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18,460 results on '"Xu, F."'

1. Emergence of High-Order Deformation in Rotating Transfermium Nuclei: A Microscopic Understanding

Author

Xu, F. F., Wang, Y. K., Wang, Y. P., Ring, P., and Zhao, P. W.

Subjects
Nuclear Theory, Nuclear Experiment
Abstract

The rotational properties of the transfermium nuclei are investigated in the full deformation space by implementing a shell-model-like approach in the cranking covariant density functional theory on a three-dimensional lattice, where the pairing correlations, deformations, and moments of inertia are treated in a microscopic and self-consistent way. The kinematic and dynamic moments of inertia of the rotational bands observed in the transfermium nuclei $^{252}$No, $^{254}$No, $^{254}$Rf, and $^{256}$Rf are well reproduced without any adjustable parameters using a well-determined universal density functional. It is found for the first time that the emergence of the octupole deformation should be responsible for the significantly different rotational behavior observed in $^{252}$No and $^{254}$No. The present results provide a microscopic solution to the long-standing puzzle on the rotational behavior in No isotopes, and highlight the risk of investigating only the hexacontetrapole ($\beta_{60}$) deformation effects in rotating transfermium nuclei without considering the octupole deformation.

Published
2024
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2. Revisiting Energy Distribution and Formation Rate of CHIME Fast Radio Bursts

Author

Zhang, K. J., Dong, X. F., Rodin, A. E., Fedorova, V. A., Huang, Y. F., Li, D., Wang, P., Li, Q. M., Du, C., Xu, F., and Zhang, Z. B.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Using a large sample of fast radio bursts (FRBs) from the first CHIME/FRB catalog, we apply the Lynden-Bell's c$^-$ method to study their energy function and formation rate evolutions with redshift. It is found with the non-parametric Kendell's $\tau$ statistics that the FRB energy strongly evolves with the cosmological redshift as $E(z)\propto(1 + z)^{5.23}$. After removing the redshift dependence, the local energy distribution can be described by a broken power-law form of $\Psi(E_{0})\propto E_{0}^{-0.38}$ for the low-energy segment and $\Psi(E_{0})\propto E_{0}^{-2.01}$ for the high-energy segment with a dividing line of $\sim2.1\times10^{40} \rm erg$. Interestingly, we find that the formation rate of CHIME FRBs also evolves with redshift as $\rho(z)\propto(1+z)^{-4.73\pm0.08}$. The local formation rate $\rho(0)$ of the CHIME FRBs is constrained to be about $ 1.25\times 10^4\rm{\,Gpc^{-3}yr^{-1}}$ that is comparable with some previous estimations. In addition, we notice the formation rate not only exceeds the star formation rate at the lower redshifts but also always declines with the increase of redshift, which does not match the star formation history at all. Consequently, we suggest that most FRBs could originate from the older stellar populations.

Published
2024

3. Ground-state mass of $^{22}$Al and test of state-of-the-art \textit{ab initio} calculations

Author

Sun, M. Z., Yu, Y., Wang, X. P., Wang, M., Li, J. G., Zhang, Y. H., Blaum, K., Chen, Z. Y., Chen, R. J., Deng, H. Y., Fu, C. Y., Ge, W. W., Huang, W. J., Jiao, H. Y., Li, H. H., Li, H. F., Luo, Y. F., Liao, T., Litvinov, Yu. A., Si, M., Shuai, P., Shi, J. Y., Wang, Q., Xing, Y. M., Xu, X., Xu, H. S., Xu, F. R., Yuan, Q., Yamaguchi, T., Yan, X. L., Yang, J. C., Yuan, Y. J., Zhou, X. H., Zhou, X., Zhang, M., and Zeng, Q.

Subjects
Nuclear Experiment
Abstract

The ground-state mass excess of the $T_{z}=-2$ drip-line nucleus $^{22}$Al is measured for the first time to be $18103(10)$ keV using the newly-developed B$\rho$-defined isochronous mass spectrometry method at the cooler storage ring in Lanzhou. The new mass excess value allowed us to determine the excitation energies of the two low-lying $1^+$ states in $^{22}$Al with significantly reduced uncertainties of 51 keV. Comparing to the analogue states in its mirror nucleus $^{22}$F, the mirror energy differences of the two $1^+$ states in the $^{22}$Al-$^{22}$F mirror pair are determined to be $-625(51)$ keV and $-330(51)$ keV, respectively. The excitation energies and the mirror energy differences are used to test the state-of-the-art \textit{ab initio} valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field theory. The mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of the $\pi s_{1/2}$ orbital., Comment: 8 pages, 5 figures

Published
2024

4. Abnormal Bifurcation of the Double Binding Energy Differences and Proton-Neutron Pairing: Nuclei Close to $N=Z$ Line from Ni to Rb

Author

Wang, Y. P., Wang, Y. K., Xu, F. F., Zhao, P. W., and Meng, J.

Subjects
Nuclear Theory
Abstract

The recently observed abnormal bifurcation of the double binding energy differences $\delta V_{pn}$ between the odd-odd and even-even nuclei along the $N=Z$ line from Ni to Rb has challenged the nuclear theories. To solve this problem, a shell-model-like approach based on the relativistic density functional theory is established, by treating simultaneously the neutron-neutron, proton-neutron, and proton-proton pairing correlations both microscopically and self-consistently. Without any \textit{ad hoc} parameters, the calculated results well reproduce the observations, and the mechanism for this abnormal bifurcation is found to be due to the enhanced proton-neutron pairing correlations in the odd-odd $N=Z$ nuclei, compared with the even-even ones. The present results provide an excellent interpretation for the abnormal $\delta V_{pn}$ bifurcation, and provide a clear signal for the existence of the proton-neutron pairing correlations for nuclei close to the $N=Z$ line., Comment: 6 pages, 4 figures

Published
2024
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6. Feedback from protoclusters does not significantly change the kinematic properties of the embedded dense gas structures

Author

Zhou, J. W., Dib, S., Wyrowski, F., Liu, T., Li, S. H., Sanhueza, P., Juvela, M., Xu, F. W., Liu, H. L., Baug, T., Peng, Y. P., Menten, K. M., Bronfman, L., and Lee, C. W.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

A total of 64 ATOMS sources at different evolutionary stages were selected to investigate the kinematics and dynamics of gas structures under feedback. We identified dense gas structures based on the integrated intensity map of H$^{13}$CO$^+$ J=1-0 emission, and then extracted the average spectra of all structures to investigate their velocity components and gas kinematics. For the scaling relations between velocity dispersion $\sigma$, effective radius $R$ and column density $N$ of all structures, $\sigma-N*R$ always has a stronger correlation compared to $\sigma-N$ and $\sigma-R$. There are significant correlations between velocity dispersion and column density, which may imply that the velocity dispersion originates from gravitational collapse, also revealed by the velocity gradients. The measured velocity gradients for dense gas structures in early-stage sources and late-stage sources are comparable, indicating gravitational collapse through all evolutionary stages. We quantitatively estimated the velocity dispersion generated by the outflows, inflows, ionized gas pressure and radiation pressure, and found that the ionized gas feedback is stronger than other feedback mechanisms. However, although feedback from HII regions is the strongest, it does not significantly affect the physical properties of the embedded dense gas structures. Combining with the conclusions in Zhou+2023 on cloud-clump scales, we suggest that although feedback from cloud to core scales will break up the original cloud complex, the substructures of the original complex can be reorganized into new gravitationally governed configurations around new gravitational centers. This process is accompanied by structural destruction and generation, and changes in gravitational centers, but gravitational collapse is always ongoing., Comment: 15 pages, accepted for publication in Astronomy & Astrophysics

Published
2023

7. The renormalization of the shell-model GT operator starting from effective field theory for nuclear systems

Author

Coraggio, L., Itaco, N., De Gregorio, G., Gargano, A., Cheng, Z. H., Ma, Y. Z., Xu, F. R., and Viviani, M.

Subjects
Nuclear Theory, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

For the first time, we approach in this work the problem of the renormalization of the Gamow-Teller decay operator for nuclear shell-model calculations by way of many-body perturbation theory, starting from a nuclear Hamiltonian and electroweak currents derived consistently by way of the chiral perturbation theory. These are the inputs we need to construct microscopically the effective shell-model Hamiltonians and decay operators. The goal is to assess the role of both electroweak currents and many-body correlations as the origins of the well-known problem of the quenching of the axial coupling constant gA. To this end, the calculation of observables related to the Gamow-Teller transitions has been performed for several nuclear systems outside the 40Ca and 56Ni closed cores and compared with the available data., Comment: 15 pages, 13 figures, 3 tables, to be published in Physical Review C

Published
2023

11. The role of three-nucleon potentials within the shell model: past and present

Author

Coraggio, L., De Gregorio, G., Fukui, T., Gargano, A., Ma, Y. Z., Cheng, Z. H., and Xu, F. R.

Subjects
Nuclear Theory
Abstract

We survey the impact of nuclear three-body forces on structure properties of nuclei within the shell model. It has long been acknowledged, since the seminal works of Zuker and coworkers, that three-body forces play a fundamental role in making the monopole component of shell-model Hamiltonians, derived from realistic nucleon-nucleon potentials, able to reproduce the observed evolution of the shell structure. In the vast majority of calculations, however, their effects have been taken into account by shell-model practitioners by introducing ad hoc modifications of the monopole matrix elements. During last twenty years, a new theoretical approach, framed within the chiral perturbation theory, has progressed in developing nuclear potentials, where two- and many-body components are naturally and consistently built in. This new class of nuclear forces allows to carry out nuclear structure studies that are improving our ability to understand nuclear phenomena in a microscopic approach. We provide in this work an update on the status of the nuclear shell model based on realistic Hamiltonians that are derived from two- and three-nucleon chiral potentials, focusing on the role of the three-body component to provide the observed shell evolution and closure properties, as well as the location of driplines. To this end, we present the results of shell-model calculations and their comparison with recent experimental measurements, which enlighten the relevance of the inclusion of three-nucleon forces to master our knowledge of the physics of atomic nuclei., Comment: Accepted for publication in Progress in Particle and Nuclear Physics

Published
2023

12. Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn’s Disease: Network Pharmacology, Molecular Docking and Experiment Validation

Author

Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, and Shen H

Subjects
qingchang tongluo decoction, crohn's disease, intestinal fibrosis, network pharmacology, pharmacology, Therapeutics. Pharmacology, RM1-950
Abstract

