2O3 particles increases, and the high-density dislocation region facilitates the dynamic recrystallization nucleation, so that the grains of the Al2O3/AZ31 composite are significantly refined. The Al2O3 particles are gradually distributed into a long strip from the initial island distribution, then distributed in a linear pattern, and finally distributed uniformly in the form of particles in the AZ31 magnesium matrix. After fourth-pass hot extrusion, the mechanical properties of Al2O3/AZ31 composite are significantly improved, and hardness, tensile strength and yield strength are 89HV, 305MPa and 198MPa, respectively. The hardness, tensile strength and yield strength increase by 19.2%, 14.8%, and 14.1%, respectively, compared with the first-pass hot extrusion.

Published
2019
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20. CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes

Author

Ding, Meng, primary, Xu, Hong-yu, additional, Zhou, Wei-yu, additional, Xia, Yi-fan, additional, Li, Bai-yu, additional, Shi, Yi-jie, additional, Dou, Xin, additional, Yang, Qi-qi, additional, Qian, Shu-wen, additional, Tang, Yan, additional, Pan, Dong-ning, additional, Liu, Yang, additional, and Tang, Qi-qun, additional

Published
2023
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21. Effect of La/Nd ratio on microstructure and tensile properties of AZ91-RE alloys

Author

CUI, Peng-xing, HU, Mao-liang, JI, Ze-sheng, WANG, Ye, GUO, Yu, and XU, Hong-yu

Abstract

The effect of La/Nd ratio on the microstructure and tensile properties of AZ91-RE alloys was studied. Typical characterization was performed to analyze the volume fraction, mean nearest neighbor distance (NND), and number density of the secondary phases. First-principles calculations were employed to determine the formation enthalpy, mechanical and thermodynamics properties of the secondary phases. The results demonstrate that the alloy with a mass fraction ratio of La to Nd (wLa/wNd) of 3:2 exhibits the finest average grain size, the smallest mean NND, and the highest total number density of secondary phases. The calculations indicate that the formation of Al11La3and Al2Nd is energetically favorable. Furthermore, Al11La3and Al2La display significantly superior deformation resistance, shear deformation resistance, solid stiffness and thermal stability compared to other secondary phases. Therefore, increasing the content of Al11La3and Al2La phases contributes to improving the mechanical properties of AZ91-RE alloy.

Published
2024
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41. An RFI Mitigation Pipeline for CRAFTS Multi-beam Data Based on Signal Cross-Correlation Function and SumThreshold Algorithm

Author

Zong-Hao Chen, Shan-Ping You, Xu-Hong Yu, Pei Wang, Di Li, Xiao-Yao Xie, Zhi-Jie Liu, Chun-Qing Wang, Peng Zeng, and Bin Zhang

Subjects
Space and Planetary Science, Astronomy and Astrophysics
Abstract

The increasing radio frequency interference (RFI) is a well-recognized problem in radio astronomy research. Pulsars and Fast Radio Bursts (FRBs) are high-priority science targets of the ongoing Commercial Radio Astronomy FAST Survey (CRAFTS). To improve the quality of RFI removal in searches of pulsars and FRBs based on CRAFTS multi-beam data, we here propose an intuitive but powerful RFI mitigation pipeline (CCF-ST). The “CCF-ST” is a spatial filter constructed by signal cross-correlation function (CCF) and Sum-Threshold (ST) algorithm. The RFI marking result is saved in a “mask” file, a binary format for RFI masks in PRESTO. Three known pulsars, PSR B0525-21, PSR B0621-04, and PSR J0943 + 2252 from CRAFTS L-band 19 beams data are used for evaluation of the performance of CCF-ST in comparison with other methods, such as PRESTO’s “rfifind”, ArPLS-ST and ArPLS-SF. The result shows that CCF-ST can reduce effective data loss rate and improves the detected signal-to-noise ratio of the pulsations by ∼26% and ∼18% respectively compared with PRESTO’s “rfifind” and ArPLS-ST. The CCF-ST also has the advantage of low computational cost, e.g., reducing the time consumption by ∼40% and memory consumption by ∼90% compared with ArPLS-SF. We expect that the new RFI mitigation and analysis toolkit (CCF-ST) demonstrated in this paper can be applied to CRAFTS and other multi-beam telescope observations to improve the data quality and efficiency of pulsar and FRB searches.

Published
2023
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