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The aim of this study was to investigate the effects of rehabilitation training on Notch1 and synaptophysin (SYN) levels in brain tissues of rats with chronic cerebral ischemia.

(1) Objective: To investigate the feasibility, safety, and effectiveness of a brain–computer interface (BCI) system with visual and motor feedback in limb and brain function rehabilitation after stroke. (2) Methods: First, we recruited three hemiplegic stroke patients to perform rehabilitation training using a BCI system with visual and motor feedback for two consecutive days (four sessions) to verify the feasibility and safety of the system. Then, we recruited five other hemiplegic stroke patients for rehabilitation training (6 days a week, lasting for 12–14 days) using the same BCI system to verify the effectiveness. The mean and Cohen’s w were used to compare the changes in limb motor and brain functions before and after training. (3) Results: In the feasibility verification, the continuous motor state switching time (CMSST) of the three patients was 17.8 ± 21.0s, and the motor state percentages (MSPs) in the upper and lower limb training were 52.6 ± 25.7% and 72.4 ± 24.0%, respectively. The effective training revolutions (ETRs) per minute were 25.8 ± 13.0 for upper limb and 24.8 ± 6.4 for lower limb. There were no adverse events during the training process. Compared with the baseline, the motor function indices of the five patients were improved, including sitting balance ability, upper limb Fugel–Meyer assessment (FMA), lower limb FMA, 6 min walking distance, modified Barthel index, and root mean square (RMS) value of triceps surae, which increased by 0.4, 8.0, 5.4, 11.4, 7.0, and 0.9, respectively, and all had large effect sizes (Cohen’s w ≥ 0.5). The brain function indices of the five patients, including the amplitudes of the motor evoked potentials (MEP) on the non-lesion side and lesion side, increased by 3.6 and 3.7, respectively; the latency of MEP on the non-lesion side was shortened by 2.6 ms, and all had large effect sizes (Cohen’s w ≥ 0.5). (4) Conclusions: The BCI system with visual and motor feedback is applicable in active rehabilitation training of stroke patients with hemiplegia, and the pilot results show potential multidimensional benefits after a short course of treatment.

Glucocorticoids (GCs) are frequently used to treat many of the acute disease manifestations associated with inflammatory and autoimmune disorders. However, Toll-like receptor (TLR) pathway-activated plasmacytoid dendritic cells (pDCs) are resistant to GC-induced apoptosis, which leads to the inefficiency of GCs in the treatment of type I interferon-related autoimmune diseases, such as systemic lupus erythematosus (SLE). Therefore, compounds promoting pDC apoptosis may be helpful for improving the efficacy of GCs. In this study, we performed screening to identify microRNAs (miRNAs) involved in TLR-inhibited GC-induced pDC apoptosis and found an array of miRNAs that may regulate pDC apoptosis. Among those demonstrating altered expression, 6 miRNAs were inhibited in TLR-activated pDCs. Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE.

Detailed and systematic analyses of the magnetic and grain-size properties of the Weihe River sediments were conducted to explore effective proxies that could reflect variations in the runoff. Ultimately, the magnetic parameter χARM/χlf was considered a reliable proxy owing to the close relationship with grain-size fraction larger than 63 μm, with a correlation coefficient of 0.90. By combining accelerator mass spectrometry radiocarbon (AMS 14C) dating, a timescale ranging from 12,900 year BP to the present was established for the section. Accordingly, the reconstructed runoff variations showed that, from 12,900 to 9,600 year BP, the hydrodynamic force of the river was relatively strong, and the runoff was large. From 9,600 to 7,500 year BP, these two parameters varied from weak to strong, and the trend continued to increase from 7,500 to 5,300 year BP. At 5,300 year BP, the sediments shifted from the fluvial to the continental environment, indicating a marked decrease in the runoff. Although the resolution and pattern of this reconstruction were rough, this is a significant analysis among the historical runoff studies based on floodplain sediments, and the results showed trends that to some extent coincide with the variations in the intensity of the East Asian Summer Monsoon. HIGHLIGHTS An integrated study of Weihe River sediments using environmental magnetism and particle size analysis.; Establishing a chronological framework for the Weihe sedimentary profile using AMS14C dating.; The magnetic ratio parameter χARM/χlf is extracted as an effective proxy for indicating river runoff.; The results show that the runoff process of the Weihe River is mainly controlled by the East Asian summer winds.;