Yanan Li,1,2,* Jingyi Hu,1,2,* Ryan Au,1– 3 Cheng Cheng,1,2 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Yuan Cui,1,2 Lei Zhu,1,2 Hong Shen1,2 1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of China; 2Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, 210029, People’s Republic of China; 3Academy of Chinese Culture and Health Sciences, Oakland, CA, 94612, USA*These authors contributed equally to this workCorrespondence: Hong Shen; Lei Zhu, Jiangsu Provincial Hospital of Chinese Medicine (Affiliated Hospital of Nanjing University of Chinese Medicine), 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu Province, People’s Republic of China, Tel\Fax +86-025- 86617141, Email shenhong999@njucm.edu.cn; zhulei5100@njucm.edu.cnBackground: Qingchang Tongluo Decoction (QTF) is clinically used for the treatment of intestinal fibrosis in Crohn’s Disease (CD). However, the role of QTF in CD-associated fibrosis and its potential pharmacological mechanism remains unclear.Purpose: The objective of this study was to elucidate the potential mechanism of QTF in treating CD-associated fibrosis, employing a combination of bioinformatics approaches — encompassing network pharmacology and molecular docking — complemented by experimental validation.Methods: To investigate the material basis and potential protective mechanism of QTF, a network pharmacology analysis was conducted. The core components and targets of QTF underwent molecular docking analysis to corroborate the findings obtained from network pharmacology. In vitro, a colon fibrotic model was established by stimulating IEC-6 cells with 10 ng/mL of transforming growth factor(TGF-β 1). In vivo, an intestinal fibrosis model was induced in BALB/c mice by TNBS. The role of QTF in inhibiting the TGF-β 1/Smad signaling pathway was investigated through RT-qPCR, Western blotting, immunohistochemistry staining, and immunofluorescence staining.Results: Network pharmacology analysis revealed that QTF could exert its protective effect. Bioinformatics analysis suggested that Flavone and Isoflavone might be the key components of the study. Additionally, AKT1, IL-6, TNF, and VEGFA were identified as potential therapeutic targets. Furthermore, experimental validation and molecular docking were employed to corroborate the results obtained from network pharmacology. RT-qPCR, Immunofluorescence, and Western blotting results demonstrated that QTF significantly improved colon function and inhibited pathological intestinal fibrosis in vivo and in vitro.Conclusion: Through the application of network pharmacology, molecular docking, and experimental validation, QTF could be confirmed to inhibit the proliferation of intestinal fibroblasts associated with CD and reduce the expression of Collagen I and VEGFA. This effect is achieved through the attenuation of ECM accumulation, primarily via the inhibition of the TGF-β 1/Smad signaling pathway. Keywords: Qingchang Tongluo Decoction, Crohn’s Disease, intestinal fibrosis, network pharmacology, Pharmacology

Published
2024

13. The Effectiveness of Electronic Cannulation Atlas in Patients with Arteriovenous Fistula

Author

Xu F, Shu P, Li C, Huo S, and Wen Z

Subjects
arteriovenous fistula, informatization, cannulation atlas, management of hemodialysis patients, complications., Medicine (General), R5-920
Abstract

Fang Xu,&ast; Peng Shu,&ast; Chenchen Li, Shanshan Huo, Zhuping Wen&ast; Nephrology Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fang Xu; Peng Shu, Nephrology Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No.26 Shengli Street, Jiang’ an District, Wuhan, Hubei Province, People’s Republic of China, Tel +8615802716692, Email 453328433@qq.com; 312855784@qq.comObjective: This study aimed to assess the effectiveness of an electronic cannulation atlas in preventing and treating complications of arteriovenous fistula.Methods: The observation group, consisting of 92 dialysis patients from July to December 2021, was managed with an electronic cannulation atlas. After 6 months, the incidence of complications such as stenosis, hematoma, thrombus, aneurysm, and cannulation failure was compared between the groups. Nurse satisfaction with the electronic cannulation atlas system was also assessed through a questionnaire.Results: The observation group had lower incidence rates of arteriovenous fistula stenosis, thrombus, aneurysm, and failure rate of cannulation compared to the control group, with statistically significant differences (p< 0.05). The incidence rates of hematoa were similar in both groups, showing no significant difference (p> 0.05). After 3 months of management, the incidence of arteriovenous fistula complications in the observation group was significantly lower than in the control group (p< 0.05). Additionally, utilizing the electronic cannulation atlas system was found to increase nurses’ job satisfaction.Conclusion: The use of electronic cannulation atlas for the treatment of patients’ arteriovenous fistula could effectively reduce the incidence of complications of patients’ arteriovenous fistula, reduce the failure rate of cannulation, reduce the workload of nurses, and improve the job satisfaction of nurses.Keywords: arteriovenous fistula, informatization, cannulation atlas, management of hemodialysis patients, complications

Published
2024

14. Dynamic Changes in the Immune Microenvironment in Tumor-Draining Lymph Nodes of a Lewis Lung Cancer Mouse Model After Microwave Ablation

Author

Sang J, Liu P, Wang M, Xu F, Ma J, Wei Z, and Ye X

Subjects
microwave ablation, lung cancer, t cells, regulatory t cells, natural killer cells, dendritic cells, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Jing Sang,1,2,&ast; Peng Liu,1,3,&ast; Meixiang Wang,1 Fengkuo Xu,1 Ji Ma,1 Zhigang Wei,1 Xin Ye1 1Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, People’s Republic of China; 2Department of Pathology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, People’s Republic of China; 3Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhigang Wei; Xin Ye, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, 250014, People’s Republic of China, Email weizhigang321321@163.com; yexintaian2020@163.comPurpose: Microwave ablation (MWA) is a minimally invasive technique for treating lung cancer. It can induce immune response; however, its effect on the immune microenvironment in tumor-draining lymph nodes (TdLN) is not well understood. This study aims to identify changes in the immune microenvironment in TdLN following MWA in a Lewis lung cancer (LLC) mouse model.Methods: LLC mouse model was established and followed by MWA. TdLN were collected at various time points, including pre-MWA and days 1, 2, 4, and 8 post-MWA. Flow cytometry was used to determine the frequencies of CD4+ T cells, CD8+ T cells, regulatory T (Treg) cells, natural killer (NK) cells, dendritic cells (DCs) and other immune cells in the TdLN. Certain cytokines were also detected.Results: Compared with pre-MWA, the frequency of CD4+ T cells significantly increased from day 1 to day 8 post-MWA. The frequency of CD8+ T cells decreased significantly on days 2 and 4, but no significant changes occurred on days 1 and 8. Significant decreases in the frequencies of Treg cells and Klrg1+ Treg cells were observed from day 1 to day 4. On days 4 and 8, there was a significant increase in the frequency of NK cells. The frequency of resident cDC2 significantly increased on day 4, whereas CD11b+ migratory cDCs increased on day 1. Additionally, on day 4, a notable rise was observed in the frequency of NK cells secreting IFN-γ, while on day 8, there was a significant increase in the frequency of CD8+ T cells secreting both IFN-γ and TNF-α.Conclusion: MWA of lung cancer can alter the immune microenvironment in the TdLN, triggering immune responses. These changes are particularly evident and intricate within the initial 4 days post-MWA. Treatment combined with MWA within a certain period may significantly enhance anti-tumor immunity.Keywords: microwave ablation, lung cancer, T cells, regulatory T cells, natural killer cells, dendritic cells

Published
2024

15. Improving Lower Limb Function and Frailty in Frail Older Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention: A Randomized Controlled Study of Neuromuscular Electrical Stimulation

Author

Pu X, Huang H, Zhao X, Liu F, Leng Y, Deng Y, Huang L, Zhou X, Xu F, Huang Y, and Guo S

Subjects
acute myocardial infarction, older, frailty, neuromuscular electrical stimulation, pci, Geriatrics, RC952-954.6
Abstract

Xiamin Pu,1 Houqiang Huang,2 Xiaolei Zhao,3 Feng Liu,1 Yebo Leng,4 Ya Deng,5 Lingyi Huang,5 Xingchen Zhou,5 Fen Xu,1 Yongli Huang,6 Shengmin Guo2 1Department of Cardiovascular Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 2Department of Nursing, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 3Department of Hematology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 4Department of Orthopedics, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 5School of Nursing, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 6Department of Outpatient, The Affiliated Hospital, Southwest Medical University, Luzhou, People’s Republic of ChinaCorrespondence: Shengmin Guo, Department of Nursing, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, People’s Republic of China, Tel +86-13980255653, Email 2930773281@qq.comBackground: A global public health problem, frailty is closely associated with poor prognosis after percutaneous coronary intervention (PCI) in older patients with acute myocardial infarction (AMI). Although exercise intervention is the most commonly used method to reverse and alleviate frailty, its application is restricted in patients with acute myocardial infarction following PCI due to cardiovascular instability and autonomic imbalance. Consequently, there is a need for a new practical intervention to address frailty syndrome in these patients.Purpose: This study aimed to investigate the effect of neuromuscular electrical stimulation in frail older AMI patients post-PCI.Patients and Methods: A single-blind, randomized controlled trial was carried out in the Department of Cardiovascular Medicine from March to October 2023. A total of 100 eligible participants were randomly divided into two groups: experimental (n = 50) and control (n = 50) groups, respectively. Both groups received usual care. The experimental group underwent neuromuscular electrical stimulation (NMES) on bilateral quadriceps and gastrocnemius muscles for 30 minutes daily from day 1 to day 7 after surgery. The primary outcomes measured included the frailty score, lower limb muscle strength, and lower limb muscle quality. Secondary outcomes included the activities of daily living score, inflammatory markers, and length of hospital stay. All participants were included in an intention-to-treat analysis after the study ended.Results: The frailty scores of the two groups exhibited a gradual decrease over time, and the scores of the experimental group were lower than those of the control group at 4 and 7 days after surgery (P< 0.001). Concurrently, the lower limb muscle strength showed an increasing trend over the time in the experimental group and a decreasing trend in the control group, and the scores of the experimental group surpassed those of the control group (p< 0.001). Moreover, a statistical difference was observed in the lower limb muscle mass across the groups after 7 days postoperatively compared with baseline on both sides (p< 0.05).Conclusion: Neuromuscular electrical stimulation has the potential to enhance lower limb function and alleviate frailty in elderly patients with acute myocardial infarction after PCI. These findings introduce a novel intervention approach for frailty management in the elderly population.Keywords: acute myocardial infarction, older, frailty, neuromuscular electrical stimulation, PCI

Published
2024

16. Complex valence-space effective operators for observables: the Gamow-Teller transition

Author

Xu, Z. C., Zhang, S., Li, J. G., Jin, S. L., Yuan, Q., Cheng, Z. H., Michel, N., and Xu, F. R.

