1. Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial
- Author
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Shengbing, Zhao, Yihang, Song, Shuling, Wang, Rong, Wang, Zhijie, Feng, Aixia, Gong, Xia, Yang, Peng, Pan, Dongmei, Yao, Jingwen, Zhang, Yaqin, Zhu, Tao, Li, Junhua, Bi, Xu, Ren, Xiufen, Tang, Qiang, Li, Dan, Yu, Jinghua, Zheng, Bo, Song, Ping, Wang, Weigang, Chen, Guochen, Shang, Yanqiu, Xu, Ping, Xu, Yuexing, Lai, Huanhai, Xu, Xiaomin, Yang, Jianqiu, Sheng, Yurong, Tao, Xinghua, Li, Yangbei, Zhu, Xiaofeng, Zhang, Hongzhang, Shen, Yingcai, Ma, Fangyu, Wang, Lin, Wu, Xianfei, Wang, Zhaoshen, Li, and Yu, Bai
- Subjects
Hepatology ,Gastroenterology - Abstract
Although the 9-minute mean withdrawal time (m-WT) is often reported to be associated with the optimal adenoma detection rate (ADR), no randomized trials of screening colonoscopy have confirmed the impact of a 9-minute m-WT on adenoma miss rate (AMR) and ADR.A multicenter tandem trial was conducted in 11 centers. Seven hundred thirty-three asymptomatic participants were randomized to receive segmental tandem screening colonoscopy with a 9-minute withdrawal, followed by a 6-minute withdrawal (9-minute-first group, 9MF, n = 366) or vice versa (6-minute-first group, 6MF, n = 367). The primary outcome was the lesion-level AMR.The intention-to-treat analysis revealed that 9MF significantly reduced the lesion-level (14.5% vs 36.6%, P0.001) and participant-level AMR (10.9% vs 25.9%, P0.001), advanced adenoma miss rate (AAMR, 5.3% vs 46.9%, P = 0.002), multiple adenomas miss rate (20.7% vs 56.5%, P = 0.01), and high-risk adenomas miss rate (14.6% vs 39.5%, P = 0.01) of 6MF without compromising detection efficiency ( P = 0.79). In addition, a lower false-negative rate for adenomas ( P = 0.002) and high-risk adenomas ( P0.05), and a lower rate of shortening surveillance schedule ( P0.001) were also found in 9MF, accompanying with an improved ADR in the 9-minute vs 6-minute m-WT (42.3% vs 33.5%, P = 0.02). The independent inverse association between m-WT and AMR remained significant even after adjusting ADR, and meanwhile, 9-minute m-WT was identified as an independent protector for AMR and AAMR.In addition to increasing ADR, 9-minute m-WT also significantly reduces the AMR and AAMR of screening colonoscopy without compromising detection efficiency.
- Published
- 2022