1. Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: an adult case report and literature review
- Author
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Mingliang Feng, Yuxiong Wang, Yuantao Wang, Yongsheng Lei, Honglan Zhou, and Xin Lian
- Subjects
0301 basic medicine ,Adult ,chromosomal rearrangement ,congenital, hereditary, and neonatal diseases and abnormalities ,Medicine (General) ,TFE3 ,Chromosomal translocation ,Case Report ,urologic and male genital diseases ,Biochemistry ,Translocation, Genetic ,Pathogenesis ,Fusion gene ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Renal cell carcinoma ,medicine ,Humans ,Carcinoma, Renal Cell ,fluorescence in situ hybridization ,neoplasms ,In Situ Hybridization, Fluorescence ,Chromosomes, Human, X ,medicine.diagnostic_test ,business.industry ,Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ,Biochemistry (medical) ,Cell Biology ,General Medicine ,medicine.disease ,TFE3+ ,Kidney Neoplasms ,eye diseases ,female genital diseases and pregnancy complications ,030104 developmental biology ,immunohistochemical staining ,030220 oncology & carcinogenesis ,Cancer research ,Immunohistochemistry ,prognosis ,Differential diagnosis ,Gene Fusion ,business ,Xp11.2/TFE3 associated renal cell carcinoma ,Fluorescence in situ hybridization - Abstract
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 ( TFE3) gene fusion is a rare and independent subtype of RCC included in the classification of MiT (microphthalmia-associated transcriptional factor) family translocation RCC. Herein, we report an adult case of Xp11.2 translocation RCC, and review the relevant literature to improve our understanding of the pathogenesis, epidemiology, clinical manifestations, diagnosis, differential diagnosis, treatment, and other aspects of the disease.
- Published
- 2020