Subjects
Nuclear Theory
Abstract

Nuclei in the vicinity of driplines have been receiving a lot of attention in nuclear structure studies. In the nuclei, the continuum coupling is crucial in reproducing weakly-bound and unbound phenomena. To calculate observables of the nuclei as open quantum systems, we have developed valence-space effective operators in the complex-energy Berggren basis using many-body perturbation theory. We focus on the Gamow-Teller $\beta$ decay in the {\it sd} shell. The two- plus three-nucleon force from the chiral effective field theory (EFT), named EM1.8/2.0, has been used. The Gamow shell model which takes the continuum coupling into account can properly reproduce experimental observations of weakly-bound and unbound states. The $\beta$-decay isospin asymmetry between the dripline nucleus $^{22}\rm Si$ and its mirror partner $^{22}\rm O$ is reproduced, in which the $s_{1/2}$ continuum plays a key role. Significant Thomas-Ehrman shift is seen through mirror energy differences between the mirror daughters $^{22}\rm Al$ and $^{22}\rm F$, in which the continuum effect plays an important role.

Published
2023
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17. An Investigation into the Effect of the Number of the Rubber Blocks of a Resilient Wheel on Wheel-Rail Noise

Author

Zhou, Q., He, Y., Xu, F., Sheng, X., Liu, Z., Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Sheng, Xiaozhen, editor, Thompson, David, editor, Degrande, Geert, editor, Nielsen, Jens C. O., editor, Gautier, Pierre-Etienne, editor, Nagakura, Kiyoshi, editor, Kuijpers, Ard, editor, Nelson, James Tuman, editor, Towers, David A., editor, Anderson, David, editor, and Tielkes, Thorsten, editor

Published
2024
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19. STCF Conceptual Design Report: Volume 1 -- Physics & Detector

Author

Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.

Published
2023
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20. Investigation of isospin-symmetry-breaking in mirror energy difference and nuclear mass with ab initio calculations

Author

Li, H. H., Yuan, Q., Li, J. G., Xie, M. R., Zhang, S., Zhang, Y. H., Xu, X. X., Michel, N., Xu, F. R., and Zuo, W.

Subjects
Nuclear Theory
Abstract

Isospin-symmetry breaking is responsible for the energy difference of excited states in mirror nuclei. It also influences the coefficient of the isobaric multiplet mass equation. In the present work, we extensively investigate isospin-symmetry breaking in medium mass nuclei within ab initio frameworks. For this, we employ the ab initio valence-space in-medium similarity renormalization group approach, in which charge-symmetry and charge-independence breakings are included in the adopted nuclear force. The mirror energies of sd- and pf- shell nuclei are computed for that matter. The effects of single-particle states on weakly bound and unbound nuclear states, especially those of the s-wave, are discussed. Predictions are also made concerning proton drip-line nuclei bearing large mirror energy difference. Finally, the coefficient of the isobaric multiplet mass equation in T = 1/2 and T = 1 isospin multiplets for A = 18 to A = 76 is calculated.

Published
2023

22. Ab initio descriptions of $A=16$ mirror nuclei with resonance and continuum coupling

Author

Zhang, S., Xu, F. R., Li, J. G., Hu, B. S., Cheng, Z. H., Michel, N., Ma, Y. Z., Yuan, Q., and Zhang, Y. H.

Subjects
Nuclear Theory
Abstract

We have used an {\it ab initio} Gamow shell model to study the isospin symmetry breaking in the $A=16$ mirror nuclei of $^{16}$F, $^{16}$N, $^{16}$Ne and $^{16}$C. Starting from a chiral interaction with two-nucleon force (2NF) at N$^3$LO and three-nucleon force (3NF) at N$^2$LO, a complex-momentum ${\it psd}$-shell Hamiltonian was constructed by employing the many-body perturbation theory in the Gamow Hartree-Fock basis which includes bound, resonant and continuum states self-consistently. Such an elaborated {\it ab initio} Gamow shell model with both continuum coupling and 3NF included can properly treat the many-body correlations of weakly bound and unbound nuclei. The mirror partners of $^{16}$F and $^{16}$N exhibit different level orders in their excitation spectra, which can be well explained by the inclusion of 3NF in the calculation. The isospin asymmetry between the mirror partners $^{16}$Ne and $^{16}$C was studied in detail by insight into their configuration structures. The interplay between 3NF and the continuum coupling is discussed in the weakly bound and unbound nuclear states., Comment: 7 pages, 4 figures

Published
2023
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23. ATOMS: ALMA Three-millimeter Observations of Massive Star-forming regions -XIII. Ongoing triggered star formation within clump-fed scenario found in the massive ($\sim1500$ $\rm M_\odot$) clump

Author

Zhang, S., Wang, K., Liu, T., Zavagno, A., Juvela, M., Liu, H., Tej, A., Stutz, A. M., Li, S., Bronfman, L., Zhang, Q., Goldsmith, P. F., Lee, C. W., Vázquez-Semadeni, E., Tatematsu, K., Jiao, W., Xu, F., Wang, C., and Zhou, J. -W.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

Whether ionization feedback triggers the formation of massive stars is highly debated. Using ALMA 3 mm observations with a spatial resolution of $\sim 0.05$ pc and a mass sensitivity of 1.1 $\rm M_\odot$ beam$^{-1}$ at 20 K, we investigate the star formation and gas flow structures within the ionizing feedback-driven structure, a clump-scale massive ($\gtrsim 1500$ $\rm M_\odot$) bright-rimmed cloud (BRC) associated with IRAS 18290-0924. This BRC is bound only if external compression from ionized gas is considered. A small-scale ($\lesssim1$ pc) age sequence along the direction of ionizing radiation is revealed for the embedded cores and protostars, which suggests triggered star formation via radiation-driven implosion (RDI). Furthermore, filamentary gas structures converge towards the cores located in the BRC's center, indicating that these filaments are fueling mass towards cores. The local core-scale mass infall rate derived from H$^{13}$CO$^+$ $J=1-0$ blue profile is of the same order of magnitude as the filamentary mass inflow rate, approximately 1 $\rm M_\odot$ kyr$^{-1}$. A photodissociation region (PDR) covering the irradiated clump surface is detected in several molecules, such as CCH, HCO$^+$, and CS whereas the spatial distribution stratification of these molecules is indistinct. CCH spectra of the PDR possibly indicate a photoevaporation flow leaving the clump surface with a projected velocity of $\sim2$ km s$^{-1}$. Our new observations show that RDI accompanied by a clump-fed process is operating in this massive BRC. Whether this combined process works in other massive BRCs is worth exploring with dedicated surveys., Comment: 34 pages with 20 figures, Accepted by MNRAS on 2022 December 28

Published
2023
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24. Nomogram for Predicting Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with Insulin Pump During Enteral Nutrition

Author

Wu J, Zhou Y, Lu X, Zhao W, and Xu F

Subjects
t2dm, hypoglycemia, enteral nutrition, insulin pump therapy, nomograms, Specialties of internal medicine, RC581-951
Abstract

Jufei Wu,1,&ast; Jishi Wu,2,&ast; Yan Zhou,3 Xiaohua Lu,4 Wane Zhao,4 Fengmei Xu1 1Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 2Department of General Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 3Department of Interventional Radiology & Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 4Department of Endocrinology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Zhou, Department of Interventional Radiology & Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China, Email 992054881@qq.com Xiaohua Lu, Department of Endocrinology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China, Email yhlu@163.comPurpose: To develop a prediction model for hypoglycemia in type 2 diabetes mellitus (T2DM) patients treated with an insulin pump during enteral nutrition.Methods: This retrospective study included T2DM patients treated with an insulin pump during enteral nutrition at the First Affiliated Hospital of Jinan University, Guangzhou Red Cross Hospital, Foshan First People’s Hospital, and Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2016 and December 2023. The patients were randomized 3:1 to the training and validation sets. The risk factors for hypoglycemia were analyzed. A prediction model was developed.Results: This study included 122 patients, and 57 patients had at least one hypoglycemic event during their hospitalization (46.72%). The multivariable logistic regression analysis showed that the time to reach the glycemic targets (odds ratio (OR)=1.408, 95% confidence interval (CI)=1.084– 1.825, P=0.006), average glycemia (OR=0.387, 95% CI=0.233– 0.643, P=0.010), coronary heart disease (OR=0.089, 95% CI=0.016– 0.497, P< 0.001), and the administration of hormone therapy (OR=6.807, 95% CI=1.128– 41.081, P=0.037) were independently associated with hypoglycemia. A nomogram was built. The receiver operating characteristics analysis showed that the area under the curve of the model was 0.872 (95% CI=0.0.803– 0.940) for the training set and 0.839 (95% CI=0.688– 0.991) in the validation set.Conclusion: A nomogram was successfully built to predict hypoglycemia in T2DM patients treated with an insulin pump during enteral nutrition, based on the time to reach the glycemic targets, average glycemia, coronary heart disease, and the administration of hormone therapy.Keywords: T2DM, hypoglycemia, enteral nutrition, insulin pump therapy, nomograms

Published
2024

25. Preparation of Hematoporphyrin-Poly(Lactic Acid) Nanoparticles Encapsulated Perfluoropentane/Salicylic Acid for Enhanced US/CEST MR Bimodal Imaging

Author

Ding L, Xu F, Luo B, Cheng L, Huang L, Jia Y, and Ding J

Subjects
contrast agent, perfluoropentane, salicylic acid, ultrasound imaging, chemical exchange saturation transfer, Medicine (General), R5-920
Abstract

