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155 results on '"Xu, Baijie"'

1. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia

Author

Zapata, Rizaldy C, Zhang, Dinghong, Libster, Avraham, Porcu, Alessandra, Montilla-Perez, Patricia, Nur, Aisha, Xu, Baijie, Zhang, Zhi, Correa, Stephanie M, Liu, Chen, Telese, Francesca, and Osborn, Olivia

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Neurosciences, Genetics, Nutrition, Behavioral and Social Science, Obesity, Aetiology, 2.1 Biological and endogenous factors, Cancer, Cardiovascular, Metabolic and endocrine, Stroke, Animals, Humans, Mice, Agouti-Related Protein, Antipsychotic Agents, Eating, Hyperphagia, Hypothalamus, Olanzapine, Receptors, Cytoplasmic and Nuclear, Weight Gain, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Antipsychotic (AP) drugs are efficacious treatments for various psychiatric disorders, but excessive weight gain and subsequent development of metabolic disease remain serious side effects of their use. Increased food intake leads to AP-induced weight gain, but the underlying molecular mechanisms remain unknown. In previous studies, we identified the neuropeptide Agrp and the transcription factor nuclear receptor subfamily 5 group A member 2 (Nr5a2) as significantly upregulated genes in the hypothalamus following AP-induced hyperphagia. While Agrp is expressed specifically in the arcuate nucleus of the hypothalamus and plays a critical role in appetite stimulation, Nr5a2 is expressed in both the CNS and periphery, but its role in food intake behaviors remains unknown. In this study, we investigated the role of hypothalamic Nr5a2 in AP-induced hyperphagia and weight gain. In hypothalamic cell lines, olanzapine treatment resulted in a dose-dependent increase in gene expression of Nr5a2 and Agrp. In mice, the pharmacological inhibition of NR5A2 decreased olanzapine-induced hyperphagia and weight gain, while the knockdown of Nr5a2 in the arcuate nucleus partially reversed olanzapine-induced hyperphagia. Chromatin-immunoprecipitation studies showed for the first time that NR5A2 directly binds to the Agrp promoter region. Lastly, the analysis of single-cell RNA seq data confirms that Nr5a2 and Agrp are co-expressed in a subset of neurons in the arcuate nucleus. In summary, we identify Nr5a2 as a key mechanistic driver of AP-induced food intake. These findings can inform future clinical development of APs that do not activate hyperphagia and weight gain.

Published
2023

4. Enzymatic Activation and Continuous Electrochemical Production of Methane from Dilute CO2Sources with a Self-Healing Capsule

Author

Wang, Jinfeng, Jing, Xu, Yang, Yang, Xu, Baijie, Jia, Ruiming, and Duan, Chunying

Abstract

Converting dilute CO2source into value-added chemicals and fuels is a promising route to reduce fossil fuel consumption and greenhouse gas emission, but integrating electrocatalysis with CO2capture still faced marked challenges. Herein, we show that a self-healing metal–organic macrocycle functionalized as an electrochemical catalyst to selectively produce methane from flue gas and air with the lowest applied potential so far (0.06 V vs reversible hydrogen electrode, RHE) through an enzymatic activation fashion. The capsule emulates the enzyme’ pocket to abstract one in situ-formed CO2-adduct molecule with the commercial amino alcohols, forming an easy-to-reduce substrate-involving clathrate to combine the CO2capture with electroreduction for a thorough CO2reduction. We find that the self-healing system exhibited enzymatic kinetics for the first time with the Michaelis–Menten mechanism in the electrochemical reduction of CO2and maintained a methane Faraday efficiency (FE) of 74.24% with a selectivity of over 99% for continuous operation over 200 h. A consecutive working lab at 50 mA·cm–2, in an eleven-for-one (10 h working and 1 h healing) electrolysis manner, gives a methane turnover number (TON) of more than 10,000 within 100 h. The integrated electrolysis with CO2capture facilitates the thorough reduction of flue gas (ca. 13.0% of CO2) and first time of air (ca. 400 ppm of CO2to 42.7 mL CH4from 1.0 m3air). The new self-healing strategy of molecular electrocatalyst with an enzymatic activation manner and anodic shifting of the applied potentials provided a departure from the existing electrochemical catalytic techniques.

