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30 results on '"Xu, Bingzhe"'

7. Worm Generator: A System for High-Throughput in Vivo Screening

Author

Yang, Anqi, Lin, Xiang, Liu, Zijian, Duan, Xin, Yuan, Yurou, Zhang, Jiaxuan, Liang, Qilin, Ji, Xianglin, Sun, Nannan, Yu, Huajun, He, Weiwei, Zhu, Lili, Xu, Bingzhe, Lin, Xudong, Yang, Anqi, Lin, Xiang, Liu, Zijian, Duan, Xin, Yuan, Yurou, Zhang, Jiaxuan, Liang, Qilin, Ji, Xianglin, Sun, Nannan, Yu, Huajun, He, Weiwei, Zhu, Lili, Xu, Bingzhe, and Lin, Xudong

Abstract

Large-scale screening of molecules in organisms requires high-throughput and cost-effective evaluating tools during preclinical development. Here, a novel in vivo screening strategy combining hierarchically structured biohybrid triboelectric nanogenerators (HB-TENGs) arrays with computational bioinformatics analysis for high-throughput pharmacological evaluation using Caenorhabditis elegans is described. Unlike the traditional methods for behavioral monitoring of the animals, which are laborious and costly, HB-TENGs with micropillars are designed to efficiently convert animals’ behaviors into friction deformation and result in a contact-separation motion between two triboelectric layers to generate electrical outputs. The triboelectric signals are recorded and extracted to various bioinformation for each screened compound. Moreover, the information-rich electrical readouts are successfully demonstrated to be sufficient to predict a drug’s identity by multiple-Gaussian-kernels-based machine learning methods. This proposed strategy can be readily applied to various fields and is especially useful in in vivo explorations to accelerate the identification of novel therapeutics.

Published
2023

8. Worm Generator: A System for High-Throughput in Vivo Screening

Author

Yang, Anqi, primary, Lin, Xiang, additional, Liu, Zijian, additional, Duan, Xin, additional, Yuan, Yurou, additional, Zhang, Jiaxuan, additional, Liang, Qilin, additional, Ji, Xianglin, additional, Sun, Nannan, additional, Yu, Huajun, additional, He, Weiwei, additional, Zhu, Lili, additional, Xu, Bingzhe, additional, and Lin, Xudong, additional

Published
2023
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10. Ferromagnetic Flexible Electronics for Brain‐Wide Selective Neural Recording

Author

Liu, Yuxin, primary, Chen, Xi, additional, Liang, Ye, additional, Song, Hao, additional, Yu, Peng, additional, Guan, Shunmin, additional, Liu, Zijian, additional, Yang, Anqi, additional, Tang, Minghui, additional, Zhou, Yajing, additional, Zheng, Ying, additional, Yang, Zhilun, additional, Jiang, Lelun, additional, He, Jufang, additional, Tan, Ning, additional, Xu, Bingzhe, additional, and Lin, Xudong, additional

Published
2022
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16. Biohybrid Triboelectric Nanogenerator for Label-Free Pharmacological Fingerprinting in Cardiomyocytes

Author

Ji, Xianglin, Fang, Peilin, Xu, Bingzhe, Xie, Kai, Yue, Haibing, Luo, Xuan, Wang, Zixun, Zhao, Xi, Shi, Peng, Ji, Xianglin, Fang, Peilin, Xu, Bingzhe, Xie, Kai, Yue, Haibing, Luo, Xuan, Wang, Zixun, Zhao, Xi, and Shi, Peng

Abstract

The development of new drugs requires high-throughput and cost-effective pharmacological assessment in relevant biological models. Here, we introduce a novel pharmacological screening platform that combines a biohybrid triboelectric nanogenerator (TENG) and informatic analysis for self-powered, noninvasive, and label-free biosensing in cardiac cells. The cyclic mechanical activity of functional cardiomyocytes is dynamically captured by a specially designed biohybrid TENG device and is analyzed by a custom-made machine learning algorithm to reveal distinctive fingerprints in response to different pharmacological treatment. The core of the TENG device is a multilayer mesh substrate with microscale-gapped triboelectric layers, which are induced to generate electrical outputs by the characteristic motion of cardiomyocytes upon pharmaceutical treatment. Later bioinformatic extraction from the recorded TENG signal is sufficient to predict a drug's identity and efficacy, demonstrating the great potential of this platform as a biocompatible, low-cost, and highly sensitive drug screening system.

Published
2020

24. Investigation of the Subcellular Neurotoxicity of Amyloid-β Using a Device Integrating Microfluidic Perfusion and Chemotactic Guidance

Author

Li, Wei, primary, Xu, Zhen, additional, Xu, Bingzhe, additional, Chan, Chung Yuen, additional, Lin, Xudong, additional, Wang, Ying, additional, Chen, Ganchao, additional, Wang, Zhigang, additional, Yuan, Qiuju, additional, Zhu, Guangyu, additional, Sun, Hongyan, additional, Wu, Wutian, additional, and Shi, Peng, additional

Published
2017
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30. Effects of in vivo exposure to polyfluorinated dibenzo- p -dioxins on organo-somatic indices and ethoxyresorufin- O -deethylase activity in mice ( Mus musculus ).

Author

Feng, Mingbao, Jin, Hao, Qu, Ruijuan, Xu, Bingzhe, and Wang, Zunyao

Subjects
FLUORINATION, DIBENZODIOXIN, SOMATIC cells, CYTOCHROME P-450 CYP1A1, CHEMICAL synthesis, LABORATORY mice
Abstract

In this study, five different congeners of polyfluorinated dibenzo-P-dioxins (PFDDs) (1,8-di-FDD, 1,3,8-tri-FDD, 1,3,6,8-tetra-FDD, 2,3,7,8-tetra-FDD and 1,2,3,4,5,6,7,8-octa-FDD), representing different numbers and positions of fluorine substituents of all 75 PFDD congeners, were synthesized and purified to evaluate their potential environmental impact on living organisms. Their toxicity was evaluated by determining the impact on the organo-somatic indices (OSI) and ethoxyresorufin-O-deethylase (EROD) activity in mice (Mus musculus) after intragastric administration with different doses (0.5–100 μg/kg body weight) for 3 days. The results showed that these PFDDs significantly inhibited the growth and changed the OSI in mouse tissues. Notably, hepatic EROD activity was markedly induced in mice after exposure to these PFDDs, probably indicating a high affinity of binding to the aryl hydrocarbon receptor. Overall, these findings provided some preliminary but alarming toxicity data of PFDDs, and filled information gaps in the toxicological databases for living organisms. [ABSTRACT FROM PUBLISHER]

Published
2016
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