Liqiong Ding,1,&ast; Fengnan Xu,1,&ast; Binhua Luo,1,&ast; Liyuan Cheng,1 Lingping Huang,2 Yanlong Jia,3 Jieqiong Ding1 1Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei Province, People’s Republic of China; 2Department of Medical Ultrasound, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei Province, People’s Republic of China; 3Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yanlong Jia, Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, 441021, People’s Republic of China, Tel +86 13669006180, Email yanlongjia@163.com Jieqiong Ding, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei Province, 437100, People’s Republic of China, Tel +86 13797244300, Email djq197911@163.comBackground: Medical imaging modalities, such as magnetic resonance imaging (MRI), ultrasound, and fluorescence imaging, have gained widespread acceptance in clinical practice for tumor diagnosis. Each imaging modality has its own unique principles, advantages, and limitations, thus necessitating a multimodal approach for a comprehensive disease understanding of the disease process. To enhance diagnostic precision, physicians frequently integrate data from multiple imaging modalities, driving research advancements in multimodal imaging technology research.Methods: In this study, hematoporphyrin-poly (lactic acid) (HP-PLLA) polymer was prepared via ring-opening polymerization and thoroughly characterized using FT-IR, 1H-NMR, XRD, and TGA. HP-PLLA based nanoparticles encapsulating perfluoropentane (PFP) and salicylic acid were prepared via emulsion-solvent evaporation. Zeta potential and mean diameter were assessed using DLS and TEM. Biocompatibility was evaluated via cell migration, hemolysis, and cytotoxicity assays. Ultrasonic imaging was performed with a dedicated apparatus, while CEST MRI was conducted using a 7.0 T animal scanner.Results: We designed and prepared a novel dual-mode nanoimaging probe SA/PFP@HP-PLLA NPs. PFP enhanced US imaging, while salicylic acid bolstered CEST imaging. With an average size of 74.43 ± 1.12 nm, a polydispersity index of 0.175 ± 0.015, and a surface zeta potential of − 64.1 ± 2.11 mV. These NPs exhibit excellent biocompatibility and stability. Both in vitro and in vivo experiments confirmed the SA/PFP@HP-PLLA NP’s ability to improve tumor characterization and diagnostic precision.Conclusion: The SA/PFP@HP-PLLA NPs demonstrate promising dual-modality imaging capabilities, indicating their potential for preclinical and clinical use as a contrast agent.Keywords: contrast agent, perfluoropentane, salicylic acid, ultrasound imaging, chemical exchange saturation transfer

Published
2024

26. Novel Carbon Dots Derived from Moutan Cortex Significantly Improve the Solubility and Bioavailability of Mangiferin

Author

Kong C, Wang K, Sun L, Zhao H, Wang T, Zhou W, Wu D, and Xu F

Subjects
moutan cortex, carbon dots, mangiferin, solubility, bioavailability, Medicine (General), R5-920
Abstract

Chuihao Kong,1,2,&ast; Kaidi Wang,1,2,&ast; Lei Sun,1,3 Hongsu Zhao,1,2 Tongsheng Wang,1 Wuxi Zhou,1 Deling Wu,1,2 Fengqing Xu1,2 1School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China; 2Anhui Province Key Laboratory of New Manufacturing Technology for Traditional Chinese Medicine Decoction Pieces, Hefei, 230012, People’s Republic of China; 3Zhejiang CONBA Pharmaceutical Co. LTD, Hangzhou, 310052, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wuxi Zhou; Fengqing Xu, School of Pharmacy, Anhui University of Chinese Medicine, 350 Longzihu Road, Xinzhan District, Hefei, 230012, People’s Republic of China, Email zhouwuxi@ahtcm.edu.cn; xufengqing@ahtcm.edu.cnBackground: Mangiferin (MA), a bioactive C-glucosyl xanthone with a wide range of interesting therapeutic properties, has recently attracted considerable attention. However, its application in biomedicine is limited by poor solubility and bioavailability. Carbon dots (CDs), novel nanomaterials, have immense promise as carriers for improving the biopharmaceutical properties of active components because of their outstanding characteristics.Methods: In this study, a novel water-soluble carbon dot (MC-CDs) was prepared for the first time from an aqueous extract of Moutan Cortex Carbonisata, and characterized by various spectroscopies, zeta potential and high-resolution transmission electron microscopy (HRTEM). The toxicity effect was investigated using the CCK-8 assay in vitro. In addition, the potential of MC-CDs as carriers for improving the pharmacokinetic parameters was evaluated in vivo.Results: The results indicated that MC-CDs with a uniform spherical particle size of 1– 5 nm were successfully prepared, which significantly increased the solubility of MA in water. The MC-CDs exhibited low toxicity in HT-22 cells. Most importantly, the MC-CDs effectively affected the pharmacokinetic parameters of MA in normal rats. UPLC-MS analysis indicated that the area under the maximum blood concentration of MA from mangiferin-MC-CDs (MA-MC-CDs) was 1.6-fold higher than that from the MA suspension liquid (MA control) after oral administration at a dose of 20 mg/kg.Conclusion: Moutan Cortex-derived novel CDs exhibited superior performance in improving the solubility and bioavailability of MA. This study not only opens new possibilities for the future clinical application of MA but also provides evidence for the development of green biological carbon dots as a drug delivery system to improve the biopharmaceutical properties of insoluble drugs. Keywords: Moutan Cortex, carbon dots, mangiferin, solubility, bioavailability

Published
2024

27. Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial

Author

Chen Y, Li WX, Wu JH, Chen GH, Yang CM, Lu H, Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Hong RX, Jiang KK, Zhong YY, Zhang G, Tienchaiananda P, Oikawa M, Yuan ZY, and Chen QJ

Subjects
adjuvant chemotherapy, capecitabine, sysucc-001, triple-negative breast cancer, tnbc, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Ying Chen,1,2,&ast; Wen-Xia Li,1,2,&ast; Jia-Hua Wu,1,2 Geng-Hang Chen,2 Chun-Min Yang,1,2 Hai Lu,1,2 Xi Wang,3 Shu-Sen Wang,4 Heng Huang,5 Li Cai,6 Li Zhao,7 Rou-Jun Peng,8 Ying Lin,9 Jun Tang,3 Jian Zeng,10 Le-Hong Zhang,11 Yong-Li Ke,12 Xian-Ming Wang,13 Xin-Mei Liu,14 An-Qin Zhang,15 Fei Xu,4 Xi-Wen Bi,4 Jia-Jia Huang,4 Ji-Bin Li,16 Dan-Mei Pang,17 Cong Xue,4 Yan-Xia Shi,4 Zhen-Yu He,18 Huan-Xin Lin,18 Xin An,4 Wen Xia,4 Ye Cao,16 Ying Guo,16 Ruo-Xi Hong,4 Kui-Kui Jiang,4 Yong-Yi Zhong,4 Ge Zhang,19 Piyawan Tienchaiananda,20 Masahiro Oikawa,21 Zhong-Yu Yuan,4 Qian-Jun Chen22,23 1Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3Department of Breast Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 5Department of Breast Oncology, Lianjiang People’s Hospital, Lianjiang, People’s Republic of China; 6Department of Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, People’s Republic of China; 7Department of Breast Oncology, Guangzhou First People Hospital, Guangzhou, People’s Republic of China; 8Department of Integrated Therapy in Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 9Department of Breast Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 10Department of Breast Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 11Department of Breast Oncology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 12Department of Breast Oncology, General Hospital of PLA Guangzhou Military Area, Guangzhou, People’s Republic of China; 13Department of Breast Oncology, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of China; 14Department of Breast Oncology, Haikou People’s Hospital, Haikou, People’s Republic of China; 15Department of Breast Oncology, Maternal and Child Health Care Hospital of Guangdong Province, Guangzhou, People’s Republic of China; 16Department of Good Clinical Practice, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 17Department of Medical Oncology, Foshan First People’s Hospital, Foshan, People’s Republic of China; 18Department of Radiotherapy, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 19Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong; 20Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand; 21The Department of Breast Surgery, New-wa-kai Oikawa Hospital, Fukuoka, Japan; 22State Key Laboratory of Traditional Chinese Medicine Syndrome/Departments of Gynecologic Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 23State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qian-Jun Chen, 55N, Neihuanxi Road, Guangzhou, Guangdong, 510006, People’s Republic of China, Tel +86 1868883505, Email cqj55@163.com Zhong-Yu Yuan, 651 Dongfeng Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13798027658, Email yuanzhy@sysucc.org.cnPurpose: Results from studies of extended capecitabine after the standard adjuvant chemotherapy in early stage triple-negative breast cancer (TNBC) were inconsistent, and only low-dose capecitabine from the SYSUCC-001 trial improved disease-free survival (DFS). Adjustment of the conventional adjuvant chemotherapy doses affect the prognosis and may affect the efficacy of subsequent treatments. This study investigated whether the survival benefit of the SYSUCC-001 trial was affected by dose adjustment of the standard adjuvant chemotherapy or not.Patients and Methods: We reviewed the adjuvant chemotherapy regimens before the extended capecitabine in the SYSUCC-001 trial. Patients were classified into “consistent” (standard acceptable dose) and “inconsistent” (doses lower than acceptable dose) dose based on the minimum acceptable dose range in the landmark clinical trials. Cox proportional hazards model was used to investigate the impact of dose on the survival outcomes.Results: All 434 patients in SYSUCC-001 trial were enrolled in this study. Most of patients administered the anthracycline-taxane regimen accounted for 88.94%. Among patients in the “inconsistent” dose, 60.8% and 47% received lower doses of anthracycline and taxane separately. In the observation group, the “inconsistent” dose of anthracycline and taxane did not affect DFS compared with the “consistent” dose. Moreover, in the capecitabine group, the “inconsistent” anthracycline dose did not affect DFS compared with the “consistent” dose. However, patients with “consistent” taxane doses benefited significantly from extended capecitabine (P=0.014). The sufficient dose of adjuvant taxane had a positive effect of extended capecitabine (hazard ratio [HR] 2.04; 95% confidence interval [CI] 1.02 to 4.06).Conclusion: This study found the dose reduction of adjuvant taxane might negatively impact the efficacy of capecitabine. Therefore, the reduction of anthracycline dose over paclitaxel should be given priority during conventional adjuvant chemotherapy, if patients need dose reduction and plan for extended capecitabine.Keywords: adjuvant chemotherapy, capecitabine, SYSUCC-001, triple-negative breast cancer, TNBC

Published
2024

28. System Modeling and Operational Characteristic Analysis for an Orbital Friction Vibration Actuator Used in Orbital Vibration Welding

Author

XU, F., HU, J., LI, Y., ZOU, J., XU, Y., and SHANG, J.

Subjects
actuator, welding, electromagnetic forces, finite element methods, motion analysis, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Computer engineering. Computer hardware, TK7885-7895
Abstract

Orbital Friction Vibration Actuator (OFVA) is a core component of Orbital Friction Welding (OFW), which is a novel apertureless welding technology utilizing friction heat to implement solid-state joining. In this paper, topology and operational principle of OFVA are introduced, the analytical formulas of the electromagnetic force for the x and y directions, which can drive the mover to generate a circular motion trajectory, are derived, and the characteristic of static electromagnetic force is predicted by analytical method and 2-D (two-dimensional) FEM (finite element method), 3-D and measurement. The coupled magnetic field-circuit-motion simulation models which are driven by current and voltage source are established, respectively, and some of its operational characteristics are analyzed. Simulation and experiment validate theoretical analysis and the feasibility of the fabricated prototype, demonstrate the good performance of the OFVA, and provide valuable reference for engineering applications.

