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Your search keyword '"Xu, Chuan-Yi"' showing total 6 results
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6 results on '"Xu, Chuan-Yi"'

4. Caveola is a key vehicle for paraquat uptake into lung

Author

Pang Qingfeng, Xu chuan-yi, Zhao jing, and Yan wen-jing

Subjects
Paraquat, Lung, Polyamine transport, Caveola, Clone (cell biology), General Medicine, respiratory system, Biology, Pharmacology, chemistry.chemical_compound, medicine.anatomical_structure, Biochemistry, chemistry, Caveolae, medicine, High incidence, Lung tissue, Polyamine
Abstract

Paraquat dichloride (PQ) is an effective and widely used herbicide for eliminating weeds. However, once being accidentally or voluntarily ingested, PQ-poisoned patients have the very high incidence of adult respiratory distress syndrome because lung can actively absorb PQ. Since the 1970s, evidence suggested that polyamine competitively inhibited uptake of PQ into lung tissue; therefore, polyamine transport system has been regarded as an important vehicle for PQ uptake into lung. However, so far, we cannot clone or detect the polyamine transport system in mammalian animal. Recent evidence from diverse sources has suggested that caveola may be an important vehicle for polyamine absorption into lung. Herein we hypothesise that caveola is a key vehicle for PQ uptake in lung and hence blocking the expression of caveola may serve as new targets for treatment of PQ poisoning.

Published
2012

6. [Value of nasal bone and serological screening for the detection of fetal chromosomal disorders in second trimester].

Author

Xu CY, Liu X, and Jin XY

Subjects
Female, Humans, Pregnancy, Pregnancy Trimester, Second, Serologic Tests, Chromosome Disorders blood, Chromosome Disorders diagnostic imaging, Nasal Bone diagnostic imaging, Ultrasonography, Prenatal
Abstract

Objective: To assess the value of fetal chromosomal abnormality screening by a maternal serum test plus fetal nasal bone length in second trimester (parallel test)., Methods: From January 2009 to December 2010, fetal nasal bone was measured at 19 - 22 weeks gestation in 6173 unselected cases. Karyotyping was performed in cases with a high risk for maternal serum test and/or abnormal fetal nasal bone length. All cases were followed-up postnatally., Results: Nasal bone was assessed successfully in 5607 cases (90.83%). Normally it is increases with gestational age. The detection rate of chromosomal abnormality was 69.64% by maternal serum test, 79.76% by maternal serum test plus hypoplastic nasal bone and 83.93% by maternal serum test plus shortened nasal bone., Conclusion: Fetal nasal bone hypoplasia is closely correlated with chromosomal abnormality. And sonographic evaluation of nasal bone may be a useful tool for screening chromosomal abnormality. The combination of maternal serum test and fetal nasal bone length will boost the detection rate of chromosomal abnormality.

Published
2012

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