Published
2024
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7. Engineering NH2‐Cu‐NH2 Triple‐atom Sites in Defective MOFs for Selective Overall Photoreduction of CO2 into CH3COCH3.

Author

Zhang, Mengrui, Zhang, Dan, Jing, Xu, Xu, Baijie, and Duan, Chunying

Subjects
COUPLING reactions (Chemistry), AMINO group, CARBON sequestration, ELECTRON capture, METAL-organic frameworks, COPPER ions, PHOTOREDUCTION
Abstract

Selective photoreduction of CO2 to multicarbon products, is an important but challenging task, due to high CO2 activation barriers and insufficient catalytic sites for C−C coupling. Herein, a defect engineering strategy for incorporating copper sites into the connected nodes of defective metal–organic framework UiO‐66‐NH2 for selective overall photo‐reduction of CO2 into acetone. The Cu2+ site in well‐modified CuN2O2 units served as a trapping site to capture electrons via efficient electron‐hole separation, forming the active Cu+ site for CO2 reduction. Two NH2 groups in CuN2O2 unit adsorb CO2 and cooperated with copper ion to functionalize as a triple atom catalytic site, each interacting with one CO2 molecule to strengthen the binding of *CO intermediate to the catalytic site. The deoxygenated *CO attached to the Cu site interacted with *CH3 fixed at one amino group to form the key intermediate CO*‐CH3, which interacted with the third reduction intermediate on another amino group to produce acetone. Our photocatalyst realizes efficient overall CO2 reduction to C3 product acetone CH3COCH3 with an evolution rate of 70.9 μmol gcat−1 h−1 and a selectivity up to 97 % without any adducts, offering a promising avenue for designing triple‐atomic sites to producing C3 product from photosynthesis with water. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Engineering NH2‐Cu‐NH2 Triple‐atom Sites in Defective MOFs for Selective Overall Photoreduction of CO2 into CH3COCH3.

Author

Zhang, Mengrui, Zhang, Dan, Jing, Xu, Xu, Baijie, and Duan, Chunying

Subjects
COUPLING reactions (Chemistry), AMINO group, CARBON sequestration, ELECTRON capture, METAL-organic frameworks, COPPER ions, PHOTOREDUCTION
Abstract

Selective photoreduction of CO2 to multicarbon products, is an important but challenging task, due to high CO2 activation barriers and insufficient catalytic sites for C−C coupling. Herein, a defect engineering strategy for incorporating copper sites into the connected nodes of defective metal–organic framework UiO‐66‐NH2 for selective overall photo‐reduction of CO2 into acetone. The Cu2+ site in well‐modified CuN2O2 units served as a trapping site to capture electrons via efficient electron‐hole separation, forming the active Cu+ site for CO2 reduction. Two NH2 groups in CuN2O2 unit adsorb CO2 and cooperated with copper ion to functionalize as a triple atom catalytic site, each interacting with one CO2 molecule to strengthen the binding of *CO intermediate to the catalytic site. The deoxygenated *CO attached to the Cu site interacted with *CH3 fixed at one amino group to form the key intermediate CO*‐CH3, which interacted with the third reduction intermediate on another amino group to produce acetone. Our photocatalyst realizes efficient overall CO2 reduction to C3 product acetone CH3COCH3 with an evolution rate of 70.9 μmol gcat−1 h−1 and a selectivity up to 97 % without any adducts, offering a promising avenue for designing triple‐atomic sites to producing C3 product from photosynthesis with water. [ABSTRACT FROM AUTHOR]

Published
2024
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13. High-Spatial-Resolution Distributed Acoustic Sensor Utilizing a Positive- and Negative-Swept Pulse

Author

Xiao, Xunzhou, He, Jun, Du, Bin, Xu, Baijie, Chen, Guanfeng, Xu, Xizhen, Chen, George Yuhui, and Wang, Yiping