Published
2013
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30. Causal Relationship of Obstructive Sleep Apnea with Bone Mineral Density and the Role of BMI

Author

Xu F, Zhang X, Zhang Y, Chen W, and Liao Z

Subjects
obstructive sleep apnea, bone mineral density, bmi, mendelian randomization., Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Fei Xu,1 XiuRong Zhang,2 YinRong Zhang,1 WenHui Chen,3 ZiCong Liao1 1General Surgery Department, Zhongshan Boai Hospital, Zhongshan, Guangdong, 528400, People’s Republic of China; 2Breast Surgery Department, Zhongshan Boai Hospital, Zhongshan, Guangdong, 528400, People’s Republic of China; 3Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, People’s Republic of ChinaCorrespondence: ZiCong Liao, General Surgery Department, Zhongshan Boai Hospital affiliated to Southern Medical University, No. 6 Chenggui Road, East Street, Zhongshan, Guangdong, 528400, People’s Republic of China, Tel +86 76088776658, Email dr_liaozc@163.com WenHui Chen, Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, Guangdong, 510630, People’s Republic of China, Tel +86 13129349492, Fax +86 20 38688608, Email jnucwh2019@163.comBackground: Observational studies have yielded conflicting evidence concerning the relationships between obstructive sleep apnea (OSA) and bone mineral density (BMD). As the exact causal inferences remain inconclusive, we conducted a two-sample Mendelian randomization (MR) to identify the causal associations between OSA and BMD.Methods: Single-nucleotide polymorphisms associated with OSA were extracted from the FinnGen study. Summary statistics for 10 BMD measured at different age or skeletal sites were obtained from the publicly available IEU GWAS database. Inverse-variance weighted (IVW) method was chosen as the primary analysis, combined with several sensitivity analyses to evaluate the robustness of results. The study design included two-sample MR and network MR.Results: Our primary MR analysis revealed that genetically predicted OSA was positively linked to increased forearm BMD (β = 0.24, 95% confidence interval [CI]: 0.06– 0.41, p = 0.009) and heel BMD (β=0.10, 95% CI = 0.02– 0.18, p = 0.018), while no significant causal relationships were observed between OSA and total body BMD, lumbar spine BMD, or femoral neck BMD (all p > 0.05). Network MR suggests that OSA might act as a mediating factor in the effect of BMI on forearm BMD and heel BMD, with a mediated portion estimated at 73% and 84%, respectively.Conclusion: Our findings provide support for a causal relationship between genetically predicted OSA and increased forearm BMD and heel BMD. Furthermore, our results suggest that OSA may play a role in mediating the influence of BMI on BMD.Keywords: obstructive sleep apnea, bone mineral density, BMI, Mendelian randomization

Published
2024

31. Oriented Graphene Oxide Scaffold Promotes Nerve Regeneration in vitro and in vivo

Author

Zhou X, Tang A, Xiong C, Zhang G, Huang L, and Xu F

Subjects
nanofibers, topographical guidance, electroactive, graphene oxide, nerve regeneration., Medicine (General), R5-920
Abstract

Xu Zhou,1,2,&ast; Aolin Tang,2,3,&ast; Chengjie Xiong,2,&ast; Guoquan Zhang,2 Liangliang Huang,1,2 Feng Xu1,2 1The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, People’s Republic of China; 2Department of Orthopaedics, General Hospital of Central Theater Command, Wuhan, 430070, People’s Republic of China; 3Department of Orthopaedics, Minda Hospital of Hubei Minzu University, Enshi, 445000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Liangliang Huang; Feng Xu, Department of Orthopaedics, General Hospital of Central Theater Command, Wuhan, 430070, People’s Republic of China, Email hll666789@163.com; fengxu1969@163.comBackground: Treating peripheral nerve injuries (PNI) with defects remains challenging in clinical practice. The commercial conduits have shown suboptimal nerve regeneration and functional recovery due to their basic tubular design without electroactive and oriented topographical cues.Purpose: To develop a new scaffold with oriented microstructure and electroactive Graphene oxide (GO) and investigate its’ therapeutic effect on nerve regeneration in vitro and in vivo.Methods: This study employed a straightforward approach to co-spin PCL and GO, yielding an oriented hybrid nanofibrous scaffold known as the O-GO/PCL scaffold. The physical and chemical properties of nanofibrous scaffold were tested by scanning electron microscopy (SEM), transmission electron microscope (TEM), tensile test and so on. Primary Schwann cells (SCs) and dorsal root ganglia (DRG) were used to investigate the impact of the newly developed scaffolds on the biological behavior of neural cells in vitro. Transcriptome sequencing (mRNA-seq) was employed to probe the underlying mechanisms of the synergistic effect of electroactive GO and longitudinal topographic guidance on nerve regeneration. Furthermore, the developed O-GO/PCL scaffold was utilized to bridge a 10-mm sciatic nerve defect in rat, aiming to investigate its therapeutic potential for peripheral nerve regeneration in vivo.Results and discussion: The SEM and TEM revealed that the newly developed O-GO/PCL scaffold showed longitudinally oriented microstructure and GO particles were homogenously and uniformly distributed inside the nanofibers. Primary SCs were utilized to assess the biocompatibility of the GO-based scaffold, revealing that negligible cytotoxicity when GO concentration does not exceed 0.5%. In vitro analysis of nerve regeneration demonstrated that axons in the O-GO/PCL group exhibited an average length of 1054.88 ± 161.32 μm, significant longer than those in the other groups (P < 0.05). Moreover, mRNA sequencing results suggested that the O-GO/PCL scaffold could enhance nerve regeneration by upregulating genes associated with neural regeneration, encompassing ion transport, axon guidance and cell–cell interactions. Most importantly, we employed the O-GO/PCL scaffold to repair a 10-mm sciatic nerve defect in rat, resulting in augmented nerve regeneration, myelination, and functional recovery.Conclusion: The O-GO/PCL scaffold with oriented microstructure and electroactive GO represents a promising heral nerve reconstruction. Keywords: nanofibers, topographical guidance, electroactive, graphene oxide, nerve regeneration

Published
2024

32. The Effectiveness of Cognitive Behavioral Therapy-Based Intervention on Improving Sleep-Related Outcomes for People with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author

Wang H, Li R, Ge L, Xu F, Wiley JA, Tang S, and Sun M

Subjects
diabetes, cognitive behavioral therapy, sleep, systematic review, meta-analysis, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Hongjuan Wang,1 Rongzhi Li,1 Lin Ge,2 Fan Xu,1 James Allen Wiley,3 Siyuan Tang,1 Mei Sun1,4 1Xiangya School of Nursing, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of Alcohol Addiction and Internet Addiction, Brain Hospital of Hunan Province (The Second People’s Hospital of Hunan Province), Changsha, Hunan Province, People’s Republic of China; 3Department of Family and Community Medicine and Institute for Health Policy Research, University of California, San Francisco, CA, USA; 4School of Nursing, Changsha Medical University, Changsha, Hunan Province, People’s Republic of ChinaCorrespondence: Siyuan Tang; Mei Sun, Xiangya School of Nursing, Central South University, Changsha, Hunan Province, 410013, People’s Republic of China, Email sytang263@csu.edu.cn; smnjw2008@126.comBackground: Sleep-related outcomes in people with diabetes are poor, which is closely linked to reducing the development of diabetes. Cognitive behavioral therapy (CBT) based intervention presents innovative solutions that can help improve sleep-related outcomes.Aim: This synthesis aims to assess the effectiveness of CBT-based intervention compared to controls in Randomized Controlled Trials (RCTs) for sleep-related outcomes among people with diabetes.Methods: Eight electronic databases were systematically searched: PubMed, EMBASE, Cochrane library, Web of Science, PsycINFO, CINAHL, China National Knowledge Infrastructure (CNKI), and Wan Fang database. We examined CBT-based intervention’s effectiveness on sleep-related outcomes in people with diabetes in RCTs identified in these databases from their inception to 1st November 2023, and updated on 15 January 2024. The risk of bias was assessed using the Cochrane Risk of Bias tool by two reviewers. The meta-analysis of included studies was conducted by RevMan 5.3 software.Results: Seven studies in total (n = 2633 participants) were included in this systematic review based on our inclusion criteria. The systematic review found CBT-based intervention significantly improved sleep quality (Pittsburgh Sleep Quality Index, PSQI scores) at immediate post-intervention [95% CI=(− 1.31 to -0.32), p = 0.001], six months [95% CI=(− 0.75 to − 0.22), p = 0.0003], and 12 months [95% CI=(− 0.72 to − 0.24), < 0.0001], compared to control groups. Furthermore, our findings demonstrated that six sessions [95% CI= (− 0.38 to − 0.13), p < 0.0001] or more than six sessions [95% CI=(− 1.76 to − 0.02), p = 0.05] of CBT-based intervention could improve sleep quality compared to controls (I2=0%). Interestingly, CBT-based intervention improves total sleep time at post-intervention in people with diabetes compared to the control group [95% CI= (− 0.57 to − 0.12), p = 0.003]. However, there was no significant that CBT-based intervention is beneficial to time to fall asleep [95% CI (− 1.89 to 0.43), p = 0.22] and sleep efficiency [95% CI (− 1.27 to 0.27), p = 0.20] after intervention, compared to control group.Conclusion: CBT-based intervention appears to have a beneficial effect on improving sleep quality and total sleep time among people with diabetes. CBT-based intervention could be considered a strategy among healthcare providers to enhance sleep quality and total sleep time for people with diabetes. More RCTs with rigorous designs and long-term follow-up are warranted to provide conclusive evidence of the CBT-based intervention on sleep-related outcomes and to explore the mechanisms by which the CBT-based interventions improve sleep-related outcomes.Keywords: diabetes, cognitive behavioral therapy, sleep, systematic review, meta-analysis

Published
2024

33. Low Levels of Metrnl are Linked to the Deterioration of Diabetic Kidney Disease

Author

Chen J, Li ZY, Xu F, Wang CQ, Li WW, Lu J, and Miao CY

Subjects
diabetic kidney disease, urinary albumin/creatinine ratio, metrnl, albumin/globulin, Specialties of internal medicine, RC581-951
Abstract

Jin Chen,1,2,&ast; Zhi-Yong Li,2,&ast; Fei Xu,2,&ast; Chao-Qun Wang,1 Wen-Wen Li,1 Jin Lu,1 Chao-Yu Miao2 1Department of Endocrinology and Metabolism, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, People’s Republic of China; 2Department of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chao-Yu Miao, Department of Pharmacology, Second Military Medical University/Naval Medical University, 325 Guo He Road, Shanghai, 200433, People’s Republic of China, Email cymiao@smmu.edu.cn Jin Lu, Department of Endocrinology and Metabolism, Changhai Hospital, Second Military Medical University/Naval Medical University, 168 Chang Hai Road, Shanghai, 200433, People’s Republic of China, Email lujin-sh@139.comObjective: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Metrnl is a secreted protein that plays an important role in kidney disease. The aim of this study was to investigate DKD-related factors and the correlation between serum Metrnl levels and the severity of DKD.Methods: Ninety-six type 2 diabetes mellitus (T2DM) patients and 45 DKD patients were included in the study. A range of parameters were measured simultaneously, including waist-to-hip ratio (WHR), body mass index (BMI), urinary albumin/creatinine ratio (UACR), monocyte–lymphocyte ratio (MLR), albumin/globulin (A/G), liver and kidney function, blood lipid profile, islet function, and others. Subsequently, the related factors and predictive significance of DKD were identified. The correlation between the relevant factors of DKD and serum Metrnl levels with DKD was evaluated.Results: The duration of the disease (OR: 1.12, 95% CI: 1.01– 1.24, P=0.031), hypertension (OR: 4.86, 95% CI: 1.16– 20.49, P=0.031), fasting blood glucose (OR: 1.23, 95% CI: 1.03– 1.48, P=0.025), WHR (OR: 2.53, 95% CI: 1.03– 6.22, P=0.044), and MLR (OR: 1.91, 95% CI: 1.18– 3.08, P=0.008) are independent risk factors for DKD (P < 0.05). Conversely, A/G (OR: 0.13, 95% CI: 0.02– 0.76, P=0.024) and Metrnl (OR: 0.99, 95% CI: 0.98– 1.00, P=0.001) have been identified as protective factors against DKD. Furthermore, the level of Metrnl was negatively correlated with the severity of DKD (rs=− 0.447, P< 0.001). The area under receiver operating characteristic (ROC) curves for the diagnostic accuracy of Metrnl for DKD is 0.765 (95% CI: 0.686– 0.844).Conclusion: The duration of the disease, hypertension, fasting blood glucose, WHR, and MLR are major risk factors for DKD. Metrnl and A/G are protective factors for DKD. Serum Metrnl concentrations are inversely correlated with DKD severity.Keywords: diabetic kidney disease, urinary albumin/creatinine ratio, Metrnl, albumin/globulin

Published
2024

34. Can Lipid-Lowering Drugs Reduce the Risk of Cholelithiasis? A Mendelian Randomization Study

Author

Dong H, Chen R, Xu F, and Cheng F

Subjects
cholelithiasis, lipid-lowering drugs, mendelian randomization analysis, hmgcr inhibitors, pcsk9 inhibitors, npc1l1 inhibitors., Infectious and parasitic diseases, RC109-216
Abstract

Hao Dong,1,&ast; Rong Chen,2,&ast; Fang Xu,3,&ast; Fang Cheng4 1Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 3Clinical Medical Laboratory Center, Taizhou People’s Hospital, Taizhou, Jiangsu, 225300, People’s Republic of China; 4Department of Gastroenterology, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430023, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fang Cheng, Department of Gastroenterology, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, No. 1 Yintan Road, Dongxihu District, Wuhan, 430023, Hubei Province, People’s Republic of China, Email 13886178189@163.comBackground and Aims: Cholelithiasis etiology intricately involves lipid metabolism. We sought to investigate the plausible causal link between genetically proxied lipid-lowering medications—specifically HMGCR inhibitors, PCSK9 inhibitors, and NPC1L1 inhibitors—and cholelithiasis risk.Methods: Our study utilized two genetic instruments for exposure to lipid-lowering drugs. These instruments encompassed genetic variants linked to low-density lipoprotein (LDL) cholesterol within or in proximity to drug target genes, along with loci governing gene expression traits of these targets. Effect estimates were derived through Inverse-variance-weighted MR (IVW-MR) and summary-data-based MR (SMR) methods.Results: Higher HMGCR-mediated LDL cholesterol levels (IVW-MR, OR = 2.15, 95% CI = 1.58– 2.94; P = 0.000) and increased HMGCR expression (SMR, OR = 1.19, 95% CI = 1.04– 1.37; P = 0.014) are linked to elevated cholelithiasis risk, suggesting potential benefits of HMGCR inhibition. In contrast, higher PCSK9-mediated LDL cholesterol levels (IVW-MR, OR = 0.72, 95% CI = 0.56– 0.94; P = 0.015) and increased PCSK9 expression (SMR, OR = 0.90, 95% CI = 0.82– 0.99; P = 0.035) both correlate with lower cholelithiasis risk, indicating that PCSK9 inhibition may elevate this risk. Nevertheless, no substantial link emerged between NPC1L1-mediated LDL cholesterol or NPC1L1 expression and cholelithiasis in both IVW-MR and SMR analyses.Conclusion: This MR investigation affirms the causal link between the utilization of HMGCR inhibitors and a diminished risk of cholelithiasis. Additionally, it indicates a causal link between PCSK9 inhibitors use and increased cholelithiasis risk. However, no significant correlation was found between NPC1L1 inhibitors use and cholelithiasis risk.Keywords: cholelithiasis, lipid-lowering drugs, Mendelian randomization analysis, HMGCR inhibitors, PCSK9 inhibitors, NPC1L1 inhibitors

Published
2024

35. Efficacy and Safety of Ketamine Compared with Placebo and Other Medications for Preventing Propofol Injection Pain in Adults: A Systematic Review and Meta-Analysis

Author

Wu Q, Xu F, Wang J, and Jiang M

Subjects
ketamine, pain, injection, propofol, meta-analysis, Medicine (General), R5-920
Abstract

Quantong Wu,1 Fuchao Xu,2 Jie Wang,3 Ming Jiang2 1Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Emergency Department, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Neurosurgery department, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Ming Jiang, Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Gulou District, Nanjing, Jiangsu, People’s Republic of China, Email 2021122013@stu.njmu.edu.cnPurpose: To systematically evaluate the effectiveness and safety of ketamine in preventing propofol injection pain (PIP).Patients and Methods: The electronic databases including PubMed, Embase, Web of Science, and Cochrane Library were searched from their inception until 2 August 2023. Randomized controlled trials (RCT) comparing ketamine with placebo or other interventions to alleviate PIP in adults were included. Fixed-effects or random-effects models were used to calculate pooled risk ratios (RR) and corresponding 95% confidence intervals (CI) based on the heterogeneity of the studies included.Results: Thirteen RCTs involving 2105 patients were included. In terms of reducing the incidence of PIP, ketamine is more effective than placebo (RR = 0.43, 95% CI = [0.34, 0.55], P < 0.00001), lidocaine (RR = 0.70, 95% CI = [0.55, 0.90], P = 0.005), dexmedetomidine (RR = 0.52, 95% CI = [0.40, 0.66], P < 0.00001), and thiopental (RR = 0.25, 95% CI = [0.08, 0.83], P = 0.02). In reducing the incidence of severe PIP, ketamine is superior to placebo (RR = 0.12, 95% CI = [0.08, 0.19], P < 0.00001), and lidocaine (RR = 0.34, 95% CI = [0.21, 0.56], P < 0.0001), except dexmedetomidine (RR = 0.20, 95% CI = [0.04, 1.13], P = 0.07), and thiopental (RR = 0.33, 95% CI = [0.04, 3.10], P = 0.33). Compared with mixed injection, separate injection of ketamine and propofol showed no significant difference in the incidence of PIP (RR = 0.96, 95% CI = [0.31, 3.00], P = 0.95) and severe PIP (RR = 1.19, 95% CI = [0.07, 21.29], P = 0.90). Based solely on the reports from the studies included, subanesthetic doses of ketamine are generally safe in preventing PIP.Conclusion: A subanesthetic dose of ketamine can effectively and safely reduce the incidence of PIP and severe PIP in adults, and is more effective than lidocaine, dexmedetomidine, and thiopental.Registration: PROSPERO CRD42023455093.Keywords: ketamine, pain, injection, propofol, meta-analysis

Published
2024

36. Evaluation of the Puritan Bennett™ 980 Ventilator System Safety and Performance in the Real-World Setting

Author

Roshon M, Khandhar PB, Biniwale M, Ramanathan R, Frazier TP, Xu F, Zhang L, Guan X, Wenling D, and Lambermont B

Subjects
ventilation, pb980, safety, complications, respiratory distress, critical care, Medical technology, R855-855.5
Abstract

Michael Roshon,1 Paras B Khandhar,2 Manoj Biniwale,3 Rangasamy Ramanathan,3 T Patrick Frazier,4 Feng Xu,5 Linlin Zhang,6 Xiangdong Guan,7 Dai Wenling,8 Bernard Lambermont9 1Department of Emergency Medicine, Penrose-St. Francis Health Services, Colorado, Springs, CO, USA; 2Pediatric Critical Care Medicine, Beaumont Children’s Hospital, Royal Oak, MI, USA; 3Division of Neonatology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; 4Department of Medicine, University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, AL, USA; 5Department of Intensive Care, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 6Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 7Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 8Department of Critical Care Medicine, Yancheng First People’s Hospital, Yancheng, People’s Republic of China; 9Department of Intensive Care, University Hospital of Liege, Liege, BelgiumCorrespondence: Michael Roshon, Email MichaelRoshon@Centura.OrgPurpose: Mechanical ventilation is a life-supporting intervention but is associated with known risks and complications. To improve the efficacy and safety profile of mechanical ventilation, manufacturers have developed advanced ventilator settings, modes, and alarm strategies to optimize ventilation for patient needs while avoiding complications. However, there is little real-world data published on the deployment of ventilator technology. The main objective of this study was to assess the clinical safety and performance of the Puritan Bennett™ 980 Ventilator System (PB980) using real-world clinical data collected from a diverse, global patient population.Methods: This was a multi-center, post-market registry study that included nine sites: four in the United States of America, one in Europe, and four in China. Patients were enrolled into the registry if they were intended to be treated with a PB980. Data collection began at the start of ventilation and continued until extubation off the ventilator or up to seven days of ventilation, whichever occurred first. Subjects were divided by age into three categories: infants (0– 365 days), pediatric (1– 17 years), and adult (18 years and older). The primary outcome was device-related complication rate.Results: Two-hundred-and-eleven subjects were enrolled (41 infants, 48 pediatric, and 122 adults). Sixteen deaths, unrelated to device deficiency, occurred during the data collection timeframe (relative frequency: 7.58, 95% CI: 4.40, 12.0). Only one device-related adverse event was reported (relative frequency: 0.47% 95% CI: 0.01%, 2.61%).Conclusion: Ventilation by the PB980 was delivered safely in this multi-center observational study, which included a diverse sample of patients with broad ventilatory needs.Plain Language Summary: Mechanical ventilation is a life supporting intervention. Much progress has been made in this field thanks to a better knowledge of respiratory physiopathology and improved ventilation delivered by modern ventilators.In this global, post-market registry study, ventilation by the Puritan Bennett™ 980 Ventilator was delivered safely to a diverse sample of patients.Keywords: ventilation, PB980, safety, complications, respiratory distress, critical care