Abstract

A distributed acoustic sensor (DAS) with a one- centimeter spatial resolution is proposed and demonstrated using pulse-compression phase-sensitive optical time-domain reflectometry (Φ-OTDR). A positive- and negative- swept pulse was used to expand the frequency modulation range of a heterodyne DAS system to achieve a high spatial resolution. A Rayleigh-enhanced single-mode fiber (eSMF) was used to magnify the backscattering signal and suppress the fading noise. The combination of pulse compression and eSMF allows the system to fully quantify perturbations with a high spatial resolution of 1.2 cm and a strain resolution of 1.46 nϵ/√Hz. In addition, the detection and positioning of multiple acoustic emission (AE) sources at frequencies of 120∼130 kHz is also demonstrated. Hence, the high-spatial-resolution DAS system proposed in this work could potentially be used for structural health monitoring for large equipment, such as spacecrafts, hypersonic vehicles, and deep-sea submersibles.

Published
2024
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20. A clinical practice guideline for the screening and assessment of enthesitis in patients with spondyloarthritis

Author

Wu, Xinyu, primary, Liu, Dong, additional, Li, Yanfei, additional, Xie, Ya, additional, Tu, Liudan, additional, Zhang, Yanli, additional, Zhang, Xi, additional, Fang, Linkai, additional, Luo, Xiqing, additional, Lin, Zhiming, additional, Liao, Zetao, additional, Rong, Limin, additional, Ren, Jie, additional, Zhou, Yuqi, additional, Yang, Niansheng, additional, Xu, Jian, additional, Zhang, Hua, additional, Xu, Baijie, additional, Wu, Zhenbiao, additional, Zhan, Feng, additional, Li, Zhenbin, additional, Xiao, Weiguo, additional, Liu, Shengyun, additional, Zhou, Yi, additional, Ye, Shanhui, additional, Lv, Qing, additional, Zhang, Lijun, additional, Zhao, Dongbao, additional, He, Shanzhi, additional, Zhao, Like, additional, Wu, Lijun, additional, Lin, He, additional, Zhu, Yunxiao, additional, Guo, Donggeng, additional, Yang, Zehong, additional, Liu, Budian, additional, Yang, Kehu, additional, and Gu, Jieruo, additional

Published
2022
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30. Nuclear receptor 5A2 regulation of Agrpunderlies olanzapine-induced hyperphagia

Author

Zapata, Rizaldy C., Zhang, Dinghong, Libster, Avraham, Porcu, Alessandra, Montilla-Perez, Patricia, Nur, Aisha, Xu, Baijie, Zhang, Zhi, Correa, Stephanie M., Liu, Chen, Telese, Francesca, and Osborn, Olivia

Abstract

Antipsychotic (AP) drugs are efficacious treatments for various psychiatric disorders, but excessive weight gain and subsequent development of metabolic disease remain serious side effects of their use. Increased food intake leads to AP-induced weight gain, but the underlying molecular mechanisms remain unknown. In previous studies, we identified the neuropeptide Agrpand the transcription factor nuclear receptor subfamily 5 group A member 2 (Nr5a2) as significantly upregulated genes in the hypothalamus following AP-induced hyperphagia. While Agrpis expressed specifically in the arcuate nucleus of the hypothalamus and plays a critical role in appetite stimulation, Nr5a2is expressed in both the CNS and periphery, but its role in food intake behaviors remains unknown. In this study, we investigated the role of hypothalamic Nr5a2in AP-induced hyperphagia and weight gain. In hypothalamic cell lines, olanzapine treatment resulted in a dose-dependent increase in gene expression of Nr5a2and Agrp. In mice, the pharmacological inhibition of NR5A2 decreased olanzapine-induced hyperphagia and weight gain, while the knockdown of Nr5a2in the arcuate nucleus partially reversed olanzapine-induced hyperphagia. Chromatin-immunoprecipitation studies showed for the first time that NR5A2 directly binds to the Agrppromoter region. Lastly, the analysis of single-cell RNA seq data confirms that Nr5a2and Agrpare co-expressed in a subset of neurons in the arcuate nucleus. In summary, we identify Nr5a2as a key mechanistic driver of AP-induced food intake. These findings can inform future clinical development of APs that do not activate hyperphagia and weight gain.

Published
2023
Full Text
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