Published
2024

37. Heme-Inducing Endothelial Pyroptosis Plays a Key Role in Radiofrequency Ablation of Hepatic Hemangioma Leading to Systemic Inflammatory Response Syndrome

Author

Yao C, Kong J, Xu F, Wang S, Wu S, Sun W, and Gao J

Subjects
hemangioma, radiofrequency ablation, systemic inflammatory response syndrome, pyroptosis, endothelial cells, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Changyu Yao,&ast; Jian Kong,&ast; Fei Xu, Shaohong Wang, Shilun Wu, Wenbing Sun, Jun Gao Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenbing Sun; Jun Gao, Department of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 5 Jingyuan Road, Shijingshan District, Beijing, 100043, People’s Republic of China, Tel +86-010-51718382, Fax +86-010-51718372, Email sunwenbing@bjcyh.com; gaojun8430@163.comPurpose: Systemic inflammatory response syndrome (SIRS) is a common complication of radiofrequency ablation (RFA) for hepatic hemangiomas. RFA can cause hemolytic reactions during hepatic hemangioma ablation. However, the mechanisms underlying RFA-induced SIRS remain unclear.Methods: We established an orthotopic liver hemangioma model and performed radiofrequency ablation. The levels of interleukin (IL)-1β and IL-18 and the production of ROS were measured. The wet-to-dry lung ratio, inflammation score, and in vivo endothelial cell permeability were examined. GSDMD−/− mice were used to investigate the effect of heme-inducing SIRS. RNA sequencing (RNA-seq) was performed to identify the main pathways underlying heme-induced SIRS. Western blotting and immunoprecipitation were used to determine the changes and interactions of associated proteins.Results: The levels of heme, IL-1β, and IL-18 were significantly increased after RFA. The wet-to-dry lung ratio increased in hepatic hemangiomas after RFA, indicating that SIRS occurred. Heme induced increased levels of IL-1β and IL-18, cell death, wet-to-dry lung radio, and inflammation score in vitro and in vivo, indicating that heme induced SIRS and pyroptosis. Furthermore, GSDMD participates in heme-induced SIRS in mice, and GSDMD deletion in mice reverses the effect of heme. Heme regulates NLRP3 activation through the NOX4/ROS/TXNIP-TRX pathway, and an N-acetyl-L-cysteine (NAC) or NOX4 inhibitor (GLX351322) reverses heme-induced SIRS.Conclusion: Our findings suggest that heme induces endothelial cell pyroptosis and SIRS in mice and decreasing heme levels and ROS scavengers may prevent SIRS in hepatic hemangioma after RFA. Keywords: hemangioma, radiofrequency ablation, systemic inflammatory response syndrome, pyroptosis, endothelial cells

Published
2024

38. Enhanced optoelectronic performance and photogating effect in quasi-one-dimensional BiSeI wires

Author

Hu, H. J., Zhen, W. L., Weng, S. R., Li, Y. D., Niu, R., Yue, Z. L., Xu, F., Pi, L., Zhang, C. J., and Zhu, W. K.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Physics - Optics
Abstract

Quasi-one-dimensional (quasi-1D) materials are a newly arising topic in low-dimensional researches. As a result of reduced dimensionality and enhanced anisotropy, the quasi-1D structure gives rise to novel properties and promising applications such as photodetectors. However, it remains an open question whether performance crossover will occur when the channel material is downsized. Here we report on the fabrication and testing of photodetectors based on exfoliated quasi-1D BiSeI thin wires. Compared with the device on bulk crystal, a significantly enhanced photoresponse is observed, which is manifested by a series of performance parameters, including ultrahigh responsivity (7 x 10$^4$ A W$^{-1}$), specific detectivity (2.5 x 10$^{14}$ Jones) and external quantum efficiency (1.8 x 10$^7$%) when $V_{\textrm {ds}}$ = 3 V, $\lambda$ = 515 nm and $P$ = 0.01 mW cm$^{-2}$. The conventional photoconductive effect is unlikely to account for such a superior photoresponse, which is ultimately understood in terms of the increased specific surface area and the photogating effect caused by trapping states. This work provides a perspective for the modulation of optoelectronic properties and performance in quasi-1D materials., Comment: 23 pages, 4 figures and SI

Published
2022
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39. Deformed in-medium similarity renormalization group

Author

Yuan, Q., Fan, S. Q., Hu, B. S., Li, J. G., Zhang, S., Wang, S. M., Sun, Z. H., Ma, Y. Z., and Xu, F. R.

Subjects
Nuclear Theory
Abstract

We have developed an {\it ab initio} deformed in-medium similarity renormalization group (IMSRG) for open-shell nuclei. This is a single-reference IMSRG in deformed Hartree-Fock (HF) basis. Deformed wave functions are more efficient in describing deformed nuclei. The broken spherical symmetry needs to be restored by angular momentum projection, which is computational expensive. The angular momentum mainly capture the static correlations and can be estimated by the projection of the HF state. In this work, we do deformed IMSRG calculation and add the correlation energy from projected HF as a leading order approximation. As the test ground, we have calculated the deformed $^{8,10}\rm Be$ isotopes with the optimized chiral interaction NNLO$_{\rm opt}$. The results are benchmarked with the no-core shell model and valence space IMSRG calculations. Then we systematically investigated the ground-state energies and charge radii of even-even isotopes from light beryllium to medium-mass magnesium. The calculated energies are extrapolated to infinite basis space by an exponential form, and compared with the extrapolated valence-space IMSRG results and experimental data available.

Published
2022
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40. STCF conceptual design report (Volume 1): Physics & detector

Author

Achasov, M., Ai, X. C., An, L. P., Aliberti, R., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, X., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X., Chen, X. F., Chen, X. R., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Cheng, T. G., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Dias, J. M., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Gao, Y. N., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gou, B., Gradl, W., Gu, J. L., Guevara, A., Gui, L. C., Guo, A. Q., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, W. H., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X., Li, X. H., Li, X. Q., Li, X. H., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liang, Y. T., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, D. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, K., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, J. X., Lu, N., Lü, Q. F., Lu, Y., Lu, Y., Lu, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Ma, Y. M., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tian, Y., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, K. P., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. W., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yuan, Z. Y., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, Q. A., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. J., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y., Zhang, Y., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Y. X., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. P., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.

Published
2024
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41. ATOMS: ALMA Three-millimeter Observations of Massive Star-forming regions -- X. Chemical differentiation among the massive cores in G9.62+0.19

Author

Peng, Y. P., Liu, T., Qin, S. -L., Baug, T., Liu, H. -L., Wang, K., Garay, G., Zhang, C., Chen, L. -F., Lee, C. W., Juvela, M., Li, D. L., Tatematsu, K., Liu, X. -C., Lee, J. -E., Luo, G., Dewangan, L., Wu, Y. -F., Zhang, L., Bronfman, L., Ge, J. X., Tang, M. Y., Zhang, Y., Xu, F. -W., Wang, Y., and Zhou, B.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Investigating the physical and chemical structures of massive star-forming regions is critical for understanding the formation and the early evolution of massive stars. We performed a detailed line survey toward six dense cores named as MM1, MM4, MM6, MM7, MM8, and MM11 in G9.62+0.19 star-forming region resolved in ALMA band 3 observations. Toward these cores, about 172 transitions have been identified and attributed to 16 species including organic Oxygen-, Nitrogen-, Sulfur-bearing molecules and their isotopologues. Four dense cores MM7, MM8, MM4, and MM11 are line rich sources. Modeling of these spectral lines reveals the rotational temperature in a range of 72$-$115~K, 100$-$163~K, 102$-$204~K, and 84$-$123~K for the MM7, MM8, MM4, and MM11, respectively. The molecular column densities are 1.6 $\times$ 10$^{15}$ $-$ 9.2 $\times$ 10$^{17}$~cm$^{-2}$ toward the four cores. The cores MM8 and MM4 show chemical difference between Oxygen- and Nitrogen-bearing species, i.e., MM4 is rich in oxygen-bearing molecules while nitrogen-bearing molecules especially vibrationally excited HC$_{3}$N lines are mainly observed in MM8. The distinct initial temperature at accretion phase may lead to this N/O differentiation. Through analyzing column densities and spatial distributions of O-bearing Complex Organic Molecules (COMs), we found that C$_{2}$H$_{5}$OH and CH$_{3}$OCH$_{3}$ might have a common precursor, CH$_{3}$OH. CH$_{3}$OCHO and CH$_{3}$OCH$_{3}$ are likely chemically linked. In addition, the observed variation in HC$_{3}$N and HC$_{5}$N emission may indicate that their different formation mechanism at hot and cold regions., Comment: 40 pages, 23 figures

Published
2022
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44. Mass measurements show slowdown of rapid proton capture process at waiting-point nucleus 64Ge

Author

Zhou, X., Wang, M., Zhang, Y. H., Litvinov, Yu. A., Meisel, Z., Blaum, K., Zhou, X. H., Hou, S. Q., Li, K. A., Xu, H. S., Chen, R. J., Deng, H. Y., Fu, C. Y., Ge, W. W., He, J. J., Huang, W. J., Jiao, H. Y., Li, H. F., Li, J. G., Liao, T., Litvinov, S. A., Liu, M. L., Niu, Y. F., Shuai, P., Shi, J. Y., Song, Y. N., Sun, M. Z., Wang, Q., Xing, Y. M., Xu, X., Xu, F. R., Yan, X. L., Yang, J. C., Yu, Y., Yuan, Q., Yuan, Y. J., Zeng, Q., Zhang, M., and Zhang, S.

Published
2023
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47. Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment

Author

Li J, Zhu N, Wang Y, Bao Y, Xu F, Liu F, and Zhou X

Subjects
metabolomics, traditional chinese medicine, type 2 diabetes mellitus, diabetic complications, diagnosis, Specialties of internal medicine, RC581-951
Abstract

Jing Li,1,&ast; Na Zhu,2,&ast; Yaqiong Wang,2 Yanlei Bao,3 Feng Xu,2 Fengjuan Liu,2 Xuefeng Zhou2 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, People’s Republic of China; 2Clinical Trial Research Center, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Central Hospital, Qingdao, People’s Republic of China; 3Department of Pharmacy, Liaoyuan People’s Hospital, Liaoyuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuefeng Zhou, Clinical Trial Research Center, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Central Hospital, No. 127, Siliunan Road, Shibei District, Qingdao, Shandong, 266042, People’s Republic of China, Tel +86 18561856181, Email zhouxuefeng5019@163.comAbstract: Diabetes is a major global public health problem with high incidence and case fatality rates. Traditional Chinese medicine (TCM) is used to help manage Type 2 Diabetes Mellitus (T2DM) and has steadily gained international acceptance. Despite being generally accepted in daily practice, the TCM methods and hypotheses for understanding diseases lack applicability in the current scientific characterization systems. To date, there is no systematic evaluation system for TCM in preventing and treating T2DM. Metabonomics is a powerful tool to predict the level of metabolites in vivo, reveal the potential mechanism, and diagnose the physiological state of patients in time to guide the follow-up intervention of T2DM. Notably, metabolomics is also effective in promoting TCM modernization and advancement in personalized medicine. This review provides updated knowledge on applying metabolomics to TCM syndrome differentiation, diagnosis, biomarker discovery, and treatment of T2DM by TCM. Its application in diabetic complications is discussed. The combination of multi-omics and microbiome to fully elucidate the use of TCM to treat T2DM is further envisioned.Keywords: metabolomics, traditional Chinese medicine, type 2 diabetes mellitus, diabetic complications, diagnosis

Published
2023

48. Rhamnolipid Micelles Assist Azithromycin in Efficiently Disrupting Staphylococcus aureus Biofilms and Impeding Their Re-Formation

Author

Lin S, Li X, Zhang Y, Zhang W, Shu G, Li H, Xu F, Lin J, and Fu H

Subjects
staphylococcus aureus, antibiofilm, rhamnolipid, biosurfactant, nanomicelle, Medicine (General), R5-920
Abstract

Shiyu Lin,&ast; Xiaojuan Li,&ast; Yuning Zhang,&ast; Wei Zhang, Gang Shu, Haohuan Li, Funeng Xu, Juchun Lin, Hualin Fu Innovative Engineering Research Center of Veterinary Pharmaceutics, Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hualin Fu, Tel +86 28 82691162, Fax +86 28 82652669, Email fuhl2005@sohu.comIntroduction: Biofilm is highly resistant to antibiotics due to its heterogeneity and is implicated in over 80% of chronic infections; these refractory and relapse-prone infections pose a huge medical burden.Methods: In this study, rhamnolipid (RHL), a biosurfactant with antibiofilm activity, was loaded with the antibiotic azithromycin (AZI) to construct a stable nanomicelle (AZI@RHL) that promotes Staphylococcus aureus (S. aureus) biofilm disruption.Results: AZI@RHL micelles made a destruction in biofilms. The biofilm biomasses were reduced significantly by 48.2% (P< 0.05), and the main components polysaccharides and proteins were reduced by 47.5% and 36.8%, respectively. These decreases were about 3.1 (15.9%), 7.3 (6.5%), and 1.9 (19.5%) times higher compared with those reported for free AZI. The disruption of biofilm structure was observed under a confocal microscope with fluorescent labeling, and 48.2% of the cells in the biofilm were killed. By contrast, the clearance rates of cells were only 20% and 17% when treated alone with blank micelles or free AZI. Biofilm formation was inhibited up to 92% in the AZI@RHL group due to effects on cell auto-aggregation and eDNA release. The rates for the other groups were significantly lower, with only 27.7% for the RHL group and 12% for the AZI group (P< 0.05). The low cell survival and great formation inhibition could reduce biofilm recolonization and re-formation.Conclusion: The antibiofilm efficacy of rhamnolipid was improved through micellar nanoparticle effects when loading azithromycin. AZI@RHL provides a one-step solution that covers biofilm disruption, bacteria inactivation, recolonization avoidance, and biofilm re-formation inhibition. Keywords: Staphylococcus aureus, antibiofilm, rhamnolipid, biosurfactant, nanomicelle

Published
2023

49. Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema

Author

Cui Y, Hu J, Li Y, Au R, Fang Y, Cheng C, Xu F, Li W, Wu Y, Zhu L, and Shen H

Subjects
network pharmacology, ulcerative colitis, enema therapy, tlr4/myd88/nf-κb pathway, Therapeutics. Pharmacology, RM1-950
Abstract

Yuan Cui,1,2 Jingyi Hu,2 Yanan Li,1,2 Ryan Au,1,2 Yulai Fang,2 Cheng Cheng,1 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Lei Zhu,2 Hong Shen2 1Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of ChinaCorrespondence: Lei Zhu; Hong Shen, Tel/Fax +86-25- 86617141, Email shenhong999@njucm.edu.cn; zhulei5100@njucm.edu.cnBackground: Baiyu Decoction (BYD), a clinical prescription of traditional Chinese medicine, has been proven to be valuable for treating ulcerative colitis (UC) by enema. However, the mechanism of BYD against UC remains unclear.Purpose: A combination of bioinformatics methods including network pharmacology and molecular docking and animal experiments were utilized to investigate the potential mechanism of BYD in the treatment of UC.Materials and Methods: Firstly, the representative compounds of each herb in BYD were detected by liquid chromatography-mass spectrometry. Subsequently, we predicted the core targets and potential pathways of BYD for treating UC through network pharmacology. And rat colitis model was established with dextran sodium sulfate. UC rats were subjected to BYD enema administration, during which we recorded body weight changes, disease activity index, and colon length to assess the effectiveness of BYD. Besides, quantitative real-time PCR, western blotting, ELISA and immunofluorescence were used to detect intestinal inflammatory factors, intestinal barrier biomarkers and TOLL-like receptor pathway in rats. Finally, the core components and targets of BYD were subjected to molecular docking so as to further validate the results of network pharmacology.Results: A total of 41 active compositions and 203 targets related to BYD-UC were subjected to screening. The results of bioinformatics analysis showed that quercetin and kaempferol may be the main compounds. Additionally, AKT1, IL-6, TP53, TNF and IL-1β were regarded as potential therapeutic targets. KEGG results explained that TOLL-like receptor pathway might play a pivotal role in BYD protecting against UC. In addition, animal experiments and molecular docking validated the network pharmacology results. BYD enema treatment can reduce body weight loss, lower disease activity index score, reverse colon shortening, relieve intestinal inflammation, protect intestinal barrier, and inhibit TOLL-like receptor pathway in UC rats. Besides, molecular docking suggested that quercetin and kaempferol docked well with TLR4, AKT1, IL-6, TP53.Conclusion: Utilizing network pharmacology, animal studies, and molecular docking, enema therapy with BYD was confirmed to have anti-UC efficacy by alleviating intestinal inflammation, protecting the intestinal barrier, and inhibiting the TOLL-like receptor pathway. Researchers should focus not only on oral medications but also on the rectal administration of medications in furtherance of the cure of ulcerative colitis. Keywords: network pharmacology, ulcerative colitis, enema therapy, TLR4/MyD88/NF-κB pathway

Published
2023

50. Higher High-Mobility Group Box-1 Levels are Associated with White Matter Lesions in Ischemic Stroke Patients

Author

Zhao J, Xu F, Xu W, Lv R, Wang J, and Yang X

Subjects
ischemic stroke, high-mobility-group box 1, white matter lesions, inflammation., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Jie Zhao,1 Fang Xu,2 Wanying Xu,1 Rong Lv,1 Juan Wang,3 Xufeng Yang1 1Department of Geriatrics, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China; 2Department of Obstetrics and Gynecology, Suzhou Wujiang District Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, 215200, People’s Republic of China; 3Department of Endocrine, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of ChinaCorrespondence: Xufeng Yang, Department of Geriatrics, Suzhou Ninth People’s Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, Jiangsu, 215200, People’s Republic of China, Tel/Fax +86 0512-82881332, Email yangxufeng2013@163.comBackground and Purpose: High-mobility group box-1 (HMGB1) is a useful biomarker for disease severity stratification and prognosis prediction. We aim to explore whether the circulating HMGB1 concentrations are associated with the white matter lesions (WMLs) burden in stroke patients.Methods: Between 2022 June and December 2022, patients with acute ischemic stroke were prospectively enrolled. HMGB1 levels were measured by an enzyme-linked immunosorbent assay after admission for all patients. The WMLs severity was assessed by the Fazekas scale. We dichotomized patients into those with moderate–severe WMLs (Fazekas score 3– 6) versus those with none–mild WMLs (Fazekas score 0– 2). Furthermore, based on the severity of periventricular WMLs (PWMLs) and deep WMLs (DWMLs), patients were categorized as none–mild (Fazekas score 0– 1) or moderate–severe (Fazekas score 2– 3).Results: A total of 287 participants (mean age: 64.9 years; 157 male) were analyzed. The median serum HMGB1 levels were 7.3 ng/mL (interquartile, 4.3 ng/mL– 12.3 ng/mL). After adjustment for potential confounders, elevated HMGB1 levels were associated with the presence of moderate–severe WMLs (first quartile vs fourth quartile, odds ratio [OR], 4.101; 95% confidence interval [CI], 1.948– 8.633; P = 0.001) and moderate–severe PWMLs (first quartile vs fourth quartile, OR, 9.181; 95% CI, 4.078– 20.671; P = 0.001). Similar results were found when the HMGB1 levels were analyzed as a continuous variable.Conclusion: This study demonstrated that increased HMGB1 levels were associated with the severity of WMLs, mainly in the periventricular region.Keywords: ischemic stroke, high-mobility-group box 1, white matter lesions, inflammation

Published
2023

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